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Prof. dr. C.J.F. van Noorden

Position
Professor
Main activities
Research, Teaching
Specialisation
Histology and Cell Biology
Focus of research

Cancer  Metabolism

Key publications
  • Molenaar RJ, Botman D, Smits MA, Hira VV, van Lith SA, Stap J, Henneman P, Khurshed M, Lenting K, Mul AN, Dimitrakopoulou D, van Drunen CM, Hoebe RA, Radivoyevitch T, Wilmink JW, Maciejewski JP, Vandertop WP, Leenders WP, Bleeker FE, van Noorden CJ, Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198. CANCER RES 2015;75 (22):4790-4802 [PubMed]
  • Molenaar RJ, van Noorden CJ, Type 2 diabetes and cancer as redox diseases?. LANCET 2014;384 (9946):853 [PubMed]
  • Chieco P, Jonker A, de Boer BA, Ruijter JM, van Noorden CJF, Image cytometry: protocols for 2D and 3D quantification in microscopic images. PROG HISTOCHEM CYTO 2013;47 (4):211-333 [PubMed]
  • Hira VVV, Ploegmakers KJ, Grevers F, Verbovšek U, Silvestre-Roig C, Aronica E, Tigchelaar W, Turnšek TL, Molenaar RJ, van Noorden CJF, CD133+ and Nestin+ Glioma Stem-Like Cells Reside Around CD31+ Arterioles in Niches that Express SDF-1α, CXCR4, Osteopontin and Cathepsin K. J HISTOCHEM CYTOCHEM 2015;63 (7):481-493 [PubMed]
  • Verma J, Lal S, van Noorden CJF, Nanoparticles for hyperthermic therapy: synthesis strategies and applications in glioblastoma. INT J NANOMED 2014;9:2863-2877 [PubMed]
All Publications
Research programmes

Cancer metabolism

Glioblastoma research is focussed on energy metabolism because we have strong indications that the Warburg effect does not apply to glioblastoma. Mitochondrial glutamine/glutamate catabolism seems to be important as energy source in cancer cells. Furthermore, the mutation in the genes of the metabolic enzymes NADP-dependent isocitrate dehydrogenase (IDH) 1 and 2 was found to be linked with prolonged survival of secondary glioblastoma patients. With the use of quantitative histochemical means, we investigate molecular mechanisms of the prolonged survival.

Faculty
Prof. dr. C.J.F. van Noorden

PhD Students
B. Arik-Yetkin BSc
Drs. M.G. Dallinga
A.E. Jadczak
M. Khurshed
C.H. Steudel
Drs. J. Verma

Other research related activities
  • Membership of editorial board / Editorship, JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
Current research funding
  • KWF Kankerbestrijding