foto

Prof. dr. A. Kalsbeek

Position
Professor
Main activities
Research
Specialisation
Experimental NeuroEndocrinology
Focus of research

- Role of the hypothalamus in neuro-endocrine regulation of energy metabolism

- Autonomic innervation of liver and adipose tissue

- Circadian control of hormone rhythms

Key publications
  • Buijs RM, Kalsbeek A, Hypothalamic integration of central and peripheral clocks. NAT REV NEUROSCI 2001;2 (7):521-526 [PubMed]
  • Klieverik LP, Janssen SF, van Riel A, Foppen E, Bisschop PH, Serlie MJ, Boelen A, Ackermans MT, Sauerwein HP, Fliers E, Kalsbeek A, Thyroid hormone modulates glucose production via a sympathetic pathway from the hypothalamic paraventricular nucleus to the liver. P NATL ACAD SCI USA 2009;106 (14):5966-5971 [PubMed]
  • Yi CX, Serlie MJ, Ackermans MT, Foppen E, Buijs RM, Sauerwein HP, Fliers E, Kalsbeek A, A Major Role for Perifornical Orexin Neurons in the Control of Glucose Metabolism in Rats. DIABETES 2009;58 (9):1998-2005 [PubMed]
  • Bruinstroop E, Pei L, Ackermans MT, Foppen E, Borgers AJ, Kwakkel J, Alkemade A, Fliers E, Kalsbeek A, Hypothalamic Neuropeptide Y (NPY) Controls Hepatic VLDL-Triglyceride Secretion in Rats via the Sympathetic Nervous System. DIABETES 2012;61 (5):1043-1050 [PubMed]
  • Yi CX, Foppen E, Abplanalp W, Gao Y, Alkemade A, la Fleur SE, Serlie MJ, Fliers E, Buijs RM, Tschöp MH, Kalsbeek A, Glucocorticoid Signaling in the Arcuate Nucleus Modulates Hepatic Insulin Sensitivity. DIABETES 2012;61 (2):339-345 [PubMed]
All Publications
Curriculum Vitae

CURRICULUM VITAE


Name: Kalsbeek, Andries

Birthdate: November 26, 1958, Drachten, The Netherlands

Citizenship: Dutch

Address (1): Department of Endocrinology and Metabolism
Academic Medical Center (AMC), G2-133
University of Amsterdam (UVA)
Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

Telephone: (+31)(0)20-5661765
Fax: (+31)(0)20-6917682

E-mail: A.Kalsbeek@amc.uva.nl

Homepage: http://www.amc.nl/?pid=2427&rm=person&medewerkerid=514


Address (2): Netherlands Institute for Neuroscience
Hypothalamic Integration Mechanisms
Meibergdreef 47
1105 BA Amsterdam, The Netherlands

Telephone: (+31)(0)20-5665500 / 65522
Fax: (+31)(0)20-5666121

E-mail: A.Kalsbeek@nin.knaw.nl

Homepage: http://www.kalsbeekgroup.nl




QUALIFICATIONS

November 1984 Master’s Degree, Biology
- Main subjects: behavioural physiology & neuroanatomy

January 1989 PhD Thesis: “Dopamine and the development of rat prefrontal
Cortex”

 

 

 

SPECIAL HONOURS, AWARDS, FELLOWSHIPS

1979 Doctorandus degree: cum laude

1988 Recipient of ETP grant for the autumn school "Genetic and Epigenetic Control of Phenotypic Expression in Nerve Cells", Italy

1989 Incentive Prize of the Amsterdam Neurological Society.

1990-1992 Recipient of a Grant from the European SCIENCE Program (A89000039)

1994 Recipient of a travelgrant to Münich from the Netherlands Organization for Scientific Research.

1994 Recipient of a 4-year NWO research grant (DFL 260.000,=) on the "Integration of circadian information in the hypothalamo-pituitary-gonadal axis. The role of the medial preoptic nucleus" (Principal Investigator)

1997 Recipient of 12-year SERVIER research grant (DFL 228.000,==) on the “SCN control of glucose homeostasis. The role of melatonin” (Principal Investigator)

1999 Recipient of a 4-year research grant from the Dutch Diabetes Foundation (DFL 346.460,=) on the “The biological clock and its control of glucose homeostasis. Central and peripheral mechanisms involving glucose counterregulation and insulin resistance” (Principal Investigator)

2000 A 2 month invited professorship at the Universite Louis Pasteur, Strasbourg, France

2001 A 1 month invited professorship at the Universite Louis Pasteur, Strasbourg, France


2001 Recipient of a 1-year research grant from the Hersenstichting Nederland (DFL 48.000,=) on the “Hypothalamic control mechanisms for the activity anticipating peak of glucocorticoids in a day active species” (Principal Investigator)

2003 A 2 month invited professorship at the Universite Louis Pasteur, Strasbourg, France

2003 Recipient of a 1-year research grant from the Hersenstichting Nederland (EURO 24.000,=) on the “Hypothalamic control mechanisms for hormonal rhythms in a day-active rodent” (Principal Investigator)

2004 Recipient of a 4-year research grant from the Dutch Diabetes Foundation (EURO 250.000,=) on the “Control of hepatic insulin resistance by the central nervous system. A study in human brain tissue and experimental animals” (Principal Investigator)

2005 A 2 month invited professorship at the Universite Louis Pasteur, Strasbourg, France

2007 Recipient of a 1-year research grant from the Hersenstichting Nederland (EURO 25.000,=) on the “Dopaminergic disfunction in schizophrenia and the development of hepatic insulin resistance”. (Principal Investigator)

2007 Recipient of a research grant from the KNAW China exchange program (EURO 82.060,=) on the “Hippocampal-hypothalamic connections and the control of the autonomic balance. Challenges to the conventional thinking about mind and body”. (Principal Investigator)

2007 A 2 month invited professorship at the Université Louis Pasteur, Strasbourg, France

2008 Recipient of a TOP research grant from ZON-MW (EURO 675.000) on the project “The Brain - Adipose Tissue axis: new connections to stay in control”. (Principal Investigator)

2011 Recipient of a STW “Perspective” program grant (EURO 6.375.000) on the project “On Time: how to fix a broken (biological) clock”. (co-applicant)

2011 Recipient of an EU collaboration program grant (EURO 2.500.000) entitled “NeuroTime” (co-applicant)

 



POSITIONS HELD

December 1984 November 1988
Ph.D Research Associate at the Netherlands Institute for Brain Research, Division of Neuroanatomy (Prefrontal Cortex & Development)

April 1989 - March 1990
Research Associate at the Netherlands Institute for Brain Research, Division of Immunocytochemistry (Hypothalamus & Physiology)

April 1990 - August 1992
Research Associate at Université Louis Pasteur, Laboratoire de Zoologie, CNRS URA 1332 Neurobiologie des Fonctions Rythmiques et Saisonnieres

September 1992 - August 1996
Research Associate at the Netherlands Institute for Brain
Research, Division of Hypothalamic Integration Mechanisms

September 1996 – December 2004
Senior scientist at the Netherlands Institute for Brain Research, Division of Hypothalamic Integration Mechanisms

January 2005 – April 2008
Team leader of the Hypothalamic Integration Mechanisms workgroup at the Netherlands Institute for Neuroscience

April 2008 –
Head of the Laboratory for Experimental Endocrinology at the Academic Medical Center of the University of Amsterdam (0.8 fte)

April 2008 –
AMC Principal Investigator at the Department of Endocrinology and Metabolism

April 2008 –
Team leader of the Hypothalamic Integration Mechanisms workgroup at the Netherlands Institute for Neuroscience (0.2 fte)

March 2012 –
Professor of Experimental Neuroendocrinology at the Academic Medical Center (AMC).

 


TEACHING

Co-promotor of theses:
R.Teclemariam-Mesbah "Rhythmic Control of Autonomic Functions. Anatomical basis for conveying timing information to the pineal and adrenal glands in rodents" (Faculty of Life Sciences, University of Strasbourg), 1991 - 1996. 10 May 1996

S. Barassin “Circadian control of melatonin release” (Faculty of Life Sciences, University of Strasbourg; Netherlands Institute for Brain Research), 1997 - 2000. 11 July 2000

I. Palm "Circadian Control of the Hypothalamo-Pituitary-Gonadal Axis", (Netherlands Institute for Brain Research), 1995 - 2001. 13 Maart 2001

S. la Fleur “Circadian control of basal and stimulated insulin release involves SCN projections to the autonomic nervous system”, (Netherlands Institute for Brain Research), 1997 – 2001. 14 Juni 2001

S. Perreau “Hypothalamic GABA release from SCN terminals and its control of circadian rhythms through the autonomic nervous system” (Faculty of Life Sciences, University of Strasbourg; Netherlands Institute for Brain Research), 1999 - 2004. 9 Juni 2004

M. Ruiter “The biological clock and its control of glucose homeostasis. Central and peripheral mechanisms involving glucose counterregulation and insulin resistance”, (Netherlands Institute for Brain Research), 2000 - 2005. 19 April 2005

C. Cailotto “The suprachiasmatic nucleus organizes daily physiology. An analysis of the role of the autonomic nervous system and peripheral clock genes”, (Faculty of Life Sciences, University of Strasbourg; Netherlands Institute for Brain Research), 2001 – 2006. 3 November 2006

L. Klieverik “The contribution of the central nervous system to metabolic effects of hyperthyroidism in liver and white adipose tissue”, (Netherlands Institute for Brain Research & Academic Medical Centre), 2004 – 2008. 17 September 2009

C. Yi “Control of hepatic insulin resistance by the central nervous system. A study in human brain tissue and experimental animals”, (Netherlands Institute for Brain Research), 2005 – 2010. 28 January 2010

J. Liu “Hypothalamic effects of estrogen on glucose metabolism and the HPA-axis”, (Academic Medical Center), 2008-2012. 4 June 2013

E. Bruinstroop “The autonomic nervous system and hepatic lipid metabolism”, (Academic medical Center), 2008-2012. 12 September 2013

 

E. Girault “Investigation of drug induced weight alterations to identify hypothalamic pathways in control of energy metabolism”, (Netherlands Institute for Neuroscience & Academic Medical Center), 2008-2012. 6 December 2013

J. Siljee “MC4R mutations; cellular toxicity in neurons and whole body regulation”, (Academic Medical Centre), 2007 – 2011.

R. v/d Spek “The Brain - Adipose Tissue axis: new connections to stay in control”, (Academic Medical Center), 2009-2013.

J.K. van den Heuvel “Brain mediators in diet-induced insulin resistance”, (Academic Medical Center), 2009-2013.

C. Diepenbroek “Hypothalamic-pancreatic interactions in diet-induced obesity”, (Academic Medical Center), 2009-2013.

E.M. de Vries “Adeno-associated viral (AAV) vector-mediated gene transfer and hypothalamic control of energy metabolism”, (Academic Medical Center), 2010-2014.

Dirk Jan Stenvers “Type 2 diabetes and the biological clock”, (Academic Medical Center), 2011-2015.

D. Herrera Moro “Sweet solutions to improve bitter remedies: hypothalamic effects of iminosugar pro-drugs”, (Academic Medical Center), 2011-2015.

J.E. Oosterman “The rhythm of feeding”, (Academic Medical Center), 2011-2015.

Yan Su “A new view on the paraventricular nucleus (PVN) and its involvement in depression”, (Netherlands Institute for Neuroscience & Academic Medical Center), 2011-2015.

Merel Rijnsburger “The neural circuitry important for diet-induced hyperphagia and centrally regulated glucose metabolism”, (Academic Medical Center), 2012-2016.

Hannah Eggink “Metabolic control of central bile acids”, (Academic Medical Center), 2012-2016.

Pawan Kumar Jha “Effects of sleep deprivation on circadian and metabolic rhythmicity in a diurnal rodent”, (Academic Medical Center & Université Louis Pasteur), 2012 – 2016.

Zhi Zhang “Effects of central thyroid hormone signalling on bone metabolism”, (Academic Medical Center), 2012-2016.

Satish Sen “Role of the nuclear receptor Rev-erbalpha in the central control of energy metabolism”, (Academic Medical Center & Université Louis Pasteur), 2013 – 2017.

