foto

Prof. J.P. Simao Henriques MD PhD

Position
Full Professor
Main activities
Education, Patient care, Research, Other
Specialisation
cardiologist
Focus of research

Acute myocardial infarction and adjuctive therapies.

Cardiac assist devices. Cardiogenic shock

Occlusive coronary artery disease.  Chronic total occlusion

Glucose metabolism in acute myocardial infarction.

Bleeding and antithrombotics in patients treated with coronary interventions

Key publications
  • Wykrzykowska Joanna J., Kraak Robin P., Hofma Sjoerd H., van der Schaaf Rene J., Arkenbout E. Karin, Ijsselmuiden Alexander J., Elias Joëlle, van Dongen Ivo M., Tijssen Ruben Y. G., Koch Karel T., Baan Jan, Vis M. Marije, de Winter Robbert J., Piek Jan J., Tijssen Jan G. P., Henriques Jose P. S. Bioresorbable Scaffolds versus Metallic Stents in Routine PCI New England journal of medicine 2017;376 (24):2319-2328 [PubMed]
  • Ouweneel Dagmar M., Eriksen Erlend, Sjauw Krischan D., van Dongen Ivo M., Hirsch Alexander, Packer Erik J. S., Vis M. Marije, Wykrzykowska Joanna J., Koch Karel T., Baan Jan, de Winter Robbert J., Piek Jan J., Lagrand Wim K., de Mol Bas A. J. M., Tijssen Jan G. P., Henriques José P. S. Percutaneous Mechanical Circulatory Support Versus Intra-Aortic Balloon Pump in Cardiogenic Shock After Acute Myocardial Infarction Journal of the American College of Cardiology 2017;69 (3):278-287 [PubMed]
  • Ouweneel Dagmar M., Schotborgh Jasper V., Limpens Jacqueline, Sjauw Krischan D., Engström A. E., Lagrand Wim K., Cherpanath Thomas G. V., Driessen Antoine H. G., de Mol Bas A. J. M., Henriques José P. S. Extracorporeal life support during cardiac arrest and cardiogenic shock: a systematic review and meta-analysis Intensive care medicine 2016;42 (12):1922-1934 [PubMed]
  • Henriques José P. S., Hoebers Loes P., Råmunddal Truls, Laanmets Peep, Eriksen Erlend, Bax Matthijs, Ioanes Dan, Suttorp Maarten J., Strauss Bradley H., Barbato Emanuele, Nijveldt Robin, van Rossum Albert C., Marques Koen M., Elias Joëlle, van Dongen Ivo M., Claessen Bimmer E. P. M., Tijssen Jan G., van der Schaaf René J., Zijlstra Felix, de Boer Menko-Jan, Michels Rolf, Meuwissen Martijn, Agostoni Pierfrancesco, van Houwelingen K. Gert, Verberne Hein J., Hirsch Alexander, Piek Jan J., de Winter Robbert J., Koch Karel T., Vis Marije M., Baan Jan, Wykrzykowska Joanna, Slagboom Ton, Amoroso Giovanni, Tuseth Vegard, Schotborgh Carl E., Bertrand Olivier, van der Ent Martin, Koolen Jacques Percutaneous Intervention for Concurrent Chronic Total Occlusions in Patients With STEMI: The EXPLORE Trial Journal of the American College of Cardiology 2016;68 (15):1622-1632 [PubMed]
  • Kikkert Wouter J., van Geloven Nan, van der Laan Mariet H., Vis Marije M., Baan Jan, Koch Karel T., Peters Ron J., de Winter Robbert J., Piek Jan J., Tijssen Jan G. P., Henriques José P. S. The prognostic value of bleeding academic research consortium (BARC)-defined bleeding complications in ST-segment elevation myocardial infarction: a comparison with the TIMI (Thrombolysis In Myocardial Infarction), GUSTO (Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries), and ISTH (International Society on Thrombosis and Haemostasis) bleeding classifications Journal of the American College of Cardiology 2014;63 (18):1866-1875 [PubMed]
All Publications
Curriculum Vitae

 

Academic Career

 

2016                                  Professor of Interventional Cardiology with focus on Cardiogenic Shock

2013                                      AMC Principal Investigator

2011                                      Master of Business and Administration. MBA degree. University of Massachusetts, USA.

2003                                      Doctor’s degree (Ph.D)

    Title of dissertation: “Primary PCI for acute myocardial infarction. Clinical and angiographic features.” University of Groningen.

