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Prof. PhD M.P. Grobusch

Position
Full Professor
Main activities
Education, Patient care, Research
Specialisation
Internal Medicine, Infectious Diseases, Tropical Medicine
Focus of research

Clinical infectious diseases with focus on malaria (epidemiology, pathophysiology, diagnosis, prophylaxis and therapy), tuberculosis (epidemiology, diagnosis and treatment, drug-resistant TB)

Key publications
  • Karimi Ouafae, Goorhuis Abraham, Schinkel Janke, Codrington John, Vreden Stephen Gerold S., Vermaat Joost S., Stijnis Cornelis, Grobusch Martin Peter Thrombocytopenia and subcutaneous bleedings in a patient with Zika virus infection Lancet 2016;387 (10022):939-940 [PubMed]
  • Schlagenhauf Patricia, Weld Leisa, Goorhuis Abraham, Gautret Philippe, Weber Rainer, von Sonnenburg Frank, Lopez-Vélez Rogelio, Jensenius Mogens, Cramer Jakob P., Field Vanessa K., Odolini Silvia, Gkrania-Klotsas Effrossyni, Chappuis Francois, Malvy Denis, van Genderen Perry J. J., Mockenhaupt Frank, Jauréguiberry Stéphane, Smith Catherine, Beeching Nicholas J., Ursing Johan, Parola Philippe, Grobusch Martin P. Travel-associated infection presenting in Europe (2008-12): an analysis of EuroTravNet longitudinal, surveillance data, and evaluation of the effect of the pre-travel consultation Lancet infectious diseases 2015;15 (1):55-64 [PubMed]
  • de Vries Sophia G., Cremers Anne L., Heuvelings Charlotte C., Greve Patrick F., Visser Benjamin J., Bélard Sabine, Janssen Saskia, Spijker René, Shaw Beth, Hill Ruaraidh A., Zumla Alimuddin, van der Werf Marieke J., Sandgren Andreas, Grobusch Martin P. Barriers and facilitators to the uptake of tuberculosis diagnostic and treatment services by hard-to-reach populations in countries of low and medium tuberculosis incidence: a systematic review of qualitative literature Lancet infectious diseases 2017;17 (5):e128-e143 [PubMed]
  • Heuvelings Charlotte C., de Vries Sophia G., Greve Patrick F., Visser Benjamin J., Bélard Sabine, Janssen Saskia, Cremers Anne L., Spijker René, Shaw Beth, Hill Ruaraidh A., Zumla Alimuddin, Sandgren Andreas, van der Werf Marieke J., Grobusch Martin P. Effectiveness of interventions for diagnosis and treatment of tuberculosis in hard-to-reach populations in countries of low and medium tuberculosis incidence: a systematic review Lancet infectious diseases 2017;17 (5):e144-e158 [PubMed]
  • Diacon Andreas H., Pym Alexander, Grobusch Martin P., de Los Rios Jorge M., Gotuzzo Eduardo, Vasilyeva Irina, Leimane Vaira, Andries Koen, Bakare Nyasha, de Marez Tine, Haxaire-Theeuwes Myriam, Lounis Nacer, Meyvisch Paul, de Paepe Els, van Heeswijk Rolf P. G., Dannemann Brian, Rolla Valeria, Dalcomo Margreth, Gripp Karla, Escada Rodrigo, Tavares Isabel, Borga Liamar, Thomas Aleyamma, Rekha Banu, Nair Dina, Chandrasekar Chockalingam, Parthasarathy Ramavaran Thiruvengadaraj, Sekhar Gomathi, Ganesh Krishnamoorthy, Rajagopalan Krishnakumar, Rajapandian Gangadevi, Dorairajalu Rajendran, Sharma Surendra Kumar, Banavaliker Jayant, Kadhiravan Tamilarasu, Gulati Vinay, Mahmud Hanif, Gupta Arvind, Bhatnagar Anuj, Jain Vipin, Hari Smriti, Gupta Yogesh Kumar, Vaid Ashok, Cirule Andra, Dravniece Gunta, Skripconoka Vija, Kuksa Liga, Kreigere Edite, Ramos Carlos Rafael Seas, Amat y Leon Ivan Arapovic Multidrug-Resistant Tuberculosis and Culture Conversion with Bedaquiline New England journal of medicine 2014;371 (8):723-732 [PubMed]
All Publications
Curriculum Vitae


Curriculum Vitae


Personal Data
Name Martin Peter Grobusch
Academic Titles Professor, Dr. med. (M.D.), M.Sc. (Lond), DTM&H (Lond), FRCP (Lond)
Specialist in Internal Medicine, Infectious Diseases, Tropical Medicine
Date of Birth 16 May 1964 in Oberhausen, Germany
Marital Status married, one daughter, one son
Professional Address Professor (Chair) of Tropical Medicine and Head, Tropical Medicine and Travel Medicine Subunit, Department of Infectious Diseases, Tropical Medicine and HIV/AIDS, Amsterdam Medical Center, University of Amsterdam, The Netherlands
Other affiliations:
Visiting Professor, Division of Infectious Diseases, Department of Infectious Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Visiting Professor, Institute of Tropical Medicine, Tübingen, Germany and Medical Research Unit, Hôpital Albert Schweitzer, Lambaréné, Gabon

Civil Service
After completing school education with the ‘Abitur’ (A level equivalent), from 10/83 to 01/85 at Dinslaken General Hospital in Accident & Emergency and Anaesthesia departments.