 

 

 

Member of thesis committee :
N. Jacob “Integration of photoperiodic information by the suprachiasmatic nuclei. Role of melatonin and the intergeniculate leaflet” (Faculty of Life Sciences, University of Strasbourg), January 1999.

F. Gauer “Régulations physiologiques d’un message endocrine donneur de temps: la sécrétion de melatonine” (Habilitation; Faculty of Life Sciences, University of Strasbourg), December 2000.

B. Zandieh-Doulabi “Expression of thyroid hormone receptor isoforms in rodents” (Dept Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam), June 2003.

A. van den Hoek “Insulin sensitivity. Modulation by neuropeptides and hormones” (Dept Endocrinology and Metabolism, Leiden University Medical Centre), April 2006

G. Tiesjema “Understanding obesity by local overexpression of neuropeptides: a viral vector based approach” (Rudolf Magnus Instituut voor Neurowetenschappen, Afdeling Farmacologie en Anatomie), March 2007.

Anniek Koolman “The role of the endocannabinoid system in the regulation of energy balance” (University Medical Center Groningen, Department of Pediatrics), June 2010.

Joram Mul “Rat models in obesity research: functions for PMCH and LPIN1 in energy homeostasis regulation” (University Medical Center Utrecht, Hubrecht Institute), June 2010.

Edwin T. Parlevliet “Gut hormones – Novel tools in the treatment of insulin resistance” (Dept Endocrinology and Metabolism, Leiden University Medical Center), October 2010.

Esther M van der Zwaal “Olanzapine-induced weight gain. Lessons learned from developing rat models” (Rudolf Magnus Instituut voor Neurowetenschappen, Afdeling Farmacologie en Anatomie), June 2011.

Jorge Mendoza “Metabolic and reward feeding synchronizes the rhythmic brain” (Département Neurobiologie des Rythmes, Institut des Neurosciences Cellulaires et Intégratives, Universite Louis Pasteur, Strasbourg, France), September 2011.

Lu Xu “The non-preganglionic Edinger-Westphal nucleus: an integration center for energy balance and stress adaptation” (Dept Cellular Animal Physiology, Radbout University Nijmegen), December 2011.

Reina Paulien Barf “Metabolic consequences of sleep restriction in rats” (Department of Neuroendocrinology, Center for Behavior and Neurosciences, University of Groningen, Groningen), May 2012.

Claudia P Coomans “Insulin sensitivity – Modulation by the brain” (Department of Endocrinology and Metabolic Disorders, Leiden University Medical Center, Leiden), June 2012.

Anke J.F. Borgers “Hypothalamic functions in patients with pituitary insufficiency” (Department of Endocrinology and Metabolism, Academic Medical Center (AMC), Amsterdam), May 2012.

Cathalijn H Leenaars “Sleep deprivation in rats: effects on learning and flexibility” (Netherlands Institute for Neuroscience, Free University Amsterdam), June 2013.

Janine Geerling “Central nervous system control of triglyceride metabolism” (Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden), October 2013.

Dirk-Jan Saaltink “Doublecortin-like knockdown in the adult mouse brain. Implications for neurogenesis, neuroplasticity and behavior” (Leiden University Medical Center, Leiden), October 2014.

 

 

 

Supervisor of student research :
C. Binneveld (psychology student, University of Utrecht): The immunocytochemical study of the development of GABA con¬tai¬ning neurons in the rat prefrontal cortex, 1987 1988.

A.J. Voogel (medicine student, University of Amsterdam): Acute and sub acute effects of postnatal MPP application in rats, 1987 ¬1988.

- R. Teclemariah (biology student, University of Paris): Examination of the efferent projections of the suprachiasmatic nucleus in the golden hamster using a combination of immunocy¬tochemical and tracer techniques, 1990-1991.

- R. Cutrera (biology student, University of Buenos Aires): Functional significance of the serotonergic projection from the raphe nuclei to the suprachiasmatic nuclei in the golden hamster, 1991-1992.

- M. Hartwich (medicine student, University of Freiburg): Origin of the substance-P containing fibers in the suprachias¬matic nuclei of the golden hamster and the laboratory rat, 1992.

- J. Van Der Vliet (Laboratory School, Utrecht): Infusion of SCN-transmitter, via microdialysis, in the SCN target areas, 1993-1994.

- E. Daalman (Laboratory School, Utrecht): Development of the transpineal microdialysis technique, 1994.

- P. Leunissen (Faculty of Biology, Free University, Amsterdam): The role of the paraventricular nucleus of the thalamus in integrating circadian input and controlling general activity, 1994.

- I. Dijkgraaf (Laboratory School, Utrecht): Rhytmic release of Vasopressin within the SCN as measured by microdialysis, 1995.

- M. Noordermeer (Laboratory School, Utrecht): Microinfusion of VIP in the MPOA of female rats and its effects on LH and corticosterone release, 1998.

- S. Mulder (Laboratory School, Utrecht): Microdialysis of GABA- and VP -(ant)agonists in the MPOA and its effects on body temperature and locomotor activity, 1998.

- A. Franke (Faculty of Biology, University of Utrecht): Importance of the vasopressinergic innervation of the PVN for the daily TSH rhythm, 1998.

- T. Van Vliet (Faculty of Biology, University of Amsterdam): SCN-lesions and its effects on hormonal parameters of cold-exposure, 1999.

- N. Van Druten (Faculty of Biology, University of Amsterdam): Daily changes in the prolactin releasing capacity of the SCN as revealed by timed Domperidone injections, 2000.

- V. Baartmans (Laboratory School, Utrecht): Day-Night difference in the hypoglycemia induced counterregulatory growth-hormone response, 2001.

- L. van Schaik (Laboratory School, Utrecht): Development of an animal model for the continuous release of corticosterone in the periphery or the central nervous system, 2003.

- J. van Ooij (Laboratory School, Leiden): Comparing the effects of PVN or ICV vasopressin administration on the release of corticosterone, 2003.

- M. Mulder (Laboratory School, Leiden): Development of corticosterone measurements by microdialysis in the CRY knock-out mice, 2003.

- I. Schalij (Laboratory School, Utrecht): PVN control of gluconeogenesis and peripheral glucose uptake in the rat, 2004.

- E. Foppen (Laboratory School, Utrecht): Hypothalamic control of the hormonal response induced by the administration of LPS, 2004.

- M.B. Bizino (Faculty of Medicine, University of Leiden): Neuronal tracing and immunohistochemical staining for the estrogen receptor α-subtype in rats. A first step in unraveling the mechanism of estrogen-induced modulation of fat distribution, 2005.

- L. Timmermans (Faculty of Biology, University of Wageningen): Circadian control of the hormonal response induced by the administration of LPS, 2005.

- R. van der Loo (Laboratory School, Leiden): Circadian control of feeding-induced insulin responses during a 4-meal-a-day schedule, 2005.

- N. Saderi (Department of Cytomorphology, Cagliari, Italy): Connectivity of VGF-containing hypothalamic neurons, 2007.

- R. Ellenbroek (LUMC, Leiden): β-cell mass: is vagal innervation a stimulatory factor? 2007.

- M. Harakalova (University of Kosice, Slovak Republic) NPY staining in post mortem human PVN and arcuate nucleus of type 2 diabetic patients. 2007.

- P. Enthoven (RUG, Groningen) Is the hypothalamic dopaminergic system involved in the control of hepatic glucose production? 2007.

- S. Janssen (RUU, Utrecht) T3 microdialysis in the hypothalamus: effects on feeding behaviour and endogenous glucose production. 2007

- T. Richter (UVA, Amsterdam) Glucose microdialysis in the hypothalamus: effects on feeding behaviour and endogenous glucose production. 2008

- H.M. Eggink (UVA, Amsterdam) Measuring gluconeogenesis and glycogenolysis in rats. 2008

- A. van Riel (UVA, Amsterdam) T3 microdialysis in the hypothalamus and glucose metabolism: effects of the autonomic input to the liver. 2008

- M. Schop (UVA, Amsterdam) Hypothalamic control of peripheral glucose homeostasis. 2008

- A. Brouwer (VU, Amsterdam) Dopaminergic control of hepatic glucose production. 2009

- D. de Jong (UVA, Amsterdam) Effects of centrally administered thyroid hormone on neuronal activity. 2009

- R. van der Doelen (Nijmegen) Effects of centrally administered thyrotropin releasing hormone (TRH) on hypothalamic c-fos expression and glucose metabolism. 2009

- A. Dobbs (UVA, Amsterdam) Effects of centrally administered neuropeptide Y (NPY) on hypothalamic c-fos expression and hepatic lipid metabolism. 2009

- H. Boswijk (Wageningen University) The effect of chronic Olanzapine administration on the insulin cascade. 2010

- Urszula Kedzierska (University of Warsaw, Poland) – Effects of food-deprivation and ICV NPY on hypothalamic NPY and c-fos immunoreactivity. 2010

- Floortje Haest (Laboratory School, Utrecht) – Effects of retro-dialyzed orexin in different hypothalamic nuclei on lipolysis as measured with stable isotopes. 2010

- Elisa Gritsch (Universität für Bodenkultur, Wien) Relation between circadian rhythms in white adipose tissue and obesity, 2011.

- Sander Bosker (Free University, Amsterdam) Hepatice triglyceride production in Zucker rats: effects of sympathetic denervation, 2011.

- Jitske Eliveld (University of Amsterdam, Amsterdam) Effects of ICV Kisspeptin on glucose metabolism, 2012.

- Aldijana Alijagic-Boers (University of Wageningen, Wageningen) Effects of PACAP and the autonomic nervous system on hepatic triglyceride secretion, 2012.

- Violeta Castela (Free University Amsterdam) Effects of PACAP and hepatic denervation on hepatic triglyceride secretion, 2013.

- Remi Jansen (Laboratory School, Utrecht) – Effects of nocturnal light on glucose tolerance, 2013

 

 

 

INTERNATIONAL CONFERENCES ORGANIZED

1995 19th International Summer School of Brain Research “Hypothalamic Integration of Circadian Rhythms”, 28-31 August 1995, Amsterdam.

2005 24th International Summer School of Brain Research “Hypothalamic Integration of Energy Metabolism”, 29 August – 1 October, Amsterdam.

2005 X. Congress of the European Pineal and Biological Rhythm Society, 1-5 September 2005, Frankfurt/Main, Germany (International Scientific Committee).

2009 Academy Colloquium “Nutrition, Metabolism and the Brain”, 11-14 May 2009, Amsterdam, The Netherlands (Main organizer).

2009 XI. Congress of the European Pineal and Biological Rhythm Society, 1-5 September 2009, Strasbourg, France (International Scientific Committee).

2011 3rd Colloquim on “Nutrition, Metabolism and the Brain”, 26-28 April 2011, Groningen, The Netherlands (Co-organizer).

2013 4th Colloquim on “Nutrition, Metabolism and the Brain”, 24-26 April 2013, Amsterdam, The Netherlands (Main organizer).

2014 ESE Basic Endocrinology Course on “Neuroendocrinology”, 15-17 January 2014, Amsterdam, The Netherlands (co-organizer).

2014 3rd Annual NeuroTime Meeting, 4 – 6 February 2014, Amsterdam, The Netherlands (Main organizer).

2014 25th Anniversary Symposium of the Netherlands Association for the Study of Obesity, 3-4 April, Oosterbeek, The Netherlands (co-organizer).

