foto

R. Swijnenburg MD PhD

Position
Medical Specialist
Main activities
Patient care, Research
Specialisation
Hepato-Pancreato-Biliary Surgery
Focus of research

As a Hepato-Pancreatico-Biliary (HPB) Surgeon, my research focusses on multimodality molecular imaging to allow integration of diagnostic and intraoperative imaging in patients suffering from tumors in the liver, pancreas and biliary tract. 

After obtaining my medical degree in 2006, I spent three years at Stanford University studying molecular imaging of embryonic stem cell transplantation, for which I  received a PhD degree at the Leiden University (Prof. dr. J.F. Hamming, Prof. Dr. R.C. Robbins and Dr. J.C. Wu). This research was supported by grants from the European Society for Organ Transplantation and the Fulbright Foundation. Upon returning to The Netherlands, I started Surgery Residency at the Leiden University Medical Center and the Bronovo Hospital in The Hague. I became interested in surgical oncology, specifically hepatobiliary and pancreatic cancers and got the opportunity to join the Image-Guided Surgery research group (Prof. Dr. C. van de Velde, Dr. A.L. Vahrmeijer) at the LUMC. In 2011, I worked full time for a year as a post-doc. During that time, my first paper as a senior author was published. In 2010, I co-founded the Lisa Waller Hayes Foundation (www.lwhfoundation.com). This foundation is dedicated to advance scientific research in the field of pancreatic cancer and to provide a platform of information to patients and their families. After finishing training as a surgical oncologist in July 2015, I did a 2-year fellowship in HPB surgery at the LUMC. During that time, I instigated renewed collaboration with Stanford University’s Multimodality Molecular Imaging Lab (Prof. Dr. S.S. Gambhir) and gathered funding from several sources to allow PhD and graduate students to spent 1-2 years at Stanford. Joint projects primarily focus on the development and clinical translation of molecularly-targeted, tumor-specific imaging agents. In August of 2018, I was appointed staff member in HPB surgery at Amsterdam UMC. In that same year, I was awarded a Young Investigator Grant by the KWF, which has allowed me to form my own research group. My first PhD candidate graduated in November of 2018. Currently, I am the supervisor (co-promotor) of 4 PhD candidates and several graduate students at Amsterdam UMC and the LUMC. Recently, I was awarded a grant by the Cancer Center Amsterdam.

Being appointed as a surgeon in both the AMC and VUmc locations, I play an active role in the alliance, specifically for the HPB department. By merging researchers and clinicians from the different biomedical imaging groups (CCA, Imaging Center), as well as the Amsterdam Skills Center (ASC), I see a great future ahead for translational molecularly targeted imaging research and implementation at Amsterdam UMC.

Key publications
  • Tummers W. S., Groen J. V., Sibinga Mulder B. G., Farina-Sarasqueta A., Morreau J., Putter H., van de Velde C. J., Vahrmeijer A. L., Bonsing B. A., Mieog J. S., Swijnenburg R. J. Impact of resection margin status on recurrence and survival in pancreatic cancer surgery British journal of surgery 2019;106 (8):1055-1065 [PubMed]
  • Tummers Willemieke S., Kimura Richard H., Abou-Elkacem Lotfi, Beinat C., Vahrmeijer Alexander L., Swijnenburg Rutger-Jan, Willmann Juergen K., Gambhir Sanjiv S. Development and preclinical validation of a cysteine knottin peptide targeting integrin avb6 for near-infrared fluorescent-guided surgery in pancreatic cancer Clinical cancer research 2018;24 (7):1667-1676 [PubMed]
  • Charehbili A., Koek M. B. G., de Mol van Otterloo J. C. A., Bronkhorst M. W. G. A., van der Zwaal P., Thomassen B., Waasdorp E. J., Govaert J. A., Bosman A., van den Bremer J., Ploeg A. J., Putter H., Meijs A. P., van de Velde C. J. H., van Gijn W., Swijnenburg R. J. Cluster-randomized crossover trial of chlorhexidine-alcohol versus iodine-alcohol for prevention of surgical-site infection (SKINFECT trial) BJS Open 2019;3 (5):617-622 [PubMed]
  • Tummers Willemieke S, Farina-Sarasqueta Arantza, Boonstra Martin C, Prevoo Hendrica A, Sier Cornelis F, Mieog Jan S, Morreau Johannes, van Eijck Casper H, Kuppen Peter J, Bonsing Bert A, Vahrmeijer Alexander L, Swijnenburg Rutger-Jan Selection of optimal molecular targets for tumor-specific imaging in pancreatic ductal adenocarcinoma Oncotarget 2017;8 (34):56816-56828 [PubMed]
  • Swijnenburg Rutger-Jan, Schrepfer Sonja, Govaert Johannes A, Cao Feng, Ransohoff Katie, Sheikh Ahmad Y, Haddad Munif, Connolly Andrew J, Davis Mark M, Robbins Robert C, Wu Joseph C Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts Proceedings of the National Academy of Sciences of the United States of America 2008;105 (35):12991-12996 [PubMed]
All Publications
Curriculum Vitae

