foto

Dr. C.A. Remme

Position
Associate professor (UHD)
Main activities
Research
Specialisation
Basic and translational cardiac electrophysiology
Focus of research
 
• Translational studies into cardiac sodium channel (dys)function and inherited sodium channelopathies (including SCN5A mutations) associated with cardiac arrhythmias and sudden cardiac death, incorporating clinical and genetic with functional and mechanistic studies in transgenic models and human induced pluripotent stem cell-derived (iPSC) cardiomyocytes.

• Basic studies aimed at (1) unraveling mechanisms by which defective sodium channels mediate cardiac conduction slowing and arrhythmogenesis, (2) the complexity of sodium channel function and regulation, and (3) their diverse (non-electrogenic) roles in cardiac structure and function.

• Identification of novel (genetic) determinants, modifiers and pathways mediating cardiac electrophysiology and arrhythmia risk.

• Translational studies aimed at identifying novel targets for the prevention and treatment of cardiac arrhythmias and sudden cardiac death.

 

 

Key publications
  • Rivaud MR, Jansen JA, Postema PG, Nannenberg EA, Mizusawa Y, van der Nagel R, Wolswinkel R, van der Made I, Marchal GA, Rajamani S, Belardinelli L, van Tintelen JP, Tanck MWT, van der Wal AC, de Bakker JMT, van Rijen HV, Creemers EE, Wilde AAM, van den Berg MP, van Veen TAB, Bezzina CR, Remme CA, A common co-morbidity modulates disease expression and treatment efficacy in inherited cardiac sodium channelopathy. EUR HEART J 2018;39 (31):2898-2907 [PubMed]
  • Marsman RFJ, Bezzina CR, Freiberg F, Verkerk AO, Adriaens ME, Podliesna S, Chen C, Purfürst B, Spallek B, Koopmann TT, Baczko I, dos Remedios CG, George AL Jr, Bishopric NH, Lodder EM, de Bakker JMT, Fischer R, Coronel R, Wilde AAM, Gotthardt M, Remme CA, Coxsackie and Adenovirus Receptor Is a Modifier of Cardiac Conduction and Arrhythmia Vulnerability in the Setting of Myocardial Ischemia. J AM COLL CARDIOL 2014;63 (6):549-559 [PubMed]
  • Bezzina CR, Barc J, Mizusawa Y, Remme CA, Gourraud JB, Simonet F, Verkerk AO, Schwartz PJ, Crotti L, Dagradi F, Guicheney P, Fressart V, Leenhardt A, Antzelevitch C, Bartkowiak S, Borggrefe M, Schimpf R, Schulze-Bahr E, Zumhagen S, Behr ER, Bastiaenen R, Tfelt-Hansen J, Olesen MS, Kääb S, Beckmann BM, Weeke P, Watanabe H, Endo N, Minamino T, Horie M, Ohno S, Hasegawa K, Makita N, Nogami A, Shimizu W, Aiba T, Froguel P, Balkau B, Lantieri O, Torchio M, Wiese C, Weber D, Wolswinkel R, Coronel R, Boukens BJ, Bézieau S, Charpentier E, Chatel S, Despres A, Gros F, Kyndt F, Lecointe S, Lindenbaum P, Portero V, Violleau J, Gessler M, Tan HL, Roden DM, Christoffels VM, Le Marec H, Wilde AA, Probst V, Schott JJ, Dina C, Redon R, Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. NAT GENET 2013;45 (9):1044-1049 [PubMed]
  • Portero V, Casini S, Hoekstra M , Verkerk AO, Mengarelli I, Belardinelli L, Rajamani S, Wilde AAM, Bezzina CR, Veldkamp MW, Remme CA, Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 in murine Scn5a-1798insD+/- and human SCN5A-1795insD+/- iPSC-derived cardiomyocytes. CARDIOVASC RES 2017;113 (7):829-838 [PubMed]
  • Rivaud MR, Agullo-Pascual E, Lin X, Leo-Macias A, Zhang M, Rothenberg E, Bezzina CR, Delmar M, Remme CA, Sodium Channel Remodeling in Subcellular Microdomains of Murine Failing Cardiomyocytes. J AM HEART ASSOC 2017;6 (12):e007622 [PubMed]
All Publications
Research programmes

Basic and translational cardiac electrophysiology

Basic and translational studies into cardiac arrhythmias and sudden cardiac death

Faculty
Dr. C.A. Remme

Postdocs
Dr. S. Casini PhD
Dr. V. Portero

PhD Students
G.A. Marchal
Drs. S. Podliesna
S.M. van der Voorn MSc (UMC Utrecht)

Others
G.A. Marchal
R. Wolswinkel BSc

Other research related activities
  • Membership of medical or scientific committee, European Working Group of Cardiac Cellular Electrophysiology (European Society of Cardiology), Chair
  • Membership of medical or scientific committee, European Society of Cardiology, ESC Media Committee
  • Membership of medical or scientific committee, European Heart Rhythm Association (EHRA), Selection Committee
  • Membership of editorial board / Editorship, PHYSIOLOGICAL REVIEWS
  • Membership of editorial board / Editorship, CARDIOVASCULAR RESEARCH
  • Membership of editorial board / Editorship, JOURNAL OF THE AMERICAN HEART ASSOCIATION
  • Membership of editorial board / Editorship, FRONTIERS IN PHYSIOLOGY
  • Membership of editorial board / Editorship, CARDIOVASCULAR DRUGS AND THERAPY
Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • Stichting AMC Foundation (Vrijgesteld)
  • ZonMw