Prof. A.A.M. Wilde PhD

Full Professor
Main activities
Patient care, Research, Other
Clinical aspects of heart failure and arrhythmias
Focus of research
  • Arrhythmias
  • Cardiomyopathy
  • Electrophysiology
  • Genetics
  • Sudden death
Key publications
  • van der Werf Christian, Kannankeril Prince J., Sacher Frederic, Krahn Andrew D., Viskin Sami, Leenhardt Antoine, Shimizu Wataru, Sumitomo Naokata, Fish Frank A., Bhuiyan Zahurul A., Willems Albert R., van der Veen Maurits J., Watanabe Hiroshi, Laborderie Julien, Haïssaguerre Michel, Knollmann Björn C., Wilde Arthur A. M. Flecainide Therapy Reduces Exercise-Induced Ventricular Arrhythmias in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia Journal of the American College of Cardiology 2011;57 (22):2244-2254 [PubMed]
  • Bezzina Connie R., Barc Julien, Mizusawa Yuka, Remme Carol Ann, Gourraud Jean-Baptiste, Simonet Floriane, Verkerk Arie O., Schwartz Peter J., Crotti Lia, Dagradi Federica, Guicheney Pascale, Fressart Véronique, Leenhardt Antoine, Antzelevitch Charles, Bartkowiak Susan, Borggrefe Martin, Schimpf Rainer, Schulze-Bahr Eric, Zumhagen Sven, Behr Elijah R., Bastiaenen Rachel, Tfelt-Hansen Jacob, Olesen Morten Salling, Kääb Stefan, Beckmann Britt M., Weeke Peter, Watanabe Hiroshi, Endo Naoto, Minamino Tohru, Horie Minoru, Ohno Seiko, Hasegawa Kanae, Makita Naomasa, Nogami Akihiko, Shimizu Wataru, Aiba Takeshi, Froguel Philippe, Balkau Beverley, Lantieri Olivier, Torchio Margherita, Wiese Cornelia, Weber David, Wolswinkel Rianne, Coronel Ruben, Boukens Bas J., Bézieau Stéphane, Charpentier Eric, Chatel Stéphanie, Despres Aurore, Gros Françoise, Kyndt Florence, Lecointe Simon, Lindenbaum Pierre, Portero Vincent, Violleau Jade, Gessler Manfred, Tan Hanno L., Roden Dan M., Christoffels Vincent M., Le Marec Hervé, Wilde Arthur A., Probst Vincent, Schott Jean-Jacques, Dina Christian, Redon Richard Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death Nature genetics 2013;45 (9):1044-1049 [PubMed]
  • Priori Silvia G., Wilde Arthur A., Horie Minoru, Cho Yongkeun, Behr Elijah R., Berul Charles, Blom Nico, Brugada Josep, Chiang Chern-En, Huikuri Heikki, Kannankeril Prince, Krahn Andrew, Leenhardt Antoine, Moss Arthur, Schwartz Peter J., Shimizu Wataru, Tomaselli Gordon, Tracy Cynthia HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes: document endorsed by HRS, EHRA, and APHRS in May 2013 and by ACCF, AHA, PACES, and AEPC in June 2013 Heart rhythm 2013;10 (12):1932-1963 [PubMed]
  • Hofman Nynke, Tan Hanno L., Alders Mariëlle, Kolder Iris, de Haij Simone, Mannens Marcel M. A. M., Lombardi Maria Paola, Lekanne Deprez Ronald H., van Langen Irene, Wilde Arthur A. M. Yield of molecular and clinical testing for arrhythmia syndromes: report of 15 years' experience Circulation 2013;128 (14):1513-1521 [PubMed]
  • Wilde Arthur A. M., Moss Arthur J., Kaufman Elizabeth S., Shimizu Wataru, Peterson Derick R., Benhorin Jesaia, Lopes Coeli, Towbin Jeffrey A., Spazzolini Carla, Crotti Lia, Zareba Wojciech, Goldenberg Ilan, Kanters Jørgen K., Robinson Jennifer L., Qi Ming, Hofman Nynke, Tester David J., Bezzina Connie R., Alders Marielle, Aiba Takeshi, Kamakura Shiro, Miyamoto Yoshihiro, Andrews Mark L., McNitt Scott, Polonsky Bronislava, Schwartz Peter J., Ackerman Michael J. Clinical Aspects of Type 3 Long-QT Syndrome: An International Multicenter Study Circulation 2016;134 (12):872-882 [PubMed]
All Publications
Curriculum Vitae

Curriculum Vitae

Name : Wilde, Arthur Arnold Maria
Address : Ringdijk 27, 3645 HE Vinkeveen
Telephone (home) : 0297-263108
Birth date and place : 7 juli 1956 te Herwen en Aerdt

Secondary School : Atheneum B

University :
1974 - 1975 : Biology, University of Amsterdam.
1975 - 1983 : Medicine, University of Amsterdam.
Nov. 1980 - Sept. 1981 : Assistant in the Laboratory of Experimental Cardiology of the Department of Clinical and Experimental Cardiology (University of Amsterdam).
Nov. 1983 : MD, University of Amsterdam.

