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PhD M.W. Veldkamp

Position
Research Associate
Main activities
Education, Research
Specialisation
Cardiac Cellular Electrophysiology
Focus of research

Research is focused on elucidating the mechanisms underlying cardiac arrhythmias in which the regulation and (mal)function of ion channels, transporters and calcium-handling proteins plays a central role. Insight into arrhythmia mechanisms is achieved by studying electrical activity with the patch-clamp technique in various preparations including: isolated neonatal and adult cardiomyocytes, isolated intracardiac neurons, mammalian cell expression systems etc. Specific projects include:
- The cardiac sodium channel as part of a multi-molecular protein complex
- Differential expression and regulation of the cardiac sodium channels localized to different subcellular micro-domains of the cardiac myocyte
- Biophysical properties of cardiac and neuronal ion channel mutations associated with arrhythmia syndromes
- The role of the cardiac autonomous nervous system in atrial fibrillation: effects of neuropeptides on atrial electrophysiology
- Functional remodeling of intracardiac neurons in heart failure
 

Key publications
  • Casini Simona, Tan Hanno L., Demirayak Ilker, Remme Carol Ann, Amin Ahmad S., Scicluna Brendon P., Chatyan Houssine, Ruijter Jan M., Bezzina Connie R., van Ginneken Antoni C. G., Veldkamp Marieke W. Tubulin polymerization modifies cardiac sodium channel expression and gating Cardiovascular research 2010;85 (4):691-700 [PubMed]
  • Casini Simona, Tan Hanno L., Bhuiyan Zahurul A., Bezzina Connie R., Barnett Phil, Cerbai Elisabetta, Mugelli Alessandro, Wilde Arthur A. M., Veldkamp Marieke W. Characterization of a novel SCN5A mutation associated with Brugada syndrome reveals involvement of DIIIS4-S5 linker in slow inactivation Cardiovascular research 2007;76 (3):418-429 [PubMed]
  • Veldkamp Marieke W., Wilders Ronald, Baartscheer Antonius, Zegers Jan G., Bezzina Connie R., Wilde Arthur A. M. Contribution of sodium channel mutations to bradycardia and sinus node dysfunction in LQT3 families Circulation research 2003;92 (9):976-983 [PubMed]
  • Veldkamp M. W., Verkerk A. O., van Ginneken A. C., Baartscheer A., Schumacher C., de Jonge N., de Bakker J. M., Opthof T. Norepinephrine induces action potential prolongation and early afterdepolarizations in ventricular myocytes isolated from human end-stage failing hearts European heart journal 2001;22 (11):955-963 [PubMed]
  • Verkerk Arie O., Remme Carol Ann, Schumacher Cees A., Scicluna Brendon P., Wolswinkel Rianne, de Jonge Berend, Bezzina Connie R., Veldkamp Marieke W. Functional Na(V)1.8 Channels in Intracardiac Neurons The Link Between SCN10A and Cardiac Electrophysiology Circulation research 2012;111 (3):333-343 [PubMed]
All Publications
Research programmes

PhD M.W. Veldkamp (Promoties)

MD PhD R. Coronel (Mechanisms of sudden cardiac death)

Current research funding
  • Bayer AG
  • Life Sciences Health TKI