Education

2015 – 2018                                      Fellowship HPB Surgical Oncology, Leiden University Medical Center (LUMC)

                                                          Focus: Hepatobiliary, pancreas and endocrine surgery

2015 – 2017                                      Training Abdominal Organ Donor Procurement Surgery, LUMC

2016 (Feb)                                         Clinical Observership HPB Surgical Oncology, Stanford University, Stanford (CA, USA)

2008 – 2015                                       Surgery Resident, LUMC and Haaglanden Medical Center; Specialization: GI Surgery - Surgical Oncology

2009 (Apr)                                         Ph.D. thesis defense; Characterization of embryonic stem cell transplantation immunobiology using molecular imaging, Leiden University

                                                           Promotors: Prof. dr. J.F. Hamming, Prof. dr. R.C. Robbins (Cardiothoracic Surgery, Stanford)

2004 – 2006                                       Internships, LUMC; M.D. since June 2006

1997 – 2003                                       Medical School, Leiden University

1990 – 1996                                       Pre-university level high school, Meridiaan College, Amersfoort

 

Positions and employment

2018 – present                                   Staff member, Hepatobiliary and Pancreatic Surgery, Amsterdam UMC, locations AMC and VUmc

2018                                                   Board Certified in abdominal organ donor procurement surgery, LUMC

2017 – present                                   Member, Committee Continues Professional Education, NVVH

2016 – 2018                                       Course Coordinator Image-Guided Interventions, Masters Clinical Technology, Leiden-Delft-Erasmus Alliance

2016 – present                                   Member, Scientific Committee, Dutch Hepatobiliary Audit

2016 – present                                   Board Certified Surgical Oncologist and Gastro-intestinal Surgeon

2014 – 2015                                       Board member, Foundation for Scientific Research in Surgical Specialties (SWOAHS)

2010 – present                                   Co-founder, Medical and Scientific Advisor of the Lisa Waller Hayes Pancreatic Cancer Foundation / Living With Hope

1999 – 2003                                       Organ allocation coordinator, Eurotransplant International Foundation, Leiden (NL)

 

Research Experience

2019 – present                                    PhD Supervisor (co-promotor) of Burak Gorgec, MD

                                                            Clinical value of MRI in colorectal liver metastases

2018 – present                                    PhD Supervisor (co-promotor) of Karen Bolhuis, MD

                                                            Treatment strategies of in colorectal cancer patients with initially unresectable liver-only metastases (CAIRO-V study)

2018 – present                                    PhD Supervisor (co-promotor) of Maurice Zwart, MSc

                                                            Implementation of robotic hepatobiliary and pancreatic surgery

2017 – present                                    PhD Supervisor (co-promotor) of Friso Achterberg, MD.

                                                            Molecular imaging of liver and pancreatic tumors

2015 – present                                    PhD Supervisor (co-promotor) of Willemieke Tummers, MD, PhD.

                                                            Thesis: Diagnostic and Intraoperative Targeted Molecular Imaging for Pancreatic Cancer (Defense 13th Nov 2018)

2011 – 2012                                       Postdoc, Department of Surgical Oncology, Leiden University Medical Center

                                                           Multimodality molecular image-guided surgical oncology

2012 – 2017                                       Principle investigator SKINFECT trial: Chlorhexidine-alcohol versus Iodine-alcohol for preoperative antisepsis, Multicenter study in region South-West

2006 – 2008                                       PhD Research Fellow, Stanford University School of Medicine, Department of Cardiothoracic Surgery and Molecular Imaging Program at Stanford, Stanford (CA, USA)

                                                           Molecular imaging of human embryonic stem cell transplantation immunobiology

2003 – 2004                                       Visiting Researcher, Stanford University School of Medicine, Department of Cardiothoracic Surgery, Stanford (CA, USA)  Embryonic stem cell transplantation for myocardial repair

