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Dr. A. van der Ende PhD

Position
Associate professor (UHD)
Main activities
Research
Specialisation
Biochemistry; Molecular Microbiology
Focus of research
  • Pathogenesis of meningococcal disease
  • Pathogenesis of invasive pneumococcal disease
  • Population structure of Neisseria meningitidis
  • Population structure of Streptococcus pneumoniae
  • Population structure of Chlamydiae
  • Molecular epidemiology and Genotyping of pathogenic bacteria
  • Bacterial Gene Expression Regulation
  • Antigenic Variation of bacterial Outer Membrane Proteins
Key publications
  • Bijlsma MW, Bekker V, Brouwer MC, Spanjaard L, van de Beek D, van der Ende A, Epidemiology of invasive meningococcal disease in the Netherlands, 1960-2012: an analysis of national surveillance data. LANCET INFECT DIS 2014;14 (9):805-812 [PubMed]
  • Bekker V, Bijlsma MW, van de Beek D, Kuijpers TW, van der Ende A, Incidence of invasive group B streptococcal disease and pathogen genotype distribution in newborn babies in the Netherlands over 25 years: a nationwide surveillance study. LANCET INFECT DIS 2014;14 (11):1083-1089 [PubMed]
  • Bijlsma MW, Brouwer MC, Spanjaard L, van de Beek D, van der Ende A, A decade of herd protection after introduction of meningococcal serogroup C conjugate vaccination. CLIN INFECT DIS 2014;59 (9):1216-1221 [PubMed]
  • Knol MJ, Wagenvoort GHJ, Sanders EAM, Elberse K, Vlaminckx BJ, de Melker HE, van der Ende A, Invasive Pneumococcal Disease 3 Years after Introduction of 10-Valent Pneumococcal Conjugate Vaccine, the Netherlands. EMERG INFECT DIS 2015;21 (11):2040-2044 [PubMed]
  • van Deursen AMM, van Mens SP, Sanders EAM, Vlaminckx BJM, de Melker HE, Schouls LM, de Greeff SC, van der Ende A, Invasive pneumococcal disease and 7-valent pneumococcal conjugate vaccine, the Netherlands. EMERG INFECT DIS 2012;18 (11):1729-1737 [PubMed]
All Publications
Curriculum Vitae

Arie van der Ende received training in chemistry and biochemistry at the University of Groningen, the Netherlands. He did a PhD in molecular genetics at the Institute of Molecular Biology at the University of Utrecht (Utrecht, the Netherlands) and thereafter he joined the laboratory of Nobel Prize laureate Professor dr. Arthur Kornberg at Stanford University (Dept. of Biochemistry, Medical School, Stanford University, Palo Alto, California, USA). Hereafter, he was Assistant Professor in Cell Biology (Dept. of Cell Biology, Medical School, University of Utrecht, Utrecht, the Netherlands). At this moment he is Associate Professor in Medical Microbiology, head of the Laboratory for Experimental Bacteriology and head of the Netherlands Reference Laboratory for Bacterial Meningitis (all at the Dept. of Medical Microbiology, Academic Medical Centre, University of Amsterdam). His research interests are the pathogenesis and molecular epidemiology of bacterial meningitis. He has teaching responsibilities in BSc courses in Medicine and BSc/MSc courses in Life Sciences.

Research programmes

Epidemiology and pathogenesis of bacterial meningitis

The research on Bacterial Meningitis benefits strongly from the Netherlands Reference Laboratory for Bacterial Meningitis (NRLBM; head: Dr. A. van der Ende) located at the Department of Medical Microbiology, AMC. The NRLBM gives access to a collection of over 10,000 bacterial isolates form patients and carriers and of human clinical specimen (liquor and serum). In addition, basic patients’ data like age, gender, date of hospital admission and place of living are available but due to cooperative studies with dr. D. van de Beek (Department of Neurology, AMC) patients’ genetic material and data like clinical features and outcome are available of about 1500 patients.
We study the molecular epidemiology and population structure of the main pathogens causing meningitis, Neisseria meningitidis and Streptococcus pneumoniae, and of Chlamydia species causing respiratory infections and sexual transmitted disease. In addition, we study the pathogenesis of meningococcal and invasive pneumococcal disease. We are particularly interested in the bacterial stress response and its regulation by small RNAs (ribo-regulation) in conjunction with alternative sigma factors like sigmaE. In collaborative studies with Dr. D. van de Beek (Department of Neurology, AMC) we investigate clinical aspects of bacterial meningitis as well correlation between clinical features, outcome and host and bacterial factors.

