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Prof. dr. M.J.A.P. Daemen

Position
Professor
Main activities
Research, Patient care
Specialisation
Cardiovascular Pathology, Atherosclerosis
Focus of research

Atherosclerosis

Plaque (in)stability

Molecular imaging of aherosclerosis

Heart and Brain connections

Key publications
  • Ritz K, Denswil NP, Stam OCG, van Lieshout JJ, Daemen MJAP, Cause and mechanisms of intracranial atherosclerosis. CIRCULATION 2014;130 (16):1407-1414 [PubMed]
  • Bink DI, Ritz K, Aronica E, van der Weerd L, Daemen MJAP, Mouse models to study the effect of cardiovascular risk factors on brain structure and cognition. J CEREBR BLOOD F MET 2013;33 (11):1666-1684 [PubMed]
  • van der Valk FM, Sluimer JC, Vöö SA, Verberne HJ, Nederveen AJ, Windhorst AD, Stroes ESG, Lambin P, Daemen MJAP, In Vivo Imaging of Hypoxia in Atherosclerotic Plaques in Humans. JACC-CARDIOVASC IMAG 2015;8 (11):1340-1341 [PubMed]
  • Daemen MJ, Ferguson MS, Gijsen FJ, Hippe DS, Kooi ME, Demarco K, van der Wal AC, Yuan C, Hatsukami TS, Carotid plaque fissure: An underestimated source of intraplaque hemorrhage. ATHEROSCLEROSIS 2016;254:102-108 [PubMed]
  • Marsch E, Sluimer JC, Daemen MJAP, Hypoxia in atherosclerosis and inflammation. CURR OPIN LIPIDOL 2013;24 (5):393-400 [PubMed]
All Publications
Research programmes

Molecular Mechanism, Imaging and Pathology of atherosclerosis

In the last 6 years the research is moving from plaque instability and imaging in the carotid artery, which was supported by the CTMM grant PARISK (PI M. Daemen) to features and mechanisms of intracranial atherosclerosis. This develops some 20 years later than extracranial atherosclerosis andshow special features such as plaque fibrosis, less plaque inflammation, while intraplque hemorrhage is rare. Even more interesting is our observation that intracranial atherosclerosis is absent in those mouse strains that develop severe extracranial atherosclerosis. We hypothesize that the intracranial endothelial cells are protective against atherosclerotic stimuli and have started mechanistic studies in collaboration with Elga de Vries (VUmc). A collaboration with Han van Lieshout (AMC) and Thijs van Osch (LUMC) focusses on the role of autoregulation in the brain (Rembrandt grant).

A CVON consortium grant (PI's M. Daemen and M. van Buchem (LUMC) called the Heart Brain Connection evaluates the hypothesis that cerebral hypoperfusion is associated with a decline of cognition and with structural brain alteraions. This is investigated in a clinical study, in the Rotterdam study and in several experimental studies. including those in mice in which we investigate the effects of cerebral hypoperfusion in mice. Non invasive imaging of intracranial vessels is quite challenging and lacks a head to head comparison with histology. To fill that gap we have started a collaboration with Jeroen Hendrikse (UMCU) who perform 3T and 7T imaging of intracanial arteries. This has resulted in a joint STW grant called Brain&Risk in which we will compare histological and non-invasive imaging features of intracranial arteries. 

Faculty
Prof. dr. M.J.A.P. Daemen

Postdocs
Dr. D. Hermkens
Dr. O. Soehnlein

PhD Students
Q. Braster MSc
Drs. N.P. Denswil
Drs. M.I. Liem MD
S. Scheffer
O.C.G. Stam
Ing. J. Verbree (LUMC)

Others
C. Mackaaij BSc
J.P.H.M. Ploegmakers BSc

Prof. A.C. van der Wal MD PhD (Cardiovascular Pathology)

Other research related activities
  • Membership of medical or scientific committee, Nederlandse Hartstichting, Netherlands Heart Institute, CVON
  • Stock / Shareholder, ACS Biomarker
  • Membership of editorial board / Editorship, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
  • Membership of medical or scientific committee, Other, DZHK Translational Research
  • Membership of medical or scientific committee, Lygature, European Lead Factory
  • Board of directors / Trustees / Supervisory board, PALGA
  • Membership of medical or scientific committee, ZonMw (Netherlands Organisation for Health Research and Development), Meer Kennis met minder dieren
Current research funding
  • Technologiestichting STW