 

Grants and Honors

2019                                                   Cancer Center Amsterdam Grant, €150.000,- (Principle Investigator)  

2017 – 2021                                       Dutch Cancer Society (KWF) Young Investigator Grant, €650.000,- (Principle Investigator)    

2016                                                   Stanford Cancer Institute Research grant, $150.000,- (Co-investigator)

2015                                                   Surgical Intuitive Research Grant, $50.000,- (Principle investigator)

2013                                                   ESSO Fellowship Grant to attend the Films Workshop for Clinical Cancer Research

2013                                                   European Research Council Advanced Grant Prof. C.J.H. van de Velde, €2.5 mln (Writing committee)

2006                                                   European Society for Organ Transplantation-Astellas Study and Research Grant, €25.000

2006                                                   Fulbright Scholarship, $12.500

2005                                                   Hippocrates Foundation Research Prize, €2.500

2003                                                   VSB Foundation study grant, €5.000

2003 and 2006                                   Professor Michaël-van Vloten research grant, €10.000

2003                                                   Leiden University Foundation study grant, €2.500                                           

 

Extracurricular activities

2000 – 2002                                       Treasurer of the 125th anniversary congress of the Medical Society Hippocrates, Kos (EL)

1999 – 2000                                       Vice-President of the Minerva Student Union                             

 

Publications (H-index 20)

Cluster‐randomized crossover trial of chlorhexidine–alcohol versus iodine–alcohol for prevention of surgical‐site infection (SKINFECT trial). Charehbili A,  Koek MB,  de Mol van Otterloo JC, Bronkhorst MW, van der Zwaal P, Thomassen B, Waasdorp EJ,  Govaert JA, Bosman A, van den Bremer J,  Ploeg AJ, Putter H, Meijs AP,  van de Velde CJ, van Gijn W,  Swijnenburg RJ. BJS Open 2019. Published online 20 May 2019

van der Poel MJ, Fichtinger RS, Bemelmans M, Bosscha K, Braat AE, de Boer MT, Dejong CHC, Doornebosch PG, Draaisma WA, Gerhards MF, Gobardhan PD, Gorgec B, Hagendoorn J, Kazemier G, Klaase J, Leclercq WKG, Liem MS, Lips DJ, Marsman HA, Mieog JSD, Molenaar QI, Nieuwenhuijs VB, Nota CL, Patijn GA, Rijken AM, Slooter GD, Stommel MWJ, Swijnenburg RJ, Tanis PJ, Te Riele WW, Terkivatan T, van den Tol PM, van den Boezem PB, van der Hoeven JA, Vermaas M, Hilal MA, van Dam RM, Besselink MG; Dutch Liver Collaborative Group. Implementation and outcome of minor and major minimally invasive liver surgery in the Netherlands. HPB (Oxford). 2019 Jun 21.

Suker M, Koerkamp BG, Coene PP, van der Harst E, Bonsing BA, Vahrmeijer AL, Mieog JSD, Swijnenburg RJ, Dwarkasing RS, Roos D, van Eijck CHJ. Yield of staging laparoscopy before treatment of locally advanced pancreatic cancer to detect occult metastases. Eur J Surg Oncol. 2019 Jun 3.

Caballero C, Burock S, Carrion-Alvarez L, Nilsson H, Ruers T, Senellart P, Rivoire M, Stattner S, Primavesi F, Troisi R, Gruenberger T, Heil J, Schnitzbauer AA, Rahbari NN, Swijnenburg RJ, Malik H, Protic M, Kataoka K, Mauer M, Ducreux M, Poston G, Evrard S. Building a collaboration to improve surgical research through. EORTC/ESSO 1409-CLIMB study: A prospective liver metastasis database with an integrated quality assurance program. Eur J Surg Oncol. 2019 May 30

Sibinga Mulder BG, Feshtali S, Fariña Sarasqueta A, Vahrmeijer AL, Swijnenburg RJ, Bonsing BA, Mieog JSD. A Prospective Clinical Trial to Determine the Effect of Intraoperative Ultrasound on Surgical Strategy and Resection Outcome in Patients with Pancreatic Cancer. Ultrasound Med Biol. 2019 Aug;45(8):2019-2026.

