MD PhD D.J. Stenvers

Research Associate
Main activities
Patient care, Research
Endocrinology and metabolism
Focus of research

The circadian timing system consists of a central brain clock and peripheral clocks in metabolic organs such as liver, pancreas and adipose tissue. The circadian system receives direct information about light and darkness from the retina, and synchronises energy metabolism with the 24-hour rhythms of light/darkness and feeding/fasting. In present society, disruption of the circadian synchrony between the 24-hour rhythms of central and peripheral clocks, hormones, the autonomic nervous system, light/dark exposure, sleep/wake behaviour and food intake may contribute to the pandemic of obesity and type 2 diabetes. Dr. Stenvers' research focuses on the use of circadian knowledge to improve human metabolic health.

Key publications
  • Stenvers Dirk Jan, van Dorp Rick, Foppen Ewout, Mendoza Jorge, Opperhuizen Anne-Loes, Fliers Eric, Bisschop Peter H., Meijer Johanna H., Kalsbeek Andries, Deboer Tom Dim light at night disturbs the daily sleep-wake cycle in the rat Scientific reports 2016;6:35662 [PubMed]
  • Stenvers Dirk J., Schouten Lydia J., Jurgens Jordy, Endert Erik, Kalsbeek Andries, Fliers Eric, Bisschop Peter H. Breakfast replacement with a low-glycaemic response liquid formula in patients with type 2 diabetes: a randomised clinical trial British journal of nutrition 2014;112 (4):504-512 [PubMed]
  • Stenvers Dirk Jan, Jongejan Aldo, Atiqi Sadaf, Vreijling Jeroen P., Limonard Eelkje J., Endert Erik, Baas Frank, Moerland Perry D., Fliers Eric, Kalsbeek Andries, Bisschop Peter H. Diurnal rhythms in the white adipose tissue transcriptome are disturbed in obese individuals with type 2 diabetes compared with lean control individuals Diabetologia 2019 [PubMed]
  • Jan Stenvers Dirk, Scheer Frank A. J. L., Schrauwen Patrick, la Fleur Susanne E., Kalsbeek Andries Circadian clocks and insulin resistance Nature reviews. Endocrinology 2019;15 (2):75-89 [PubMed]
All Publications