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PhD C.C. Paulusma

Position
Assistant Professor
Main activities
Research
Specialisation
Biochemistry, cell biology, phospholipid transport, Hepatobiliary transport, cholestasis
Focus of research

Our research is centered around the cellular and pathophysiological functions of P4 ATPases, lipid flippases that are implicated in the biogenesis of transport vesicles. Genome-wide association studies predict a role for various P4 ATPases as predisposing factors in complex diseases, including atherosclerosis, rheumatoid arthritis, type 2 diabetes and Alzheimer’s disease. It is our goal to delineate the role of P4 ATPases in aforementioned diseases.

Key publications
  • de Waart Dirk R., Naik Jyoti, Utsunomiya Karina S., Duijst Suzanne, Ho-Mok Kam, Bolier A. Ruth, Hiralall Johan, Bull Laura N., Bosma Piter J., Oude Elferink Ronald P. J., Paulusma Coen C. ATP11C targets basolateral bile salt transporter proteins in mouse central hepatocytes Hepatology (Baltimore, Md.) 2016;64 (1):161-174 [PubMed]
  • Vaz Frédéric M., Paulusma Coen C., Huidekoper Hidde, de Ru Minke, Lim Cynthia, Koster Janet, Ho-Mok Kam, Bootsma Albert H., Groen Albert K., Schaap Frank G., Oude Elferink Ronald P. J., Waterham Hans R., Wanders Ronald J. A. Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype Hepatology (Baltimore, Md.) 2015;61 (1):260-267 [PubMed]
  • van der Mark Vincent A., de Waart D. Rudi, Ho-Mok Kam S., Tabbers Merit M., Voogt Heleen W., Oude Elferink Ronald P. J., Knisely A. S., Paulusma Coen C. The lipid flippase heterodimer ATP8B1-CDC50A is essential for surface expression of the apical sodium-dependent bile acid transporter (SLC10A2/ASBT) in intestinal Caco-2 cells BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2014;1842 (12 Part A):2378-2386 [PubMed]
  • Kunne Cindy, de Graaff Marijke, Duijst Suzanne, de Waart Dirk R., Oude Elferink Ronald P. J., Paulusma Coen C. Hepatic cytochrome P450 deficiency in mouse models for intrahepatic cholestasis predispose to bile salt-induced cholestasis Laboratory investigation; a journal of technical methods and pathology 2014;94 (10):1103-1113 [PubMed]
  • Paulusma Coen C., Houwen Roderick H. J., Williamson Patrick L. The flip side of cardiolipin import Nature medicine 2011;17 (4):413 [PubMed]
All Publications
Research programmes

Prof. PhD R.P.J. Oude Elferink (Hepatic metabolism and transport processes)