Buisman FE, Homs MYV, Grünhagen DJ, Filipe WF, Bennink RJ, Besselink MGH, Borel Rinkes IHM, Bruijnen RCG, Cercek A, D'Angelica MI, van Delden OM, Donswijk ML, van Doorn L, Doornebosch PG, Emmering J, Erdmann JI, IJzerman NS, Grootscholten C, Hagendoorn J, Kemeny NE, Kingham TP, Klompenhouwer EG, Kok NFM, Koolen S, Kuhlmann KFD, Kuiper MC, Lam MGE, Mathijssen RHJ, Moelker A, Oomen-de Hoop E, Punt CJA, Te Riele WW, Roodhart JML, Swijnenburg RJ, Prevoo W, Tanis PJ, Vermaas M, Versleijen MWJ, Veuger FP, Weterman MJ, Verhoef C, Groot Koerkamp B. Adjuvant hepatic arterial infusion pump chemotherapy and resection versus resection alone in patients with low-risk resectable colorectal liver metastases - the multicenter randomized controlled PUMP trial. BMC Cancer. 2019 Apr 5;19(1):327.

van der Werf LR, Kok NFM, Buis CI, Grünhagen DJ, Hoogwater FJH, Swijnenburg RJ, Dulk MD, Dejong KCHC, Klaase JM; Dutch Hepato Biliary Audit Group. Implementation and first results of a mandatory, nationwide audit on liver surgery. HPB (Oxford). 2019 Mar 26. pii: S1365-182X(19)30107-8.

Tummers WS, Groen JV, Sibinga Mulder BG, Farina-Sarasqueta A, Morreau J, Putter H, van de Velde CJ, Vahrmeijer AL, Bonsing BA, Mieog JS, Swijnenburg RJ. Impact of resection margin status on recurrence and survival in pancreatic cancer surgery. Br J Surg 2019 Jul;106(8):1055-1065.

Hanna-Sawires RG, Groen JV, Klok FA, Tollenaar RAEM, Mesker WE, Swijnenburg RJ, Vahrmeijer AL, Bonsing BA, Mieog JSD. Outcomes following pancreatic surgery using three different thromboprophylaxis regimens. Br J Surg. 2019 May;106(6):765-773.

Tummers WS, Miller SE, Teraphongphom NT, van den Berg NS, Hasan A, Longacre TA, Fisher GA, Bonsing BA, Vahrmeijer AL, Gambhir SS, Swijnenburg RJ, Rosenthal EL, Poultsides GA. Detection of visually occult metastatic lymph nodes using molecularly targeted fluorescent imaging during surgical resection of pancreatic  cancer. HPB (Oxford). 2019 Jul;21(7):883-890.

Tummers WS, Warram JM, van den Berg NS, Miller SE, Swijnenburg RJ, Vahrmeijer AL, Rosenthal EL. Recommendations for reporting on emerging optical imaging agents to promote clinical approval. Theranostics. 2018 Oct 22;8(19):5336-5347.

Sibinga Mulder BG, Visser K, Feshtali S, Vahrmeijer AL, Swijnenburg RJ, Hartgrink HH, van den Boom R, Burgmans MC, Mieog JSD. Gadoxetic acid-enhanced magnetic resonance imaging significantly influences the clinical course in patients with colorectal liver metastases. BMC Med Imaging. 2018 Nov 15;18(1):44.

Handgraaf HJM, Sibinga Mulder BG, Shahbazi Feshtali S, Boogerd LSF, van der Valk MJM, Fariña Sarasqueta A, Swijnenburg RJ, Bonsing BA, Vahrmeijer AL, Mieog JSD. Staging laparoscopy with ultrasound and near-infrared fluorescence imaging to detect occult metastases of pancreatic and periampullary cancer. PLoS One. 2018 Nov 1;13(11)

Hoogstins CES, Boogerd LSF, Sibinga Mulder BG, Mieog JSD, Swijnenburg RJ, van de Velde CJH, Farina Sarasqueta A, Bonsing BA, Framery B, Pèlegrin A, Gutowski M, Cailler F, Burggraaf J, Vahrmeijer AL. Image-Guided Surgery in Patients with Pancreatic Cancer: First Results of a Clinical Trial Using SGM-101, a Novel Carcinoembryonic Antigen-Targeting, Near-Infrared Fluorescent Agent. Ann Surg Oncol. 2018 Oct;25(11):3350-3357.

Tummers WS, Willmann JK, Bonsing BA, Vahrmeijer AL, Gambhir SS, Swijnenburg RJ. Advances in Diagnostic and Intraoperative Molecular Imaging of Pancreatic Cancer. Pancreas. 2018 Jul;47(6):675-689.

