foto

Prof. dr. S. Middeldorp MD PhD

Position
Professor
Main activities
Research, Patient care
Specialisation
Vascular Medicine, research line of Thrombosis and Haemostasis
Focus of research

Etiology and treatment of venous thromboembolism

Key publications
  • Connolly SJ, Milling TJ Jr, Eikelboom JW, Gibson CM, Curnutte JT, Gold A, Bronson MD, Lu G, Conley PB, Verhamme P, Schmidt J, Middeldorp S, Cohen AT, Beyer-Westendorf J, Albaladejo P, Lopez-Sendon J, Goodman S, Leeds J, Wiens BL, Siegal DM, Zotova E, Meeks B, Nakamya J, Lim WT, Crowther M [Contributors: Connolly SC, Crowther M, Eikelboom J, Gibson M, Milling TJ, Albaladejo P, Cohen A, Lopez-Sendon J, Middeldorp S, Schmidt J, Verhamme P, Beyer-Westendorf J, Wyse DG, Garcia D, Prins M, Nakamya J, Büller HR, Mahaffey K, Alexander J, Demchuk A, Raskob G, Schulman S, Meeks B, Zotova E, Holadyk-Gris I, Pinto T, Behr M, Lim T, Anand R, Bastani A, Caterino J, Clark C, Concha M, Cornell J, Eriksson E, Fermann G, Fulmer J, Goldstein J, Kereiakes D, Lotfipour S, Milling T, Moll S, Pallin D, Patel N, Refaai M, Rehman M, Schmaier A, Schwarz E, Shillinglaw W, Sinert R, Singer A, Takata T, Venkat A, Weinstein D, Welker J, Welsby I, Wiener S, Wilson J, Blostein M, van Keer L, Verschuren F, Coppens M, van Wissen S, Alikhan R, Breen K, Hall R]] , Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors. NEW ENGL J MED 2016;375 (12):1131-1141 [PubMed]
  • Büller HR, Décousus H, Grosso MA, Mercuri M, Middeldorp S, Prins MH, Raskob GE, Schellong SM, Schwocho L, Segers A, Shi M, Verhamme P, Wells P [Contributors: Büller H, Agnelli G, Angchaisuksiri P, Banyai M, Bauersachs R, van Bellen B, Blüguermann J, Boda Z, Bounameaux H, Brenner B, Brighton T, Castañon JD, Chechulov P, Chlumský Y, Cohen A, Davidson B, Decousus H, Eriksson H, Gallus A, Gudz I, Jacobson B, Heng LL, Lyons R, Meijer K, Minar E, Monreal M, Nakamura M, Oh D, Öngen G, Parakh R, Piovella F, Raskob G, Rehm J, Sandset PM, Schellong S, Smith M, Sokurenko G, Tomkowski W, Torp-Pedersen C, Verhamme P, Wang C, Wang Y, Weitz J, Wells P, Yanushko V, Yin WH, Prins M, Beenen L , Brandjes D, MacGillavry M, Kaplowitz N, Otten HM, Pessayre D, Peters R, Roos Y, Slagboom T, Eikelboom J, Crowther M, Roberts R, Vanassche T, Vandenbriele C, Debaveye B, Segers A, Dani V, van Bergen P, Gerrits P, Mercuri M, van Kranen R, Lanz H, Grosso M, Schwocho L, Kappelhoff J, Franc J, Shi M, Zhang G, Lin M, Crerand W, Giordano C, Skinner