 

 

 

MISCELLANEOUS

- Topic editor Circadian Rhythms and Metabolism for “Molecular Metabolism”

- Member of the Dutch Endocrinology Society (NVE)

- Member of the International Brain Research Organization (IBRO)

- Member of the Society for Research on Biological Rhythms (SRBR)

- Treasurer of the European Biological Rhythm Society (EBRS)

- Member of the European Neuroendocrine Society (ENEA)

- Member of the Society for Neuroscience (SFN)

- Treasurer of the Netherlands Association for the Study of Obesity (NASO)



PUBLICATIONS                                H-factor = 43 (December 2013)

(a) Key publications
BUIJS, R.M. and A. KALSBEEK - The day-night balance of everyday life: Central and peripheral clocks interacting in the hypothalamus. Nature Neurosci Rev 2(2001)521-526.
IF = 25.9

KREIER,F. E.FLIERS, P.J. VOSHOL, C.G. VAN EDEN, L.M. HAVEKES, A. KALSBEEK, C. VAN HEIJNINGEN, A.A. SLUITER, T.C. METTENLEITER, J.A. ROMIJN, H.P.SAUERWEIN and R.M. BUIJS - Selective parasympathetic innervation of subcutaneous and intra-abdominal fat - functional implications. J.Clin.Invest. 110(2002)1243-1250.
IF = 16.6

KLIEVERIK L.P., S. JANSSEN, E. FOPPEN, P.H. BISSCHOP, M. SERLIE, A. BOELEN, M.T. ACKERMANS, H.P. SAUERWEIN, E. FLIERS & A. KALSBEEK – Thyroid hormone modulates glucose production via a sympathetic pathway from the hypothalamic paraventricular nucleus to the liver. PNAS 106(2009)5966-5971.
IF = 9.4

YI, C.X., M..J. SERLIE, M.T. ACKERMANS, E. FOPPEN, R.M. BUIJS, H.P. SAUERWEIN, E FLIERS and A. KALSBEEK - A major role for perifornical orexin neurons in the control of glucose metabolism. Diabetes 58(2009)1998-2005.
IF = 8.4

KALSBEEK, A., S.E. LA FLEUR, C. VAN HEIJNINGEN and R.M. BUIJS – Suprachiasmatic GABAergic inputs to the PVN control plasma glucose concentrations in the rat via sympathetic innervation of the liver. J Neurosci 24(2004)7604-7613.
IF = 7.5

 


(b) Papers >100 citations
1. VOORN, P., A. KALSBEEK ,B. JORRITSMA BYHAM, R.M. BUIJS and H.J. GROE¬NEWEGEN The pre and postnatal development of the dopaminer¬gic innervation in the striatum of the rat. Neuroscience, 25(1¬98¬8)857 887
345

2. KALSBEEK, A., P. VOORN, R.M. BUIJS and H.B.M. UYLINGS Development of the dopaminergic innervation in the prefrontal cortex of the rat. J.Comp.Neurol., 269(1988)58 72.
252

3. BUIJS, R.M. and A. KALSBEEK - The day-night balance of everyday life: Central and peripheral clocks interacting in the hypothalamus. Nature Neurosci. Rev. 2(2001)521-526.
236

4. BUIJS, R.M., J. WORTEL, J.J. VAN HEERIKHUIZE, M.G.P. FEENSTRA, G.J. TER HORST, H.J. ROMIJN and A. KALSBEEK - Anatomical and functional demonstration of a multisynaptic suprachiasmatic nucleus adrenal (cortex) pathway. Eur.J.Neurosci. 11(1999)1535-1544.
217

5. KREIER,F., E.FLIERS, P.J. VOSHOL, C.G. VAN EDEN, L.M. HAVEKES, A. KALSBEEK, C. VAN HEIJNINGEN, A.A. SLUITER, T.C. METTENLEITER, J.A. ROMIJN, H.P.SAUERWEIN and R.M. BUIJS - Selective parasympathetic innervation of subcutaneous and intra-abdominal fat - functional implications. J.Clin.Invest. 110(2002)1243-1250.
190

6. BUIJS, R.M., C.G. VAN EDEN, V.D. GONCHARUK, and A. KALSBEEK – The biological clock tunes the organs of the body: timing by hormones and the autonomic nervous system. J.Endocrinol. 177(2003)17-26.
157

7. KALSBEEK, A., VAN HEERIKHUIZE,J.J., VAN DER WOUDE,T.P., WORTEL,J. and R.M.BUIJS - A diurnal rhythm of stimulatory input to the hypothalamo-pituitary-adrenal system as revealed by timed intrahypothalamic administration of the vasopressin V1-antagonist. J.Neuroscience 16(1996) 5555-5565.
156

8. KALSBEEK, A., TECLEMARIAM-MESBAH, R. and PÉVET,P. - Efferent projections of the suprachiasmatic nuclei in the golden ham¬ster (Mesocricetus auratus). J.Comp.Neurol., 332(1993)293-314.
147

9. KALSBEEK, A., BUIJS,R.M.,VAN HEERIKHUIZE,J.J.,ARTS,M. and VAN DER WOUDE T.P. - Vasopressin containing neurons of the suprachiasmatic nuclei inhibit corticosterone release. Brain Res., 580(1992)62-67
139

10. BUIJS, R.M., S.E.LA FLEUR, C. VAN HEIJNINGEN, J. WORTEL, L. ZUIDDAM, T.C. METTENLEITER, K. NAGAI, A. KALSBEEK and A. NIIJIMA - The suprachiasmatic nucleus balances sympathetic and parasympathetic output to peripheral organs through separate preautonomic neurons. J. Comp. Neurol. 464(2003)36-48.
135

11. KALSBEEK, A., I.F. PALM, S.E. LA FLEUR, F.A.J.L. SCHEER, S. PERREAU-LENZ, M. RUITER, F. KREIER, C. CAILOTTO and R.M. BUIJS – SCN OUTPUTS AND The hypothalamic balance of life. J Biol Rhythms 21(2006)458-469.
128

12. KALSBEEK, A. and R.M. BUIJS - Output pathways of the mammalian suprachiasmatic nucleus: coding circadian time by transmitter selection and specific targeting. Cell Tissue Res. 309(2002)109-118.
121

13. KALSBEEK,A., E. FLIERS, J.A. ROMIJN, S.E. LA FLEUR, J. WORTEL, E. ENDERT and R.M. BUIJS - The suprachiasmatic nucleus directly generates the diurnal changes in plasma leptin levels. Endocrinology 142(2001)2677-2685.
110

 

 

 

(c) Full papers
1. KALSBEEK, A., R.M.BUIJS, M.A.HOFMAN, M.A.H.MATTHIJSSEN,C.W.POOL and H.B.M.UYLINGS Effects of neonatal thermal lesioning of the mesocortical dopaminergic projection on the development of the rat prefrontal cortex. Devel.Brain Res.,32(1987)123 132.

2. KALSBEEK, A., P.VOORN,R.M.BUIJS and H.B.M.UYLINGS Development of the dopaminergic innervation in the prefrontal cortex of the rat. J.Comp.Neurol.,269(1988)58 72.

3. KALSBEEK, A., J.P.C.DE BRUIN,M.G.P.FEENSTRA and H.B.M.UYLINGS Neonatal thermal lesions of the mesolimbocortical dopaminergic projection decrease food hoarding behavior. Brain Res.,475(19¬88)80 90.

4. VOORN, P., A.KALSBEEK,B.JORRITSMA BYHAM,R.M.BUIJS and H.J.GROE¬NEWEGEN The pre and postnatal development of the dopaminer¬gic innervation in the striatum of the rat. Neuroscience,25(1¬98¬8)857 887

5. KALSBEEK, A., J.P.C.DE BRUIN,M.A.H.MATTHIJSSEN and H.B.M.UYLINGS Ontogeny of open field activity in rats after neonatal lesio¬ning of the mesocortical dopaminergic projection, Be¬hav. Brain Res., 32(1989)115-127.

6. KALSBEEK, A., M.G.P.FEENSTRA,H.VAN GALEN and H.B.M.UYLINGS Monoamine and metabolite levels in the prefrontal cortex and the mesolimbic forebrain following neonatal lesions of the ventral tegmental area. Brain Res., 479(1989)339 343.

7. KALSBEEK, A., M.A.H.MATTHIJSSEN and H.B.M.UYLINGS - Morphometric analysis of prefrontal cortical development following neonatal lesioning of the dopaminergic mesocortical projection. Exp.Br¬ain Res., 78(1989)279-289.

8. STAM, C.J., J.P.C. DE BRUIN,A.M. VAN HAELST, J.J. VAN DEN GUGTEN and A.KALSBEEK The influence of the mesocortical dopaminer¬gic system on activity, food hoarding, aggression and spatial delayed alternation in male rats. Behav.Neurosci., 103(¬1989)24-35.

9. MATTHIJSSEN, M.A.H., A.KALSBEEK and F.H. DE JONGE - Sparing of male and female sexual behaviour after neonatal depletion of the dopaminergic mesocortical projection. Neurosci. Res. Comm., 6(199¬0)95-103.

10. FEENSTRA, M.G.P., VOOGEL, A.J., KALSBEEK, A and ROLLEMA, H. - Insensitivity of early postnatal rat brain dopaminergic sys¬tems to 1-methyl-4-phenylpyridinium ion (MPP+). Biog. Amin¬es., 7(1990)425-434.

11. KALSBEEK, A., BUIJS, R.M., VAN HEERIKHUIZE, J.J., ARTS, M. and VAN DER WOUDE T.P. - Vasopressin containing neurons of the suprachiasmatic nuclei inhibit corticosterone release. Brain Res., 580(1992)62-67

12. LAKHDAR-GHAZAL, N., KALSBEEK,A. and PÉVET,P. - Sexual dimorphism and seasonal variation in vasoactive intestinal peptide immu¬noreactivity in the suprachiasmatic nucleus of Jerboa (Jaculus orientalis). Neurosci.Lett., 144(1992)29-33

13. FEENSTRA, M.G.P., KALSBEEK, A. and VAN GALEN, H. - Neonatal lesi¬ons of the ventral tegmental area affect monoaminergic respon¬ses to stress in the medial prefrontal cortex and other dopa¬mine projection areas in adulthood. Brain Res.,596(1992)169-182

14. CUTRERA, R., KALSBEEK, A. and PÉVET,P. - No Triazolam induced c-fos expression in the raphe nuclei of the golden hamster. Brain Res.,602(1993)14-20.

15. KALSBEEK, A., TECLEMARIAM-MESBAH ,R. and PÉVET,P. - Efferent projections of the suprachiasmatic nuclei in the golden ham¬ster (Mesocricetus auratus). J.Comp.Neurol.,332(1993)293-314.

16. BUIJS, R.M.,KALSBEEK,A.,VAN DER WOUDE,T.P. and VAN HEERIKHUI¬ZE,J. - Suprachiasmatic nucleus lesion increases corticostero¬ne secretion. Am.J.Physiol.,264(1993)R1186-R1192.

17. KALSBEEK, A., RIKKERS, M.,VIVIEN-ROELS, B. and PÉVET,P. - Vasopressin and Vasoactive Intestinal Peptide infused in the paraventricular nucleus of the hypothalamus elevate plasma melatonin levels. J.Pineal Res.,15(1993)46-52.

18. HERMES, M.L.H.J.,KALSBEEK,A.,BUIJS,R.M.,KIRSCH,R. and PÉVET,P. - Induction of arousal in hibernating European hamsters (Cricetus cricetus) by vasopressin infusion in the lateral septum. Brain Res.,631(1993)313-316.

19. CUTRERA, R.A., KALSBEEK, A. and PÉVET,P. - Specific destruction of the serotonergic innervation in the suprachiasmatic nuclei prevents Triazolam induced phase advances of hamster activity rhythms. Behav.Brain Res. 62(1994)21-28.

20. MASSON-PÉVET, M., GEORGE, D., KALSBEEK, A., SABOUREAU, M., LAKHDAR-GHAZAL, N. and PÉVET, P. - An attempt to correlate brain areas containing melatonin-binding sites with rhythmic functions : A study in five hibernators species. Cell Tiss.Res. 278(1994)97-106.

21. HARTWICH, M., KALSBEEK, A., PEVÉT, P. and NÜRNBERGER, F. - Effects of illumination and enucleation on Substance P-immunoreactive structures in subcortical visual centers of the Golden Hamster and the Wistar rat. Cell Tiss.Res. 277(1994)351-361.

22. KALSBEEK, A., BUIJS, R.M., ENGELMANN, M., WOTJAK, C.T. and LANDGRAF, R. - In vivo measurement of a diurnal variation in vasopressin release in the rat suprachiasmatic nucleus. Brain Res. 682(1995)75-82.

