foto

A.A. te Velde PhD

Position
Research Associate
Main activities
Education, Research
Specialisation
Immunology
Focus of research

Study of chronic intestinal inflammation (inflammatory bowel disease, IBD): pathophysiology and therapeutic interventions.

  • role of DAMPs
  • immunological phenotype of IBD patients correlated with clinical phenotype and genetic profile 
  • New markers of therapeutic efficacy
  • role of microplastics
  • Voedinghelpt.nl 
  • General: fatigue in chronic immune diseases, MyOwnResearch

Tools:

  • different mouse colitis models
  • human tissues and isolated cells
  • citizen science
Key publications
  • Sahami S., Kooij I. A., Meijer S. L., van den Brink G. R., Buskens C. J., te Velde A. A. The Link between the Appendix and Ulcerative Colitis: Clinical Relevance and Potential Immunological Mechanisms American journal of gastroenterology 2016;111 (2):163-169 [PubMed]
  • te Velde Anje A., Bezema Tjitske, van Kampen Antoine H. C., Kraneveld Aletta D., 't Hart Bert A., van Middendorp Henriet, Hack Erik C., van Montfrans Joris M., Belzer Clara, Jans-Beken Lilian, Pieters Raymond H., Knipping Karen, Huber Machteld, Boots Annemieke M. H., Garssen Johan, Radstake Tim R., Evers Andrea W. M., Prakken Berent J., Joosten Irma Embracing Complexity beyond Systems Medicine: A New Approach to Chronic Immune Disorders Frontiers in immunology 2016;7:587 [PubMed]
  • Zeeff Sophia B., Kunne Cindy, Bouma Gerd, de Vries Rob B., te Velde Anje A. Actual Usage and Quality of Experimental Colitis Models in Preclinical Efficacy Testing: A Scoping Review Inflammatory bowel diseases 2016;22 (6):1296-1305 [PubMed]
  • te Velde Anje A. The C-Type Lectin Mincle: Clues for a Role in Crohn's Disease Adjuvant Reaction Frontiers in immunology 2017;8:1304 [PubMed]
  • Barnig Cindy, Bezema Tjitske, Calder Philip C., Charloux Anne, Frossard Nelly, Garssen Johan, Haworth Oliver, Dilevskaya Ksenia, Levi-Schaffer Francesca, Lonsdorfer Evelyne, Wauben Marca, Kraneveld Aletta D., te Velde Anje A. Activation of Resolution Pathways to Prevent and Fight Chronic Inflammation: Lessons From Asthma and Inflammatory Bowel Disease Frontiers in immunology 2019;10:1699 [PubMed]
All Publications
Research programmes

A.A. te Velde PhD (Pathophysiology of inflammatory bowel diseases)

The pathophysiology of inflammatory bowel diseases has been studied in three different mouse models of experimental colitis, DSS, TNBS and the CD45RB transfer colitis (te Velde et al, 2006). Following this, a critical appraisal of the current practice in murine TNBS-induced colitis has been written (te Velde et al, 2006). Also, in a follow up study the role of overlapping gene expression in the mouse models is studied in human inflammatory bowel diseases (te Velde et al, submitted). In an other study the balance between inhibitory signals (provided by the C-type lectins (CLRs) and activation signals (provided by the Toll-like receptors (TLRs) and NACHT-LRR (NLRs) in relation to IBD is studied. Mutations in one or more of the involved pattern recognition receptors (PRRs) might disturb this precious balance. This study has resulted in a grant (MLDS) in which we will determine if single nucleotide polymorphisms (SNPs) in genes clustered in the IBD2 and IBD6 susceptibility loci for IBD (especially C-type lectins) and NACHT-LRR members (especially NALP-3) play a role in the pathogenesis of inflammatory bowel diseases. Finally apoptose in relation to IBD has been studied (Verstege et al, 2006 and van den Brande et al, 2007). 

Theme: Immunity and Infections

Others
C. Kunne BEng PhD
F.H. van Dooren BEng

Prof. W.J. de Jonge PhD (Gastro-Intestinal diseases)

Prof. G.R.A.M. D'Haens PhD (CHRONIC INFLAMMATORY BOWEL DISEASES)

Current research funding
  • AMC
  • Life Sciences Health TKI