S.E.J.A. de Rooij

Full Professor
Main activities
Education, Patient care, Research
Internal Medicine & Geriatric Medicine
Focus of research

The research of de Rooij's group considers the effects of acute illness on the aging process.

Three major research lines focus on (A) pathophysiology of delirium and the role of delirium in functional and cognitive outcome of acute illness (AMC Delirium Study), (B) functional and cognitive decline in hospital patients and in community dwelling persons, and (C) Adverse drug events (ADEs) and the transition of care. This research seeks to combine fundamental studies with both innovative health services research and clinical trials in older persons.

All three research lines share the common goal of preventing functional and cognitive decline as a consequence of acute diseases in older persons.
On behalf of the Dutch National Programme for the Elderly Care grants for 11 studies, including three clinical trials, were obtained. All studies started in 2009-2010 in close collaboration with investigators of the departments of Traumatology, Orthopaedic Surgery, Clinical Informatics, Clinical Research Unit, Intensive Care, General Practice, Social Medicine and Clinical Epidemiology, Biostatistics and Bioinformatics. See also

Ongoing clinical trials:

  1. The MAPLE study: Melatonin Against PLacebo in Elderly patients with hip fracture investigates in four hospitals the role of melatonin in the prophylactic treatment to prevent older hip fracture patients from delirium.
  2. The FIT study, a randomised clinical trial, investigates in three large rural and city regions the scope for early identification of frail elderly at risk for functional decline in over 10.000 community dwelling elderly. Its follow-up offers the opportunity to study various forms of functional and cognitive impairment in the course of time in relation to care as usual versus a multi-intervention by trained nurses and GPs. 
  3. Another randomised clinical trial entitled Transitional Care Bridge investigates in three hospitals the outcome of acutely admitted elderly patients receiving care at home after discharge from a community care nurse versus usual care.
Key publications
  • van Munster Barbara C., de Rooij Sophia E. J. A. Hospitalization and Cognitive Function in Older Adults JAMA 2010;303 (21):2137-2138 [PubMed]
  • Hamaker Marije E., Jonker Judith M., de Rooij Sophia E., Vos Alinda G., Smorenburg Carolien H., van Munster Barbara C. Frailty screening methods for predicting outcome of a comprehensive geriatric assessment in elderly patients with cancer: a systematic review lancet oncology 2012;13 (10):E437-E444 [PubMed]
  • van Eijk Maarten M., van den Boogaard Mark, van Marum Rob J., Benner Paul, Eikelenboom Piet, Honing Marina L., van der Hoven Ben, Horn Janneke, Izaks Gerbrand J., Kalf Annette, Karakus Attila, Klijn Ine A., Kuiper Michael A., de Leeuw Frank-Erik, de Man Tjarda, van der Mast Roos C., Osse Robert-Jan, de Rooij Sophia E., Spronk Peter E., van der Voort Peter H., van Gool Willem A., Slooter Arjen J. Routine use of the confusion assessment method for the intensive care unit: a multicenter study American journal of respiratory and critical care medicine 2011;184 (3):340-344 [PubMed]
  • Portegijs Erja, Buurman Bianca M., Essink-Bot Marie-Louise, Zwinderman Aeilko H., de Rooij Sophia E. Failure to Regain Function at 3 months After Acute Hospital Admission Predicts Institutionalization Within 12 Months in Older Patients Journal of the American Medical Directors Association 2012;13 (6):569.e1-569.e7 [PubMed]
  • Bootsma A. M. Jikke, Buurman Bianca M., Geerlings Suzanne E., de Rooij Sophia E. Urinary incontinence and indwelling urinary catheters in acutely admitted elderly patients: relationship with mortality, institutionalization, and functional decline Journal of the American Medical Directors Association 2013;14 (2):147.e7-147.12 [PubMed]
All Publications
Research programmes

S.E.J.A. de Rooij (Aspects of acute hospitalisation in the elderly (thesis 5-10-2006))

Main topics of research

1. delirium and delirium pathophysiology

2. innovative health services research aiming at improvement of functional and cognitive outcome after acute illness

3. falls & fall realted injury

4. recognition and prevention of ADEs

5. early identification of older persons at risk for poor outcomes (at ICU- in hospital-among community dwelling older persons)


B.C. van Munster

PhD Students
M. Pol

Current research funding
  • Stichting Amsterdams Universititeitsfonds