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Prof. dr. E.S.G. Stroes MD PhD

Position
Professor
Main activities
Research, Patient care
Specialisation
Vascular Medicine
Focus of research

- Novel lipidlowering modalities to improve cardiovascular outcome in high-risk patients

- Role of (modulating) inflammation to reduce residual cardiovascular risk

- Working towards precision medicine to improve cardiovascular outcome by means of 'multi-modality' imaging and proteomics

Key publications
  • van der Valk FM, Bekkering S, Kroon J, Yeang C, van den Bossche J, van Buul JD, Ravandi A, Nederveen AJ, Verberne HJ, Scipione C, Nieuwdorp M, Joosten LAB, Netea MG, Koschinsky ML, Witztum JL, Tsimikas S, Riksen NP, Stroes ESG, Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans. CIRCULATION 2016;134 (8):611-624 [PubMed]
  • Viney NJ, van Capelleveen JC, Geary RS, Xia S, Tami JA, Yu RZ, Marcovina SM, Hughes SG, Graham MJ, Crooke RM, Crooke ST, Witztum JL, Stroes ES, Tsimikas S, Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials. LANCET 2016;388 (10057):2239-2253 [PubMed]
  • Jakulj L, van Dijk TH, de Boer JF, Kootte RS, Schonewille M, Paalvast Y, Boer T, Bloks VW, Boverhof R, Nieuwdorp M, Beuers UHW, Stroes ESG, Groen AK, Transintestinal Cholesterol Transport Is Active in Mice and Humans and Controls Ezetimibe-Induced Fecal Neutral Sterol Excretion. CELL METAB 2016;24 (6):783-794 [PubMed]
  • Robinson JG, Farnier M, Krempf M, Bergeron J, Luc G, Averna M, Stroes ES, Langslet G, Raal FJ, El Shahawy M, Koren MJ, Lepor NE, Lorenzato C, Pordy R, Chaudhari U, Kastelein JJP [Contributors: Caccavo A, Codutti O, Gelersztein E, Vico M, Zaidman C, Majul C, Balthazar Y, Capiau L, Vrolix M, Vermeersch P, Gotchev D, Todorov G, Tumbev H, Tzekova M, Gronkova N, Dimov B, Nikolaeva A, Devedzhiev T, Mincheva V, D'Ignazio G, Dzongowski P, Elliott T, Hart R, Hoag G, Martinho V, O'Mahony M, Tellier G, Bergeron J, Pandey S, Heaton K, Constance C, Phaneuf DC, Shu D, Narvaez NC, Cañon CO, Cardenas SP, Loayza MS, de Salazar DM, Lopez RB, Gomez JI, Mendoza JA, Cure CC, Ceska R, Zidkova E, Jansky P, Egstrup K, Klausen IBC, Lomholdt J, Gislason G, Torp-Pedersen C, Poulsen S, Kuusela M, Kekki S, Nieminen S, Tuomilehto J, Boye A, Bruckert E, Cadinot D, Farnier M, Lejay D, Luc G, Revol T, Schaupp T, Krempf M, Bonnet J, Paillard F, Moulin P, Junggeburth J, Isermann B, Zühlke M, Züchner D, Theis E, Stößel J, König HJ, Rinke A, Piechatzek R, Contzen C, Lappo M, Himpel-Boenninghoff AA, Meissner G, Maus O, Degtyareva E, Schulze ED, Horacek T, Marten I, Becher P, Matoltsy A, Nyirati G, Paragh G, Zilahi Z, Nagy K, Kanakaridisz N, Beke E, Biro J, Schnabel R, Elias M, Gavish D, Francis A, Nseir W, Zimlichman R, Averna M, Pozzi C, Lembo G, Bucci M, Mezzetti A, Rubba P, de Pellegrin AM, Salvioni A, de Cesare N, Briones IR, Campos PF, Rosas EL, Espinosa EV, Salazar MA, Ruiz AB, Furusho LC, Olvera I, Stroes E, van den