Prof. M.J.M. Serlie PhD

Full Professor
Main activities
Patient care, Research
Endocrinology, Metabolism and Nutrition
Focus of research

The research group focusses on translational research in the field of obesity. First, we aim to identify metabolic pathways that are involved in insulin resistance and second, we are studying the interaction between nutrition, metabolism and the brain. We use different methods to address those questions, i.e. human intervention studies, hyperinsulinemic euglycemic clamps, stable isotopes, liver magnetic resonance spectroscopy, functional MRI, SPECT and tissue biopsies (liver, muscle and adipose tissue).

Since the lab performs translational research, we collaborate with basis research scientists within the AMC and from Yale and Harvard University in the US.


Key publications
  • ter Horst Kasper W., Gilijamse Pim W., Versteeg Ruth I., Ackermans Mariette T., Nederveen Aart J., la Fleur Susanne E., Romijn Johannes A., Nieuwdorp Max, Zhang Dongyan, Samuel Varman T., Vatner Daniel F., Petersen Kitt F., Shulman Gerald I., Serlie Mireille J. Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans Cell reports 2017;19 (10):1997-2004 [PubMed]
  • van Galen Katy A., ter Horst Kasper W., Booij Jan, la Fleur Susanne E., Serlie Mireille J. The role of central dopamine and serotonin in human obesity: lessons learned from molecular neuroimaging studies Metabolism: clinical and experimental 2018;85:325-339 [PubMed]
  • Versteeg Ruth I., Schrantee Anouk, Adriaanse Sofie M., Unmehopa Unga A., Booij Jan, Reneman Liesbeth, Fliers Eric, la Fleur Susanne E., Serlie Mireille J. Timing of caloric intake during weight loss differentially affects striatal dopamine transporter and thalamic serotonin transporter binding FASEB journal 2017;31 (10):4545-4554 [PubMed]
  • Koopman Karin E., Caan Matthan W. A., Nederveen Aart J., Pels Anouk, Ackermans Mariette T., Fliers Eric, la Fleur Susanne E., Serlie Mireille J. Hypercaloric diets with increased meal frequency, but not meal size, increase intrahepatic triglycerides: a randomized controlled trial Hepatology (Baltimore, Md.) 2014;60 (2):545-553 [PubMed]
  • de Weijer Barbara A., van de Giessen Elsmarieke, Janssen Ignace, Berends Frits J., van de Laar Arnold, Ackermans Mariette T., Fliers Eric, la Fleur Susanne E., Booij Jan, Serlie Mireille J. Striatal dopamine receptor binding in morbidly obese women before and after gastric bypass surgery and its relationship with insulin sensitivity Diabetologia 2014;57 (5):1078-1080 [PubMed]
All Publications
Research programmes

Prof. M.J.M. Serlie PhD (Obesity, metabolism and the brain)

PhD Students
A. Emanuel

L.L. Koekkoek

Current research funding
  • AMC (Vrijgesteld)
  • Mediq Tefa B.V.
  • Novo Nordisk B.V.
  • UMC St. Radboud
  • ZonMw