Dr. J.H. Akkerdaas

Main activities
Allergy research
Focus of research
  • Protein-chemistry and molecular biology of respiratory and food allergens: what makes an allergen an allergen?
  • Innovative approaches for in vitro and in vivo diagnosis of IgE-mediated allergy: from allergen extracts to molecular diagnostics.
  • Innovative biopharmaceutical approaches for allergen-specific immunotherapy: recombinant technology, novel adjuvants and administration routes.
  • Immuno-epidemiology of respiratory and food allergies: the role of allergen exposure, environment, diet, infections and lifestyle in the development of allergy.
  • Mouse models of allergy and asthma: how are sensitization and disease expression regulated?


Key publications
  • Zuidmeer-Jongejan L, Fernández-Rivas M, Winter MGT, Akkerdaas JH, Summers C, Lebens A, Knulst AC, Schilte P, Briza P, Gadermaier G, van Ree R, Oil body-associated hazelnut allergens including oleosins are underrepresented in diagnostic extracts but associated with severe symptoms. CLIN TRANSL ALLERGY 2014;4 (1):4 [PubMed]
  • Burney PGJ, Potts J, Kummeling I, Mills ENC, Clausen M, Dubakiene R, Barreales L, Fernandez-Perez C, Fernandez-Rivas M, Le TM, Knulst AC, Kowalski ML, Lidholm J, Ballmer-Weber BK, Braun-Fahlander C, Mustakov T, Kralimarkova T, Popov T, Sakellariou A, Papadopoulos NG, Versteeg SA, Zuidmeer L, Akkerdaas JH, Hoffmann-Sommergruber K, van Ree R, The prevalence and distribution of food sensitization in European adults. ALLERGY 2014;69 (3):365-371 [PubMed]
  • Amoah AS, Obeng BB, Larbi IA, Versteeg SA, Aryeetey Y, Akkerdaas JH, Zuidmeer L, Lidholm J, Fernández-Rivas M, Hartgers FC, Boakye DA, van Ree R, Yazdanbakhsh M, Peanut-specific IgE antibodies in asymptomatic Ghanaian children possibly caused by carbohydrate determinant cross-reactivity. J ALLERGY CLIN IMMUN 2013;132 (3):639-647 [PubMed]
  • Masthoff LJN, Mattsson L, Zuidmeer-Jongejan L, Lidholm J, Andersson K, Akkerdaas JH, Versteeg SA, Garino C, Meijer Y, Kentie P, Versluis A, den Hartog Jager CF, Bruijnzeel-Koomen CAFM, Knulst AC, van Ree R, van Hoffen E, Pasmans SGMA, Sensitization to Cor a 9 and Cor a 14 is highly specific for a hazelnut allergy with objective symptoms in Dutch children and adults. J ALLERGY CLIN IMMUN 2013;132 (2):393-399 [PubMed]
  • Flinterman AE, Akkerdaas JH, den Hartog Jager CF, Rigby NM, Fernandez-Rivas M, Hoekstra MO, Bruijnzeel-Koomen CA, Knulst AC, van Ree R, Pasmans SG, Lipid transfer protein-linked hazelnut allergy in children from a non-Mediterranean birch-endemic area. J ALLERGY CLIN IMMUN 2008;121 (2):423-428.e2 [PubMed]
All Publications
Research programmes

Prof. dr. R. van Ree (Molecular mechanisms of disease induction, symptom expression, immunotherpay and prevention in IgE-mediated allergy)