M, Hurley S, Lovelace G, Barrier R, Betcher J, Alvarez C, Amuchastegui LM, Blüguermann J, Cassettari A, Ceressetto J, Hrabar N, Macin S, Mahuad C, Oberti P, Santini F, Baker RI, Blombery P, Brighton T, Carroll P, Chong B, Coughlin P, Crispin P, Fletcher J, Gallus A, Serisier DJ, Tran H, Chan N, Stafford L, Ward C, Baghestanian M, Kyrle PA, Eischer L, Traby L, Marschang P, Mathies R, Pilger E, Brodmann M, Roithinger F, Weltermann A, Adzerikho I, Davidovskaya E, Gorokhovsky S, Maslianski B, Kulik A, Yanushka A, de Vleeschauwer P, Debing E, Duchateau J, Gustin M, Hainaut P, Vandekerkhof J, Verhamme P, Peerlinck K, Verstraeten P, Wautrecht JC, Motte S, Annichino-Bizzacchi JM, Mello TBT, Menezes FH, Burihan M, Cavalcanti M, Correa J, Correa de Carvalho F, Cukier A, Manenti E, Manenti ER, Sacilotto R, Timi JM, van Bellen B, Kahn SR, Kovacs M, Langner AL, VanSpronsen H, Ritchie B, Shafai-Sarshar R, Shivakumar S, Anderson D, Robinson K, Gallant B, Wells P, Karovitch A, Scarvelis D, Carrier M, Bai CX, Chen RC, Cheng ZZ, Du YC, Hu XY, Gu YQ, Hao QL, Sun SB, Wang C, Jiang L, Liu CJ, Liu CW, Liu S, Wang XX, Ye XF, Ma Z, Qin ZQ, Qin XJ, Tian HY, Wang YQ, Shi ZY, Wen FQ, Wu Q, Yang YH, Kuang TG, Yang H, Ying KJ, Ma GF, Yuan YD, Yu J, Gong XW, Zhang FX, Zhang J, Zhang SX, Zhang JW, Zhang L, Zhao JC, Huang B, Zhao J, Chlumsky J, Hola D, Hirmerova J, Hutyra M, Klimsa Z, Holub M, Kovarova K, Lang P, Ryba M, Podoubský R, Matoska P, Mayer O, Patek F, Tupa M, Spacek R, Urbanova R, Blazejova S, Vitovec M, Andersen B, Brønnum-Schou J, Dominguez H, Egstrup K, Auscher S, Jeppesen J, Asferg C, Vishram J, Nielsen H, Galsgaard I, Michaelsen M, Haugaard-Nielsen B, Ostergaard O, Poulsen SH, Torp-Pedersen C, Masik S, Kadarik M, Meriste S, Paumets M, Laheäär M, Raidjuk L, Accassat S, Buchmuller A, Mismetti P, Achkar A, Aquilanti S, Rifaï A, Breuil N, Schmidt J, Brisot D, Brousse C, de la Fuentes PT, Chakra M, Crestani B, Desormais I, Lacroix P, Diamand JM, El Kouri D, Clairand R, Elias A, Ferrari E, Doyen D, Chiche O, Grange C, Guenneguez H, Lacut K, Couturaud F, Mottier D, Leroux L, Lorcerie B, de Maistre E, Berthier S, Mahe I, Martin M, Meneveau N, Meyer G, Sanchez O, Montaclair K, Pavic M, Pernod G, Imbert B, Quere I, Galanaud JP, Roy PM, Sevestre MA, Simoneau G, Stephan D, Aleil B, Mirea C, Trinh-Duc A, von Bilderling PB, Beyer-Westendorf J, Werth S, Köhler C, Halbritter K, Diehm C, Espinola-Klein C, Weisser G, Franke D, Heuer