Dr. ir. I.C. Gaemers

Research Quality and Preclinical Project Management
Focus of research

Main activities (50/50)

Tytgat Institute Research Quality management
The Tytgat Institute(TI) has an ISO15189 international accreditation for its research activities (Dutch Board of Accreditation, #M304) and is compliant with GcLP. For this I:
* design, implement and manage the TI quality system (QS)for research and preclinical studies
* am internal auditor and external auditor host
* perform Process analyses & Risk management
* validate processes, and coordinate equipment and assay validation
* perform Management Review of quality and general policy
* coordinate all aspects of TI Standard Operating Procedures (SOPs)
* train and inform TI staff on TI QS, auditing and risk management
* am SMART advisor for general management (Annual Plan, Action Plan, QPI’s)
* am Quality manual author

(Pre)clinical Project Management:
The Tytgat Institute performs research and services for fee for external partners (pharma & CRO). For this I
* Manage all aspects of Tytgat Institute "external" preclinical studies (Set-up, Deliverables, Budget, Staff planning, Sample logistics, Data storage, Contracts and Invoicing)
* am Tytgat institute’s intermediair/contact for CRO and pharmaceutical companies


Tel: +31205668832



Key publications
  • de Oliveira MC, Gilglioni EH, de Boer BA, Runge JH, de Waart DR, Salgueiro CL, Ishii-Iwamoto EL, Oude Elferink RPJ, Gaemers IC, Bile acid receptor agonists. INT747 and INT777 decrease oestrogen deficiency-related postmenopausal obesity and hepatic steatosis in mice. BBA-MOL BASIS DIS 2016;1862 (11):2054-2062 [PubMed]
  • Gasparin FRS, Carreño FO, Mewes JM, Gilglioni EH, Pagadigorria CLS, Natali MRM, Utsunomiya KS, Constantin RP, Ouchida AT, Curti C, Gaemers IC, Elferink RPJO, Constantin J, Ishii-Iwamoto EL, Sex differences in the development of hepatic steatosis in cafeteria diet-induced obesity in young mice. BBA-MOL BASIS DIS 2018;1864 (7):2495-2509 [PubMed]
  • Kunne C, Acco A, Duijst S, de Waart DR, Paulusma CC, Gaemers I, Oude Elferink RPJ, FXR-dependent reduction of hepatic steatosis in a bile salt deficient mouse model. BBA-MOL BASIS DIS 2014;1842 (5):739-746 [PubMed]
  • Schaap FG, Kremer AE, Lamers WH, Jansen PLM, Gaemers IC, Fibroblast growth factor 21 is induced by endoplasmic reticulum stress. BIOCHIMIE 2013;95 (4):692-699 [PubMed]
All Publications
Research programmes

Prof. dr. R.P.J. Oude Elferink PhD (Hepatic metabolism and transport processes)