Berg R, Basart D, Köse V, Kentgens S, Peeters M, Hoogendijk J, Voors-Pette C, Agous I, van Kempen W, Lingan GR, Kooy A, Troquay R, Herrman J, Hoivik H, Langslet G, Norheim P, Risberg K, Høivik HO, Elle S, Derezinski T, Miekus P, Ogorek M, Szymkowiak K, Cesar M, Gawron A, Dabrowska M, Blach E, Konieczny M, Sidor M, Matias F, da Silva PM, Carvalho D, Mendonca I, Andor M, Andrei L, Podoleanu C, Pop C, Chizhov P, Chumakova G, Goloschekin B, Libov I, Paltsman Z, Strutinskiy A, Koziolova N, Breedt J, Ebrahim I, Ellis G, Fulat M, van Rensburg DJ, Raal F, van Dyk C, Vally T, van der Walt E, Kotzé H, Landman C, Tayob M, Caixas A, García LR, Fernandez-Cruz A, Gil-Extremera B, Grijalvo OM, Plana N, Fuentes F, Valdivielso P, Fraile B, Borgencrantz B, Larnefeldt H, Tengmark BO, Eriksson M, Olsson-Önerud Å, Amalyan W, Dyadyk O, Koval O, Kushnir M, Svintsitskiy A, Kovalyov O, Bondarchuk O, Tashchuk V, Barna O, Prokhorov O, Karpenko O, Stanciu D, Pawa R, Balaji H, Doig F, Harvey P, Ranganath L, Massalski W, Hassanin H, Timmis H, Pavel-Knox I, Abdulhakim E, Oyesile B, Horvathova V, Donnachie H, Kondagunta V, Shaw H, Thomas H, Kadr H, Gunstone A, Lip G, Ellery A, Kerrane J, Sarker A, Wong Yk, Soran H, Maw K, Andersen J, Blair-Britt L, Huffman C, Kivitz A, Marple R, Patron A, Schear M, Allegar N, Awasty V, Casanova R, Chaykin L, Cohen L, Collins H, Collins G, Elkin G, Reyes H, Feld L, Fuller G, Glover R, Greenwald J, Herrod J, Kaye W, Kimmel M, Kolettis E, Lakin G, Lorch D, Palatnik M, Patel R, Reichman A, Rohlf J, Shockey G, Shore K, Radin D, Alvarado O, Bellingar B, Egelhof R, McKnight T, Plevin S, Pritchard J, Reddy R, Velazquez F, Bolster E, Broker R, Butuk D, Cheung D, Cohen K, Golden G, Murray A, Naccarato T, Uusinarkaus K, Pudi K, Graff A, Blumberg V, Dunn F, Toth P, Anspach R, Chuang R, Meli J, Nevins B, Wayne J, Schmidt L, Levinsky D, Rubino J, Shealy N, Torres D, West J, Jain R, Vardi G, Singh N, Thew S, Lo E, Heitner J, Gerber J, Malik A, Weinstein D, Prashad R, Koren M, Ghitis A, David W, Reis G, Kinzfogl G, Haught H, Kantaros L, O'dea D, Weiss D, Kassas S, Hunter J, Mollod M, Khan N, Henderson D, Gatien L, Schramm R, Madder R, El Shahawy M, Voyce S, Nadar V, Stich M, Kumar M, Black R, Treasure C, Lebeis M, McCullough P, Lepor N, Moriarty P, Waxler A, Talreja D, Gen M, Dohad S, East C, Conrad G, Asbill B, Roberts J, Robinson J, Zarich S, Davis B, Krolick M, Sherman H, Thompson P]] , Efficacy and Safety of Alirocumab in Reducing Lipids and Cardiovascular Events. NEW ENGL J MED 2015;372 (16):1489-1499 [PubMed]
  • Duivenvoorden R, Tang J, Cormode DP, Mieszawska AJ, Izquierdo-Garcia D, Ozcan C, Otten MJ, Zaidi N, Lobatto ME, van Rijs SM, Priem B, Kuan EL, Martel C, Hewing B, Sager H, Nahrendorf M, Randolph GJ, Stroes ESG, Fuster V, Fisher EA, Fayad ZA, Mulder WJM, A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation. NAT COMMUN 2014;5:3065 [PubMed]
All Publications
Research programmes