H, Horacek T, Kahrmann G, Kroening R, Lawall H, Roecken M, Schellong SM, Pomper L, Voigts B, Bernhard S, Frommhold R, Stellbrink C, Boda Z, Ilonczai P, Olah Z, Razso K, Schlammadinger A, Farkas K, Kolossváry E, Szabó I, Frankfurter Z, Gasztonyi B, Gurzó M, Klucsik Z, Kovacs A, Szigeti S, Varga C, Landi A, Nyirati G, Pecsvarady Z, Riba M, Sámson Z, Sipos G, Szigyártó M, Sebő N, Szabó TJ, Toth K, Agarwal S, Arneja J, Babhulkar S, Balaji R, Banker D, Bhagavan NK, Bhonagiri S, Mehta A, Dayasagar Rao V, Desai P, Desai SC, Chandrashekar AR, Singh R, Deshpande A, Dharmadhikari A, Durairaj N, Ghaisas N, Gupta S, Jain R, Jindal R, Kamerkar D, Kothiwale VA, Kothurkar A, Kulkarni R, Kumar S, Mody B, Nagabhushan KN, Pandharpurkar HK, Joshi S, Parakh R, Grover T, Patel J, Patel K, Dudhagra N, Pawar N, Penurkar M, Pinjala R, Rai K, Rao B, Raval M, Raval A, Mehta P, Ravi Kishore AG, Saravanan S, Shetty P, Srinivas A, Suresh KR, Sumanthraj K, Girija KR, Vinod MV, Gavish D, Ashkenazy B, Braester A, Caraco Y, Elias M, Goldstein L, Grossman E, Lahav M, Lishner M, Lugassy G, Oliven A, Rachmilevitz R, Tzoran I, Brenner B, Yeganeh S, Zeltser D, Zimlichman R, Ageno W, Barillari G, Pasca S, Bortoluzzi C, Cattaneo M, Falanga A, Ghirarduzzi A, Lodigiani C, Picchi C, Iosub DI, Porreca E, Prandoni P, Quintavalla R, Siragusa S, Akita T, Aoyama T, Fujimoto K, Hanzawa K, Ikeda U, Iwata H, Kobayashi T, Kondo K, Kurimoto T, Maeda H, Mo M, Munemasa M, Murakami H, Nishi Y, Nishibe T, Nishigami K, Nunohiro T, Obayashi T, Satoh T, Satokawa H, Shimizu K, Shiroma H, Sonoda M, Suzuki Y, Taniguchi S, Tsujita K, Yamada N, Yasuda C, Yoshida H, Chang HJ, Choi WI, Kwon KY, Rho BH, Choi JS, Hong YS, Joh JH, Kim DJ, Kim HS, Kim SH, Kim YK, Kim KU, Kim JY, Kwon TW, Lee TS, Lim SY, Mun YC, Oh DY, Park KH, Yun WS, Yoon HI, Diaz-Castañon J, Flota LF, Galindo J, Gomez Lara J, Jerjes-Sanchez C, Palomar-Lever A, Rodriguez D, Higareda I, Boersma WG, de Graaff CS, Oudeman L, Brans E, Bredie SJH, Dees A, Erdkamp F, Peters F, Fijnheer R, Gerdes VEA, Griffioen A, Jie KSG, Meijer K, Kooistra H, Wiewel-Verschueren S, Middeldorp S, Kamphuisen PW, van Es J, Eerenberg ES, Swart Heikens J, ten Cate H, ten Wolde M, Hes R, Atalay S, Harper P, Merriman E, Ockelford P, Hulton MH, Phillips J, Royle G, Ford A, Smith M, Ghanima W, Amundsen H, Sandset PM, Abola MT, Ganzon MS, Germar A, Checinski P, Kwasniewski A, Tomkowski W, Zechowicz T, Apartsin K, Arutyunov G, Barbarash