R.M. van Hest PhD

Other Academic Staff
Main activities
Patient care, Research
Clinical Pharmacology
Focus of research

Population pharmacokinetic-pharmacodynamic modeling of antimicrobial drugs: exposure optimisation studies, dose individualisation studies, concentration-effect relationship studies as well as studies into the relationship between drug concentration and the risk for acquiring drug resistance).
Collaboration with the Molecular Biology and Microbial Food Safety research group of the Swammerdam Institute for Life Sciences of the University of Amsterdam (Dr. Benno ter Kuile, PhD)
Collaboaration with the departement of Intensive Care Medicine (Prof. dr. J. Wauters) and the departement of Hospital Pharmacy (Prof. dr. I. Spriet) of the University Hospitals Leuven, Belgium

Population pharmacokinetic-pharmacodynamic modeling of antihypertensive drugs: dose individualisation studies, concentration-effect relationship studies

Clinical pharmacological research of prothrombin complex concentrate (dose optimisation studies).
Collaboration with the department of Haematology of the University Medical Center Groningen (Prof. dr. K. Meijer) and the Central Hospital Pharmacy, The Hague (Dr. N. Khorsand)


Key publications
  • van Hest Reinier M., van Gelder Teun, Vulto Arnold G., Shaw Leslie M., Mathot Ron A. A. Pharmacokinetic modelling of the plasma protein binding of mycophenolic acid in renal transplant recipients Clinical pharmacokinetics 2009;48 (7):463-476 [PubMed]
  • de Winter Brenda C. M., van Gelder Teun, Mathot Ron A. A., Glander Petra, Tedesco-Silva Helio, Hilbrands Luuk, Budde Klemens, van Hest Reinier M. Limited sampling strategies drawn within 3 hours postdose poorly predict mycophenolic acid area-under-the-curve after enteric-coated mycophenolate sodium Therapeutic drug monitoring 2009;31 (5):585-591 [PubMed]
  • Khorsand Nakisa, Giepmans Lisette, Meijer Karina, van Hest Reinier M., Veeger Nic J. G. M. A low fixed dose of prothrombin complex concentrate is cost effective in emergency reversal of vitamin K antagonists Haematologica 2013;98 (6):e65-e67 [PubMed]
  • van Rijn-Bikker Petra C., Ackaert Oliver, Snelder Nelleke, van Hest Reinier M., Ploeger Bart A., Koopmans Richard P., Mathôt Ron A. A. Pharmacokinetic-pharmacodynamic modeling of the antihypertensive effect of eprosartan in Black and White hypertensive patients Clinical pharmacokinetics 2013;52 (9):793-803 [PubMed]
  • Khorsand Nakisa, Veeger Nic J. G. M., van Hest Reinier M., Ypma Paula F., Heidt Jeroen, Meijer Karina An observational, prospective, two-cohort comparison of a fixed versus variable dosing strategy of prothrombin complex concentrate to counteract vitamin K antagonists in 240 bleeding emergencies Haematologica 2012;97 (10):1501-1506 [PubMed]
All Publications
Research programmes

Prof. R.A.A. Mathot PhD (Population pharmacokinetic-pharmacodynamic (PK-PD) research)