Novel anti-atherogenic strategies targeting the vessel wall

During the past decade the applicant has focused at the pathophysiology of atherogenesis, focusing at the role of the vessel wall as a potential new therapeutic target. In the quest to optimize therapeutic options for patients at increased cardiovascular diseases, several lines of research are being pursued:

Imaging: Early treatment of atherosclerotic disease requires careful phenotyping of patients and early detection of atherosclerotic disease. In collaboration with Nederveen (Dept radiology), the applicant has focused at 3T-magnetic resonance of predominantly the carotid artery as a surrogate marker for atherogenesis/cardiovascular disease.
In collaboration with Dr Hein Verberne (Nuclear medicine, AMC) the applicant has also focused at the vessel wall inflammation. Using translational protocols, the impact of inflammation throughout the course of atherogenesis is evaluated, using multi-modality imaging as well as innovative anti-inflammatory compounds. 

Precision medicine: In collaboration with Prof Groen and Nieuwdorp, and dr Levin, deep-machine learning strategies are designed, aiming to unravel circulating plasma markers predicting presence/absence of atherosclerotic disease. This research is part of a ERA-CVD program, collaborating with Koenig (Munchen, Germany) and Catapano (Milano, Italy)

Residual risk: LDL lowering reduces CV risk by 30%, most likely limited by the fact that statins stabilize the disease without the potential to induce reversibility of the lesions. Novel exciting lipid particles are currently being addressed, which contribute to the residual risk following optimal LDLc lowering regimens. These comprise remnant cholesterol and Lp(a). Defining pro-atherogenic pathways and novel modalities to antagonize this effect complements the quest for novel anti-atherogenic compounds.

Faculty
Prof. dr. E.S.G. Stroes MD PhD
Prof. dr. G.K. Hovingh MD PhD
Dr. ir. A.J. Nederveen
Prof. dr. M. Nieuwdorp MD PhD

Postdocs
Dr. M. Bahjat
Dr. J. Kroon PhD

PhD Students
L. Ali
Drs. M.A.W. Van den Boogert MD
Drs. K.E.C. Bouter
A.J. Cupido MD MSc
K.E. Dzobo
T.W. Emans
M.L. Hartgers
R.M. Hoogeveen MD
Y. Kaiser
L.F. Reeskamp MD
J.G. Schnitzler
L.C.A. Stiekema
Drs. R.P. Surendran
R. Verbeek
Q. Zhang MSc
K.H. Zheng MD

Prof. dr. M. Nieuwdorp MD PhD (Gutmicrobiota as novel diagnostic and therapeutic targets in cardiometabolism)

Other research related activities
  • Membership of medical or scientific committee, Other, Chair Dutch Atherosclerosis Society
  • Membership of medical or scientific committee, Vascular Biology Working group, vascular research society
  • Board of directors / Trustees / Supervisory board, LEEFH, raad van toezicht
  • Membership of advisory board / Consultant, Vascular Research Network
Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • Amgen BV
  • Amsterdam Gastroenterology and Metabolism Res. Institute
  • Athera Biotechnologies AB
  • BioCryst Pharmaceuticals, Inc.
  • Boehringer Ingelheim BV
  • Daiichi/NIET GEBRUIKEN IS OUD ADRES!!
  • Daiichi Sankyo Inc.
  • Elsevier B.V.
  • Europese Unie
  • Idorsia Pharmaceuticals Ltd.
  • IQVIA RDS Switzerland Sarl
  • Medical Research BV
  • Nederlandse Hartstichting
  • Portola Pharmaceuticals Inc.
  • Radboud Universiteit Nijmegen
  • Regeneron Pharmaceuticals, Inc.
  • Resverlogix Corp.
  • Stichting AMC Foundation (Vrijgesteld)
  • Thrombosis Research Institute
  • UBC Late Stage (UK) Limited
  • UniQure Biopharma BV
  • Vascular Research Network BV
  • ZonMw
  • ZonMw (Vrijgesteld)