O, Burov Y, Chechulov P, Varaksina E, Chernyatina M, Gladchenko M, Belikov L, Fokin A, Gubenko A, Igor K, Olga M, Kazakov Y, Kazakov A, Krasavin V, Linev K, Plechev V, Shesternya P, Shkurin V, Shvalb P, Sokurenko G, Sonkin I, Remizov A, Chernykh K, Staroverov I, Subbotin Y, Zeltser M, Seletsky A, Iliynykh A, Zilber A, Zubareva N, Tkachenko I, Pakhomova A, Raghuram J, Ng HJ, Sin K, Adler D, Weber F, van der Jagt R, Basson M, Becker J, Ellis G, Isaacs R, Jacobson B, Louw S, van Rensburg J, Siebert H, Skosana F, van Marle J, van Zyl L, le Roux R, Williams P, Cereto F, Garcia-Bragado F, Miranda RT, Carlsson A, Eriksson H, Villegas-Scivetti M, Ottosson E, Sjalander A, Torstensson I, Banyai M, Afarideh R, Gallino A, Mazzolai L, Righini M, Staub D, Chen CJ, Chiang CE, Wang KL, Chiu KM, Huang JH, Lai WT, Pai PY, Lin KH, Wang JH, Wu CC, Yin WH, Huang CL, Angchaisuksiri P, Kulpraneet M, Rojnuckarin P, Öngen G, Duman B, Ozkan S, Savas I, Selçuk T, Tuncay E, Gerasymov V, Gubka O, Gudz I, Voloshyn M, Nikulnikov P, Danylets A, Prasol V, Rusyn V, Sergeev O, Shtutin O, Skupyy O, Tatarin A, Venger I, Cohen AT, Patel R, Hunt BJ, Kesteven P, Robson L, MacCallum P, Nokes T, Rose P, Acs P, Gordan L, Bhatia A, Ali M, Amin D, Masson J, Gavi E, Ayele E, Ayeni O, Canosa R, Chavous D, Chen D, Comerota A, Concha M, Cunanan-Bush M, Daboul N, Daggubati S, Dang N, DiBella N, Driver A, Dulgeroff A, Fraiz J, Friedlander A, Galvez A, Jani C, Johnson S, Khandelwal P, Kingsley E, Kingsley J, Hutchinson L, Lavender R, Lyons R, Guzley G, Martinez R, Metjian A, Moran J, Nadar V, Pish R, Pullman J, Quaranta AJ, Ravi C, Refaai M, Rehm J, Richards D, Richwine R, Sachdeva S, Seibert A, Sharma A, Stricklin D, Tannenbaum A, Tin-U C, Vora K, Watkins D, Willms D]] , Edoxaban versus Warfarin for the Treatment of Symptomatic Venous Thromboembolism. NEW ENGL J MED 2013;369 (15):1406-1415 [PubMed]
  • Cunha MLR , Bakhtiari K, Peter J, Marquart JA, Meijers JCM, Middeldorp S, A novel mutation in the F5 gene (factor V Amsterdam) associated with bleeding independent of factor V procoagulant function. BLOOD 2015;125 (11):1822-1825 [PubMed]
  • de Jong PG, Goddijn M, Middeldorp S, Antithrombotic therapy for pregnancy loss. HUM REPROD UPDATE 2013;19 (6):656-673 [PubMed]
  • Reitsma PH, Versteeg HH, Middeldorp S, Mechanistic View of Risk Factors for Venous Thromboembolism. ARTERIOSCL THROM VAS 2012;32 (3):563-568 [PubMed]
All Publications
Curriculum Vitae

