Prof. dr. M.B. van Herk

Main activities
Image guided radiotherapy, image registration, 4D image processing
Focus of research
My reseach focuses on the accuracy of cancer treatment, and specifically radiotherapy. I have successfuly developed image guidance solutions to improve the accuracy but also study diverse sources of inaccuracy should as organ motion, interobserver variation in target volume delineation, and microscopic spread of tumor. I spend 4 days a week at the AVL hospital. My one day at AMC focuses on the integration of macroscopic and microscopic imaging.

Key publications
  • Sonke JJ, Lebesque J, van Herk M, Variability of four-dimensional computed tomography patient models. INT J RADIAT ONCOL 2008;70 (2):590-598 [PubMed]
  • McDermott LN, Wendling M, Nijkamp J, Mans A, Sonke JJ, Mijnheer BJ, van Herk M, 3D in vivo dose verification of entire hypo-fractionated IMRT treatments using an EPID and cone-beam CT. RADIOTHER ONCOL 2008;86 (1):35-42 [PubMed]
  • Kruis MF, van de Kamer JB, Houweling AC, Sonke JJ, Belderbos JSA, van Herk M, PET motion compensation for radiation therapy using a CT-based mid-position motion model: methodology and clinical evaluation. INT J RADIAT ONCOL 2013;87 (2):394-400 [PubMed]
  • Bohoslavsky R, Witte MG, Janssen TM, van Herk M, Probabilistic objective functions for margin-less IMRT planning. PHYS MED BIOL 2013;58 (11):3563-3580 [PubMed]
  • van Herk M, Ploeger L, Sonke JJ, A novel method for megavoltage scatter correction in cone-beam CT acquired concurrent with rotational irradiation. RADIOTHER ONCOL 2011;100 (3):365-369 [PubMed]
All Publications
Curriculum Vitae
Marcel van Herk has been active in radiotherapy in the Netherlands Cancer Institute (NKI) since late 1982. As medical physics student he started on the development of a liquid ionization imaging device that later became the Varian PortalVision system for electronic portal imaging. During this PhD at the NKI the detector was further developed and commercialized and the focus of the work started shifting to image processing, correction procedures and margins. Starting during a Postdoc at Harvard in 1992, his work included 3D image processing, first CT-MR image registration for treatment planning, later measuring organ motion and other uncertainties in radiotherapy such as delineation variability. Much of this work has been integrated in the Elekta Synergy cone-beam CT image guidance system developed jointly in a consortium with Elekta and David Jaffray. The NKI still develops the 3D and 4D image reconstruction software and analysis software for this product. Recent interests include probabilistic planning and data mining of clinical trial databases. Since 2005 Marcel has a professor appointment (part time) at the University of Amsterdam.

Other research related activities
  • Contribution to guidelines and protocols, ICRU
  • Contribution to training of professionals, ESTRO