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Dr. J.W. Ganzevoort MD PhD

Position
Scientific staff member (UD)
Main activities
Patient care
Specialisation
Gynecologist, Perinatologist
Focus of research

Hypertensive disorders of pregnancy (preeclampsia, HELLP-syndrome): management during pregnancy; recurrence risks in next pregnancies; long-term (vascular) morbidity; 

Diagnosis and management of Fetal growth Restriction

Key publications
  • Gordijn SJ, Beune IM, Thilaganathan B, Papageorghiou A, Baschat AA, Baker PN, Silver RM, Wynia K, Ganzevoort W, Consensus definition of fetal growth restriction: a Delphi procedure. ULTRASOUND OBST GYN 2016;48 (3):333-339 [PubMed]
  • van Oostwaard MF, Langenveld J, Schuit E, Papatsonis DNM, Brown MA, Byaruhanga RN, Bhattacharya S, Campbell DM, Chappell LC, Chiaffarino F, Crippa I, Facchinetti F, Ferrazzani S, Ferrazzi E, Figueiró-Filho EA, Gaugler-Senden IPM, Haavaldsen C, Lykke JA, Mbah AK, Oliveira VM, Poston L, Redman CWG, Salim R, Thilaganathan B, Vergani P, Zhang J, Steegers EAP, Mol BWJ, Ganzevoort W, Recurrence of hypertensive disorders of pregnancy: an individual patient data metaanalysis. AM J OBSTET GYNECOL 2015;212 (5):624.e1-624.17 [PubMed]
  • Lees CC, Marlow N, van Wassenaer-Leemhuis A, Arabin B, Bilardo CM, Brezinka C, Calvert S, Derks JB, Diemert A, Duvekot JJ, Ferrazzi E, Frusca T, Ganzevoort W, Hecher K, Martinelli P, Ostermayer E, Papageorghiou AT, Schlembach D, Schneider KTM, Thilaganathan B, Todros T, Valcamonico A, Visser GHA, Wolf H [Contributors: Aktas A, Borgione S, Chaoui R, Cornette JMJ, Diehl T, van Eyck J, Fratelli N, van Haastert IL, Lobmaier S, Lopriore E, Missfelder-Lobos H, Mansi G, Martelli P, Maso G, Maurer-Fellbaum U, van Charante NM, de Tollenaer SM, Napolitano R, Oberto M, Oepkes D, Ogge G, van der Post J, Prefumo F, Preston L, Raimondi F, Reiss IKM, Scheepers HCJ, Schuit E, Center J, Skabar A, Spaanderman M, Weisglas-Kuperus N, Zimmermann A, Moore T, Johnson S, Rigano S]] , 2 year neurodevelopmental and intermediate perinatal outcomes in infants with very preterm fetal growth restriction (TRUFFLE): a randomised trial. LANCET 2015;385 (9983):2162-2172 [PubMed]
  • Magee LA, von Dadelszen P, Rey E, Ross S, Asztalos E, Murphy KE, Menzies J, Sanchez J, Singer J, Gafni A, Gruslin A, Helewa M, Hutton E, Lee SK, Lee T, Logan AG, Ganzevoort W, Welch R, Thornton JG, Moutquin JM, Less-Tight versus Tight Control of Hypertension in Pregnancy. NEW ENGL J MED 2015;372 (5):407-417 [PubMed]
  • Ganzevoort W, Alfirevic Z, von Dadelszen P, Kenny L, Papageorghiou A, van Wassenaer-Leemhuis A, Gluud C, Mol BW, Baker PN, STRIDER: Sildenafil Therapy In Dismal prognosis Early-onset intrauterine growth Restriction--a protocol for a systematic review with individual participant data and aggregate data meta-analysis and trial sequential analysis. SYST REV 2014;3 (1):23 [PubMed]
All Publications
Curriculum Vitae

