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Prof. dr. A.M.M. van Pelt

Position
Professor
Main activities
Research
Specialisation
Research
Focus of research

Spermatogenesis and Stem Cells

 

Key publications
  • Mulder CL, Catsburg LAE, Zheng Y, de Winter-Korver CM, van Daalen SKM, van Wely M, Pals S, Repping S, van Pelt AMM, Long-term health in recipients of transplanted in vitro propagated spermatogonial stem cells. HUM REPROD 2018;33 (1):81-90 [PubMed]
  • Jan SZ, Vormer TL, Jongejan A, Röling MD, Silber SJ, de Rooij DG, Hamer G, Repping S, van Pelt AMM, Unraveling transcriptome dynamics in human spermatogenesis. DEVELOPMENT 2017;144 (20):3659-3673 [PubMed]
  • Nickkholgh B, Mizrak SC, van Daalen SKM, Korver CM, Sadri-Ardekani H, Repping S, van Pelt AMM, Genetic and epigenetic stability of human spermatogonial stem cells during long-term culture. FERTIL STERIL 2014;102 (6):1700-7.e1 [PubMed]
  • Chikhovskaya JV, Jonker MJ, Meissner A, Breit TM, Repping S, van Pelt AMM, Human testis-derived embryonic stem cell-like cells are not pluripotent, but possess potential of mesenchymal progenitors. HUM REPROD 2012;27 (1):210-221 [PubMed]
  • Sadri-Ardekani H, Akhondi MA, van der Veen F, Repping S, van Pelt AMM, In Vitro Propagation of Human Prepubertal Spermatogonial Stem Cells. JAMA-J AM MED ASSOC 2011;305 (23):2416-2418 [PubMed]
All Publications
Curriculum Vitae

Education: Biology, University Utrecht

PhD degree: March 1992, Thesis: The role of retinoids in spermatogenesis

Career:

Feb 2018 - onwards       Professor Translantional Reproductive Biology, Laboratory for Reproductive Biology, Center for Reproductive Medicine, AMC, Amsterdam, The Netherlands
Nov 2012 - Feb 2018     Associate Professor (PI) Laboratory for Reproductive Biology, Center for Reproductive Medicine, AMC, Amsterdam, The Netherlands
Apr 2007 - Nov 2012     Senior researcher/Assistant Professor Laboratory for Reproductive Biology, Center for Reproductive Medicine, AMC, Amsterdam, The Netherlands
Feb 2001 - Apr 2007     Assistant Professor Department of Endocrinology, Faculty of Science, UU, Utrecht, The Netherlands
Apr 1992 - Feb 2001     Post-doc positions UMCU, Utrecht, The NetherlandsOct 1996 - Jan 1997     University Teacher Veterinary School, UU, Utrecht, The Netherlands

Other tasks

Febr 2016 – onwards    Member of the (AMC) EU support group
April 2013                     Organizer of the annual meeting of the Dutch Society of Stem Cell Research (DSSCR)
Jan 2012 - onwards      Secretary and Member of the Board of the Dutch Society of Stem Cell Research (DSSCR)
July 2011 - onwards     Member of the Board of Reviewing Editors of scientific journal: ‘Biology of Reproduction’ 2011
June 2011- onwards     Member of ESHRE Fertility Preservation Task Force Subgroup II: Fertility preservation for boys and men
Jan 2011 - onwards      Member of the international review committee of the German Research Foundation (Deutsche Forschungsgemeinschaft) for the evaluation of research unit FOR 1041/2
Jan 2010 - onwards      Member of the Editorial board of a new Scientific Journal “Spermatogenesis”
May 2010 - onwards     Member of European Society for Human Reproduction and Embryology (ESHRE)
May 2008 - onwards     Member of the Dutch Society for Stem Cell Research (DSSCR)
March 2007-onwards    Member of the International Society for In Vitro Methods (INVITROM)
Oct 2000 - Febr 2005   Assistant coordinator of the EC program QLK-2000-00305
Oct 1994 - dec 1997     Secretary of the Dutch/Belgium meetings “Retinoids and Development”