Achterberg FB, Burgmans MC, Kapitein E, Ceha H, Hartgrink HH, Swijnenburg RJ. Ontwikkelingen in lokale behandeling van colorectale levermetastasen. Ned Tijdschr Oncol 2018.

Tummers WS, Miller SE, Teraphongphom NT, Gomez A, Steinberg I, Huland DM, Hong S, Kothapalli SR, Hasan A, Ertsey R, Bonsing BA, Vahrmeijer AL, Swijnenburg RJ, Longacre TA, Fisher GA, Gambhir SS, Poultsides GA, Rosenthal EL. Intraoperative Pancreatic Cancer Detection using Tumor-Specific Multimodality Molecular Imaging. Ann Surg Oncol. 2018 Jul;25(7):1880-1888.

Tummers WS, Kimura RH, Abou-Elkacem L, Vahrmeijer AL, Swijnenburg RJ, Willmann JK, Gambhir SS. Development and preclinical validation of a cysteine knottin peptide targeting Integrin αvβ6 for near-infrared fluorescent-guided surgery in pancreatic cancer. Clin Cancer Res. 2018 Apr 1;24(7):1667-1676.

Handgraaf HJM, Boogerd LSF, Shahbazi Feshtali S, Fariña Sarasqueta A, Snel M,  Swijnenburg RJ, Vahrmeijer AL, Bonsing BA, Mieog JSD. Intraoperative Near-Infrared Fluorescence Imaging of Multiple Pancreatic Neuroendocrine Tumors:  A Case Report. Pancreas. 2018 Jan;47(1):130-133.

Kooreman NG, de Almeida PE, Stack JP, Nelakanti RV, Diecke S, Shao NY, Swijnenburg RJ, Sanchez-Freire V, Matsa E, Liu C, Connolly AJ, Hamming JF, Quax PHA, Brehm MA, Greiner DL, Shultz LD, Wu JC. Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics. Cell Rep. 2017 Aug 22;20(8):1978-1990.

Sibinga Mulder BG, Mieog JSD, Farina Sarasqueta A, Handgraaf HJ, Vasen HFA, Swijnenburg RJ, Luelmo SAC, Feshtali S, Inderson A, Vahrmeijer AL, Bonsing BA, Wezel TV, Morreau H. Diagnostic value of targeted next-generation sequencing in patients with suspected pancreatic or periampullary cancer. J Clin Pathol. 2017. Aug 3.

Handgraaf HJM, Boogerd LSF, Höppener DJ, Peloso A, Sibinga Mulder BG, Hoogstins CES, Hartgrink HH, van de Velde CJH, Mieog JSD, Swijnenburg RJ, Putter  H, Maestri M, Braat AE, Frangioni JV, Vahrmeijer AL. Long-term follow-up after near-infrared fluorescence-guided resection of colorectal liver metastases: A retrospective multicenter analysis. Eur J Surg Oncol. 2017 Aug;43(8):1463-1471.

Tummers WS, Farina-Sarasqueta A, Boonstra MC, Prevoo HA, Sier CF, Mieog JS, Morreau J, van Eijck CH, Kuppen PJ, van de Velde CJ, Bonsing BA, Vahrmeijer AL, Swijnenburg RJ. Selection of optimal molecular targets for tumor-specific imaging in pancreatic ductal adenocarcinoma. Oncotarget. 2017 May 26;8(34):56816-56828.

de Rooij T, van Hilst J, Vogel JA, van Santvoort HC, de Boer MT, Boerma D, van den Boezem PB, Bonsing BA, Bosscha K, Coene PP, Daams F, van Dam RM, Dijkgraaf MG, van Eijck CH, Festen S, Gerhards MF, Groot Koerkamp B, Hagendoorn J, van der  Harst E, de Hingh IH, Dejong CH, Kazemier G, Klaase J, de Kleine RH, van Laarhoven CJ, Lips DJ, Luyer MD, Molenaar IQ, Nieuwenhuijs VB, Patijn GA, Roos D, Scheepers JJ, van der Schelling GP, Steenvoorde P, Swijnenburg RJ, Wijsman JH, Abu Hilal M, Busch OR, Besselink MG; Dutch Pancreatic Cancer Group. Minimally invasive versus open distal pancreatectomy (LEOPARD): study protocol for a randomized controlled trial. Trials. 2017 Apr 8;18(1):166.