    Promotor: prof. dr. F. Zijlstra

1984 - 1992                         Medical School, Medical Degree, Faculty of Medicine, University of Amsterdam

 

 

Medical Career

2008-present                    Head of Catheterization Laboratory, Academic Medical Center

2003-2005                         Fellowship interventional cardiology, Academic Medical Center

2003                                    Staff Cardiologist, Academic Medical Center

1997-2003                         Trainee residency Cardiology, Sophia Hospital and Ziekenhuis de Weezenlanden,       Zwolle. (Dr. J.C.A. Hoorntje)

1996                                    Residency Cardiology, Sophia Hospital, Zwolle

1994-1995                          Residency Cardiothoracic Surgery, St Antonius ziekenhuis, Nieuwegein

1993-1994                          Residency Cardiothoracic Surgery, OLVG Hospital, Amsterdam,

1992-1993                          House Officer at different departments in England

 

 

Post-doc Courses

2016                                      BROK (Good Clinical Practice) re-registration

2016                                      Teach the teacher (Feedback)

2014                                      Academic Medical Center Leadership program

2012                                      BROK (Basiscursus Regelgeving and Organisatie Klinisch Onderzoekers)

                                               (Certificaat, BR-A697).

2010                                      Teach the teacher

2007                                      TOEFL. Test of English as a foreign language. (Score 115/120)

2007                                      Master of Medical Management. ACPE – section I

2002                                      Cursus Klinische Epidemiologie Schiermonnikoog (LUMC)

 

Acquired Funding/ Research Grants  (M = main applicant, C = Co-applicant)

2014: M: Abbott Vascular            (AIDA)                   (k€1400)

2014: C:  NWO                                  (QvL)                   (k€400)

2014: M: InspireMD                       (Master II)           (k€120)

2013: M: Abiomed Inc.                  (PhDgrant)          (k€120)

2012: M: Abiomed Inc.                 (Japan FUP)         (k€20)

2011: M: Abiomed Inc.                  (FIM RP)              (k€26)

2010: M: Bbraun Medical             (DARE)                 (k€890)

2010: M: Abbott Vascular            (IECR)                   (k€23)

2009: M: Abiomed Inc.                  (MACH 3)            (k€150)

2008: M: NUTS OHRA                    (less bleeds)       (k€81)

2007: M: Abiomed Inc.                  (MACH)               (k€172)

2007: M: Abbott Vascular            (Explore)              (k€1400)

2007: M: Abiomed Inc.                 (Impress)             (k€1000)

2006: M: Novo Nordisk                (Glirami)              (k€132)

 

 

Supervisor PhD students University of Amsterdam

Completed

R.J. van der Schaaf         “Clinical Outcomes in high-risk STEMI patients with Mulitvessel Disease”

                                               2010, May 20

K.D. Sjauw                          “Percutaneous Mechanical Cardiac Assist Devices in Acute Myocardial Infarction and High-Risk PCI”  2010 November 19,

B.E.P.M. Claessen           Prognostic Factors in Primary and Elective Percutaneous Coronary

                                               Intervention”    2011, October 5

A.E. Engstrom                   “Percutaneous Mechanical Support Percutaneous Mechanical circulatory

                                               Support for Treatment and Prevention of Hemodynamic Instability”                                                                   2012, June 29

M.M. Vis                             “Cardiogenic Shock in Acute Myocardial Infarction. Clinical outcome and

                                               predictors” 2012, November 9

W.J. Kikkert                       Ischemic events and bleeding complications after primary percutaneous

                                               coronary intervention” 2015, January 30

 

Ongoing

L.P.C. Hoebers                 (2016)

D.M. Ouweneel               (2016)

I.M. van Dongen             (2017)

K.Y. Lam                           (2017)

J.E Elias                             (2018)

 

 

International opponent/reading committee PhD defence

Vegard Tuseth                  “Percutaneous left ventricular assist device in cardiac arrest”, Faculty of Medicine, University of Bergen, Norway, 2009 December 16

Grete Slettom                  “A systematic approach to the use of Insulin to prevent repefusion injury in

porcine ST elevation myocardial infarction”, Faculty of Medicine, University of Bergen, Norway,  2014 October 27

Supervision of BSc/MSc students, Faculty of Medicine University of Amsterdam

  • Karlijn Boots                                 Faculty of Medicine AMC, Planned graduation in 2016

  • Justin de Brabander                    Faculty of Medicine AMC, graduated in 2015

  • Jasper Schotborgh                       Faculty of Medicine AMC, graduated in 2015

