Prof. MD MSc PhD M.G.H. Besselink

Full Professor
Main activities
Patient care, Research
Hepato-Pancreato-Biliary surgery
Focus of research
Pancreatic and Hepatobiliary (HPB) surgery
  1. Minimally invasive pancreas and liver surgery
  2. Dutch Pancreatic Cancer Group: optimizing outcomes of pancreatic surgery
  3. Dutch Pancreas Biobank: translational research pancreatic and peri-ampullary cancer
  4. Dutch Pancreatitis Study Group: improving clinical treatment of acute and chronic pancreatitis


Key publications
  • de Rooij Thijs, Klompmaker Sjors, Abu Hilal Mohammad, Kendrick Michael L., Busch Olivier R., Besselink Marc G. Laparoscopic pancreatic surgery for benign and malignant disease Nature reviews. Gastroenterology & hepatology 2016;13 (4):227-238 [PubMed]
  • de Rooij Thijs, Lu Martijn Z., Steen M. Willemijn, Gerhards Michael F., Dijkgraaf Marcel G., Busch Olivier R., Lips Daan J., Festen Sebastiaan, Besselink Marc G. Minimally Invasive Versus Open Pancreatoduodenectomy: Systematic Review and Meta-analysis of Comparative Cohort and Registry Studies Annals of surgery 2016;264 (2):257-267 [PubMed]
  • de Rooij Thijs, Jilesen Anneke P., Boerma Djamila, Bonsing Bert A., Bosscha Koop, van Dam Ronald M., van Dieren Susan, Dijkgraaf Marcel G., van Eijck Casper H., Gerhards Michael F., van Goor Harry, van der Harst Erwin, de Hingh Ignace H., Kazemier Geert, Klaase Joost M., Molenaar I. Quintus, Nieveen van Dijkum Els J., Patijn Gijs A., van Santvoort Hjalmar C., Scheepers Joris J., van der Schelling George P., Sieders Egbert, Vogel Jantien A., Busch Olivier R., Besselink Marc G. A nationwide comparison of laparoscopic and open distal pancreatectomy for benign and malignant disease Journal of the American College of Surgeons 2015;220 (3):263-270.e1 [PubMed]
  • Ahmed Ali Usama, van der Sluis Pieter C., Issa Yama, Habaga Ibrahim Abou, Gooszen Hein G., Flum David R., Algra Ale, Besselink Marc G. Trends in Worldwide Volume and Methodological Quality of Surgical Randomized Controlled Trials Annals of surgery 2013;258 (2):199-207 [PubMed]
All Publications
Curriculum Vitae


  • 2013 (sept-), HPB surgeon, AMC Amsterdam
  • 2013 (jan-aug), Fellow Laparoscopic HPB surgery, University Hospital Southampton
  • 2012, Fellow Hepato-Pancreato-Biliary (HPB) surgery, AMC Amsterdam
  • 2005-2011, Training gastrointestinal and oncological surgery, UMC Utrecht and St.Antonius Nieuwegein

Positions National

  • 2014 Oncology Committee - Netherlands Federation UMCs (NFU)
  • 2013 Scientific committee Dutch Hepato Biliary Audit (DHBA)
  • 2013 Chair scientific committee Dutch Pancreatic Cancer Audit (DPCA)
  • 2012 Co-founder and board Dutch Pancreatic Cancer Group (DPCG;
  • 2011 Initiator and co-founder Dutch Pancreatic Biobank (
  • 2002 Co-founder and board Dutch Pancreatitis Study Group (DPSG;

Positions International

  • 2015 Steering Committee, European guideline pancreatic cysts (EPC, EAHPBA, ESGE)
  • 2015 Steering Committee, European consensus minimally invasive pancreatic surgery (EAES)
  • 2015 Steering Committee, International consensus minimally invasive pancreatic resection (IHPBA)
  • 2015 Steering Committee, Consensus locally advanced pancreatic cancer, American Hepato-Pancreato-Biliary Association (AHPBA)
  • 2014 Steering Comittee, European guidelines chronic pancreatitis HaPanEU, United European Gastroenterology (UEG)
  • 2014 Scientific Advisory Committee, Pancreatic Cancer Action UK
  • 2014 Ethicon European Center of Excellence for laparoscopic pancreatic surgery
  • 2014 Scientific Advisory Board, Int. Association Pancreatology (IAP)
  • 2013 Coordinator IAP/APA evidence-based guidelines acute pancreatitis
  • 2013 Expert Panel Euro Pancreatic Cancer Index 2013
  • 2013 Education and Training Committee, Int. HPB Association (IHPBA)
  • 2013 Scientific Committee, European-African HPB Association (E-AHPBA)


