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Dr. K.A. Reedquist

Position
Scientific staff member (UD)
Main activities
Research
Specialisation
Signal transduction of rheumatoid arthritis and immune-mediated inflammatory disease
Focus of research

Research in our group focuses on the identification of key intracellular signalling pathways which mediate the switch from acute to chronic inflammation, and perpetuate established inflammation, in complex autoimmune diseases such as rheumatoid arthritis (RA).  These studies provide a fundamental understanding of the pathophysiological mechanisms of chronic inflammation, identify new targets in the treatment of RA and other autoimmune diseases, and apply a translational pre-clinical and clinical approaches to understanding the efficacy (or lack of efficacy) of novel and established therapeutic compounds in RA.

Much of our work is centered around the regulation and function of Ras superfamily small GTPase signalling pathways in immune and stromal cells in the RA synovium.  Specific research questions that we are currently exploring include:

How do functional interactions between Ras family GTPases regulate qualitative T cell immune responses?

How do Ras family GTPase-dependent proliferative and survival signals integrate with inflammatory signals in the RA synovium to perpetuate cellular hyperplasia and promote joint destruction?

Can changes in Ras family GTPase signaling pathways be used as biochemical fingerprints to predict or detect the development of erosive inflammatory arthritis?

Key publications
  • Grabiec AM, Reedquist KA, The ascent of acetylation in the epigenetics of rheumatoid arthritis. NAT REV RHEUMATOL 2013;9 (5):311-318 [PubMed]
  • Grabiec AM, Korchynskyi O, Tak PP, Reedquist KA, Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay. ANN RHEUM DIS 2012;71 (3):424-431 [PubMed]
  • Krausz S, Garcia S, Ambarus CA, de Launay D, Foster M, Naiman B, Iverson W, Connor JR, Sleeman MA, Coyle AJ, Hamann J, Baeten D, Tak PP, Reedquist KA, Angiopoietin-2 promotes inflammatory activation of human macrophages and is essential for murine experimental arthritis. ANN RHEUM DIS 2012;71 (8):1402-1410 [PubMed]
  • de Launay D, van de Sande MGH, de Hair MJH, Grabiec AM, van de Sande GPM, Lehmann KA, Wijbrandts CA, van Baarsen LGM, Gerlag DM, Tak PP, Reedquist KA, Selective involvement of ERK and JNK mitogen-activated protein kinases in early rheumatoid arthritis (1987 ACR criteria compared to 2010 ACR/EULAR criteria): a prospective study aimed at identification of diagnostic and prognostic biomarkers as well as therapeutic targets. ANN RHEUM DIS 2012;71 (3):415-423 [PubMed]
  • Grabiec AM, Krausz S, de Jager W, Burakowski T, Groot D, Sanders ME, Prakken BJ, Maslinski W, Eldering E, Tak PP, Reedquist KA, Histone Deacetylase Inhibitors Suppress Inflammatory Activation of Rheumatoid Arthritis Patient Synovial Macrophages and Tissue. J IMMUNOL 2010;184 (5):2718-2728 [PubMed]
All Publications