23. KALSBEEK, A., DRIJFHOUT, W.J., WESTERINK, B.H.C., VAN HEERIKHUIZE, J.J., VAN DER WOUDE, T.P., VAN DER VLIET, J. and BUIS, R.M. - GABA receptors in the region of the dorsomedial hypothalamus of rats are implicated in the control of melatonin and corticosterone release. Neuroendocrinology 63(1996)69-78.

24. KALSBEEK, A. VAN DER VLIET, J. and BUIJS, R.M. - Decrease of endogenous vasopressin release necessary for expression of the circadian rise in plasma corticosterone: A reverse microdialysis study. J. Neuroendocrinol. 8(1996)299-307.

25. KALSBEEK, A., VAN HEERIKHUIZE,J.J., VAN DER WOUDE,T.P., WORTEL,J. and R.M.BUIJS - A diurnal rhythm of stimulatory input to the hypothalamo-pituitary-adrenal system as revealed by timed intrahypothalamic administration of the vasopressin V1-antagonist. J.Neuroscience 16(1996) 5555-5565.

26. TECLEMARIAM-MESBAH,R., KALSBEEK,A., PEVET,P. and BUIJS,R.M. - Direct vasoactive intestinal polypeptide-containing projection from the suprachiasmatic nucleus to spinal cord projecting hypothalamic paraventricular neurons. Brain Res. 748(1997)71-76.

27. TECLEMARIAM-MESBAH,R., KALSBEEK, A., BUIJS,R.M. and PEVET,P. - Oxytocin innervation of spinal preganglionic neurons projecting to the superior cervical ganglion in the rat. Cell Tiss. Res. 287(1997)481-486.

28. BUIJS, R.M., J. WORTEL, J.J. VAN HEERIKHUIZE and A. KALSBEEK - Novel environment induced inhibition of corticosterone secretion: physiological evidence for a suprachiasmatic nucleus mediated neuronal hypothalamo-adrenal cortex pathway. Brain Res. 758(1997)229-236.

29. KALSBEEK, A. and J.H. STRUBBE - Circadian control of insulin secretion and glucose homeostasis is independent of the temporal distribution of feeding. Physiol. Behav. 63(1998)553-560.

30. KALSBEEK, A., VAN HEERIKHUIZE, J.J., WORTEL, J. and R.M. BUIJS - Restricted daytime feeding modifies suprachiasmatic nucleus vasopressin release in rats. J. Biol. Rhythms 13(1998)18-29.

31. BUIJS, R.M., J. WORTEL, J.J. VAN HEERIKHUIZE, M.G.P. FEENSTRA, G.J. TER HORST, H.J. ROMIJN and A. KALSBEEK - Anatomical and functional demonstration of a multisynaptic suprachiasmatic nucleus adrenal (cortex) pathway. Eur.J.Neurosci. 11(1999)1535-1544.

32. KALSBEEK, A., R.A. CUTRERA, J.J. VAN HEERIKHUIZE, J. VAN DER VLIET and R.M. BUIJS - GABA release from SCN terminals is necessary for the light-induced inhibition of nocturnal melatonin release in the rat. Neuroscience 91(1999)453-461.

33. PALM, I.F., E.M. VAN DER BEEK, V.M. WIEGANT, R.M. BUIJS AND A. KALSBEEK - Vasopressin induces an LH surge in ovariectomized, estradiol-treated rats with lesions of the suprachiasmatic nucleus. Neuroscience 93(1999)659-666.

34. BARASSIN, S., M. SABOUREAU, A. KALSBEEK, B. BOTHOREL, B. VIVIEN-ROELS, A. MALAN, R.M. BUIJS, B. GUARDIOLA-LEMAITRE and P. PEVET - Interindividual differences in the pattern of melatonin secretion of the Wistar rat. J. Pineal Res. 27(1999)193-201.

35. FLEUR, la S.E., A. KALSBEEK, J. WORTEL and R.M. BUIJS - A suprachiasmatic nucleus generated rhythm in basal glucose concentrations. J. Neuroendocrinol. 11(1999)643-652.

36. BARASSIN, S., A. KALSBEEK, M. SABOUREAU, B. BOTHOREL, B. VIVIEN-ROELS, A. MALAN, R.M. BUIJS and P. PEVET - Potentiation effect of vasopressin on melatonin secretion as determined by transpineal microdialysis in the rat. J. Neuroendocrinol. 12(2000)61-68.

37. KALSBEEK, A., S. BARASSIN, J.J. VAN HEERIKHUIZE, J. VAN DER VLIET & R.M. BUIJS - Restricted daytime feeding attenuates reentrainment of the circadian melatonin rhythm after an 8-h phase advance of the light-dark cycle. J. Biol. Rhythms 15(2000)57-66.

38. KALSBEEK, A.,M.L. GARIDOU, I.F. PALM, J. VAN DER VLIET, V. SIMONNEAUX, P. PEVET and R.M. BUIJS - Melatonin sees the light: Blocking GABA-ergic transmission in the paraventricular nucleus induces daytime secretion of melatonin. Eur.J.Neurosci. 12(2000)3146-3154.

39. KALSBEEK, A., E. FLIERS, A.N. FRANKE and R.M. BUIJS - Functional connections between the suprachiasmatic nucleus and the thyroid gland as revealed by lesioning and viral tracing techniques in the rat. Endocrinology 141(2000)3832-3841.

40. FLEUR, la S.E., A. KALSBEEK, J. WORTEL and R.M. BUIJS - Polysynaptic neural pathways between the hypothalamus, including the suprachiasmatic nucleus, and the liver. Brain Res. 871(2000)50-56.

41. PALM, I.F., E.M. VAN DER BEEK,V.M. WIEGANT, R.M. BUIJS and A. KALSBEEK - The stimulatory effect of vasopressin on the luteinizing hormone surge in ovariectomized, estradiol-treated rats is time dependent. Brain Res. 901(2001)109-116.

42. PALM, I.F., E.M. VAN DER BEEK, J.J.M. SWARTS, J. VAN DER VLIET, V.M. WIEGANT, R.M. BUIJS and A. KALSBEEK - Control of the estradiol-induced prolactin surge by the suprachiasmatic nucleus. Endocrinology 142(2001)2296-2302.

43. KALSBEEK, A., E. FLIERS, J.A. ROMIJN, S.E. LA FLEUR, J. WORTEL, E. ENDERT and R.M. BUIJS - The suprachiasmatic nucleus directly generates the diurnal changes in plasma leptin levels. Endocrinology 142(2001)2677-2685.

44. La FLEUR, S.E., A. KALSBEEK, J. WORTEL, M. FEKKES and R.M. BUIJS - A daily rhythm in glucose tolerance. A role for the suprachiasmatic nucleus. Diabetes 50(2001)1237-1243.

45. BUIJS, R.M. and A. KALSBEEK - The day-night balance of everyday life: Central and peripheral clocks interacting in the hypothalamus. Nature Neuroscience Reviews 2(2001)521-526.

46. La FLEUR, S.E., A. KALSBEEK, J. WORTEL, J. VAN DER VLIET and R.M. BUIJS - Role for the pineal and melatonin in glucose homeostasis: pinealectomy increases night time glucose concentrations. J.Neuroendocrinol. 13(2001)1025-1032.

47. KALSBEEK, A. and R.M. BUIJS - Output pathways of the mammalian suprachiasmatic nucleus: coding circadian time by transmitter selection and specific targeting. Cell Tissue Res. 309(2002)109-118.

48. KREIER,F. E.FLIERS, P.J. VOSHOL, C.G. VAN EDEN, L.M. HAVEKES, A. KALSBEEK, C. VAN HEIJNINGEN, A.A. SLUITER, T.C. METTENLEITER, J.A. ROMIJN, H.P.SAUERWEIN and R.M. BUIJS - Selective parasympathetic innervation of subcutaneous and intra-abdominal fat - functional implications. J.Clin.Invest. 110(2002)1243-1250.

49. FLIERS, E., J.A. ROMIJN, H.P. SAUERWEIN, A. KALSBEEK and R.M. BUIJS - Vet als geïnnerveerde klier. Ned.T.v.Gen. 146(2002)1976-1979.

50. PERREAU, S., A. KALSBEEK, M.L. GARIDOU, J. WORTEL, J. VAN DER VLIET, C. VAN HEIJNINGEN, V. SIMONNEAUX, P. PEVET and R.M. BUIJS - Suprachiasmatic control of melatonin synthesis in the rat: inhibitory and stimulatory clock outputs. Eur.J.Neurosci. 17(2003)221-228.

51. BUIJS, R.M., C.G. VAN EDEN, V.D. GONCHARUK, and A. KALSBEEK – The biological clock tunes the organs of the body: timing by hormones and the autonomic nervous system. J.Endocrinol. 177(2003)17-26.

52. SCHEER, F.A.J.L, A. KALSBEEK and R.M. BUIJS – Cardiovascular control by the suprachiasmatic nucleus: neural and neuroendocrine mechanisms in human and rat. Biol Chem 384(2003)697-709.

53. BUIJS, R.M., S.E.LA FLEUR, C. VAN HEIJNINGEN, J. WORTEL, L. ZUIDDAM, T.C. METTENLEITER, K. NAGAI, A. KALSBEEK and A. NIIJIMA - The suprachiasmatic nucleus balances sympathetic and parasympathetic output to peripheral organs through separate preautonomic neurons. J. Comp. Neurol. 464(2003)36-48.

54. RUITER, M., S.E. LA FLEUR, C. VAN HEIJNINGEN, A. KALSBEEK and R.M. BUIJS - The daily rhythm in plasma glucagon concentrations in the rat is modulated by the biological clock and by feeding behaviour. Diabetes 52(2003)1709-1715.

55. FLIERS, E., F.KREIER, P.J. VOSHOL, L.M. HAVEKES, H.P. SAUERWEIN, A. KALSBEEK, R.M. BUIJS, J.A. ROMIJN. White adipose tissue: getting nervous. J Neuroendocrinol 15(2003)1005-1010.

56. KREIER, F., A. YILMAZ, A. KALSBEEK, E. FLIERS, J.A. ROMIJN, H. SAUERWEIN and R.M. BUIJS – Hypothesis: Shifting the equilibrium from activity to food leads to autonomic unbalance and the metabolic syndrome. Diabetes 52(2003)2652-2656.

57. FLIERS, E., H.P. SAUERWEIN, J.A. ROMIJN, P. REISS, M. VAN DER VALK, A. KALSBEEK, F. KREIER, R.M. BUIJS. HIV-associated adipose redistribution syndrome is a selective neuropathy. Lancet 362(2003)1758-1760.

58. KALSBEEK, A., M. RUITER, S.E. LA FLEUR,C. VAN HEIJNINGEN and R.M. BUIJS – The diurnal modulation of hormonal responses in the rat varies with stimuli. J Neuroendocrinol 15(2003)1144-1155.

59. KREIER, F., A. KALSBEEK, M. RUITER, A. YILMAZ, J.A. ROMIJN, H.P. SAUERWEIN, E. FLIERS, And R.M. BUIJS – Central nervous determination of food storage – A daily switch from conservation to expenditure. Implications for the metabolic syndrome. Eur J Pharmacol 480(2003)51-65.

60. PERREAU-LENZ, S., P. PEVET, R.M. BUIJS and A. KALSBEEK – The biological clock: A bodyguard of temporal homeostasis. Chronobiol Int 21(2004)1-25.

61. VERHAGEN, L.A.W., P. PEVET, M. SABOUREAU, B. SICARD, B. NESME, B. CLAUSTRAT, R.M. BUIJS and A. KALSBEEK – Temporal organization of the 24-h corticosterone rhythm in the diurnal murid rodent Arvicanthis ansorgei Thomas 1910. Brain Res 995(2004)197-204.

62. PERREAU-LENZ, S., A. KALSBEEK, P. PEVET and R.M. BUIJS – Glutamatergic clock output stimulates melatonin synthesis at night. Eur J Neurosci. 19(2004)318-324.

63. ZANDIEH-DOULABI, B., M. PLATVOET-TER SCHIPHORST, A. KALSBEEK, E. FLIERS, O. BAKKER and M. WIERSINGA – Diurnal variation in rat liver TRά mRNA is dependent on the biological clock in the suprachiasmatic nucleus (SCN), while that of TRβ1 mRNA is modified by food. Endocrinology 145(2004)1284-1289.

