PhD R.J. van Holst

Associate Professor
Main activities
pathological gambling, alcohol dependence, functional MRI, neuropsychology
Focus of research

Throughout my career, I pursued a clear line of research that focused on understanding why people make unfortunate decisions and display harmful behaviours, and importantly, why don’t they stop?! My Ph.D. elucidated specific neurobiological characteristics of pathological gambling and its similarities and differences with alcohol dependence. Directly after obtaining my Ph.D. I received an ECNP Research Grant, enabling me to focus on the neural correlates of risky decision-making at the University of Cambridge. With my NWO Rubicon fellowship grant, I focused on elucidating the role of dopamine in pathological gambling using PET scans at the Donders Institute.

Since dysfunctional decision-making and dopamine functioning underlie more psychiatric disorders than pathological gambling alone, I am intrigued to find the common denominator across psychiatric disorders. Therefore, I expanded my research to also include game addiction, obsessive-compulsive disorder, and obesity, for which I collaborated with different international research groups. To better understand food-related motivational processes I currently collaborate on a translational study using optogenetics in mice.

With a personal ABC-talent grant in 2014, I moved to the AMC to study the neural fundaments of confidence estimation in compulsive behaviour and be co-promotor of two Ph.D. students investigating habitual behaviour and the effect of non-invasive brain stimulation in addiction. In the coming years, I will use a variety of neuroimaging techniques (fMRI/PET), brain-activity modulators (rTMS/pharmaca) and approaches (network/DSM/transdiagnostic) to psychiatry with the aim to contribute to the understanding of the neural fundamentals of psychiatric disorders, especially of disorders in which people display faulty decision-making.

Key publications
  • van Holst Ruth J., Sescousse Guillaume, Janssen Lieneke K., Janssen Marcel, Berry Anne S., Jagust William J., Cools Roshan Increased Striatal Dopamine Synthesis Capacity in Gambling Addiction Biological psychiatry 2018;83 (12):1036-1043 [PubMed]
  • van Holst Ruth J., van Timmeren Tim, Goudriaan Anneke E. Are There Differences in Disruptions of Reward Processing Between Substance Use Disorder and Gambling Disorder? JAMA psychiatry 2017;74 (7):759-+ [PubMed]
  • van Timmeren Tim, Daams Joost G., van Holst Ruth J., Goudriaan Anna E. Compulsivity-related neurocognitive performance deficits in gambling disorder: A systematic review and meta-analysis Neuroscience and biobehavioral reviews 2018;84:204-217 [PubMed]
  • Lebreton Maël, Langdon Shari, Slieker Matthijs J., Nooitgedacht Jip S., Goudriaan Anna E., Denys Damiaan, van Holst Ruth J., Luigjes Judy Two sides of the same coin: Monetary incentives concurrently improve and bias confidence judgments Science advances 2018;4 (5) [PubMed]
  • Sescousse Guillaume, Ligneul Romain, van Holst Ruth J., Janssen Lieneke K., de Boer Femke, Janssen Marcel, Berry Anne S., Jagust William J., Cools Roshan Spontaneous eye blink rate and dopamine synthesis capacity: preliminary evidence for an absence of positive correlation European journal of neuroscience 2018;47 (9):1081-1086 [PubMed]
All Publications
Research programmes

Prof. PhD A.E. Goudriaan (Neurobiological mechanisms of action and treatment effects in addictive disorders)