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Dr. I. Klaassen PhD

Position
Scientific staff member (UD)
Main activities
Research
Specialisation
Molecular mechanisms of diabetic retinopathy and macular degeneration
Focus of research

Molecular mechanisms in the pathology of diabetic retinopathy and age-related macular degeneration. Special interest in the blood-retinal barrier and microvascular permeability.

Molecular regulation of angiogenic tip cells.

Website: www.ocular-angiogenesis.nl

Key publications
  • Klaassen I, van Noorden CJF, Schlingemann RO, Molecular basis of the inner blood-retinal barrier and its breakdown in diabetic macular edema and other pathological conditions. PROG RETIN EYE RES 2013;34:19-48 [PubMed]
  • Wisniewska-Kruk J, Hoeben KA, Vogels IMC, Gaillard PJ, van Noorden CJF, Schlingemann RO, Klaassen I, A novel co-culture model of the blood-retinal barrier based on primary retinal endothelial cells, pericytes and astrocytes. EXP EYE RES 2012;96 (1):181-190 [PubMed]
  • Klaassen I, Hughes JM, Vogels IMC, Schalkwijk CG, van Noorden CJF, Schlingemann RO, Altered expression of genes related to blood-retina barrier disruption in streptozotocin-induced diabetes. EXP EYE RES 2009;89 (1):4-15 [PubMed]
  • Kuiper EJ, van Nieuwenhoven FA, de Smet MD, van Meurs JC, Tanck MW, Oliver N, Klaassen I, van Noorden CJF, Goldschmeding R, Schlingemann RO, The Angio-Fibrotic Switch of VEGF and CTGF in Proliferative Diabetic Retinopathy. PLOS ONE 2008;3 (7):e2675 [PubMed]
  • Siemerink MJ, Klaassen I, Vogels IMC, Griffioen AW, van Noorden CJF, Schlingemann RO, CD34 marks angiogenic tip cells in human vascular endothelial cell cultures. ANGIOGENESIS 2012;15 (1):151-163 [PubMed]
All Publications
Curriculum Vitae

Dr. Klaassen was trained at the University of Groningen (Molecular Biology and Biochemistry), VU University Amsterdam (Ph.D.), and the University of Amsterdam (Postdoc in Ophthalmology).

Research programmes

Prof. dr. R.O. Schlingemann MD PhD (Ocular angiogenesis and Ocular imaging)