64. ZANDIEH-DOULABI, B., M. PLATVOET-TER SCHIPHORST, A. KALSBEEK, O. BAKKER and M. WIERSINGA - Hyper- and hypothyroidism change the expression and diurnal variation of thyroid hormone receptor isoforms in rat liver without major changes in their zonal distribution. Mol Cell Endocrinol 219(2004)69-75.

65. KALSBEEK, A., S.E. LA FLEUR, C. VAN HEIJNINGEN and R.M. BUIJS – Suprachiasmatic GABAergic inputs to the PVN control plasma glucose concentrations in the rat via sympathetic innervation of the liver. J Neurosci 24(2004)7604-7613.

66. PERREAU-LENZ, S., A. KALSBEEK, J. VAN DER VLIET, P. PEVET and R.M. BUIJS – In vivo evidemce for clock controlled offset of melatonin synthesis. Neuroscience 130(2005)797-803.

67. KALSBEEK, A., R.M. BUIJS, T.J. VISSER and E. FLIERS – Daily variations in type II 5’iodothyronine deiodinase activity in the rat brain as controlled by the biological clock. Endocrinology 146(2005)1418-1427.

68. CAILOTTO, C., S.E. La FLEUR, C. VAN HEIJNINGEN, A. KALSBEEK, M. FEENSTRA, P. PEVET and R.M. BUIJS – The suprachiasmatic nucleus controls the daily variation of plasma glucose via its autonomic output to the liver: Are the clock genes involved? Eur J Neurosci 22(2005)2531-2540.

69. KLIEVERIK, L., KALSBEEK, A. and E. FLIERS – Autonomic innervation of the thyroid gland and its functional implications. Hot Thyroidology 2005, 1.

70. KREIER, F., KAP, Y.S., METTENLEITER, T.C., VAN HEIJNINGEN, C., VAN DER VLIET, J.,KALSBEEK, A., SAUERWEIN, H.P., FLIERS, E., ROMIJN, J.A. and R.M. BUIJS – Tracing from fat tissue, liver and pancreas: A neuroanatomical framework for the role of the brain in type 2 diabetes. Endocrinology 147(2006)1140-1147.

71. RUITER, M., R.M. BUIJS and A. KALSBEEK –Hormones and the autonomic nervous system are involved in suprachiasmatic nucleus modulation of glucose homeostasis. Current Diabetes Reviews 2(2006)213-226.

72. KALSBEEK, A., S. PERREAU-LENZ and R.M. BUIJS – A network of (autonomic) clock outputs. Chronobiol Int 23(2006)210-215.

73. WU, Y.H., FISCHER, D.F., KALSBEEK, A., GARIDOU-BOOF, M.L., VAN DER VLIET, J., VAN HEIJNINGEN, C., LIU, R.Y., ZHOU, J.N. and D.F.SWAAB – Pineal molecular clock oscillation is disturbed in Alzheimer disease, due to functional disconnectivity with the “master clock”. Faseb J 20(2006)1874-1876.

74. KALSBEEK, A., I.F. PALM, S.E. LA FLEUR, F.A.J.L. SCHEER, S. PERREAU-LENZ, M. RUITER, F. KREIER, C. CAILOTTO and R.M. BUIJS – SCN outputs and the hypothalamic balance of life. J Biol Rhythms 21(2006)458-469.

75. BOLK, N., VISSER, T.J., KALSBEEK, A., VAN DOMBURG, R.T., and BERGHOUT, A. – Effects of evening versus morning thyroxine ingestion on serum thyroid hormone profiles in hypothyroid patients. Clin Endocrinol 66(2007)43-48.

76. KREIER, F., KALSBEEK, A., SAUERWEIN, H.P., FLIERS, E., ROMIJN, J.A. and R.M. BUIJS – “Diabetes of the elderly” and type 2 diabetes in younger patients: possible role of the biological clock. Exp Gerontol 42(2007)22-27.

77. KALSBEEK, A., F. KREIER, E. FLIERS, H.P. SAUERWEIN, J.A. ROMIJN and R.M. BUIJS – Minireview: Circadian control of metabolism by the SCN. Endocrinology 148(2007)5635-5639.

78. TIESJEMA, B., S.E. LA FLEUR, C.M.C. LUIJENDIJK, A. KALSBEEK and R.A.H. ADAN – Differential effects of rAAV-mediated NPY overexpression in the PVN an LH on energy balance. J Neurosci 27(2007).14139-14146.

79. CAILOTTO, C., S.E. La FLEUR, C. VAN HEIJNINGEN, A. KALSBEEK, M. FEENSTRA, P. PEVET and R.M. BUIJS – Daily rhythms in metabolic liver enzymes and plasma glucose require a balance in the autonomic output to the liver. Endocrinology 149(2008)1914-1925.

80. KALSBEEK, A., VERHAGEN, L.A.W., SCHALIJ, I., FOPPEN, E., SABOUREAU, M., BOTHOREL, B., BUIJS, R.M. & P. PEVET – Opposite actions of hypothalamic vasopressin in circadian corticosterone rhythm in nocturnal versus diurnal species. Eur J Neurosci 27(2008)818-827.

81. KLIEVERIK L.P., H.P. SAUERWEIN, M.T. ACKERMANS, E. FLIERS & A. KALSBEEK - Effects of Thyrotoxicosis and selective hepatic autonomic denervation on hepatic glucose metabolism in rats. Am J Physiol 294(2008)E513-520.

82. ACKERMANS, M.T., KLIEVERIK, L.P., ENDERT, E., SAUERWEIN, H.P., KALSBEEK, A. and E. FLIERS – Plasma insulin concentrations during a hyperglycaemic clamp: what do we measure? Ann Clin Biochem 45(2008)430-431.

83. YI, C.X., E. CHALLET, P. PEVET, A. KALSBEEK, C. ESCOBAR and R.M. BUIJS – Circulating ghrelin mimetic attenuates phase-shifts and light-induced fos expression in the suprachiasmatic nucleus. Eur J Neurosci 27(2008)1965-1972.

84. VAN DEN HOEK AM, C VAN HEIJNINGEN, JP SCHRODER-VAN DER ELST, DM OUWENS, HAVEKES LM, ROMIJN JA, PIJL, H. and A. KALSBEEK - Intracerebroventricular administration of NPY hampers insulin action to suppress endogenous glucose production via the sympathetic nervous system. Diabetes 57(2008)2304-2310.

85. KALSBEEK, A., E. FOPPEN, I. SCHALIJ, C. VAN HEIJNINGEN, J. VAN DER VLIET, E. FLIERS and R.M. BUIJS – Circadian control of the daily plasma glucose rhythm: interplay of GABAergic and glutamatergic (clock) outputs. PloS One 3(2008)e3194.

86. KLIEVERIK L.P., S. JANSSEN, E. FOPPEN, P.H. BISSCHOP, M. SERLIE, A. BOELEN, M.T. ACKERMANS, H.P. SAUERWEIN, E. FLIERS & A. KALSBEEK – Thyroid hormone modulates glucose production via a sympathetic pathway from the hypothalamic paraventricular nucleus to the liver. PNAS 106(2009)5966-5971.

87. KLIEVERIK L.P., E. FOPPEN, M.T. ACKERMANS, M.J. SERLIE, H.P. SAUERWEIN, T.S. SCANLAN, D.K.GRANDY, A. KALSBEEK & E. FLIERS – Central effects of thyronamines on glucose metabolism in the rat. J Endocrinol 201(2009)377-386.

88. MISTLBERGER, R.E., R.M. BUIJS, E. CHALLET, C. ESCOBAR, G.J. LANDRY, A. KALSBEEK, P. PEVET and S. SHIBATA – Standards of evidence in chronobiology: critical review of a report that restoration of Bmal1 expression in the dorsomedial hypothalamus is sufficient to restore circadian food anticipatory rhythms in Bmal1-/- mice. J Circadian Rhythms 7(2009)3.

89. CAILOTTO, C., LEI, J., J. VAN DER VLIET, C. VAN HEIJNINGEN, C. VAN EDEN, A. KALSBEEK, P. PEVET and R.M. BUIJS – Light, time-dependently, affects the functionality of organs via the autonomic nervous system. PLoS One 4(2009)e5650.

90. YI, C.X., M..J. SERLIE, M.T. ACKERMANS, E. FOPPEN, R.M. BUIJS, H.P. SAUERWEIN, E FLIERS and A. KALSBEEK - A major role for perifornical orexin neurons in the control of glucose metabolism. Diabetes 58(2009)1998-2005.

91. MISTLBERGER, R.E., BUIJS, R.M., CHALLET, E., ESCOBAR, C., LANDRY, G.J., KALSBEEK, A., PEVET, P., SHIBATA, S. - Food anticipation in Bmal1-/- and AAV-Bmal1 rescued mice: a reply to Fuller et al. J Circadian Rhythms 7(2009)11.

92. KLIEVERIK, L.P., COOMANS, C.P., ENDERT, E., SAUERWEIN, H.P., HAVEKES, L.M., VOSHOL, P.J., RENSEN, P.C., ROMIJN, J.A., KALSBEEK, A., FLIERS, E. - Thyroid hormone effects on whole-body energy homeostasis and tissue-specific fatty acid uptake in vivo. Endocrinology 150(2009)5639-48.

93. MUL, J.D., YI, C.-X., VAN DEN BERG, S.A., RUITER, M., TOONEN, P.W., VAN DER ELST, M.C.J., VOSHOL, P.J., ELLENBROEK, B.A., KALSBEEK, A., LA FLEUR, S.E. and CUPPEN, E. - Pmch expression during early development is critical for normal energy homeostasis. Am J Physiol 298(2010)E477-E488.

94. FLIERS, E., KLIEVERIK, L.P AND KALSBEEK, A. – Novel neural pathways for metabolic effects of thyroid hormone. Tr Endocrinol Metab 21(2010)230-236.

95. YI, C.-X., LA FLEUR, S.E., FLIERS, E. AND KALSBEEK A. – The role of the autonomic nervous liver innervation in the control of energy metabolism. Biochimica et Biophysica Acta - Molecular Basis of Disease 1802(2010)416-431.

96. YI, C.-X., SUN, N., ACKERMANS, M.T., FOPPEN, E., SHI, J., BUIJS, R.M., SERLIE, M.J., FLIERS, E. AND KALSBEEK, A. - Pituitary adenylate cyclase-activating polypeptide stimulates glucose production through glycogenolysis and via the hepatic sympathetic innervation in rats. Diabetes 59(2010)1591-1600.

97. KALSBEEK, A., YI, C.-X., LA FLEUR, S.E. and FLIERS, E. – The hypothalamic clock and its control of glucose homeostasis. Tr Endocrinology Metab 21(2010)402-410.

98. KALSBEEK, A., FLIERS, E., HOFMAN, M.A., SWAAB, D.F. and BUIJS, R.M. – Vasopressin and the output of the biological clock. J Neuroendocrinol 22(2010)362-372.

99. LA FLEUR, S.E., C.M.C. LUIJENDIJK,A.J. VAN ROZEN, A. KALSBEEK and R.A.H. ADAN – A free-choice high-fat high-sugar induces glucose intolerance and insulin unresponsiveness to a glucose load not explained by obesity. Int J Obesity 35(2011)595-604.

100. ACKERMANS, M.T., KLIEVERIK, L.P., RINGELING, P., ENDERT, E., KALSBEEK, A., FLIERS, E. - An online solid-phase extraction-liquid chromatography-tandem mass spectrometry method to study the presence of thyronamines in plasma and tissue and their putative conversion from 13C6-thyroxine. J Endocrinol 206(2010)327-34.

101. KALSBEEK, A.,BRUINSTROOP, E., YI, C.-X., KLIEVERIK, L.P., LA FLEUR, S.E., FLIERS, E. – Hypothalamic control of energy metabolism via the autonomic nervous system. Ann NY Acad Sci 1212(2010)114-129.

