Dr. ir. A.J. Nederveen

Main activities
MR Physics, Medical Physics
Focus of research

This research line focusses on designing and validating quantitative MRI methods, mainly in the field of cardiovascular, muscular and oncologic imaging.

Key publications
  • Froeling M, Oudeman J, Strijkers GJ, Maas M, Drost MR, Nicolay K, Nederveen AJ, Muscle changes detected with diffusion-tensor imaging after long-distance running. RADIOLOGY 2015;274 (2):548-562 [PubMed]
  • van der Valk FM, Bekkering S, Kroon J, Yeang C, van den Bossche J, van Buul JD, Ravandi A, Nederveen AJ, Verberne HJ, Scipione C, Nieuwdorp M, Joosten LAB, Netea MG, Koschinsky ML, Witztum JL, Tsimikas S, Riksen NP, Stroes ESG, Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans. CIRCULATION 2016;134 (8):611-624 [PubMed]
  • Heijtel DFR, Mutsaerts HJMM, Bakker E, Schober P, Stevens MF, Petersen ET, van Berckel BNM, Majoie CBLM, Booij J, van Osch MJP, VanBavel E, Boellaard R, Lammertsma AA, Nederveen AJ, Accuracy and precision of pseudo-continuous arterial spin labeling perfusion during baseline and hypercapnia: a head-to-head comparison with ¹⁵O H₂O positron emission tomography. NEUROIMAGE 2014;92:182-192 [PubMed]
  • Figee M, Luigjes J, Smolders R, Valencia-Alfonso CE, van Wingen G, de Kwaasteniet B, Mantione M, Ooms P, de Koning P, Vulink N, Levar N, Droge L, van den Munckhof P, Schuurman PR, Nederveen A, van den Brink W, Mazaheri A, Vink M, Denys D, Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder. NAT NEUROSCI 2013;16 (4):386-387 [PubMed]
  • Visser ME, Wagener G, Baker BF, Geary RS, Donovan JM, Beuers UHW, Nederveen AJ, Verheij J, Trip MD, Basart DCG, Kastelein JJP, Stroes ESG, Mipomersen, an apolipoprotein B synthesis inhibitor, lowers low-density lipoprotein cholesterol in high-risk statin-intolerant patients: a randomized, double-blind, placebo-controlled trial. EUR HEART J 2012;33 (9):1142-1149 [PubMed]
All Publications
Research programmes

Applied MR Physics

This research line focusses on designing and validating quantitative MRI methods, mainly in the field of cardiovascular, muscular and oncologic imaging.

MRI of the arterial wall is a promising technique allowing plaque phenotyping. Plaque segmentation based on MRI data is however still cumbersome because of the lack of a normalized intensity unit for MRI, motion artefacts, and the rather low (anisotropic) resolution. We are developing a pipeline for quantitative plaque analysis on MRI (T1, T2, ADC) that will allow clinical implementation of high resolution MRI based carotid plaque phenotyping in patients at increased cardiovascular risk. Carotid MR is further improved by designing MR methods to accurately measure wall shear stress (WSS) patterns in 3D.

Arterial spin labeling (ASL) is a non-invasive magnetic resonance imaging (MRI) technique for the quantification of cerebral perfusion. ASL does not involve intravenous injection of contrast agents or exposure to ionizing radiation. It is an attractive tool in the pediatric population and in longitudinal studies with repeated measurements. Previously our group studied ASL in a group of children suffering from sickle cell disease. Abnormal perfusion patterns may predict silent infarctions in this patient population. This research is presently being continued in a larger group of adult patients. ASL is also applied in neurodegenerative diseases such as Alzheimer’s disease, since perfusion deficits detected by ASL are believed to be associated with disease progression.

Measuring the diffusion directional anisotropy enables reconstructions of local muscle fiber bundle orientations, which can be combined to provide three dimensional visualizations of muscle architecture. We aim to develop anatomical MRI and DTI protocols to advance tools for muscle segmentation and quantification of muscle specific architectural parameters. The combination of muscle DTI and MR elastography delivers a unique window on muscle pathology. Clinical applications comprise the imaging of the pelvic floor, the heart muscle, forearm muscles and nerves, upper leg muscles (postpolio syndrome) and the gluteus maximus muscle.

Quantitative imaging also bears promise in the field of oncology. We have built a strong program for evaluating and predicting tumour response based on functional imaging. We pioneered the benefit of 7T high field imaging for probing the metabolic constituents of tumour tissue.

Dr. ir. A.J. Nederveen
Drs. P.F.C. Groot
Dr. J.M. den Harder

Dr. ir. A.J. Bakermans
Dr. ir. M.W.A. Caan
Ir. P. de Heer
Dr. ir. P. van Ooij

PhD Students
K.P.A. Baas MSc
C.P.S. Blanken
M.R.R. Daal
L.M. Gottwald
L. Hashemi
V.A.T. Houttu
Drs. C.S. de Jonge
R. Klaassen MSc
J.R.C. Monte
E.S. Peper
B.A. Runderkamp
A. van Schelt
J. Schoormans
L. Secondulfo
M.A. Troelstra
L. Václavů MSc
Q. Zhang MSc
K.H. Zheng MD
Ir. L. Voskuilen (ACTA)

Prof. dr. C.B.L.M. Majoie (Neuroradiology, Neurovascular diseases: imaging and endovascular treatment of acute stroke)

Prof. dr. J. Stoker (Abdominal imaging)

Prof. dr. E.S.G. Stroes MD PhD (Novel anti-atherogenic strategies targeting the vessel wall)

Current research funding
  • AMC
  • Children's Hospital Los Angeles
  • Technologiestichting STW
  • Universiteit Twente
  • ZonMw (Vrijgesteld)