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Dr. C.C. Paulusma

Position
Scientific staff member (UD)
Main activities
Research
Specialisation
Biochemistry, cell biology, phospholipid transport, Hepatobiliary transport, cholestasis
Focus of research

Our research is centered around the cellular and pathophysiological functions of P4 ATPases, lipid flippases that are implicated in the biogenesis of transport vesicles. Genome-wide association studies predict a role for various P4 ATPases as predisposing factors in complex diseases, including atherosclerosis, rheumatoid arthritis, type 2 diabetes and Alzheimer’s disease. It is our goal to delineate the role of P4 ATPases in aforementioned diseases.

Key publications
  • de Waart DR, Naik J, Utsunomiya KS, Duijst S, Ho-Mok K, Bolier AR, Hiralall J, Bull LN, Bosma PJ, Oude Elferink RPJ, Paulusma CC, ATP11C targets basolateral bile salt transporter proteins in mouse central hepatocytes. HEPATOLOGY 2016;64 (1):161-174 [PubMed]
  • Vaz FM, Paulusma CC, Huidekoper H, de Ru M, Lim C, Koster J, Ho-Mok K, Bootsma AH, Groen AK, Schaap FG, Oude Elferink RPJ, Waterham HR, Wanders RJA, Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype. HEPATOLOGY 2015;61 (1):260-267 [PubMed]
  • van der Mark VA, de Waart DR, Ho-Mok KS, Tabbers MM, Voogt HW, Oude Elferink RPJ, Knisely AS, Paulusma CC, The lipid flippase heterodimer ATP8B1-CDC50A is essential for surface expression of the apical sodium-dependent bile acid transporter (SLC10A2/ASBT) in intestinal Caco-2 cells. BBA-MOL BASIS DIS 2014;1842 (12 Part A):2378-2386 [PubMed]
  • Kunne C, de Graaff M, Duijst S, de Waart DR, Oude Elferink RPJ, Paulusma CC, Hepatic cytochrome P450 deficiency in mouse models for intrahepatic cholestasis predispose to bile salt-induced cholestasis. LAB INVEST 2014;94 (10):1103-1113 [PubMed]
  • Paulusma CC, Houwen RHJ, Williamson PL, The flip side of cardiolipin import. NAT MED 2011;17 (4):413 [PubMed]
All Publications
Research programmes

Prof. dr. R.P.J. Oude Elferink PhD (Hepatic metabolism and transport processes)

Other research related activities
  • Membership of medical or scientific committee, Board member of the Dutch Society for Hepatology (2008-2014).
  • Membership of medical or scientific committee, Board member of the Dutch Experimental Gastroenterology and Hepatology Meeting commitee (2008-2014).