102. KALSBEEK, A., YI, C.-X., LA FLEUR, S.E., BUIJS, R.M., FLIERS, E. – Suprachiasmatic nucleus and autonomic nervous system influences on awaking from sleep. Int Rev Neurobiol 93(2010)91-107.

103. YI, C.-X., KALSBEEK, A., TSCHÖP, M. – Autonomic MC sets the metabolic tone. Cell Metab 13(2011)121-123.

104. KALSBEEK, A., LA FLEUR, S.E., SCHEER, F.A., PERREAU-LENZ, S., YI, C.-X., FLIERS, E. & BUIJS, R.M. - SCN control of energy metabolism during circadian disruption. FEBS Lett 585(2011)1412-1426.

105. ALKEMADE, A., FRIESEMA, E.C.H., KALSBEEK, A., SWAAB, D.F., VISSER, .J., FLIERS, E. – Expression of thyroid hormone transporters in the human hypothalamus. J Clin Endocrinol Metab 96(2011)E967-971.

106. LIU, J., QI, X.R., HU, P., MENG, F.T, KALSBEEK, A., ZHOU, J.N. – Acute restraint stress increases intrahypothalamic estradiol concentrations in conjunction with increased hypothalamic oestrogen receptor β and aromatase mRNA expression in female rats. J Neuroendocrinol 23(2011)435-434.

107. KALSBEEK, A., YI, C.-X., CAILOTTO, C., LA FLEUR, S.E., FLIERS, E. and BUIJS, R.M. – Mammalian clock output mechanisms. Essays in Biochemistry, 49(2011)137-151.

108. KALSBEEK, A., VAN DER SPEK, R., LEI, J., ENDERT, E., BUIJS, R.M., FLIERS, E. – Circadian rhythms in the hypothalamo-pituitary-adrenal (HPA) axis. Mol Cell Endocrinol 349(2012)20-29.

109. KLIEVERIK, L.P., KALSBEEK, A., ACKERMANS, M.T., SAUERWEIN, H.P., WIERSINGA, W.M. & FLIERS, E. - Energy homeostasis and body weight before and after cessation of block and replacement therapy in euthyroid patients with Graves disease. Int J Endocrinol 2011(2011)715370.

110. KALSBEEK, A., YI, C.-X., LA FLEUR, S.E., & FLIERS, E. – De rol van de biologische klok en het autonome zenuwstelsel bij wakker worden. Neuropraxis 6(2011)159-171.

111. BOELEN, A., VAN BEEREN, M., VOS, X., SUROVTSEVA, O., BELEGRI, E., SAALTINK, D.J., VREUGDENHIL, E., KALSBEEK, A., KWAKKEL, J. and FLIERS, E. - Leptin administration restores the fasting induced increase of hepatic type 3 deiodinase expression in mice. Thyroid 22(2012)192-199.

112. YI, C.-X, FOPPEN, E., ABPLANALP, W., GAO, Y., ALKEMADE, A., SERLIE, M.J., FLIERS, E., BUIJS, R.M., TSCHOP, M.H. & KALSBEEK, A. - Glucocorticoid signaling in the arcuate nucleus modulates hepatic insulin sensitivity. Diabetes 61(2012)339-345.

113. LEENAARS, C.H.C., KALSBEEK, A., HANEGRAAF, M.A.J., FOPPEN, E., JOOSTEN, R.N.J.M.A., POST, G., DEMATTEIS, M., FEENSTRA, M.G.P., AND VAN SOMEREN, E.J.W. - Unaltered instrumental learning and attenuated body weight gain during non-rotating shift-work in rats. Chronobiol Int 29(2012)344-355.

114. DONJACOUR, C.E.H.M., KALSBEEK, A., OVEREEM, S., LAMMERS, G.J., PEVET, P., BOTHOREL, B., PIJL, H. and AZIZ, N.A. – Altered circadian rhythm of melatonin concentrations in hypocretin deficient men. Chronobiol Int. 29(2012)356-362.

115. BRUINSTROOP, E., PEI, L., ACKERMANS, M., FLIERS, E., KALSBEEK, A. – Hypothalamic neuropeptide Y (NPY) controls hepatic VLDL triglyceride secretion via the sympathetic nervous system. Diabetes 61(2012)1043-1050.

116. ALKEMADE, A., C.X. YI, L. PEI, M. HARAKALOVA, D.F. SWAAB, S.E. LA FLEUR, E. FLIERS and A. KALSBEEK – AgRP and NPY expression in the hypothalamic infundibular nucleus correlate with body mass index, whereas changes in aMSH are related to type 2 diabetes. J Clin Endocrinol Metab 97(2012)E925-E933.

117. ALKEMADE, A, UNMEHOPA, U.A., HESSEL, E.V.S., SWAAB, D.F., KALSBEEK, A., FLIERS, E. - Suppressor of cytokine signaling 3 in the human hypothalamus. Peptides 35(2012)139-142.

118. LIU, J., BISSCHOP, P., EGGELS, L., FOPPEN, E., FLIERS, E., ZHOU, J.N., KALSBEEK, A. – Intrahypothalamic estrogen rapidly modulates HPA-axis activity in female rats. Endocrinology 153(2012)3337-3344.

119. KALSBEEK, A., J. LIU, J. LEI, L. TIMMERMANS, E. FOPPEN, C. CAILOTTO, E. FLIERS - Differential involvement of the suprachiasmatic nuclei in LPS-induced plasma glucose and corticosterone responses. Chronobiol Int 29(2012)835-849.

120. FRIESEMA, E.C.H., T.J. VISSER, A.J. BORGERS, A. KALSBEEK, D.F. SWAAB, E. FLIERS, A. ALKEMADE - Thyroid hormone transporters and deiodinases in the developing human hypothalamus. Eur J Endocrinol 167(2012)379-386.

121. GIRAULT, E.M., A. ALKEMADE, E. FOPPEN, M.T. ACKERMANS, E. FLIERS, A. KALSBEEK - Acute peripheral but not central administration of the antipsychotic drug Olanzapine induces hyperglycemia associated with hepatic insulin resistance in male rats. Plos One 7(2012)43244.

122. YI, C.X., GERICKE, M., KRUGER, M., ALKEMADE, A., KABRA, D.G., HANSKE, S., FILOSA, J., PFLUGER, P., BINGHAM, N., WOODS, S.C., HERMAN, J., KALSBEEK, A., BAUMANN, M., LANG, R., STERN, J.E., BECHMANN, I. & TSCHOP, M.H. – High caloric diet triggers hypothalamic angiopathy. Mol Metab 1(2012)95-100.

123. LIU, J., P.H. BISSCHOP, L. EGGELS, E. FOPPEN, .M.T. ACKERMANS, J.N. ZHOU, E. FLIERS and A. KALSBEEK – Intrahypothalamic estradiol regulates glucose metabolism via the sympathetic nervous system in female rats. Diabetes 62(2013)435-443.

124. COOMANS, C.P., S.A.A. VAN DEN BERG, E.A. LUCASSEN, T. HOUBEN, A.C.M. PRONK, R. VAN DER SPEK, A. KALSBEEK, N.R. BIERMASZ, K.W. VAN DIJK, J.A. ROMIJN and J.H. MEIJER – The suprachiasmatic nucleus controls circadian energy metabolism and hepatic insulin sensitivity. Diabetes 62(2013)1102-1108.

125. SILJEE-WONG, J., U.A. UNMEHOPA, A. KALSBEEK, D.F. SWAAB, E. FLIERS, A. ALKEMADE - Melanocortin-4 Receptor distribution in the human hypothalamus. Eur J Endocrinol 168(2013)361-369.

126. BRUINSTROOP, E., LA FLEUR, S.E., ACKERMANS, M., FOPPEN, E., WORTEL, J., KOOIJMAN, S., BERBEE, J.F., RENSEN, P.C., FLIERS, E., KALSBEEK, A. – The autonomic nervous system regulates postprandial liver lipid metabolism. Am J Physiol 304(2013)E1089-E1096.

127. GIRAULT, E.M., TOONEN, P.W., EGGELS, L., FOPPEN, E., ACKERMANS, M.T., LA FLEUR, S.E., FLIERS, E., KALSBEEK, A. - Olanzapine-induced changes in glucose metabolism are independent of the melanin-concentrating hormone system. Psychoneuroendocrinology 38(2013)2640-2646.

128. GIRAULT, E.M., FOPPEN, E., ACKERMANS, M.T., FLIERS, E., KALSBEEK, A. - Central administration of an orexin receptor 1 antagonist prevents the stimulatory effect of Olanzapine on endogenous glucose production. Brain Res 1527(2013)238-245.

129. DIEPENBROEK, C., SERLIE, M.J., FLIERS, E., KALSBEEK, A., LA FLEUR, S.E. – Brain areas and pathways in the regulation of glucose metabolism. Biofactors 39(2013)505-513.

130. DONJACOUR, C.E.H.M., AZIZ, N.A., OVEREEM, S., KALSBEEK, A., LAMMERS, PIJL, H., LAMMERS, G.J. – Glucose and fat metabolism in narcolepsy and the effect of Sodium Oxybate: a hyperinsulinemic clamp study. Sleep (In Press).

131. GIRAULT, E.M., B. GUIGAS, A. ALKEMADE, E. FOPPEN, M.T. ACKERMANS, E. FLIERS, A. KALSBEEK - Olanzapine-induced adiposity resulting from a fuel substrate switch is independent of acute glucoregulatory effects. Naunyn Schmiedeberg’s Archives of Pharmacology (In Press).

132. DIEPENBROEK, C., G. VAN DER PLASSE, L. EGGELS, M. RIJNSBURGER, M. FEENSTRA, A. KALSBEEK, D. DENYS, E. FLIERS, M.J. SERLIE, S.E. LA FLEUR - Alterations in glucose metabolism during deep brain stimulation in the shell region of the nucleus accumbens in rats. Frontiers in Autonomic Neuroscience (In Press).

VAN DEN HEUVEL JK, L. EGGELS, A.J. VAN ROZEN, M.C.M. LUIJENDIJK, E. FLIERS, A. KALSBEEK, R.A.H. ADAN, S.E. LA FLEUR – Increased Neuropeptide Y sensitivity as an explanation for sustained hyperphagia in obesity induced by a free-choice high-fat high-sugar diet. Submitted.

VAN DEN HEUVEL JK, EGGELS L, FLIERS E, KALSBEEK A, ADAN RAH, LA FLEUR SE. Central leptin suppresses feeding despite arcuate POMC and NPY leptin insensitivity in rats on a high-fat high-sugar diet. Submitted.

STENVERS, D.J., SCHOUTEN, L.J., JURGENS, J., ENDERT, E., KALSBEEK, A., FLIERS, E., BISSCHOP, P.H. – Breakfast replacement with a low glycemic index liquid formula in type 2 diabetes: A randomized clinical trial. Submitted.

BRUINSTROOP, E., ELIVELD, J., FOPPEN, E., BUSKER, S., ACKERMANS, M., HOUTEN, S., FLIERS, E., KALSBEEK, A. – Sympathetic and parasympathetic hepatic denervation modulate dyslipidemia in obese Zucker (fa/fa) rats. Submitted.

OOSTERMAN, J.E., FOPPEN, E., VAN DER SPEK, R., FLIERS, E., KALSBEEK, A., LA FLEUR, S.E. – The timing of saturated fat and liquid sugar intake is important for food efficiency and body weight gain in male Wistar rats. Submitted.

PALM, I.F., J. KASTELIJN, T.H. HORVATH, A. KALSBEEK and E.M. VAN DER BEEK – The input of vasopressin-containing fibers onto gonadotropin –releasing hormone neurons is sex-specific and originates in the suprachiasmatic nucleus. Submitted.

 


(d) Book chapters
1. UYLINGS,H.B.M.,VAN EDEN,C.G.,PARNAVELAS,J.G. and KALSBEEK,A. - The prenatal and postnatal development of rat cerebral cortex. In: B.Kolb and R.C.Tees (Eds.): The Cerebral Cortex of the Rat, M.I.T. Press, Cambridge, pp. 35-76, 1990.