Saskia Middeldorp, MD, qualified as a medical doctor at the University of Amsterdam in 1992. She received her training in internal medicine at the Academic Medical Center in Amsterdam and obtained her board licence in 1999 (subspecialty Vascular Medicine, 2002). Since December 2010, she is professor and co-chair of the Department of Vascular Medicine of the Academic Medical Center. She leads the residency program of vascular medicine and is head of the trial unit of the Department. Her present research focuses on several aspects of hereditary and acquired thrombophilia, women’s issues in thrombosis and haemostasis, and the clinical evaluation of new anticoagulants.

Additional information:

Dr Middeldorp defended her thesis entitled “Clinical and laboratory studies in hereditary and acquired prothrombotic states” in 2000. She was Associate Professor of the Department of Vascular Medicine in the Academic Medical Center (until December 2006) and co-director of the Dutch Cochrane Centre (2003-2005). From December 2006 to July 2010, she was Associate Professor in the Departments of Clinical Epidemiology and Internal Medicine at the Leiden University Medical Center. She was project leader of the NEO Study, a large population-based cohort of obese individuals that aims to study the etiology of various conditions and diseases in obesity.

Professor Middeldorp held a research fellowship (2003-2007) and was Clinical Established Investigator (2008-2010) of the Netherlands Heart Foundation. She holds a VIDI grant from the Netherlands Organisation for Scientific Research (NWO) (2012-present). She is co-chair of the Scientific Subcommittee of Women’s Issues in Thrombosis and Haemostasis of the International Society of Thrombosis and Haemostasis (ISTH), a Member of the Advisory Board of The Journal of Thrombosis and Haemostasis (2001), is Editor of The Cochrane Collaborative Review Group on Peripheral Vascular Diseases (2003), Member of the Scientific Advisory Boards of the Netherlands Heart Foundation (2007-2010) and Dutch Thrombosis Foundation (2007). She has co-authored over 160 peer-reviewed papers and several book chapters, and reviews manuscripts for international scientific journals.
She is co-author of the Pregnancy chapter of the ACCP guidelines on Antithrombotic management (2012). 

Research programmes

Vascular Medicine

Lines of research are:
1) Reproductive issues in thrombosis and haemostasis. This includes the topic of
thrombophilia and reproduction that is subject of this research proposal. Furthermore,
diagnostic, prophylactic and therapeutic management of venous thromboembolism in
pregnant women is part of this research line.
2) Genetic and acquired risk factors for venous thromboembolism. This research line has
the overall aim to identify novel genetic risk factors, by means of classical linkage
analysis and next generation whole exome sequencing in families that have been
collected because of an unexplained tendency to familial venous thromboembolism. It
also aims to translate the findings to the clinical implications of thrombophilia.
3) New anticoagulant drugs. This research line includes the aim to identify determinants
of recurrent thrombosis and bleeding in patients using the new anticoagulant drugs
(collaboration Dr J.W. Eikelboom, McMaster University, Hamilton, Canada). Furthermore,
clinical application of the new drugs is part of this research line.
4) The applicant was project leader and initiated the NEO Study, a large populationbased
cohort of obese individuals that aims to study the etiology of various conditions
and diseases in obesity (2006-2010). She still collaborates on vascular aspects of obesity
(collaboration Prof. dr. F.R. Rosendaal, LUMC).

Faculty
Prof. dr. S. Middeldorp MD PhD
M. Coppens MD PhD

PhD Students
Drs. R. Bavalia MD
Drs. L.F.M. Beenen
I.M. Bistervels
F.T.M. Bosch
Drs. M.L.R. Cunha
Y.C.L. Haan
E.N. Hamulyak MD
Drs. D.L. Horjus
V.L.B.I. Jansen
Drs. F.A. Karamat MD
N. Kraaijpoel MD
F.I. Mulder
L.J.J. Scheres
W. Thijs MD (Leiden University Medical Center)

Prof. dr. H.R. Büller (Venous and arterial thromboembolic diseases)

Other research related activities
  • Contribution to guidelines and protocols, ACCP guidelines on use of anticoagulant drugs in pregnancy
  • Membership of medical or scientific committee, Nederlandse Hartstichting, WAC3 diagnose en therapie
  • Membership of medical or scientific committee, Nederlandse Trombosestichting, Wetenschappelijke Adviesraad
  • Membership of advisory board / Consultant, GR (GezondheidsRaad, Dutch Health Council)
  • Contribution to guidelines and protocols, Health Council on New Oral Anticoagulants 2012
  • Membership of advisory board / Consultant, GR (GezondheidsRaad, Dutch Health Council)
  • Contribution to guidelines and protocols, Health Council on New Oral Anticoagulants 2012
  • Membership of advisory board / Consultant, GR (GezondheidsRaad, Dutch Health Council)
  • Membership of advisory board / Consultant, GR (GezondheidsRaad, Dutch Health Council)
  • Membership of advisory board / Consultant, GR (GezondheidsRaad, Dutch Health Council)
  • Contribution to guidelines and protocols, Health Council on New Oral Anticoagulants 2012
  • Contribution to guidelines and protocols, Health Council on New Oral Anticoagulants 2012
Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • Aspen Pharma Ireland Ltd.
  • Bayer AG
  • BAYER B.V.
  • Daiichi Sankyo Europe GmbH
  • Exom Group
  • IQVIA RDS Netherlands B.V.
  • NIEUWE DEB IND
  • PAREXEL Nederland B.V.
  • Stichting AMC Foundation (Vrijgesteld)
  • Trombose Stichting Nederland
  • ZonMw