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Prof. dr. S.E. La Fleur

Position
Professor
Main activities
Research
Specialisation
Neurobiology of Energy Metabolism
Focus of research

Our research aims to unravel the mechanistic link between diet composition and the development of obesity and diabetes as a first step towards a better understanding of the pathogenesis of Type 2 Diabetes Mellitus, focusing on the role of the brain.

 

Key publications
  • Koopman KE, Roefs A, Elbers DCE, Fliers E, Booij J, Serlie MJ, La Fleur SE, Brain dopamine and serotonin transporter binding are associated with visual attention bias for food in lean men. PSYCHOL MED 2016;46 (8):1707-1717 [PubMed]
  • van den Heuvel JK, Furman K, Gumbs MCR, Eggels L, Opland DM, Land BB, Kolk SM, S Narayanan N, Fliers E, Kalsbeek A, DiLeone RJ, la Fleur SE, Neuropeptide Y activity in the nucleus accumbens modulates feeding behavior and neuronal activity. BIOL PSYCHIAT 2015;77 (7):633-641 [PubMed]
  • La Fleur SE, Luijendijk MCM, van der Zwaal EM, Brans MAD, Adan RAH, The snacking rat as model of human obesity: effects of a free-choice high-fat high-sugar diet on meal patterns. INT J OBESITY 2014;38 (5):643-649 [PubMed]
  • Koopman KE, Caan MWA, Nederveen AJ, Pels A, Ackermans MT, Fliers E, la Fleur SE, Serlie MJ, Hypercaloric diets with increased meal frequency, but not meal size, increase intrahepatic triglycerides: a randomized controlled trial. HEPATOLOGY 2014;60 (2):545-553 [PubMed]
  • Koopman KE, Booij J, Fliers E, Serlie MJ, la Fleur SE, Diet-induced changes in the Lean Brain: Hypercaloric high-fat-high-sugar snacking decreases serotonin transporters in the human hypothalamic region. MOL METAB 2013;2 (4):417-422 [PubMed]
All Publications
Curriculum Vitae

Grants and Honors (selection)

2016    NWO-VICI grant "To be ready or not for glucose challenges; a critical role for the brain's reward center"

2012    STW open competition grant 'Nutrients to modulate obesity-associated brain inflammation'

2012     STW perspective grant  'Enlightened Meals'

2008    ZonMW-VIDI grant “Brain mediators in obesity and insulin resistance”

2008    Alan N. Epstein Research Award, Society for the Study of Ingestive Behavior

2004    ZonMW-VENI grant “The hepatic vagus and the melanocortin system in diet-induced obesity”

2002    Novo Nordisk Award for Endocrinology

 

Research Experience

02/2017- present

Professor, Dept Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands

10/2016- present

Honorary group leader, Metabolism and Reward Group, Netherlands Institute for Neuroscience, Royal Academy of Arts and Sciences, Amsterdam, the Netherlands

11/2014-05/2015

Visiting Professor, Unit of Functional and Adaptive Biology, CNRS-UNiversite Paris Diderot-Paris 7, Paris, France

07/2011-02/2017

Associate Professor, Dept Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands

12/2008- 7/2011

Group leader/Scientific Staff Member, Dept Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands

11/2004-12/2008

Postdoc/Assistant Professor, Dept. Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

8/2001- 11/2004

Postdoctoral fellow, Dept. Physiology, University of California San Francisco, San Francisco, USA.  supervisor: Prof. dr. Mary F Dallman

3/1997 – 8/2001

PhD student (OIO), Netherlands Institute for Brain Research, Amsterdam, the Netherlands. Supervisors: dr. A Kalsbeek & Prof. dr. RM Buijs

 

Education

2001

PhD degree in Neuroscience. Thesis title: “The Suprachiasmatic Nucleus Generated Rhythm in Blood   Glucose; a Role for the Autonomic Nervous System” Supervisors: Dr. A. Kalsbeek & Prof. dr. R.M. Buijs (Netherlands Institute for Brain Research, Amsterdam, the Netherlands) Thesis defense: 14/06/2001, University of Amsterdam, the Netherlands

1997         

Master’s degree (‘doctoraal’) in (Medical) Biology, University of Groningen, The Netherlands
 

Research programmes

Brain mediators in diet-induced obesity and diabetes

Type 2 Diabetes Mellitus is a rapidly growing epidemic. Obesity has been identified as one of the main risks for this disease and increased intake of saturated fat and sugar increases the risk to develop Obesity and Type 2 Diabetes Mellitus. Our first interest is to understand how nutrients affect the brain and how these changes mediate the overeating as observed in (most) obese people. Secondly, although peripheral actions of both fat and sugar will affect glucose metabolism, it does not explain why some obese individuals become diabetic and why others do not. We therefore focus on the effects of nutrients on the brain as an alternative route via which high caloric diets might mediate the development of diabetes.

We study these research questions with a translational approach using both diet-induced obese animals and human experimental studies. This translational approach is possible because of a close collaboration with the group of dr MJ Serlie within the Department of Endocrinology and Metabolism and the group of Prof dr J Booij from the Department of Nuclear Medicine.

Faculty
Prof. dr. S.E. La Fleur

Postdocs
Dr. C. Diepenbroek
Dr. J.D. Mul

PhD Students
E. Belegri MSc
K.A. van Galen
M.C. Gumbs MSc
Drs. M. Kiliçarslan
L.L. Koekkoek
I.V. Milanova MSc
M. Slomp
A. Joshi MSc (University of Strasbourg, France)
M. Ugur MSc (University of Strasbourg, France)
S.R. Ursem (VUMC)

Others
L. Eggels BSc
K. Lamuadni
U.A. Unmehopa BSc

Other research related activities
  • Membership of editorial board / Editorship, APPETITE
  • Membership of editorial board / Editorship, JOURNAL OF NEUROENDOCRINOLOGY
  • Membership of editorial board / Editorship, FRONTIERS IN NEUROSCIENCE
  • Membership of advisory board / Consultant, NWO: Netherlands Organisation
  • Membership of advisory board / Consultant, ERC (European Research Council)
Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • NWO