Prof. C.I.J. Ponsioen MD PhD

Full Professor
Main activities
Patient care, Research
Gastroenterology & Hepatology
Focus of research

Inflammatory Bowel Disease.

Primary Sclerosing Cholangitis

Key publications
  • Rossen Noortje G., Fuentes Susana, van der Spek Mirjam J., Tijssen Jan G., Hartman Jorn H. A., Duflou Ann, Löwenberg Mark, van den Brink Gijs R., Mathus-Vliegen Elisabeth M. H., de Vos Willem M., Zoetendal Erwin G., D'Haens Geert R., Ponsioen Cyriel Y. Findings From a Randomized Controlled Trial of Fecal Transplantation for Patients With Ulcerative Colitis Gastroenterology 2015;149 (1):110-118.e4 [PubMed]
  • Ponsioen Cyriel Y., Chapman Roger W., Chazouillères Olivier, Hirschfield Gideon M., Karlsen Tom H., Lohse Ansgar W., Pinzani Massimo, Schrumpf Erik, Trauner Michael, Gores Gregory J. Surrogate Endpoints for Clinical Trials in Primary Sclerosing Cholangitis: Review and Results From an International PSC Study Group Consensus Process Hepatology (Baltimore, Md.) 2016;63 (4):1357-1367 [PubMed]
  • Boonstra Kirsten, Weersma Rinse K., van Erpecum Karel J., Rauws Erik A., Spanier B. W. Marcel, Poen Alexander C., van Nieuwkerk Karin M., Drenth Joost P., Witteman Ben J., Tuynman Hans A., Naber Anton H., Kingma Paul J., van Buuren Henk R., van Hoek Bart, Vleggaar Frank P., van Geloven Nan, Beuers Ulrich, Ponsioen Cyriel Y., Abilakh Missier E. T., Baak L. C., van Bentem N., van den Brande J. M., Brink M. A., Bruins Slot W., Cahen D. L., Claessen M. M., Depla A. C., de Groot G., van den Hazel S. J., Janse M., Klompmaker I. J., Korkmaz K. S., Kuyvenhoven J. Ph, Ledeboer M., Loffeld B. C., Loffeld R. J., Mallant-Hent R. C., Oosting P. R., Riemens S. C., Schmidt Böhmer J., Scholten P., Stadhouders P. H., Tan G., Teunen A., Thijs J. C., Verhagen M. A., Viergever P. P., Vrij A. A., Weinhardt O., Witteman E. M. Population-based epidemiology, malignancy risk, and outcome of primary sclerosing cholangitis Hepatology (Baltimore, Md.) 2013;58 (6):2045-2055 [PubMed]
All Publications
Research programmes

Prof. C.I.J. Ponsioen MD PhD (PSC and inflammatory bowel disease)

1. Primary sclerosing cholangitis (PSC): in search for the missing link between the colon and the liver.

Over the last 5 years we have set up a collaborative programme in the Netherlands to accrue a large population-based cohort of PSC patients (and primary biliary cirrhosis and IBD patients, as well as healthy controls) to study the epidemiology and clinical course of PSC. Together with the UMCGroningen we lead the International PSC Study Group iChip subphenotyping project, in which we investigate gene-phenotype associations in 3500 PSC patients.

The cause of PSC and the nature of its relation to IBD is still elusive. Our research is focused on understanding the crosstalk between the colon and the bile ducts by studying the aberrant gut homing lymphocyte mechanism.

As for clinical studies my group focuses on defining the most appropriate surrogate parameters for clinical trials. In addition I lead the international multicenter IIS DILSTENT trial, in which we compare two endoscopic treatments for dominant bile duct strictures.


2. Inflammatory Bowel disease.

My group investigates the role of faecal microbiota in ulcerative colitis; we have conducted a randomized trial of fecal transplantation in ulcerative colitis, the TURN trial, which has yielded a wealth of data. This has prompted us to design TURN2, building on the results of TURN1.

Together with the department of surgery we drive the LIR!C trial, in which we compare laparoscopic ileocecal resection with infliximab for exacerbation of Crohn's disease.

Medewerkers buiten research programmes van afdeling Maag-Darm-Leverziekten


Current research funding
  • Boston Scientific International SA
  • EASL
  • Life Sciences Health TKI
  • Maag, Lever, Darm Stichting
  • PSC Partners Seeking a Cure
  • Pliant Therapeutics Inc.
  • Shire Pharmaceutical Development Ltd
  • Siemens Healthcare Nederland B.V.
  • Stichting Auto Immuun Onderzoek
  • Takeda Nederland bv
  • ZonMw