  • Anna van Haersma de With       Faculty of Medicine AMC, graduated in 2011

  • Fleur Tjong                                    Faculty of Medicine AMC, graduated in 2008

  • Willy Boom,                                  Faculty of Medicine AMC, graduated in 2007

  • Carolien Geesink,                         Faculty of Medicine AMC, graduated in 2007

  • Alexander Maccloud,                  Faculty of Medicine AMC, graduated in 2006

  • Nienke Stegenga                        Faculty of Medicine AMC, graduated in 2006

  • Marjan Mangal                           Faculty of Medicine AMC, graduated in 2006

     

    Supervision of BSc/MSc students other Universities

  • Robin Wesslink                               Faculty of Technical Medicine, University of Twente, 2016

  • Wouter Kikkert                               Faculty of Medicine, University of Groningen, graduated in 2010

  • Krischan D Sjauw                            Faculty of Medicine, University of Groningen, graduated in 2005

  •  

    Awards/Honours

  • Second prize of The Einthoven dissertation award for best dissertation of the year 2003.

  • Isala Werkpaard Award for best publication of the year 1999 

     

International Research Network Activities

2016- present   Collaboration on PhD project (M Frydland) on biomarkers in AMC cardiogenic shock database. Prof. dr C. Hassager, University of Copenhagen, Denmark.

2011 - 2012       Collaboration on PhD project (LP Hoebers) on the SCAAR database with Prof. dr E. Olmerovic and dr. T Remundal, University of Gothenburg, Sweden.

2010 - 2011       Collaboration on PhD project (BE Claessen) on a range of projects with Prof. dr G. Dangas and Prof.dr. G.W. Stone, Columbia University, New York, USA

2001- 2003        Collaboration on PhD project University of Gent, Belgium (prof.dr. P. Gheeraert)

1992                   Junior researcher, Experimental Physiology, University of Lisbon, Portugal 

 

Organizational (AMC) Network activities

  • Integrated member of the management team of the AMC Heartcenter Division.

  • Initiator and coordinator of potential collaboration (AMC/OLVG)  setting up PCI facility on Aruba   

 

Membership of editorial boards

2010 - present  Journal Medical Sciences

2011 - present  Journal of Geriatric Cardiology

 

Membership of professional societies

  • Netherlands Society of Cardiology

  • Working Group on Interventional Cardiology of the European Society of Cardiology

  • Member of the European Society of Cardiology

 

Membership of Scientific committees

  • Bleemacs registry (2015-present)

  • TransCatheter Therapeutics (TCT) meeting (2014- present)

  • Dutch revascularization and Electrophysiology Summit (2012-present)

  • Member of the scientific activities committee, Acute Cardiac Care Association (2012-2015)

  • Reviewer for The Danish Council for Strategic Research. (2012)

 

Course Director

  • Amsterdam (AMC;VUMC;OLVG) Regional PCI Complication meetings (3x/year; 2013-present)

  • 4th Indo European Course on Revascularization, August 24-26, 2010

  • 1st Annual Chronic Total Occlusion Symposium, November 13 2009

  • Percutaneous valve Procedures, October 9, 2009

  • AMC CTO Summit, November 21, 2008

 

Teaching activities

  • University of Amsterdam for the Medical School/Curriculum. Cardiogenic shock.

  • Formal supervisor of subspecialty fellowship interventional cardiology.

 

Lectures

Over 200 presentations worldwide.

Over 50 invited lectures at scientific meetings such as European Society of Cardiology (ESC), EuroPCR, Transcatheter Therapeutics (TCT), American college of Cardiology (ACC), American Heart Association (AHA), Society for Cardiovascular Angiography and Interventions (SCAI) and various (inter)-national scientific society meetings

Selection of subjects

  • Cardiogenic shock

  • Acute Myocardial infarction

  • Percutaneous coronary intervention

  • Circulatory support devices

  • Multivessel coronary artery disease

  • Chronic total occlusion

  • Intracoronary stents/balloons

 

         International peer reviewed scientific publications: See Appendix

Hirsch Index: 35

 

Book

Howard Cohen and Jose PS Henriques (editors). Percutaneous Ventricular Support, An issue of

                Interventional Cardiology Clinics. Elsevier, Philadelphia, 2013.

