- Ritz Katja, Denswil Nerissa P., Stam Olga C. G., van Lieshout Johannes J., Daemen Mat J. A. P. Cause and mechanisms of intracranial atherosclerosis Circulation 2014;130 (16):1407-1414 [PubMed]
- Bink Diewertje I., Ritz Katja, Aronica Eleonora, van der Weerd Louise, Daemen Mat J. A. P. Mouse models to study the effect of cardiovascular risk factors on brain structure and cognition Journal of cerebral blood flow and metabolism 2013;33 (11):1666-1684 [PubMed]
- van der Valk Fleur M., Sluimer Judith C., Vöö Stefan A., Verberne Hein J., Nederveen Aart J., Windhorst Albert D., Stroes Erik S. G., Lambin Philippe, Daemen Mat J. A. P. In Vivo Imaging of Hypoxia in Atherosclerotic Plaques in Humans JACC. Cardiovascular imaging 2015;8 (11):1340-1341 [PubMed]
- Daemen Mat J., Ferguson Marina S., Gijsen Frank J., Hippe Daniel S., Kooi M. Eline, Demarco Kevin, van der Wal Allard C., Yuan Chun, Hatsukami Thomas S. Carotid plaque fissure: An underestimated source of intraplaque hemorrhage Atherosclerosis 2016;254:102-108 [PubMed]
- Marsch Elke, Sluimer Judith C., Daemen Mat J. A. P. Hypoxia in atherosclerosis and inflammation Current opinion in lipidology 2013;24 (5):393-400 [PubMed]
Prof. PhD M.J.A.P. Daemen (Molecular Mechanism, Imaging and Pathology of atherosclerosis)
In the last 6 years the research is moving from plaque instability and imaging in the carotid artery, which was supported by the CTMM grant PARISK (PI M. Daemen) to features and mechanisms of intracranial atherosclerosis. This develops some 20 years later than extracranial atherosclerosis andshow special features such as plaque fibrosis, less plaque inflammation, while intraplque hemorrhage is rare. Even more interesting is our observation that intracranial atherosclerosis is absent in those mouse strains that develop severe extracranial atherosclerosis. We hypothesize that the intracranial endothelial cells are protective against atherosclerotic stimuli and have started mechanistic studies in collaboration with Elga de Vries (VUmc). A collaboration with Han van Lieshout (AMC) and Thijs van Osch (LUMC) focusses on the role of autoregulation in the brain (Rembrandt grant).
A CVON consortium grant (PI's M. Daemen and M. van Buchem (LUMC) called the Heart Brain Connection evaluates the hypothesis that cerebral hypoperfusion is associated with a decline of cognition and with structural brain alteraions. This is investigated in a clinical study, in the Rotterdam study and in several experimental studies. including those in mice in which we investigate the effects of cerebral hypoperfusion in mice. Non invasive imaging of intracranial vessels is quite challenging and lacks a head to head comparison with histology. To fill that gap we have started a collaboration with Jeroen Hendrikse (UMCU) who perform 3T and 7T imaging of intracanial arteries. This has resulted in a joint STW grant called Brain&Risk in which we will compare histological and non-invasive imaging features of intracranial arteries.
BEng J. Verbree
BSc C. Mackaaij
BSc J.P.H.M. Ploegmakers
Prof. MD PhD A.C. van der Wal (Cardiovascular Pathology)
- Nederlandse Hartstichting
- Technologiestichting STW