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Prof. dr. J.C.M. Meijers

Main activities
Research
Focus of research
  • Mechanism of coagulation
  • Regulation of coagulation by the protein C system
  • Regulation of coagulation by plasma protease inhibitors
  • Mechanism of fibrinolysis
Key publications
  • Cunha MLR , Bakhtiari K, Peter J, Marquart JA, Meijers JCM, Middeldorp S, A novel mutation in the F5 gene (factor V Amsterdam) associated with bleeding independent of factor V procoagulant function. BLOOD 2015;125 (11):1822-1825 [PubMed]
  • van Montfoort ML, Kuijpers MJE, Knaup VL, Bhanot S, Monia BP, Roelofs JJTH, Heemskerk JWM, Meijers JCM, Factor XI regulates pathological thrombus formation on acutely ruptured atherosclerotic plaques. ARTERIOSCL THROM VAS 2014;34 (8):1668-1673 [PubMed]
  • van Montfoort ML, Stephan F, Lauw MN, Hutten BA, van Mierlo GJ, Solati S, Middeldorp S, Meijers JCM, Zeerleder S, Circulating nucleosomes and neutrophil activation as risk factors for deep vein thrombosis. ARTERIOSCL THROM VAS 2013;33 (1):147-151 [PubMed]
  • Agar C, de Groot PG, Mörgelin M, Monk SDDC, van Os GMA, Levels JHM, de Laat B, Urbanus RT, Herwald H, van der Poll T, Meijers JCM, beta(2)-Glycoprotein I: a novel component of innate immunity. BLOOD 2011;117 (25):6939-6947 [PubMed]
  • Eerenberg ES, Kamphuisen PW, Sijpkens MK, Meijers JC, Buller HR, Levi M, Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. CIRCULATION 2011;124 (14):1573-1579 [PubMed]
All Publications
Research programmes

Biochemistry of hemostasis and thrombosis

The blood coagulation system is an essential host defense mechanism. Better insights in blood platelets, blood coagulation, the regulation of the coagulation system and fibrinolysis have lead and will lead to new risk factors for venous thrombosis and to targets for therapy for venous and arterial thrombosis. Our research group aims to (better) undertand the mechanisms of initiation and regulation of the coagulation and fibrinolytic systems. The focus of research is on the interaction between coagulation and fibrinolysis. Other research lines are the interaction of the hemostatic system with bacteria, and characterization of lipoproteins with proteomic techniques.

Theme: Cardiovascular Diseases

Faculty
Prof. dr. J.C.M. Meijers

Postdocs
Dr. K. Bakhtiari (Sanquin)
T. Plug (Sanquin)
Dr. I. Stroo PhD (Sanquin)

PhD Students
A. Barroeta
Drs. M.L.R. Cunha
Drs. J.E. Molhoek (UMCU)

Others
W.F. Kopatz
J.A. Marquart (Sanquin)
Ing. J. Peter BSc