PhD A. van der Horst

Research Associate
Main activities
Interfractional organ motion during radiotherapy; image-guided adaptive radiotherapy
Focus of research

Image-guided adaptive radiotherapy

Fiducial markers

MRI, CT and cone-beam CT imaging

Gastric cancer

Motion of target and organs during radiotherapy

The stomach is a highly mobile and deformable organ. In collaboration with the Dept. of Radiotherapy at the Netherlands Cancer Institute (NKI-AVL), we aim to develop and implement CBCT-guided and MR-guided adaptive radiotherapy for patients with gastric cancer, thus improving the treatment for this patient group.

Key publications
  • van der Horst Astrid, Versteijne Eva, Besselink Marc G. H., Daams Joost G., Bulle Esther B., Bijlsma Maarten F., Wilmink Johanna W., van Delden Otto M., van Hooft Jeanin E., Franken Nicolaas A. P., van Laarhoven Hanneke W. M., Crezee Johannes, van Tienhoven Geertjan The clinical benefit of hyperthermia in pancreatic cancer: a systematic review International journal of hyperthermia 2018;34 (7):969-979 [PubMed]
  • Houweling Antonetta C., Crama Koen, Visser Jorrit, Fukata Kyohei, Rasch Coen R. N., Ohno Tatsuya, Bel Arjan, van der Horst Astrid Comparing the dosimetric impact of interfractional anatomical changes in photon, proton and carbon ion radiotherapy for pancreatic cancer patients Physics in medicine and biology 2017;62 (8):3051-3064 [PubMed]
  • Houweling Antonetta C., Fukata Kyohei, Kubota Yoshiki, Shimada Hirofumi, Rasch Coen R. N., Ohno Tatsuya, Bel Arjan, van der Horst Astrid The impact of interfractional anatomical changes on the accumulated dose in carbon ion therapy of pancreatic cancer patients Radiotherapy and oncology 2016;119 (2):319-325 [PubMed]
  • van der Horst Astrid, Lens Eelco, Wognum Silvia, de Jong Rianne, van Hooft Jeanin E., van Tienhoven Geertjan, Bel Arjan Limited role for biliary stent as surrogate fiducial marker in pancreatic cancer: stent and intratumoral fiducials compared International journal of radiation oncology, biology, physics 2014;89 (3):641-648 [PubMed]
  • van der Horst Astrid, Wognum Silvia, Dávila Fajardo Raquel, de Jong Rianne, van Hooft Jeanin E., Fockens Paul, van Tienhoven Geertjan, Bel Arjan Interfractional position variation of pancreatic tumors quantified using intratumoral fiducial markers and daily cone beam computed tomography International journal of radiation oncology, biology, physics 2013;87 (1):202-208 [PubMed]
All Publications
Curriculum Vitae

Research experience

2018–2021       Project Leader
      KWF project #10882 Individualized image-guided adaptive radiotherapy for resectable gastric cancer: now and in the future

2016–present   Managing Editor
      Journals: Radiation Measurements; Applied Radiation & Isotopes


2012–present   Postdoctoral researcher
     Department of Radiation Oncology, AMC, Amsterdam

2009–2012        Postdoctoral researcher
     Department of Physics and Astronomy, VU University, Amsterdam

2006–2009        Postdoctoral researcher
     Department of Physics, Simon Fraser University, Vancouver, Canada

2001–2006        PhD student
     FOM Institute for Atomic and Molecular Physics, Amsterdam, and
     Debye Institute for Nanomaterials Science, Utrecht University, Utrecht


Research programmes

PhD A. Bel (Innovative image guided radiotherapy)

PhD J. Crezee (Hyperthermia)

Prof. PhD C.R.N. Rasch (Image guided and physics application in the clinic)

Current research funding
  • KWF Kankerbestrijding