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Dr. C.M.S. Ribeiro PhD

Position
Scientific staff member (UD)
Main activities
Research, Teaching
Specialisation
Autophagy Mechanisms in Antiviral Immunity and Chronic Inflammation
Focus of research

 

Our research group focuses on elucidating the mechanisms governing autophagy pathways, ultimately aiming to maximize the therapeutic potential of targeting autophagy to intervene in chronic viral infections and inflammatory diseases.  

 

Our major research lines are:

1) Molecular Regulation of Degradative Autophagy and Secretory Autophagy in Viral Infections, with particular emphasis on HIV-1 and Dengue virus infection.  

2) Function of Autophagy Molecules and Autophagy Vesicles  on Virus Restriction, Molecular Inflammation and T-cell mediated Immunity - using ex vivo explant tissue models and organoid technology. 

3) Impact of Autophagy Mechanisms and Polymorphisms in Clinical Disease Outcomes

 

Contact information: c.m.ribeiro@amc.uva.nl

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Key publications
  • Ribeiro CMS, Sarrami-Forooshani R, Setiawan LC, Zijlstra-Willems EM, van Hamme JL, Tigchelaar W, van der Wel NN, Kootstra NA, Gringhuis SI, Geijtenbeek TBH, Receptor usage dictates HIV-1 restriction by human TRIM5α in dendritic cell subsets. NATURE 2016;540 (7633):448-452 [PubMed]
  • Hertoghs N, Geijtenbeek TBH, Ribeiro CMS, Interplay between HIV-1 innate sensing and restriction in mucosal dendritic cells: balancing defense and viral transmission. CURR OPIN VIROL 2017;22:112-119 [PubMed]
  • van den Berg LM, Ribeiro CMS, Zijlstra-Willems EM, de Witte L, Fluitsma D, Tigchelaar W, Everts V, Geijtenbeek TBH, Caveolin-1 mediated uptake via langerin restricts HIV-1 infection in human Langerhans cells. RETROVIROLOGY 2014;11 (1):123 [PubMed]
  • Sarrami-Forooshani R, Mesman AW, van Teijlingen NH, Sprokholt JK, van der Vlist M, Ribeiro CMS, Geijtenbeek TBH, Human immature Langerhans cells restrict CXCR4-using HIV-1 transmission. RETROVIROLOGY 2014;11 (1):52 [PubMed]
  • Ribeiro CMS, Hermsen T, Taverne-Thiele AJ, Savelkoul HFJ, Wiegertjes GF, Evolution of Recognition of Ligands from Gram-Positive Bacteria: Similarities and Differences in the TLR2-Mediated Response between Mammalian Vertebrates and Teleost Fish. J IMMUNOL 2010;184 (5):2355-2368 [PubMed]
All Publications
Research programmes

Prof. dr. T.B.H. Geijtenbeek (Dendritic cells in infection and immunity)

Other research related activities
  • Membership of medical or scientific committee, University of Amsterdam & VU University Amsterdam, Amsterdam Young Academy - AYA
  • Membership of medical or scientific committee, University of Amsterdam, University Forum
Current research funding
  • AMC (Vrijgesteld)
  • ZonMw