Sibinga Mulder BG, Mieog JS, Handgraaf HJ, Farina Sarasqueta A, Vasen HF, Potjer TP, Swijnenburg RJ, Luelmo SA, Feshtali S, Inderson A, Vahrmeijer AL, Bonsing BA, van Wezel T, Morreau H. Targeted next-generation sequencing of FNA-derived DNA in pancreatic cancer. J Clin Pathol. 2016 Sep 26.

Ibrahim IS, Bonsing BA, Swijnenburg RJ, Welling L, Veenendaal RA, Wasser MN, Morreau H, Inderson A, Vasen HF. Dilemmas in the management of screen-detected lesions in patients at high risk for pancreatic cancer. Fam Cancer. 2016 Jul 12.

Boogerd LS, Handgraaf HJ, Lam HD, Braat AE, Baranski AG, Swijnenburg RJ, Frangioni JV, Vahrmeijer AL, Ringers J. Application of near-infrared fluorescence imaging during modified associating liver partition and portal vein ligation for staged hepatectomy. Surgery. 2016 May;159(5):1481-2.

de Geus SW, Boogerd LS, Swijnenburg RJ, Mieog JS, Tummers WS, Prevoo HA, Sier CF, Morreau H, Bonsing BA, van de Velde CJ, Vahrmeijer AL, Kuppen PJ. Selecting Tumor-Specific Molecular Targets in Pancreatic Adenocarcinoma: Paving the Way for Image-Guided Pancreatic Surgery. Mol Imaging Biol. 2016 Apr 29.

Charehbili A , Swijnenburg RJ, van de Velde CJ, van den Bremer J, van Gijn W. A retrospective analysis of surgical-site infections in a center that instantly switched from iodine-alcohol to chlorhexidine-alcohol for preoperative antisepsis. Surg Inf  2014 Jun;15(3):310-3

Verbeek FP, Schaafsma BE, Tummers QR, van der Vorst JR, van der Made WJ, Baeten CI, Bonsing BE, Frangioni JV, van der Velde CJ, Vahrmeijer AL, Swijnenburg RJ. Optimization of near-infrared fluorescence cholangiography for open and laparoscopic surgery. Surg Endos 2014 Apr;28(4):1076-82

van der Vorst JR, Schaafsma BE, Verbeek FP, Swijnenburg RJ, Tummers QR, Hutteman M, Hamming JF, Kievit J, Frangioni JV, van de Velde CJ, Vahrmeijer AL. Intraoperative near-infrared fluorescence imaging of parathryoid adenomas with use of low-dose methylene blue. Head Neck 2014 Jun;36(6):853-8. 

Verbeek FP, van der Vorst JR, Schaafsma BE, Swijnenburg RJ, Gaarenstroom KN, Elzevier HW, van de Velde CJ, Frangioni JV, Vahrmeijer AL. Intraoperative near infrared fluorescence-guided identification of the ureters using low-dose methylene blue. J Urol. 2013 Aug;190(2):574-9.

van der Vorst JR, Schaafsma BE, Verbeek FP, Swijnenburg RJ, Hutteman M, Liefers GJ, van de Velde CJ, Frangioni JV, Vahrmeijer AL. Dose optimization for near-infrared fluorescence sentinel lymph node mapping in melanoma patients. Br J Dermatol. 2013 Jan;168(1):93-8

Verbeek FP, van der Vorst JR, Schaafsma BE, Hutteman M, Bonsing BA, van Leeuwen FW, Frangioni JV, van de Velde CJ, Swijnenburg RJ, Vahrmeijer AL. Image-guided hepatopancreatobiliary surgery using near-infrared fluorescent light. J Hepatobiliary Pancreat Sci. 2012

Swijnenburg RJ, Crane LM, Buddingh KT, van de Velde CJ, Vahrmeijer AL, van Dam GM. Intraoperatieve beeldvorming met fluorescentie. Ned Tijdschr Geneeskd. 2012; 156(11):A4316.

Swijnenburg RJ, Keizer J, Heslinga JM. Acute mesenteric venous thrombosis. Br J Surg 2010;97:1837

Swijnenburg RJ, Govaert JA, van der Bogt KE, Pearl JI, Huang M, Stein W, Hoyt G, Vogel H, Contag CH, Robbins RC, Wu JC. Timing of bone marrow cells has minimal effects on cell viability and cardiac recovery after myocardial infarction. Circulation Cardiovasc Imaging. 2010 Jan;3(1):77-85.