2. KALSBEEK,A.,DE BRUIN,J.P.C.,FEENSTRA,M.P.C. and UYLINGS,H.B.M. - Age-dependent effects of lesioning the mesocortical dopamine system upon prefrontal cortex morphometry and PFC-related behaviors. In: H.B.M.Uylings, C.G. Van Eden, J.P.C. De Bruin, M.A.Corner and M.G.P.Feenstra (Eds.): Function, Plasticity and Pathology of the Prefrontal Cortical Systems in Human and Animal Nervous System, Progress in Brain Research., Vol.85, pp. 257-283, 1991.

3. BUIJS,R.M.,HERMES,M.L.H.J.,KALSBEEK,A.,VAN DER WOU¬DE,T.P. and VAN HEERIKHUIZE,J.J. - Vasopressin: distribution, origin and functions in the central nervous system, In: S.Jard and R.Jam¬ison (Eds.): Vasopressin. John Libbey Eurotext/INSERM, Paris, pp. 149-158, 1991.

4. KALSBEEK,A. and BUIJS,R.M. - Peptidergic transmitters of the suprachiasmatic nuclei and the control of circadian rhythmici¬ty, In: J.Joosse, R.M.Buijs and F.J.H.Tilders (Eds.): The Peptidergic Neuron, Progress in Brain Research, Vol.92, pp. 321-334, 1992.

5. KALSBEEK,A.,VOORN,P. and BUIJS,R.M. Development of dopamine-containing systems in the CNS. In: A.Björklund, T.Hökfelt and M.Tohyama (Eds.): Ontogeny of Transmitters and Peptides in the Central Nervous System, Handbook of Chemical Neuroa¬natomy, Vol.10, Am¬sterdam, Elsevier, pp. 63-112, 1992

6. TECLEMARIAM-MESBAH,R.,KALSBEEK,A. and PÉVET,P. Efferent projections of the suprachiasmatic nucleus and the transmission of photoperiodic information to the pineal gland. In: Y.Touitou, J.Arendt and P.Pévet (Eds.): Melatonin and the pineal gland - From basic science to clinical application, Amsterdam, Excerpta Medica, pp. 159-162, 1993

7. BUIJS,R.M. and KALSBEEK,A. Vasopressin neurotransmission: Involvement in temperature regulation and stress response. In: P.Gross, D.Richter, G.L.Robertson (Eds.): Vasopressin. John Libbey Eurotext, Berlin, pp. 233-242, 1993.

8. TECLEMARIAM-MESBAH,R.,KALSBEEK,A. and PÉVET,P. Afferent projections on preganglionic neurons projecting to the superior cervical ganglion: implication on transmission of photoperiodic information from the SCN to the pineal. In: M.Moller and P.Pévet (Eds.): Advances in Pineal Research, Vol.8, Amsterdam, Excerpta Medica, pp. 51-55, 1994

9. BUIJS,R.M. and KALSBEEK,A. Anatomy and Physiology of vasopressin pathways: from temperature regulation to corticotrophin-inhibiting neurotransmission. In: T. Saito, K. Kurokawa & S. Yoshida (Eds.): Neurohypophysis: Recent Progress of Vasopressin and Oxytocin Research, Amsterdam, Elsevier Science B.V., 1995.

10. KALSBEEK,A. and R.M.BUIJS Rhythms of inhibitory and excitatory output from the circadian timing system as revealed by in vivo micr odialysis. In: R.M.Buijs, A.Kalsbeek, M.Mirmiran, C.M.A. Pennartz, H.J.Romijn (Eds.): Hypothalamic Integration of Circadian Rhythms, Progress in Brain Research, Vol.111, Amsterdam, Elsevier, pp.273-293, 1996.

11. KALSBEEK,A., J.H.STRUBBE and R.M.BUIJS Circadian control of corticosterone, melatonin and insulin release: important roles for suprachiasmatic nucleus efferents and the autonomic nervous system. In: Y. Touitou (Ed.), International Congress on Chronobiology, Amsterdam, Elsevier, pp.411-414, 1998.

12. BUIJS, R.M., M.H.L.J. HERMES and A. KALSBEEK - The suprachiasmatic nucleus - paraventricular nucleus interactions. A bridge to the neuroendocrine and autonomic nervous system. In: I.J.A Urban, J.P.H. Burbach and D. De Wied (Eds.), Advances in Brain Vasopressin, Progress in Brain Research, Vol.119, Amsterdam, Elsevier, pp.365-382, 1998.

13. KALSBEEK, A., I.F. PALM, S.E. la FLEUR and R.M.BUIJS - Circadian control of hormonal rhythms: important roles for suprachiasmatic nucleus efferents and the autonomic nervous system. In: A.L. Van Bemmel, D.G.M. Beersma, H. Folgering, W.F. Hofman and G.S.F. Ruigt (Eds.), Sleep-Wake Research in the Netherlands, Vol.10, Dutch Society for Sleep-Wake Research, Maastricht, pp.25-36, 1999.

14. BUIJS,R.M., M.L.H.J. HERMES, J.P. DAI, F. SCHEER and A. KALSBEEK - Circadian organization of the autonomic nervous system. In: G.J. ter Horst (Ed.), The Nervous System and the Heart, Humana Press Inc., pp.117-157, 2000.

15. KALSBEEK, A. and R.M. BUIJS - Neurochemistry of the daily melatonin rhythm as controlled by the suprachiasmatic nucleus. In: C. Haldar, S.K. Maitra and M. Singaravel (Eds.), Treatise on Pineal Gland and Melatonin, Science Publishers Inc, Plymouth, pp. 395-405, 2002.

16. KALSBEEK, A., I.F.PALM and R.M.BUIJS - Central vasopressin systems and steroid hormones. In D. Poulain, S. Oliet and D. Theodosis (Eds.). Vasopressin and Oxytocin: From Genes to Clinical Applications. Progress in Brain Research, Vol.139, Amsterdam, Elesevier, pp. 57-73, 2002.

17. RUITER, M., R.M. BUIJS, A. KALSBEEK – Biological clock control of glucose metabolism – Timing metabolic homeostasis. In Pandi et al. (Eds) Neuroendocrine correlates of sleep/wakefulness. Kluwer, pp 87-117, 2005

18. KALSBEEK, A., RUITER, M., LA FLEUR, S.E., CAILOTTO, C., KREIER, F. and R.M. BUIJS - The hypothalamic clock and its control of glucose homeostasis. In: A. Kalsbeek, E. Fliers, M.A. Hofman, D.F. Swaab, E.J.W. Van Someren and R.M. Buijs (Eds): Hypothalamic Integration of Energy Metabolism, Progress in Brain Research, Vol. 153, Amsterdam, Elsevier, 287-312, 2006.

19. BUIJS, R.M., F.A. SCHEER, F. KREIER, C. YI, N. BOS, V. GONCHARUK and A. KALSBEEK - Organization of circadian functions: interaction with the body. In: A. Kalsbeek, E. Fliers, M.A. Hofman, D.F. Swaab, E.J.W. Van Someren and R.M. Buijs (Eds): Hypothalamic Integration of Energy Metabolism, Progress in Brain Research, Vol. 153, Amsterdam, Elsevier, pp. 345-363, 2006

20. BUIJS, R.M. and KALSBEEK, A. – Neuroendocrine regulation and the autonomic nervous system. In: Encyclopedia of Neuroscience, Amsterdam, Elsevier, 2008.

21. BUIS, R.M., C. ESCOBAR and A. KALSBEEK – Circadian metabolic rhythms regulated by the suprachiasmatic nucleus. In: The New Encyclopedia of Neuroscience, Amsterdam, Elsevier, pp. 915-923, 2009.

22. GIRAULT, E.M., YI, C.X., FLIERS, E. and KALSBEEK, A. – Orexins, feeding, and energy balance. In: A. Shekhar (Ed): Orexin/Hypocretin System, Progress in Brain Research, Vol. 198, Amsterdam, Elsevier, pp. 47-64, 2012.

23. STENVERS, D.J., C.F. JONKERS, E. FLIERS, P.H.L.T. BISSCHOP and A. KALSBEEK – Nutrition and the circadian timing system. In: A. Kalsbeek, M. Merrow, T. Roenneberg and R. Foster (Eds): The Neurobiology of Circadian Timing, Progress in Brain Research, Vol. 199, pp. 359-376, Amsterdam, Elsevier, 2012.

24. VAN DER SPEK, R., F. KREIER, E. FLIERS and A. KALSBEEK – Circadian rhythms in white adipose tissue. In: A. Kalsbeek, M. Merrow, T. Roenneberg and R. Foster (Eds): The Neurobiology of Circadian Timing, Progress in Brain Research, Vol. 199, pp. 183-201, Amsterdam, Elsevier, 2012.

25. KALSBEEK, A. and E. FLIERS – Hypothalamus. In: D.W. Pfaff (Ed): Neuroscience in the 21st Century, Berlin, Springer Science, 2012.

26. KALSBEEK, A. and M.A. HOFMAN – Hypothalamus and Circadian Rhythms. In: B. Dudas (Ed): The Human Hypothalamus: Anatomy, Functions and Disorders, pp. 283-309, NOVA Science Publishers, 2013.

27. KALSBEEK, A. and E. FLIERS – Daily regulation of hormone profiles. In: A. Kramer and M. Merrow (Eds): Circadian Clocks, Handbook of Experimental Pharmacology, Vol. 217, pp. 185-226, Springer-Verlag Berlin Heidelberg, 2013.

28. LA FLEUR, S.E. and A. KALSBEEK – Increased risk of diabetes due to obesity: does chronodisruption play a role? In: M. Garaulet & J.M. Ordovás (Eds.): Chronobiology and Obesity, Springer Science, New York, 2013.

29. LA FLEUR, S.E., E. FLIERS and A. KALSBEEK – Neuroscience of glucose homeostasis. In: D.W. Zochodne & R.A. Malik (Eds.), Handbook of Clinical Neurology, Vol.: Diabetes and the Nervous System, Section: Fundamental Studies of Diabetic Neuroscience, Elsevier

30. KALSBEEK, A., Y. SU, E. FLIERS and S.E. LA FLEUR – The hypothalamo-pituitary-adrenal axis: circadian dysregulation and obesity. In: J.A. Russell & M.A. Shipston (Eds.): International Neuroendocrine Federation (INF) Masterclass Series: Stress Neuroendocrinology, John Wiley & Sons, Ltd., West Sussex, In Press.

31. KALSBEEK, A., E. BRUINSTROOP, C.X. YI, L. KLIEVERIK, J. LIU and E. FLIERS – Hormonal control of metabolism by the hypothalamus – autonomic nervous system – liver axis. In: A.J. van der Lely & P. Delhanty (Eds.): Frontiers in Hormone Research - How the Gut and Brain Control Energy Metabolism, Karger, Basel, In Press.

 

 


(e) Books edited
Buijs, R.M., Kalsbeek,A., Mirmiran,M., Pennartz,C.M.A., Romijn,H.J. - Progress in Brain Research, Vol.108 Hypothalamic Integration of Circadian Rhythms, Elsevier Science Publishers, Amsterdam, 1996.

A. Kalsbeek, E. Fliers, M.A. Hofman, D.F. Swaab, E.J.W. Van Someren and R.M. Buijs - Progress in Brain Research, Vol. 153 Hypothalamic Integration of Energy Metabolism, Elsevier Science Publishers, Amsterdam, 2006.

A. Kalsbeek, M. Merrow, T. Roenneberg and R. Foster – Progress in Brain Research, Vol. 199 The Neurobiology of Circadian Timing, Elsevier Science Publishers, Amsterdam, 2012.

 

 

 

 

(f) Invited papers read at an International Congress
1. Neonatal depletion of the mesocortical dopamine system. Beha¬vioural, biochemical and morphological consequen-ces, ISPN meeting, Groningen, The Netherlands, August 1988.

2. Age-dependent effects of lesioning the mesocor¬tical dopami¬ne system upon prefrontal cortex morpho¬metry and PFC-rela¬ted behaviour, 16th Int. Summer School of Brain Re¬search, Amster¬dam, The Netherlands, August 1989.

3. Peptidergic Transmitters of the Suprachiasmatic Nuclei in the Control of Circadian Rhythmicity, 11th Interna¬tional Symposium on Neuro¬secretion "The Peptidergic Neuron", Amsterdam, The Netherlands, June 1991.