Curriculum Vitae 

1999 Medical degree (cum laude); BIG-registration#: 39049404801
1999 - 2004 PhD-researcher, Dept. Obstetrics & Gynecology, Academisch Medisch Centrum (AMC), Universiteit van Amsterdam. Supervisor H. Wolf (AMC); Prof. Dr. JIP de Vries; “Preeclampsia Eclampsia TRial Amsterdam” Clinical trial on effects of plasma volume expansion on hemodynamics and clinical outcomes in patients with severe early-onset hypertensive disorders of pregnancy (preeclampsia, HELLP-syndrome, severe fetal growth restriction).
2004 - 2010 Resident Gynecology, Cluster AMC, Professor OP Bleker and Professor MJ Heineman; Spaarne Ziekenhuis Haarlem/Hoofddorp, MH Emanuel; Zaans Medisch Centrum (ZMC), H Doornbos;
07-09-2007 PhD-thesis Universiteit van Amsterdam. Promotores Prof. Dr. JAM van der Post & Prof. Dr. GJ Bonsel; Co-promotores Dr. H. Wolf & Prof. Dr. JIP de Vries. Title: Plasma volume expansion in early-onset hypertensive disorders of pregnancy
2010-2012 Gynecologist, Fellowship Perinatology, AMC
2012-present Gynecologist Perinatologist, AMC
 

Research projects involved

2000 - PETRA, RCT plasma volume expansion in temporising management of severe early-onset hypertensive disorders of pregnancy
2006 - Truffle, RCT in monitoring and intervention strategy in severe early fetal growth restriction
2007 - TOTEM, RCT immediate delivery versus temporising management of severe early-onset hypertensive disorders of pregnancy (Duvekot)
2008 - Glycocalyx in pre-eclampsia (Van den Born)
2009 - prediction modelling in recurrence of hypertensive disorders of pregnancy. Meta-analysis. Cohort studies and individual patient data meta-analysis.
2009 - CHIPS, RCT management of chronic hypertension in pregnancy (Magee)
2010 - Queen of hearts, hypertensive disorders of pregnancy and long-term cardiovascular risks: retrospective and prospective cohort studies (including planned intervention studies)
2013 - STRIDER, RCT sildenafil for severe early-onset FGR, main applicant
2017 - Dutch TRUFFLE, Cohort with nested RCT on early intervention (delivery) in children identified as FGR by abnormal Doppler studies within a group of SGA-children, main applicant
2013 - ObsEva, Phase 1-? Studies for new tocolytic drug
 

Courses followed

2008 Operatieve Verloskunde - Leiderdorp, NL
2009 NLS Provider Course - Riel, NL
2010 ISUOG Advanced Course Ultrasound in Obstetrics - London, UK
2010 ISSHP - Melbourne, Australia
2011 SMFM - San Francisco, USA
2011 MOET Provider Course - Riel, NL
2011 & 2012 & 2013 Teach The Teacher – Communication skills - Amsterdam, NL
 

Teaching positions

Member of team training residents Gynecology & Obstetrics, interns (co-assistenten).
Teacher at Amstel Academie for Obstetric Nursing  

Memberships

Organisations: NVOG, KNMG, ISSHP, ISUOG.
ICT-committee of the CPZ (College Perinatale Zorg)
Editor of the NTOG 

Research programmes

Placental disorders of Pregnancy: Fetal Growth Restriction and Hypertension

The program focuses on the maternal-fetal syndromes of placental insufficiency, the maternal including pre-eclampsia and HELLP-syndrome; the fetal including fetal growth restriction.

I am leading in international consensus procedures on nomenclature, international cooperation in the STRIDERproject (with five simultaneous RCTs) on treatment of FGR, TRUFFLE projects on diagnosis/monitoring/intervention in FGR.

Faculty
Dr. J.W. Ganzevoort MD PhD

PhD Students
C.M. Bruin
S.E. Damhuis
Drs. A. Pels MD
M. Smies
Drs. I. Beune MD (UMCG)

Others
Drs. F. Beukers MD

Prof. dr. J.A.M. van der Post MD PhD (Reproductive Health, placental disease and maternal and fetal diseases)

Other research related activities
  • Contribution to guidelines and protocols, Landelijke richtlijn Foetale Groeirestrictie
  • Contribution to guidelines and protocols, Regioprotocol hypertensie in zwangerschap
  • Membership of editorial board / Editorship, NEDERLANDS TIJDSCHRIFT VOOR OBSTETRIE & GYNAECOLOGIE
  • Contribution to training of professionals, VU University Medical Center
  • Contribution to training of professionals, University of Amsterdam
  • Contribution to training of professionals, Amstel Academie
Current research funding
  • Crediteurenadm. VUmc, p/a Profource Service Center
  • University of British Columbia
  • ZonMw