Feb. 1984 - Dec. 1988 : Researcher in the laboratory of Experimental Cardiology of the department of Clinical and Experimental Cardiology (University of Amsterdam, headed by Prof.Dr. M.J. Janse). A significant part of the research was performed at the University of Bern, Switserland (Physiologisches Institut headed by Prof.Dr. A.G. Kléber).
Feb. 1988 : Ph.D. Thesis: Myocardial ischemia and hypoxia. Cellular ionic and electrical activity. University of Amsterdam.
Promotor: Prof.Dr. M.J. Janse, Co-promotor: Prof.Dr. A.G. Kléber

Jan. 1989 - March 1991 Resident Internal Medicine, AMC Amsterdam (Prof.Dr. J. Vreeken).
April 1991 - Oct. 1994 : Resident Cardiology, AMC Amsterdam, registered per 1-10-1994.
(Dr. G.K. David; Prof.Dr. K.I. Lie).
April 1994 - Oct. 1995: Resident Clinical Electrophysiology, University Hospital Utrecht, Utrecht (AZU, Prof.Dr. R.N.W. Hauer).
October 1994 Appointed as Cardiologist (University teacher) in the AMC (until August 1999 40% in the AZU, Department of Clinical EP).
From Aug. 1999 University Master teacher (University of Amsterdam)
Aug. 1999: Head of the laboratory of Experimental Cardiology (AMC).

March 2000 Appointed as Professor in Cardiology with special interest in the Experimental Cardiology (University of Amsterdam).
February 2003 Appointed as Professor in Cardiology and Head of the Department of Clinical and Experimental Cardiology (University of Amsterdam)

2012 - Chair of the Heart Centre Division, AMC, Amsterdam, NL

2011 - Appointed as visiting professor at King Abdullahsiz University Hospital, Jeddah (KAS).
2013 - Appointed as visiting professor at Columbia University, NY (NY, USA).

Scientific profile and honors
1995 Appointed by the Netherlands Heart Foundation as a Clinical Established Investigator (1996-2000).

2005: 30th annual conference of the International Society for Computerized Electrocardiography: “The Kenichi Harumi lecture“ (Lihue, USA).
2007 The 10th annual Gordon K. Moe visiting professorship at the Masonic Medical Research Laboratory. Utica (NY, USA).
2009 Descartes-Huygens Prize (French Academy of Sciences)
2011 “The Dan May lecture” (Nashville, TN, USA).
2011 Appointed as member of the Dutch Academy of Science (KNAW)
2012 Distinguished Scientist Award, Heart Rhythm Society (USA).

2014 London (UK): The Michael Davis memorial lecture
2015 Aomori (Japan): Honorary lecture “Lake Kawaguchi conference on Sudden Cardiac Death”

2000-2013 Numerous prizes by the PhD students working in the group (poster prizes, travel grants, young investigator prizes).

Visiting Professorships:

USA: Utica 2007, MAYO clinics 2008, Columbia NY 2007-2016 (yearly). Washington University St Louis 2012, Ceders Sinaï Los Angeles (CA) 2012.

Japan: Osaka 2009.

Australia: Sydney 2013.

Kingdom of Saudi Arabia: Jeddah 2011, 2012, 2013, 2014.


Keynote lectures
Germany 2006: 33rd International Congress of Electrocardiology
UK 2008: British Cardiac Society annual meeting.
KSA 2008: The 19th scientific sess. of the Saudi Heart Association.
Japan 2009: Japanese IVF Registry 2009.
France 2009: 2nd Denis Escande symposium.
Germany 2009: klinische Rhythmologie
Italy 2010: Symposium VF: how to prevent and treat
Turkey 2010: PEDIRHYTHM 4.
Ireland 2010: The Irish Heart Foundation. SCD prevention IV.

China 2013: 5th ventricular arrhythmia symposium China.
Australia 2013: 61st annual Scientific Sessions of the Card. Soc. of Aust. & NZ.
South Korea 2014: National Cardiology Society Annual meeting.
Japan 2014: 29th Annual Scientific Sess. of Japanese Heart Rhythm Society.
Australia 2014: International Clinical Cardiovascular Genetics Conference.


Editorial board:

Associate Editor Cardiovascular Research (1995-2003).
Associate Editor Neth Heart J (1997- ).
Associate Editor Europace (2007-2014).
Associate Editor Heart Rhythm (2014- ).

Member Editorial Board J Cardiovasc Electrophysiology (2002- ).
Member Editorial Board Heart Rhythm (2004-2013).
Member Editorial board Circ Arrhythmia & Electrophysiol (2008- ).
Member Editorial board Europace (2014- ).

Member Editorial Board Can J Cardiology (2014- ).


Research programmes

Prof. A.A.M. Wilde PhD (Clinical and Basic Electrophysiology)

The project aimed to identify disease-causing genes and to unravel the pathophysiological basis of inherited cardiac diseases. The focus was placed on genotype-phenotype studies in different cardiomyopathies, among which hypertrophic cardiomyopathy and arrhythmogenic cardiomyopathy, and in primary arrhythmias syndromes (Long QT syndrome, Brugada syndrome). Diverse genetic aspects of the Long QT syndrome were also addressed. In addition, the focus was shifted towards the role of more frequently occurring genetic aberrancies on electrocardiographic parameters. Finally, we continued to sample patients with ischemia-induced ‘primary’ VF and demonstrated that a strong genetic component is involved.

Theme: Cardiovascular Diseases

This research group participates in the Heart Failure Research Centre

C.E. Conrath PhD
R.E. Knops
P.G. Meregalli PhD
P.G. Postema PhD

A.S. Amin PhD
N. Hofman PhD

N. Bruinsma
C. van der Werf PhD

Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • Europese Unie
  • Guidant Europe NV, a Boston Scientific Company
  • Medtronic Bakken Research Center BV
  • Nederlandse Hartstichting
  • Netherlands Heart Institute
  • TOP Medical B.V.
  • University of British Colombia
  • ZonMw