 

Textbook contributions

Bimmer E. Claessen , Emmanouil S. Brilakis , Usman Baber,   Jose PS Henriques, Roxana Mehran,

George D. Dangas.  Rationale and Technique for Percutaneous Coronary Intervention of Chronic Total Occlusions. In: Lanzer, P (Ed). Panvascular Medicine (2281-2297) Springer, London, 2014

BE Claessen and JPS Henriques. Vasoactive and antiarrhythmic drugs during percutaneous coronary

intervention. In:  Dangas, GD (Ed). Interventional Pharmacology, An issue of Interventional Cardiology Clinics, 1st Edition. (665-671) Elsevier, Philadelphia, USA, 2013

D Burkhoff, M Moscucci, JPS Henriques..Percutaneous Circulatory Support:  Intra-Aortic Balloon

Counterpulsation, Impella, TandemHeart and Extracorporeal Bypass. In:  Moscucci, M (Ed). Baim & Grossman's Cardiac   Catheterization, Angiography, and Intervention, 8th ed. (601-627). Lippincott Williams & Wilkins, Philadelphia, USA 2012

JPS Henriques. Left ventricular support for STEMI interventions. In: Mehta, S (Ed). Textbook of STEMI

                interventions. HMP Communications, USA, 2012.

AE Engström, SS Basra, B. Kar, JPS Henriques Percutaneous left ventricular assist devices. Past, Present

and Future. In: Sabaté, M (Ed). Percutaneous Cardiac Interventions beyond stenting. Tips and tricks for new technology. PCR publishing / EUROPA EDITION, 2010

JPS Henriques.  Haemodynamic support in high-risk patients. In:  De Luca, G. and Lansky, A. (Eds).

Mechancial Reperfusion For STEMI: From Randomized Trial to Clinical Practice.(162-170). CRC Press, USA,  2010 

JPS Henriques. Left ventricular support for STEMI interventions. In: Mehta S. (Ed). Textbook of STEMI

                interventions. 2008. (317-327). HMP Communications, USA, 2008

 

Reviewer for journals (selection)

New England Journal of Medicine

Lancet

Circulation

Circulation Cardiovascular interventions

Journal of American College of Cardiology

Journal of American College of Cardiology Cardiovascular interventions

European Heart Journal

European Journal of Heart Failure

Heart

American Journal of Cardiology

EuroIntervention

International Journal of Cardiology

 

Reviewer for funding agencies/research councils

NWO

NHS

ZonMw

 

Steering committee

Global CVAD registry

Abiomed Protect II trial

Abiomed Protect I trial

Member of the Global Impella Steering Committee

 

Advisory Board

 Abiomed Inc (2005- present) 

 The Medicine company (2012)

 

Principal investigator of clinical trials

 

AIDA trial. Amsterdam Investigator-initiateD Absorb Strategy All-comers Trial (AIDA Trial): A Clinical

Evaluation Comparing the Efficacy and Performance of ABSORB™ Everolimus Eluting Bioresorbable Vascular Scaffold Strategy Versus the XIENCE Family (XIENCE PRIME™ or XIENCE Xpedition™) Everolimus Eluting Coronary Stent Strategy in the Treatment of Coronary Lesions in Consecutive All-comers. (Co-Principal investigator)

Master II trial MGuard™ Prime Stent System Clinical Trial in Patients with Acute ST Elevation Myocardial

                Infarction (Co-Principal investigator)

Explore trial. An European Multi-center, randomized trial to study the impact of percutaneous coronary

intervention on left ventricular function in patients with a non-infarct related chronic total occlusion after ST-elevation myocardial infarction: PCI vs. conservative approach in CTO patients after STEMI. (Chairman, Principal Investigator).

Impress in Severe Shock trial. A multicenter, randomized trial of the Impella cVAD versus Intra Aortic

Balloon Counter Pulsation (IABP) therapy for acute ST-elevation myocardial infarction patients treated with primary PCI in severe and deep cardiogenic shock. (Chairman, Principal Investigator).

DARE trial. DARE-Trial Drug eluting bAlloon for in-stent Restenosis. Multi-center, randomized trial to

study the effect of the SeQuent Please drug-eluting balloon versus the Xience Prime drug-eluting stent for the treatment of in-stent restenosis. (Co-Principal investigator)

Use of the Impella RP 4.0 in patients with right ventricular failure. FIRST IN MAN clinical trial.

                (Chairman, Principal Investigator).

Impress in STEMI Trial. An European Multi-center, randomized trial of the Impella* recover LP 2,5 (left

ventricular assist) device versus Intra Aortic Balloon Counter Pulsation (IABP) therapy for large anterior acute ST-elevation myocardial infarction patients treated with primary PCI. (Chairman, Principal Investigator).