University Training
Medical School from 1985 to 1992 in Giessen and Bonn. Internships e.g. at the Bernhard Nocht Institute Hamburg (Tropical Medicine) and in Kotagiri District Hospital, Nilgiris, Tamil Nadu, India. Sojourn in Burkina Faso and Togo (assistance with constructing a rural health post). ‘Practical Year’ in Langnau, Switzerland (surgery), St. Augustin (pediatrics) and Bonn (infectious diseases with focus on HIV/AIDS).

Dissertation (M.D. thesis)
Promotion (award of doctorate) in spring 1993 for the M.D. thesis ‘In vitro methods for the development of antimalarial drugs as an alternative to animal testing, exemplified by the development of mefloquine’ (Prof. HM Seitz, Institute for Medical Parasitology, University of Bonn, Germany).

Professional Experience
Junior House Officer from 08/92 to 08/93 at the Ayr Hospital, Scotland, with focus on acute and emergency medicine. Since 09/93 Senior House Officer at the Dept. of Infectious Diseases, Virchow University Hospital, Berlin. Extensive clinical experience in internal medicine (inpatient care, acute medicine, intensive care, infectious diseases policlinics). Participation in student teaching, external lecturing (e.g. at the Berlin Tropical Institute), planning and implementation of clinical studies. Extensive working experience in the departmental day clinic (HIV/AIDS, acute infectious diseases and tropical medicine/travel medicine). Specialisation (‘Facharzt’) in internal medicine in 10/00 (MRCP equivalent). Since 10/01 research work at the Institute of Tropical Medicine, Tuebingen, Germany, with focus on malaria research (human susceptibility against P.f. infection; malaria pigment kinetics, therapy studies) and teaching. Supervision of clinical studies, patient care and teaching in Libreville (Unité de Recherches du Paludisme, Centre Hôpitalier), and Lambaréné (Hôpital Albert Schweitzer), both Gabon. 11/02 specialisation in Tropical Medicine, 12/02 Infectious Diseases Specialisation certificate (DGI). Assistant Professor (Privatdozent) since 20-01-04. July 2004 - Appointment as Chair/Full Professor and Head of the Infectious Diseases Unit, University of the Witwatersrand, Johannesburg, South Africa, as of August 2005. Extensive undergraduate and postgraduate examination and teaching experience (e.g. facilitation of SA’s DTM&H course; convener/co-organizer of the Infectious Diseases Subspecialty college exams); implementation of a general Infectious Disease Service at Helen Joseph Hospital, a secondary care academic teaching hospital of Wits; provision of academic and clinical consultancy to Sizwe Hospital, a 260-bed M/XDR-TB hospital including setting up a M/XDR-TB clinical research facility; provision of academic headship to the whole Division of Infectious Diseases at Wits; establishment of Infectious Diseases as a training subspecialty in South Africa (together with 3 colleagues); teaching and research networking activities throughout Africa and Europe; leadership in and contribution to a range of major funding proposals to, amongst others, NIH, Bill & Melinda Gates Foundation, EDCTP and DFG. March 2010 – Appointment as Chair of Tropical Medicine at Amsterdam University, The Netherlands, with effect of 1 June 2010.

Postgraduate Studies
From 09/95 to 12/96 on a DAAD (German Academic Exchange Service) grant at the London School of Hygiene and Tropical Medicine (LSHTM), England. 1 year course ‘Master of Science - Infection and Health In The Tropics’ (clinical tropical medicine, epidemiology, public health plus a period at the Albert Schweitzer Hospital at Lambaréné, Gabon, for malaria research). ‘Diploma in Tropical Medicine and Hygiene’ (DTM&H). After completion of the taught courses extension for another 4 months of research at the molecular malaria research unit at LSHTM.