4. Circadian Control of Hormonal Rhythms, 19th Int. Summer School of Brain Re¬search, Amster¬dam, The Netherlands, August 1995

5. Circadian rhythms in hormonal release and the importance of SCN transmitters and the autonomic system, Int. Conference on Circadian Light Reception and Regulation, Lyon, France, May 1996.

6. Circadian control of corticosterone, melatonin and insulin release: important roles for suprachiasmatic nucleus efferences and the autonomic nervous system, Endocrine Rhythms: Roles of the Sleep-Wake Cycle, the Circadian Clock and the Environment. Diagnostic and Therapeatic Implications, Paris, France, May 1997.

7. SCN-control of feeding-induced corticosterone and insulin release, International Congress on Chronobiology, Paris, France, September 1997.

8. SCN control of neuroendocrine rhythms, 1998 Workshop on Steroid Hormones and Brain Functions, Breckenridge, Colorado, USA, March 1998.

9. SCN control of neuroendocrine systems, 4th International Congress of Neuroendocrinology, Kitakyushu, Japan, October 1998.

10. SCN-morphology, physiology and pathology, First Joint Scientific Meeting of the Belgian and Dutch Sleep Societies BASS and NSWO, Heeze, The Netherlands, November 1998.

11. Circadian Rhythmicity and the Control of Food Intake and Metabolism. Central Pathways, 19th European Winterconference on Brain Research, Plagne Lauze, France, March 1999

12. GABA release from SCN projections to hypothalamic target areas and its implication in the melatonin rhythm, 8th Meeting of the European Pineal Society, Tours, France, June 1999.

13. Nervous Pathways and Neurotransmitters involved in the SCN - Driven Daily Rythm of Melatonin, International Congress on Chronobiology, Washington, USA, September 1999.

14. Control and regulation of circadian outputs, Society for Research on Biological Rhythms, Amelia Island, USA, May 2000.

15. SCN control of hormonal rhythms: an important role for the autonomic nervous system, School of Biological Sciences, University of Surrey, Guilford, United Kingdom, June 2000

16. The central pacemaker: coding circadian time for remote areas, FENS2000, Brighton, United Kingdom, June, 2000.

17. Control and regulation of circadian outputs, Erasmus Summer School, University of Strasbourg, France, July 2000

18. Hormonal control of bio-rhythms, 14th International Congress of Comparative Endocrinology, Napoli, Italy, May, 2001.

19. Vasopressin and Steroid Hormones, World Congress on Neurohypophysial Hormones (WCNH), Bordeaux, France, September, 2001.

19. Output mechansisms of the mammalian biological clock, 21st Concgress of European Comparative Endocrinologists, Bonn, Germany, August, 2002.

20. SCN transmitters and the timing of hormonal rhythms, 55 Mosbacher Kolloquium “The rhythm of life: molecular mechanisms of circadian clocks”, Mosbach, Germany, March, 2003.

21. Integration of central clock outputs into peripheral hormonal rhythms, Annual Meeting of the Britisch Society for Neuroendocrinology, Manchester, United Kingdom, September 2003.

22. Neural pathways employed by the central pacemaker to transmit its rhythmic output, CIE expert symposiun on the “Non-visual effects of Light”, Vienna, Austria, October 2004.

23. Outputs of the biological clock and its control of the daily corticosterone and melatonin rhythms, African Neuroscience School on “Hormones and the Brain”, Rabat, Morocco, March 2005.

24. The hypothalamic clock and its control of glucose homeostasis, 24th International Summer School of Brain Research on “Hypothalamic Integration of Energy Metabolism”, Amsterdam, The Netherlands, August 2005

25. The network of (autonomic) clock outputs, Xth EPBRS congress on “A multidisciplinary Biological Rhythms Congress”, Frankfurt/Main, Germany, September 2005

26. Circadian rhythms, Amsterdam-China Symposium, Amsterdam, The Netherlands, October, 2005.

27. Neuroregulation of daily rhythms in lipid and glucose metabolism, 50.Symposion der Deutschen Gesellschaft für Endokrinologie, Essen, Germany, March 2006

28. The hypothalamic clock and its control of glucose and lipid metabolism, 26th European Winter Conference on Brain Research, Villars sur Ollon, Switzerland, March 2006.

29. Circadian control of metabolism by the SCN, VI International Congress of Neuroendocrinology, Pittsburgh, USA, June 2006

30. Sympathetic system in the multi-oscillatory mammalian circadian world, 2nd Mediterranean Collogue of Neuroscience, Marrakech, Morocco, December 2006.

31. Circadian and autonomic control of autonomic neurons in the PVN, NEUREX Symposium on Circadian Clocks and Metabolism, Strasbourg, France, February 2007.

32. Hypothalamic control of hormone rhythms and the autonomic nervous system, Huazhong University of Science and Technology, Wuhan, China, March 2007.

33. Hypothalamic integration of circadian rhythms and energy metabolism, University of Science and Technology of China, Hefei, China, March 2007.

34. Circadian and autonomic control of autonomic neurons in the PVN, Nutrition, Metabolism, and the Brain, Satellite meeting of the European Congress on Obesity, Budapest, Hungary, April 2007.

35. The mammalian circadian clock: output pathway, 2nd World Congress of Chronobiology, Tokyo, Japan, November 2007.

36. Rhythms in the periphery – The role of melatonin, 10th Gordon Research Conference on Pineal Cell Biology, Il Ciocco, Italy, April 2008.

37. Visualizing feeding pathways in the brain, 13th Congress of the International Federation of Societies for Histochemistry and Cytochemistry, Gdansk, Poland, August 2008.

38. Site specific signaling in the rat hypothalamus as a determinant of endogenous glucose production, 13th Meeting of the European Neuroendocrine Association, Antalya, Turkey, October 2008.

39. Autonomic clocks and circadian rhythms, 19th International Symposium on the Autonomic Nervous System, Hawai, USA, October 2008.

40. Thyroid hormone modulates hepatic glucose production via a sympathetic pathway from the hypothalamic paraventricular nucleus to the liver, 11th European Congress of Endocrinology, Istanbul, Turkey, April 2009.

41. SCN neuronal outputs as mediators of peripheral circadian structures, XIth Congress of the European Biological Rhythms Society, Strasbourg, France, August 2009

42. Vasopressin and the output of the biological clock, 8th World Congress on Neurohypophysial Hormones, Kitakyushu, Japan, September 2009.

43. Hypothalamic control of hepatic glucose metabolism, Neuroscience Seminar Series, Faculty of Life Sciences, University of Manchester, February, 2010

44. Tracking dawn and dusk, Assembling a multi-cellular circadian pacemaker, Lorenz Center, Leiden, August, 2010.

45. Hypothalamic control of hepatic glucose metabolism, Metabolic Diseases Institute, University of Cincinnati, November, 2010

45. Communication between brain and liver – What is the message? German Metabolic Society, Fulda, March 2011.

46. Hypothalamic neuropeptide Y (NPY) controls hepatic VLDL triglyceride secretion in rats via the sympathetic nervous system, Benjamin Franklin Lafayette Seminar, Frejus (France), June 2011.

47. The hypothalamic clock and its control of glucose homeostasis, Bregenz School on Endocrinology, Bregenz, Austria, July 2011.

48. Clocks, Sleep and Metabolism, XIIth Congress of the European Biological Rhythms Society, Oxford, August 2011.

49. Invloed van de biologische klok op obesitas en diabetes, Voedings- en gezondheidscongres, Brussel, November, 2011.

50. The hypothalamus and the temporal control of energy metabolism, Neurex Workshop on the Neural Processing of Time, Strasbourg, France, January 2012.

51. Metabolic rhythms and the interplay of hypothalamic, autonomic and peripheral clocks, Gordon Research Conference on Pineal Cell Biology: Links to Circadian Clocks, Sleep and Metabolism , Galveston, Texas , January 2012.

52. Circadian regulation of glucose and lipid metabolism: neural and endocrine mechanisms, Annual Meeting of the Associated Professional Sleep Societies (APSS), Boston, USA, June 2012.

53. A central role for thyroid hormones in glucose metabolism, British Society for Neuroendocrinology, Aberdeen,
Scotland, July 2012.

54. Autonomic clocks and sleep, 21st Congress of the European Sleep Research Society, Versailles, France, September 2012.

55. The sympathetic system as an output of the central clock. It’s role in metabolic rhythms, 4th Conference of the Mediterranean Neuroscience Society, Istanbul, Turkey, October 2012.

56. The sympathetic system as an output of the central clock. It’s role in metabolic rhythms, University of Santiago de Compostela - Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain, March 2013.

57. Hypothalamic control of glucose metabolism as revealed by microdialysis, Zhejiang University School of Medicine, Hangzhou, China, April 2013

58. Hypothalamic and clock control of energy metabolism via the autonomic nervous system, 11th Society of Neuroscientists of Africa (SONA) International Conference, Rabat, Morocco, June 2013

59. Nutrition and the circadian timing system, Lorentz Conference on “Clinical Relevance of Circadian Rhythms”, Leiden, The Netherlands, August 2013

60. Circadian rhythms, autonomic nervous system, HPA-axis activity and metabolic control, Symposium on Stress Hormones and control of Metabolism at the ISPNE, Leiden, August 2013

60. Outputs of the clock and diurnality: the control of corticosterone secretion and glucose homeostasis, International Conference on the “Understanding the Neural Basis of Diurnality”, Strasbourg, France, November 2013

61. Neural regulation of hepato-gastric functions, 4th Versailles International Neurosciences in Intensive Care Symposium (VINCS) on The Neurobiological Control of Response to Stress in Critical Illness, Versailles, France, June 2014

 

 

 

 

 

(h) General Public

1. VPRO televisie, Labyrint “Nieuw Licht op de Biologische Klok”, 10 October 2012

2. Wetenschapsrubriek Radio Noord-Holland, 16 October 2012

3. Publieksmiddag “Wijzer of DNA: de klok bepaalt”, 4 November 2012, Leiden

4. Omnium Omrop Fryslan, 6 December 2012

5. Voeding & Visie, Eten en de Biologische Klok, 25(1)9-11, 2012

6. Esta, Weg met de Wekker, 8/13, 12-17, 2013

7. Zin, Leven als onze voorouders. Waarom we het voorbeeld van de oermens moeten volgen, 101:114-118, 2013

8. Intermediair, Baas over je bioritme, 01 / 08 / 2013

9. Telegraaf, Onze klok loopt vast, 14 September 2013

10. Omrop Fryslan, Interview, 22 September 2013

11. Publieksdag Hersenstichting Nederland, Voeding, Brein en Ritme, 11 October 2013

12. GezondNU, Zoek het licht. Waarom daglicht de beste slaappil is, November 2013

 

Research programmes

Hypothalamic Integration Mechanisms

This research group participates in the Amsterdam Center for Metabolism

Faculty
Prof. dr. A. Kalsbeek

PhD Students
S.E. Arroyo (NIN)
E. Belegri MSc
F. Cázarez-Márquez MSc
P. de Goede
S. Kavraal (NIN)
L.L. Koekkoek
I.V. Milanova MSc
L. Saad
R.D.C. van der Spek MSc
X. Wang
Y. Wei
Drs. E. Angelopoulou (Universite Louis Pasteur (ULP), Strasbourg)
Drs. S. Kavraal (Universite Louis Pasteur (ULP), Strasbourg)
Drs. S. Loyola (Universite Louis Pasteur (ULP), Strasbourg)
Drs. A. Masis Vargas (University Louis Pasteur (ULP), Strasbourg)
Drs. O. Ozyildirim (Universite Louis Pasteur (ULP), Strasbourg)
Drs. S. Sen
X.L. Wang MSc (University of Strasbourg)

Others
E. Foppen
E. Frankin
R.D. Jansen (NIN)

Other research related activities
  • Teamleader at the Netherlands Institute for Neuroscience (NIN), KNAW (Royal Netherlands Academy of Science)
  • Boardmember, European Biological Rhythm Society (EBRS)
  • Boardmember, Netherlands Association for the Study of Obesity (NASO)