Prof. dr. C. Ince

Main activities
Cardiovascular aspects of surgery and intensive care medicine
Focus of research

Cardiovascular aspects of Surgery and Critical Illness.

The Laboratory of Translational Physiology at the Academic Medical Center is dedicated to research into cardiovascular aspects of perioperative medicine (e.g. surgery and intensive care medicine) with an emphasis on organ function, (micro)circulation and cellular and mitochondrial oxygenation. Its research is strongly translational where (pahto)physiological and therapeutic concepts were developed in the laboratory are applied to clinical practice. Research topics include sepsis, acute kidney injury, myocardial depression, ischemia reperfussion, hemorheology, resuscitation and fluid therapy related to surgery and critical care medicine. Basic science interests related to these subjects are focused on renal and heart failure, red blood cell (pahto)physiology, cellular oxygen metabolism, nitric oxide and oxygen radical species and mitochondiral oxygenation and bioenergetics. To carry out these investigations and conduct translational research from bench to bedside we also carry out Research and development on clinical and experimental medical technology which are directed at optical spectroscopy of tissue and mitochondrial oxygenation and clinical microcirculation imaging

Key publications
  • Ince C, van Kuijen AM, Milstein DMJ, Yürük K, Folkow LP, Fokkens WJ, Blix AS, CHRISTMAS 2012: RESEARCH Why Rudolph's nose is red: observational study. BMJ-BRIT MED J 2012;345:e8311 [PubMed]
  • Ince C, Groeneveld ABJ, The case for 0.9% NaCl: is the undefendable, defensible?. KIDNEY INT 2014;86 (6):1087-1095 [PubMed]
  • Ince C, Guerci P, Why and when the microcirculation becomes disassociated from the macrocirculation. INTENS CARE MED 2016;42 (10):1645-1646 [PubMed]
  • Matejovic M, Ince C, Chawla LS, Blantz R, Molitoris BA, Rosner MH, Okusa MD, Kellum JA, Ronco C [Contributors: Kellum J, Okusa M, Ronco C, Rosner M, Agarwal A, Basile DP, Blantz R, Bonventre JV, Cantaluppi V, Chawla LS, Dong Z, Griffin M, Harris R, Humphreys B, Ince C, Matejovic M, McKay D, Mehta R, Molitoris B, Murray P, Nangaku M, Pickkers P, Portilla D, Rabb H, Singbartl K, Swaminathan S, Unwin R, Yang L]] , Renal Hemodynamics in AKI: In Search of New Treatment Targets. J AM SOC NEPHROL 2016;27 (1):49-58 [PubMed]
  • Wilson MH, Davagnanam I, Holland G, Dattani RS, Tamm A, Hirani SP, Kolfschoten N, Strycharczuk L, Green C, Thornton JS, Wright A, Edsell M, Kitchen ND, Sharp DJ, Ham TE, Murray A, Holloway CJ, Clarke K, Grocott MPW, Montgomery H, Imray C [Contributors: Ahuja V, Aref-Adib G, Burnham R, Chisholm A, Clarke K, Coates D, Coates M, Cook D, Cox M, Dhillon S, Dougall C, Doyle P, Duncan P, Edsell M, Edwards L, Evans L, Gardiner P, Grocott M, Gunning P, Hart N, Harrington J, Harvey J, Holloway C, Howard D, Hurlbut D, Imray C, Ince C, Jonas M, van der Kaaij J, Khosravi M, Kolfschoten N, Levett D, Luery H, Luks A, Martin D, McMorrow R, Meale P, Mitchell K, Montgomery H, Morgan G, Morgan J, Murray A, Mythen M, Newman S, O'Dwyer M, Pate J, Plant T, Pun M, Richards P, Richardson A, Rodway G, Simpson J, Stroud C, Stroud M, Stygall J, Symons B, Szawarski P, van Tulleken C, Vercueil A, Wandrag L, Wilson M, Windsor J]] , Cerebral venous system and anatomical predisposition to high-altitude headache. ANN NEUROL 2013;73 (3):381-389 [PubMed]
All Publications
Research programmes

Cardiovascular aspects of Surgery and Critical Illness

Our research group has three main lines of research; 1)Clinical microcirculation research in perioperative phase 2)The red blood cell in critical illnes and surgery, 3)Experimental investigations into microcirculatory and mitochondrial dysfunction in sepsis, shock and resuscitation. Our research is translational in nature where we develop concepts and techniques fron bench-to-bedside. In theme 1 we identified 5 different classes of microcirculatory alterations in distributive shock. We identified microcirculatory recruitment maneuvers in the treatment of sepsis, and developed microcirculation research in cardiac and maxillofacial surgery. In theme 2 we investigated how storage affects the quality of blood transfusions. We found that fluid resuscitation causes enhancement in renal  oxygen consumption and redistribution of oxygen transport. This line of research resulted in a grant awarded by the Landsteiner Foundation for Blood Transfusion Research. In theme 3 we developed a two-wave length technique for measuring the redistribution of tissue oxygenation in organs. Our year was rounded off by our publication in Nature Methods where we identified an endogenous mitochondrial molecule, protoporyphrin IX, with which, using quenching of delayed fluorescence, mitochondrial pO2 can be measured quantitatively  in vivo. This new technique is expected to provide important new insights into the nature of mitochondrial dysfunction in critical illness.

Theme: Cardiovascular Diseases

Prof. dr. C. Ince
B. Ergin MSc

E.C. Boerma MD PhD
Dr. D.M.J. Milstein

PhD Students
B. Ergin MSc
M.P. Hilty
B. Kappler
Z. Uz
P. Guerci (University Hospital Nancy)
H.W. He (University Union Hospital Peking)

Y. Ince