Theme: Infection and Immunity
 

This research group participates in CINIMA

Faculty
Dr. A. van der Ende PhD
Dr. Y. Pannekoek

PhD Students
K.K. Jim MD
Drs. M.M. Koopmans MD
P.H.C. Kremer MD
B.C.L. van der Putten MSc (Amsterdam Institute for Global Health and Development)

Others
A.W.M. Arends-van 't Klooster
Ing. S. Bovenkerk
M. Feller
Ing. W.C. Keijzers
Ing. K. Schipper
Ing. I.G. Schuurman

Other research related activities
  • Head of the Netherlands Reference Laboratory for Bacterial Meningitis, Academic Medical Center
  • Member of The management committee, Neisseria MLST website (http://neisseria.org/nm/typing/mlst/mlst-info/nmeningitidis/nmeningitidis-info.htm
  • Convenerof the EMGM Working Group “European Meningococcal Epidemiology in Real Time (EMERT), EMGM
  • Member of the Scientific Committee of the 10th EMGM congress, 2009, Manchester, UK, The European Meningococcal Disease Society
  • Member of the Scientific Committee of the 11th EMGM congress, 2011, Ljubljana, Slovenia, The European Meningococcal Disease Society
  • Member of the Scientific Committee of the 12th EMGM congress, 2013, Bad Loipersdorf, Austria, The European Meningococcal Disease Society
  • ECDC national expert on laboratory surveillance of N. meningitidis, European Centre for Disease Control
  • Other, European Centre for Disease Control
  • Member of the management group of the Laboratory surveillance and External Quality Assurance (EQA) of invasive bacterial diseases in EU (IBD-LabNet) Consortium, European Centre for Disease Control (ECDC) sponsored consortium. Framework Contract No ECDC/08/008 and Framework Contract ECDC/2011/014)
  • Coordinator (together with Dominique Caugant, Oslo, Norway and Mary Slack, London, UK) of the IBD-LabNet work package “Evaluation of current typing and subtyping methods that are currently used for the laboratory surveillance of Streptococcus pneumoniae in Member States, Iceland, Liechtenstein and Norway, IBD-LabNet Consortium, European Centre for Disease Control (ECDC) sponsored consortium. Framework Contract No ECDC/08/008 and Framework Contract ECDC/2011/014)
  • Coordinator (together with Karin Elberse, Bilthoven, the Netherlands) of IBD-LabNet work package 7: Harmonization and standardization of methods for DNA-based typing of S. pneumoniae, IBD-LabNet Consortium, European Centre for Disease Control (ECDC) sponsored consortium. Framework Contract No ECDC/08/008 and Framework Contract ECDC/2011/014)
  • Project leader (together with Dominique A. Caugant, Oslo; Ulrich Vogel, Würzburg; Matthias Frosch, Würzburg) of the IBD-LabNet work package 8 “Maintenance and extending the existing meningococcal strain collection”, IBD-LabNet Consortium, European Centre for Disease Control (ECDC) sponsored consortium. Framework Contract No ECDC/08/008 and Framework Contract ECDC/2011/014)
  • Member of the of the “European Meningococcal Strain Collection (EMSC) management group (IBD-LabNet), IBD-LabNet Consortium, European Centre for Disease Control (ECDC) sponsored consortium. Framework Contract No ECDC/08/008 and Framework Contract ECDC/2011/014)
Current research funding
  • AMC
  • Eurofins Central Laboratory
  • GlaxoSmithKline Biologicals SA
  • Pfizer B.V. (4726)
  • RIVM