Grants:
FCT SR&TD SFRH/BPD/104820/2014: Effect of endocrine disruptors on spermatogenesis and testicular cancer: where does the protective role of regucalcin fit in? (Post Doc fellow Sara Carina Lima Correia) (2015-2018)
Marie Curie FP7-PEOPLE-2013-ITN 603568: Development of in vitro and in vivo strategies to avoid and cure male infertility (2014-2018) (coordinator & PI)
ZonMW TAS 116003002: Spermatogonial stem cell transplantation to restore fertility in childhood cancer survivors. (2014-2022) (PI)
KiKa 86 Restoring fertility in infertile childhood cancer survivors: bringing autotransplantation of human spermatogonial stem cells to the clinic. (2012-2014) (PI)
FCT SR&TD SFRH/BD/60945/2009: Regucalcin, a new sex steroid target gene and an apoptosis regulator in spermatogenesis? (PhD fellow Sara Carina Lima Correia) (2009-2014)
KIKA Autotransplantation of spermatogonial stem cells: preserving reproductive potential in childhood cancer patients. (2008-2012) (PI)
European Science Foundation (EuroSTELLS) Translational stem cell research: from basic biology to regenerative medicine. (04-ESTELLS-F01-029 )(2005-2008) (PI)
ZON/MW (Proefdieren Begrensd) Development of in vitro test strategies for reproductive toxicity on male germ cell lines. (3170.0067) (2004-2007) (PI)
EU (Quality of Life and Management of Living Resources) The impact of developmental exposure to weak (environmental) estrogens on the incidence of diseases in target organs later in life. (QLK-2000-00305) (2001-2005) (Assistant Coordinator & PI)
NIH (USA) In vitro development of undifferentiated spermatogonia. (HD 36476) (1999-2002) (co-PI)
Platform Alternatieven voor Dierproeven (ZON) The establishment of spermatogonial stem cell lines.(96-38) (1997-2001)(PI)
NWO-MW The regulation of proliferation and differentiation of spermatogonia and the role of vitamin A. (903-44-101) (1992-1996)

PhD students
Completed
R van den Ham Dec 2000
M.P.A. van Bragt June 2008
G. Carlomagno January 2011
H. Sadri-Ardekani December 2011
M. Noordam May 2012
J. Chikhovskaya November 2013
L. Visser November 2014
S.C. de Lima Correia December 2014
B. Nick Kholgh June 2015
S.Z. Jan June 2018
C.L. Mulder June 2018

ongoing

R. Struijk
J. Eliveld
I. Masliukaite
J.M.D. Portela
J.A. Onofre
J.M. Serrano
Q. Lei
J.W. Bruggeman


Post Docs
completed
S.C. Mizrak 2007-2012
T. Vormer 2009-2013
Ongoing
S.C. de Lima Correia 2015- now
 

Research programmes

Human Reproductive Biology

Spermatogenesis & Stem Cells: We aim to unravel the mechanism of spermatogonial stem cell renewal and differentiation up to sperm and use this knowledge to understand spermatogenic failure in men. We aim to develop a clinical application of human SSC autotransplantation as a way to preserve reproductive potential for instance in young boys diagnosed with cancer.

 

Faculty
Prof. dr. A.M.M. van Pelt

Postdocs
S.C. de Lima Correia PhD (CICS-UBI, Covilhã, Portugal)
Dr. S.C. Mizrak MD PhD
T.L. Vormer PhD

PhD Students
J.W. Bruggeman
J. Eliveld MSc
Q. Lei MSc
I. Masliukaite MSc
J.A. Meza
J.M.D. Portela MSc
J.M. Serrano
R.B. Struijk MSc

Others
A.E. Catsburg BSc
S.K.M. van Daalen BSc
C.M. Korver BSc

Prof. dr. S. Repping (Reproduction & Development -- Human Reproduction)

Prof. dr. F. van der Veen (Reproduction and development])

Other research related activities
  • Membership of advisory board / Consultant, The international visitation review committee of the German Research Foundation (Deutsche Forschungsgemeinschaft)
  • Secretary, Dutch Society for Stem Cell Research
  • Membership of medical or scientific committee, ESHRE, Fertility Preservation Task Force Subgroup II: Fertility preservation for boys and men
Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • ZonMw