Govaert JA, Swijnenburg RJ, Schrepfer S, Xie X, van der Bogt KE, Hoyt G, Stein W, Ransohoff KJ, Robbins RC, Wu JC. Poor functional recovery after transplantation of diabetic bone marrow stem cells in ischemic myocardium. J Heart Lung Transplant. 2009 Nov;28(11):1158-1165.e1.

Van der Bogt KE, Sheik AY, Schrepfer S, Hoyt G, Cao F, Ransohoff K, Swijnenburg RJ, Pearl JI, Lee A, Fischbein M, Contag CH, Robbins RC, Wu JC. Comparison of different adult stem cell types for treatment of myocardial ischemia. Circulation 2008;118[14 suppl]:S121-9

Swijnenburg RJ, Schrepfer S, Govaert JA, Cao F, Ransohoff K, Sheikh AY, Haddad M, Connolly AJ, Davis MM, Robbins RC, Wu JC. Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenographs. PNAS 2008 Sep 2;105(35):12991-6

Swijnenburg RJ, Schrepfer S, Cao F, Pearl JI, Xie X, Connolly AJ, Robbins RC, Wu JC. In vivo imaging of embryonic stem cells reveals patterns of survival and immunological rejection following transplantation. Stem Cells and Development 2008. Dec;17(6):1023-9.

Swijnenburg RJ, Van der Bogt KE, Sheikh AY, Cao F, Wu JC. Clinical hurdles for transplantation of cardiomyocytes derived from human embryonic stem cells: Role of molecular imaging. Curr Opin Biotechnol. 2007 Feb;18(1):38-45

Van der Bogt KE,  Swijnenburg RJ, Cao F, Wu JC. Molecular Imaging of Human Embryonic Stem Cells: Keeping an Eye on Differentiation, Tumorigenicity and Immunogenicity. Cell Cycle 2006 Dec;5(23):2748-52.

Kofidis T, Lebl DR, Swijnenburg RJ, Greve JM, Klima U, Gold J, Xu C, Robbins RC. Allopurinol/uricase and ibuprofen enhance engraftment of cardiomyocyte-enriched human embryonic stem cells and improve cardiac function following myocardial injury. Eur J Cardiothorac Surg. 2006 Jan;29(1):50-5.

Swijnenburg RJ, Tanaka M, Vogel H, Baker J, Kofidis T, Gunwan F, Lebl DR, Caffarelli AD, de Bruin JL, Fedoseyeva EV and Robbins RC. Embryonic Stem Cell Immunogenicity Increases upon Differentiation Following Transplantation into Ischemic Myocardium. Circulation 2005;112[suppl I]:I-166-I-172.

Tanaka M, Swijnenburg RJ, Gunawan F, Cao YA, de Bruin JL, Kofidis T, Fedoseyeva EV, Contag CH and Robbins RC. In Vivo Visualization of Cardiac Allograft Rejection and Trafficking Passenger Leucocytes Using Bioluminescence Imaging. Circulation 2005;112[suppl I]:I-105-I-110.

Coa YA, Bachmann MH, Beilhack A, Yang Y, Tanaka M, Swijnenburg RJ, Reeves R, Taylor-Edwards C, Schulz S, Doyle TC, Fathman CG, Robbins RC, Herzenberg LA, Negrin RS, Contag CH. Molecular Imaging Using Labeled Donor Tissues Reveals Patterns of Engraftment, Rejection, and Survival in Transplantation. Transplantation 2005;80(1):134-139.

Kofidis T, de Bruin JL, Yamane T, Tanaka M, Lebl DR, Swijnenburg RJ, Weissman IL and Robbins RC. Stimulation of Paracrine Pathways with Growth Factors Enhances Embryonic Stem cell Engraftment and Host Specific Differentiation in the Heart Following Ischemic Myocardial Injury. Circulation 2005;111(19):2486-93.

Kofidis T, de Bruin JL, Yamane T, Balsam LB, Lebl DR, Swijnenburg RJ, Tanaka M, Weissman IL, Robbins RC. Insulin-like growth factor promotes engraftment, differentiation, and functional improvement after transfer of embryonic stem cells for myocardial restoration. Stem Cells. 2004;22(7):1239-45.