Miscellaneous
Languages - German (native speaker), excellent knowledge of English, good working knowledge of French, Dutch (beginner’s level)
Travel/Professional Experience outside of Europe – Africa; India, Kasachstan, Japan, South East Asia; South America; USA and Canada
Conference Organisation - IPPNW German Congress, Bonn 09/91; 3rd and 4th German Congress on Infectious Diseases and Tropical Medicine, Berlin 03/95 and 03/97; ‘The wish to help is not enough’, Development Aid Conferences of the Berlin Medical Association 10/97, 10/98 and 10/99; ‘Tropical Medicine and Global Infectious Diseases’, DTG Annual Meeting, Würzburg 09/04 (Scientific Advisory Board), 6th EDCTP Forum Addis Abeba, Ethiopia, 9 – 12 October 2011
Publication in Peer-Reviewed Journals – 131 as of May 2011 (plus 8 papers in non-peer-reviewed journals and 13 book chapters)
Peer Reviews – Journals - Acta Tropica, African Journal of Biotechnology, Antimicrobial Agents and Chemotherapy, BMC Infectious Diseases, BMC Medicine, BMC Public Health, British Medical Bulletin, British Medical Journal, Chemotherapy, Clinical Epidemiology, Clinical Infectious Diseases, Dengue Bulletin, Der Hautarzt, Emerging Infectious Diseases, European Journal of Clinical Microbiology and Infectious Diseases, European Respiratory Journal, Experimental Parasitology, Expert Review of Anti-Infective Therapy, International Journal of Microbiology, Investigacion Clinica (Venezuela), Journal of Acquired Immune Deficiency Syndromes, Journal of Clinical Pathology, Journal of Infectious Diseases, Journal of Rheumatology, Journal of Travel Medicine, Medizinische Klinik, Nature Reviews Microbiology, Parasite Immunology, Parasites and Vectors, Parasitology Research, PLoS One, Research and Reports in Tropical Medicine, Scandinavian Journal of Infectious Diseases, Sierra Leone Journal of Biomedical Research, Southern African Journal of Epidemiology and Infection, The Lancet, The Lancet Infectious Diseases, Therapy, Transactions of the Royal Society of Tropical Medicine and Hygiene, Trends in Parasitology, Tropical Medicine & International Health; Vaccine; Wiener Klinische Wochenschrift; Book articles – Checkliste Innere Medizin, 3rd. ed.; Conference abstracts – 3rd MIM Pan-African Malaria Conference, Arusha, Tanzania, Nov. 2002; 5th EDCTP Conference, Arusha, Tanzania, October 2009; Funding proposals – Bill and Melinda Gates Foundation; EDCTP; Medical Research Council (MRC); Swiss National Science Foundation; The Wellcome Trust, UK Scientist assessments – National Research Foundation, South Africa; Poster Prize Committee - DTG Annual Meeting, Würzburg 09/04; Award review Committee – Rolex Awards for Enterprise 2008
Editorial Boards – The Lancet - Editorial Consultant; Malaria Journal - Editorial Board Member; International Journal of Human Parasitic Diseases – Editor-in-Chief; Therapy – Guest Editor for Special Issue on Malaria, January 2010; Malaria Research and Treatment – Editorial Board Member; Section Editor: Clinical Malaria in Hommel, Kremsner: Malaria (Standard textbook to be published in 2012)
Memberships – American Society of Tropical Medicine and Hygiene (ASTMH); German Society of Infectious Diseases (DGI); German Society of Tropical Medicine and Hygiene (DTG); Infectious Diseases Society of South Africa (IDSSA); International Physicians for the Prevention of Nuclear War/Physicians in Social Responsibility (IPPNW); International Society of Infectious Diseases (ISID); International Society of Travel Medicine (ISTM), IPTi Development Consortium, Paul-Ehrlich-Gesellschaft für Chemotherapie (PEG); Royal Society of Tropical Medicine and Hygiene (RSTMH), European Surveillance Network for Imported Infectious Diseases (TropNetEurop) , GeoSentinel/EuroTravNet; International Society of Travel Medicine (ISTM); Nederlandse Internisten Vereniging (NIV), Nederlandse Vereniging voor Parasitologie (NVP), Nederlandse Vereniging voor Infectieziekten (VIZ), Nederlandse Vereniging voor Tropische geneeskunde (NVTG)
Consultancies
Member of the Clinical Guidelines Development Committee of the German Society of Tropical Medicine (DTG) since June 2001
Member of the Speakers’ Committee of the Malaria Work Group of the Paul-Ehrlich Gesellschaft fuer Chemotherapie (PEG) since June 2003
Member of the Editorial Consultants Board, The Lancet, since June 2005
Executive Committee Member of the School of Medicine, Faculty of Health Sciences, Wits University, since August 2005
College of Medicine (SA) Infectious Diseases Subspecialty Committee Member, up from October 2005
Johannesburg General Hospital Antimicrobial Committee, up from June 2006
EDCTP (European & Developing Countries Clinical Trials Platform) proposals reviewer, Scientific Review Committee (SRC) Chair, since November 2005
ECDC (European Centre for Disease Prevention and Control) proposals reviewers roster member, since November 2005
EC (European Community) proposals reviewer, since November 2005
IPTi Consortium Executive Committee member, since January 2006
Advisory Committee to the Gauteng DoH on XDR-TB, since September 2006
Wits’ Council Re-Admissions Committee, since October 2006
Wits Faculty of Medicine Research Committee, since August 2007
Wits Senate Member, since November 2008
Consultant to the Bill & Melinda Gates Foundation re: Grant proposal progress evaluation, Kaufmann et al., TB Biomarkers, Addis Abeba (Ethiopia) study site, 2008
Consultant to the UBS/Optimus Foundation re: Grant proposal progress evaluation, May et al., Fever Dx and Tx in African children algorithm development, ´Kumasi (Ghana) study site, 2008
EDCTP Partnership Board Member, since February 2009
Executive Board Member of the Infectious Diseases Society of South Africa (IDSSA), since August 2009
Foundation Member of AIGHD Executive Board (since January 2011)
Chair of DSMB for the ‘Comparative, open-label, dose and regimen optimization follow-up study of intravenous and intramuscular artesunate in African children with severe malaria’ (sponsor: Tübingen University)
Evaluation commission Institute of Social Medicine at Zuerich University, Oct 2010
Co-Site Director of AMC EuroTravNet site (since January 2011)
ISTM, Co-Chair Research and Awards Committee meeting (since May 2011)
HIV/Nat Thailand Advisory Board Member (since June 2011)
ISTM International Outreach Task Force (since July 2011, founding member)