Paradigm trial. A single-center, randomized trial of the strict glycaemic control in ST-elevation

myocardial infarction patients with the Paradigm® Real-Time system versus routine therapy. (Co-Principal investigator)

 

Local Principal Investigator of clinical trials

 

Prison 4 trial. Hybrid Sirolimus-eluting stent with bioresorbable polymer versus Everolimus –eluting stent

with durable polymer for total coronary occlusions in native coronary arteries. Primary Stenting of Occluded Native Coronary Arteries IV. (PRISON IV)

HEBE 3 study. A Single Dose of Erythropoietin in ST-elevation Myocardial Infarction.

Prison 3 trial. A randomized comparison of sirolimus-eluting stent implantation with zotarolimus-eluting

stent implantation for the treatment of total coronary occlusions: rationale and design of the PRImary Stenting of Occluded Native coronary arteries III (PRISON III) study

DAPA (Defibrillator After Primary Angioplasty) – Randomized Trial. Implantable Defibrillator early after

                Primary PCI for ST-Elevation Myocardial Infarction.

The Glucose-Insulin-Potassium Study (GIPS)-II Glucose-insulin-potassium infusion in patients with acute

                myocardial infarction without signs of heart failure.

 

European Principal Investigator in Global Clinical trial 

 

TOSCA 5 (CTO-201) A 2-stage study to evaluate single doses of MZ-004 at different dose levels in patients with chronic

                total occlusions. (Single non US center)

ABIOMED PROTECT II (Food Drug Administration Pivotal Trial). Randomized trial to study safety and   

effectiveness of the Impella 2.5 as compared to optimal medical management with an Intra-Aortic Balloon Pump (IABP) during "high-risk" angioplasty procedures.  (Single non US center)

ABIOMED PROTECT I (Food Drug Administration Approval Trial). A Prospective Feasibility Trial

                Investigating the use of the IMPELLA® RECOVER® LP 2.5 System in Patients Undergoing

High Risk PCI. IDE Number:  G050017. (Single non US center)

Research programmes

Prof. J.P. Simao Henriques MD PhD (Low circulatory output in acute coronary syndromes)

Acute myocardial infarction
In the Netherlands, 28500 patients suffer from an acute myocardial infarction every year and around 2400 patients present with cardiogenic shock.

Cardiogenic shock
Cardiogenic shock is a state of insufficient circulation to the organs due to poor pump function of the heart. This condition requires intensive care management, including mechanical ventilation, renal function replacement (dialysis), and various other supportive therapies.
Despite all efforts, these patients have a poor prognosis with a short term mortality of around 50%. Pharmacological support and the use of intra-aortic counterpulsation (IABP) improve hemodynamic parameters, but have failed to demonstrate better outcome in patients with cardiogenic shock.

Heartpumps
A temporary heartpump during the acute event may support the heart and circulation until the heart is recovered and able to resume its function. Especially nowadays where all patients with an acute myocardial infarction undergo immediate revascularization, recovery is a real option. Temporary heartpumps can support the circulation during a limited time period, up one or two weeks

Clinical course
The clinical course of these patients can be summarized into 3 categories:
1) functional recovery, after which the patient can leave the hospital
2) insufficient cardiac recovery with need for a permanent cardiac function replacement by a permanent surgical left ventricular assist device (LVAD or in dutch ‘steunhart’) or heart transplantation
3) death as a result of heart failure, multi-organ failure or other complications. 

It is clear that the best option for the patient is functional recovery. Biochemical and hemodynamic parameters that predict clinical outcome are needed to predict and further define patients that respond to temporary mechanical assistance. 

An open Coronary Artery is always better than an occluded one

An acute occlusion of a coronary artery is the main reason for an acute myocardial infarction. In the Netherlands, 28500 patients suffer from an acute myocardial infarction every year. Half of these patients have additional coronary artery disease, defined as multivessel disease. A total of 10% of all patients with an acute myocardial infarction have an additional chronic total coronary occlusion. These patients have reduced pump function and additional revascularization may improve the pumping and overall function of the heart. It is important to further define those patients who might benefit from such therapy in a variety of clinical entities

Others
B.E.P.M. Claessen MD PhD
W.J. Kikkert PhD
M.M. Vis PhD

Current research funding
  • AMC
  • Abbott B.V.
  • Abbott Vascular International
  • AstraZeneca BV
  • Crediteurenadm. VUmc, p/a Profource Service Center
  • Getinge Netherlands B.V.
  • Medinol Ltd.
  • Medtronic Bakken Research Center BV
  • NIEUWE DEB IND