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Prof. dr. E.C. de Jong PhD

Main activities
Research, Teaching
Focus of research

Our immune system is critically important in eliminating pathogens that invade our body, including bacteria, viruses and parasites. To effectively challenge various classes of pathogens, the development of specific types of antigen-specific T cells is required, which activate different pathogen-tailored effector mechanisms. Protection against endosomal pathogens requires type 1 T helper (Th1) cells, protection against helminths Th2 cells, protection against bacteria Th17 cells and protection against viruses cytotoxic T (Tc) cells. Importantly, the function of these effector T cells is inhibited by T regulatory (Tr) cells, that prevent in this way excessive host tissue damage, autoimmunity and allergy. These different effector T cells develop from multipotent naive T cells. Our work has contributed to the concept that dendritic cells (DCs) are specialized antigen-presenting cells that orchestrate the development of protective type of effector T cell responses by their ability to sense different pathogen classes. An important research theme in my group is the question to what extent there are specialized DC subsets and by what mechanism DCs promote the development of Th1, Th2, Th17 or Treg cells. Secondly, this knowledge is applied in the development of novel therapies for immunological, inflammatory diseases such as allergic disorders.

Key publications
  • den Dunnen J, Vogelpoel LTC, Wypych T, Muller FJM, de Boer L, Kuijpers TW, Zaat SAJ, Kapsenberg ML, de Jong EC, IgG opsonization of bacteria promotes Th17 responses via synergy between TLRs and Fc gamma RIIa in human dendritic cells. BLOOD 2012;120 (1):112-121 [PubMed]
  • van der Aar AMG, Sibiryak DS, Bakdash G, van Capel TMM, van der Kleij HPM, Opstelten DJE, Teunissen MBM, Kapsenberg ML, de Jong EC, Vitamin D3 targets epidermal and dermal dendritic cells for induction of distinct regulatory T cells. J ALLERGY CLIN IMMUN 2011;127 (6):1532-U334 [PubMed]
  • de Wit J, Souwer Y, van Beelen AJ, de Groot R, Muller FJM, Klaasse Bos H, Jorritsma T, Kapsenberg ML, de Jong EC, van Ham SM, CD5 costimulation induces stable Th17 development by promoting IL-23R expression and sustained STAT3 activation. BLOOD 2011;118 (23):6107-6114 [PubMed]
  • van der Aar AMG, Picavet DI, Muller FJ, de Boer L, van Capel TMM, Zaat SAJ, Bos JD, Janssen H, George TC, Kapsenberg ML, van Ham SM, Teunissen MBM, de Jong EC, Langerhans cells favor skin flora tolerance through limited presentation of bacterial antigens and induction of regulatory T cells. J INVEST DERMATOL 2013;133 (5):1240-1249 [PubMed]
  • Bakdash G, Vogelpoel LTC, van Capel TMM, Kapsenberg ML, de Jong EC, Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells. MUCOSAL IMMUNOL 2015;8 (2):265-278 [PubMed]
All Publications
Curriculum Vitae

Positions and Employment
1991-1996 : PhD student at UTOX, Utrecht University and TNO-Nutrition. Supervisors: Prof.Dr. W. Seinen, Dr. A.H. Penninks, Prof. Dr. M.L. Kapsenberg
Thesis: Food allergy: human lymphocyte responses to peanut proteins
1996-2002 Post-doctoral fellow, Department of Cell Biology and Histology, AMC, UvA, The Netherlands
2002-2007 Senior Postdoc, Department of Cell Biology and Histology, AMC, UvA, The Netherlands
2007-2014 Assistant Professor, Department of Cell Biology and Histology, AMC, UvA, The Netherlands
2014- present Professor of Cellular Immune Regulation, Department of Cell Biology and Histology, AMC, UvA, The Netherlands

Research programmes

Functional Biology of Human Dendritic Cells

Faculty
Prof. dr. E.C. de Jong PhD

Postdocs
Dr. T. Groot Kormelink

PhD Students
Drs. P.P.S. Balraadjsing
S. Busold
F.M.J. Hafkamp
Drs. F. Lin
K. Liu MD
S. Mol
N.A. Nagy
D. Schluep

Others
Ing. T.M.M. van Capel
Drs. E.W. Taanman-Kueter

Current research funding
  • AMC
  • Galapagos B.V.
  • Leids Universitair Medisch Centrum
  • Life Sciences Health TKI
  • Stichting ReumaNederland