Examination boards
DTM&H course, Wits University, Johannesburg, since 2005; final year MB BCh examinations, Wits University, Johannesburg, since 2005; GEMP III and IV examinations, Wits University, Johannesburg, since 2006; SA College of Medicine Infectious Diseases subspecialty examiners’ board up from 2008 and convener of the Johannesburg exam in May 2009

 

 


Grants and Awards

German Academic Exchange Service (DAAD) 1995/96
Sponsoring of ‘Master of Science’ course at the London School of Hygiene and Tropical Medicine (LSHTM). In addition, financing of DTM&H course, support of a research trip to Lambaréné, Gabon, financing of additional research sojourn at the LSHTM (molecular parasitology research).

German Research Community (DFG) and The Lancet 1999
Travel Grants to facilitate active participation at an Infectious Diseases Conference in Buenos Aires, Argentina.
Merck, Sharp and Dohme 2000
Infectious Diseases Grant for a malaria therapy research project at Mahidol University Bangkok, Thailand.

Physikalisch-Technische Bundesanstalt Berlin, 2001
Helmholtz-Fonds Award for flowcytometric investigations for malaria diagnosis (together with J Neukammer and B Kraemer).

The Lancet 2002
Lancet Travel Grant to facilitate active participation at a malaria conference in Arusha, Tanzania.

German National Genome Research Network (NGFN) 2003
Travel Grant for ‘excellent poster presentation’ for NGFN symposium 2003.

International Research Promotion Council 2004
Nomination for the ‘Eminent Scientist of The Year’ Award for work on rapid immunochromatographic malarial antigen detection.

Royal College of Physicians 2010
Awarding of the status of a ‘Fellow of the Royal College of Physicians’, London, UK
 

Research programmes

Prof. PhD M.P. Grobusch (Ongoing Research Projects (Selection) as of November 2011)

Tuberculosis drug target identification: the coronin I pathway. Together with Prof. Jean Pieters, University of Basle, CH. Funded by UBS OPTIMUS Foundation

Optimizing drug-resistant TB patient management in Johannesburg, South Africa. Funded by the National Research Foundation South Africa

TMC-207 phase II trials (contributor at Sizwe Hospital site in SA and National PI, South Africa)

 

PROMPT trial for early Tb treatment in HIV positive individuals (contributor to Lambarene site/Gabon). 4-African country trial funded by EDCTP

 

StaphNet Consortium consortium contributor to characterize staphylococcal disease and strains in sub-Saahran Africa. Funded by DFG

CESSARI consosrtium for cystic echinococcosis in sub-Saahran Africa. Funded by DFG

 

- to be updated regularly

 

Faculty
MD PhD G.J. de Bree
MD PhD A. Goorhuis
PhD S. Hermans
C. Stijnis
Prof. PhD M. van Vugt

PhD Students
J. Elsinga
E.F. Forero
E. Ivan
M. Vincente Gonzalez

Medewerkers buiten research programmes van afdeling Inwendige Geneeskunde: Infec./Trop./Aids

Current research funding
  • Europese Unie
  • Gilead Sciences, Inc.
  • Ministerie van Defensie (Kerkrade)
  • Ned. ver. voor Tropische Geneeskunde en Int. Gezondheidszorg (NVTG)
  • Quintiles West Africa Limited
  • TravelAlert