  • Surgery for pancreatic cancer ("alvleesklierkanker") and IPMN/cysts,  Whipple/PPPD
  • Laparoscopic pancreatic surgery; incl laparoscopic Whipple, laparoscopic distal pancreatectomy 
  • Laparoscopic liver surgery; incl laparoscopic hemi-hepatectomy
  • Ablation for locally non-resectable pancreatic cancer with irreversible electroporation (Nanoknife) and radiofrequency ablation (RFA)
  • Surgery for acute and chronic pancreatitis 


  • 2011 Rising Star Award, Association of National European and Mediterranean Societies of Gastroenterology
  • 2010 Nominee for “Zorgveiligprijs” (safe care price), Dutch Healthcare Inspectorate (IGZ) for the project “Nationwide Online Expertpanel”
  • 2009 AstraZeneca Gastrointestinal Research Award, Dutch Gastroenterological Association (NVGE), for best gastroenterological PhD thesis in 2008
  • 2009 Schoemaker Award, The Association of Surgeons of the Netherlands for best surgical PhD-thesis in 2008


Research programmes

Prof. MD MSc PhD M.G.H. Besselink (Pancreatic and Hepato-Biliary Surgery)

Pancreatic and Hepatobiliary (HPB) surgery

  1. Minimally invasive pancreas and liver surgery, ablation
  2. Dutch Pancreatic Cancer Audit: optimizing outcomes of pancreatic surgery
  3. Dutch Pancreas Biobank: translational research pancreatic and peri-ampullary cancer
  4. Dutch Pancreatitis Study Group: improving clinical treatment of acute and chronic pancreatiti

Ad 1: This includes laparoscopic pancreatic surgery (Nationwide LEOPARD-1 and -2 trials), laparoscopic liver surgery (Nationwide LAELIVE project) and treatment of locally irresectable pancreatic cancer with induction chemotherapy and ablation strategies for locally advanced pancreatic cancer and biliary cancer (IMPALA project: irreversible electroporation and Nationwide PELICAN trial: radiofrequency ablation). The group involves pancreatic surgeons, interventional radiologists, gastroenterologists, medical oncologists, radiologists, pathologists and 6 PhD students.

Ad 2-3: Marc Besselink co-founded the Dutch Pancreatic Cancer Group (DPCG), is the chair of the scientific committee and the manager of the Dutch Pancreatic Biobank (PancreasParel). The DPCG consists of 90 medical specialists, 8 PhD students and nurses involved with the care for pancreatic cancer in 17 Dutch hospitals, including all university medical centers.

Ad 4: Marc Besselink co-founded the Dutch Pancreatitis Study Group (DPSG) of which the first 5 randomized controlled trials were all published in the top 3 general-medical journals.PROPATRIA-Lancet 2008, PANTER-New Engl J Med 2010, PENGUIN-JAMA 2012, PYTHON-New Engl J Med 2014. PONCHO-Lancet 2016. The DPSG consisting of 120+ medical specialists, 6 PhD students and 2 nurses involved with the care for pancreatitis patients in 25 Dutch hospitals including all university medical centers. Current projects (2017) include the POINTER trial.


Prof. PhD O.R.C. Busch
MD MSc PhD J.E. van Hooft
Prof. PhD H.W.M. van Laarhoven
MD K.P. van Lienden
PhD H. Wilmink

MD PhD H.C. van Santvoort

PhD Students
MD D. Da Costa
MD N.J. Schepers
MD M.S. Walma

BSc T. de Rooij

Current research funding
  • AMC (Vrijgesteld)
  • Allergan Pharmaceuticals International Ltd
  • Celgene International Il Sаrl
  • Covidien AG
  • Fonds NUTS-OHRA
  • Intuitive Surgical Sаrl
  • KWF Kankerbestrijding
  • Mylan Healthcare B.V.
  • Stichting Nationaal Fonds tegen kanker
  • UEG United European Gastroenterology
  • Zealand Pharma A/S
  • ZonMw