foto

PhD E.E.J.M. Creemers

Position
Research Associate
Main activities
Research
Specialisation
Molecular biologist
Focus of research

Our lab studies specific facets of RNA biology, such as alternative splicing, circular RNA formation and the function of RNA binding proteins in the setting of heart failure. By combining molecular biological techniques, mouse genetics and physiological cardiac phenotyping we analyze the function of genes related to RNA processing in the heart.

Key publications
  • van den Hoogenhof Maarten M. G., Beqqali Abdelaziz, Amin Ahmad S., van der Made Ingeborg, Aufiero Simona, Khan Mohsin A. F., Schumacher Cees A., Jansweijer Joeri A., van Spaendonck-Zwarts Karin Y., Remme Carol Ann, Backs Johannes, Verkerk Arie O., Baartscheer Antonius, Pinto Yigal M., Creemers Esther E. RBM20 Mutations Induce an Arrhythmogenic Dilated Cardiomyopathy Related to Disturbed Calcium Handling Circulation 2018;138 (13):1330-1342 [PubMed]
  • Houweling Arjan C., Beaman Glenda M., Postma Alex V., Blair Gainous T., Lichtenbelt Klaske D., Brancati Francesco, Lopes Filipa M., van der Made Ingeborg, Polstra Abeltje M., Robinson Michael L., Wright Kevin D., Ellingford Jamie M., Jackson Ashley R., Overwater Eline, Genesio Rita, Romano Silvio, Camerota Letizia, D'Angelo Emanuela, Meijers-Heijboer Elizabeth J., Christoffels Vincent M., McHugh Kirk M., Black Brian L., Newman William G., Woolf Adrian S., Creemers Esther E. Loss-of-function variants in myocardin cause congenital megabladder in humans and mice Journal of clinical investigation 2019;129 (12):5374-5380 [PubMed]
  • Aufiero Simona, Reckman Yolan J., Pinto Yigal M., Creemers Esther E. Circular RNAs open a new chapter in cardiovascular biology Nature reviews. Cardiology 2019 [PubMed]
  • Khan Mohsin A. F., Reckman Yolan J., Aufiero Simona, van den Hoogenhof Maarten M. G., van der Made Ingeborg, Beqqali Abdelaziz, Koolbergen Dave R., Rasmussen Torsten B., van der Velden Jolanda, Creemers Esther E., Pinto Yigal M. RBM20 Regulates Circular RNA Production From the Titin Gene Circulation research 2016;119 (9):996-1003 [PubMed]
  • Creemers Esther E., Bawazeer Amira, Ugalde Alejandro P., van Deutekom Hanneke W. M., van der Made Ingeborg, de Groot Nina E., Adriaens Michiel E., Cook Stuart A., Bezzina Connie R., Hubner Norbert, van der Velden Jolanda, Elkon Ran, Agami Reuven, Pinto Yigal M. Genome-Wide Polyadenylation Maps Reveal Dynamic mRNA 3'-End Formation in the Failing Human Heart Circulation research 2016;118 (3):433-438 [PubMed]
All Publications
Research programmes

Prof. PhD Y. Pinto (Molecular genetics of heart failure)

PhD E.E.J.M. Creemers (Promoties)

Current research funding
  • AMC
  • AMC (Vrijgesteld)