Swijnenburg RJ, Lange CP, Salm LP. Non-invasieve visualisatie van coronairarteriele stenosen; ontwikkeling van Coronary Magnetic Resonance Angiography. Ned Tijdschr Geneesk Studenten Ed 2004 maart; 7(1)

 

Selection of presentations

Swijnenburg RJ. Strategies for Radiology and Surgery to Work Together to Optimize Fluorescence-guided Surgery (Invited).

International society for strategic studies on radiology (IS3R) symposium – August 2019

 

Swijnenburg RJ. Molecular Imaging to guide Hepatobiliary and Pancreatic Surgery (Invited)

MIPS seminar Stanford University – Feb 2019

 

Tummers WS, Swijnenburg RJ, Kimura RH, Abou-Elkacem L, Vahrmeijer AL, Willmann JK, Gambhir SS. Development and preclinical validation of a cysteine knottin peptide targeting Integrin αvβ6 for near-infrared fluorescent-guided surgery in pancreatic cancer.

EAHPBA 2017, Mainz (GE) and Dutch Surgical Society Annual Meeting 2017, Veldhoven (NL)

 

Charehbili A , Koek M, van de Velde CJ, van Gijn W, Swijnenburg RJ. Chlorhexidine-alcohol versus iodine-alcohol for preoperative antisepsis: the SKINFECT trial.

29th European Congress on Surgical Infections, Amsterdam (NL)

 

Charehbili A , Swijnenburg RJ, van de Velde CJ, van den Bremer J, van Gijn W. A retrospective analysis of surgical-site infections in a center that instantly switched from iodine-alcohol to chlorhexidine-alcohol for preoperative antisepsis.

29th European Congress on Surgical Infections, Amsterdam (NL)

 

Tummers WS, Farina-Sarasqueta A, Boonstra MC, Prevoo HA, Sier CF, Mieog JS, Morreau H, vd Velde CJ, van Eijck CH, Bonsing BA, Vahrmeijer AL, Swijnenburg RJ. Patterns of biomarker expression on pancreatic ductal adenocarcinoma following neoadjuvant radiochemotherapy: Implications for tumor-specific molecular imaging.

Dutch Surgical Society Annual Meeting 2016, Veldhoven (NL)

 

Tummers WS, Farina-Sarasqueta A, Boonstra MC, Cohen D, Prevoo HA, Sier CF, Mazar AP, Mieog JS, Morreau H, vd Velde CJ, Bonsing BA, Vahrmeijer AL, Swijnenburg RJ. Identification of biomarkers for tumor-specific molecular imaging in pancreatic ductal adenocarcinoma.

IHPBA World Congress, Sao Paolo(Brazil) 2016

 

de Geus SW, Swijnenburg RJ, Prevoo HA, Sier CF, Bonsing BA, Morreau H, van de Velde CJ, Vahrmeijer AL, Kuppen PJ. Selecting tumor-specific biomarkers in pancreatic and periampullary cancer: paving the way for image-guided surgery

European Society for Surgical Oncology Meeting, Liverpool (GB) 2014

 

Swijnenburg RJ, Pearl J, Cao F, Vogel H, Hamming JF, Robbins RC, Wu JC. Characterization of human embryonic stem cell immunogenicity in allogeneic humanized mice.

European Society for Surgical Research Annual Congress, Geneva (Switzerland) 2010

 

Swijnenburg RJ, Govaert JA, Stein W, van der Bogt KE, Pearl JI, Hoyt G, Vogel H, Robbins RC, Wu JC. Effect of Timing of Bone Marrow Cell Delivery on Cell Viability and Cardiac Recovery Following Myocardial Infarction. Circulation 2008;118(18 Supll 2):S790

American Heart Association’s Scientific Sessions, New Orleans (LA, USA) 2008

 

Swijnenburg RJ, Schrepfer S, Govaert JA, Cao F, Sheikh AY, Fischbein MP, Robbins RC, Wu JC. Immunosuppressive Therapy Mitigates Murine T-Cell Mediated Rejection of Human Embryonic Stem Cells following Transplantation.

The International Society for Heart and Lung Transplantation Scientific Sessions, Boston (MA, USA) 2008

 

Swijnenburg RJ, Tanaka M, Vogel H, Baker J, Gunawan F, Lebl DR, Caffarelli AD, Kofidis T and Robbins RC. Embryonic Stem Cell Immunogenicity Increases upon Differentiation in Ischemic Myocardium. Circulation 2004 Oct 26;110(17 Suppl 3):III-507

American Heart Association’s Scientific Sessions, New Orleans (LA, USA) 2004

 

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