Dr. M.J.M. Serlie

Scientific staff member (UD)
Main activities
Patient care, Research
Endocrinology, Metabolism and Nutrition
Focus of research

The research group focusses on translational research in the field of obesity. First, we aim to identify metabolic pathways that are involved in insulin resistance and second, we are studying the interaction between nutrition, metabolism and the brain. We use different methods to address those questions, i.e. human intervention studies, hyperinsulinemic euglycemic clamps, stable isotopes, liver magnetic resonance spectroscopy, functional MRI, SPECT and tissue biopsies (liver, muscle and adipose tissue).

Since the lab performs translational research, we collaborate with basis research scientists within the AMC and from Yale and Harvard University in the US.


Key publications
  • ter Horst KW, Gilijamse PW, Versteeg RI, Ackermans MT, Nederveen AJ, la Fleur SE, Romijn JA, Nieuwdorp M, Zhang D, Samuel VT, Vatner DF, Petersen KF, Shulman GI, Serlie MJ, Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans. CELL REP 2017;19 (10):1997-2004 [PubMed]
  • van Galen KA, ter Horst KW, Booij J, la Fleur SE, Serlie MJ, The role of central dopamine and serotonin in human obesity: lessons learned from molecular neuroimaging studies. METABOLISM 2018;85:325-339 [PubMed]
  • Versteeg RI, Schrantee A, Adriaanse SM, Unmehopa UA, Booij J, Reneman L, Fliers E, la Fleur SE, Serlie MJ, Timing of caloric intake during weight loss differentially affects striatal dopamine transporter and thalamic serotonin transporter binding. FASEB J 2017;31 (10):4545-4554 [PubMed]
  • Koopman KE, Caan MWA, Nederveen AJ, Pels A, Ackermans MT, Fliers E, la Fleur SE, Serlie MJ, Hypercaloric diets with increased meal frequency, but not meal size, increase intrahepatic triglycerides: a randomized controlled trial. HEPATOLOGY 2014;60 (2):545-553 [PubMed]
  • de Weijer BA, van de Giessen E, Janssen I, Berends FJ, van de Laar A, Ackermans MT, Fliers E, la Fleur SE, Booij J, Serlie MJ, Striatal dopamine receptor binding in morbidly obese women before and after gastric bypass surgery and its relationship with insulin sensitivity. DIABETOLOGIA 2014;57 (5):1078-1080 [PubMed]
All Publications
Research programmes

Obesity, metabolism and the brain

Dr. M.J.M. Serlie

PhD Students
K.A. van Galen
Drs. P.W. Gilijamse
Drs. A.V. Hartstra MD
Drs. M. Kiliçarslan
S.M. Oussaada MD
J. van Son
Drs. A. Emanuel (VUMC)

L.L. Koekkoek

Current research funding
  • AMC (Vrijgesteld)
  • Mediq Tefa B.V.
  • Novo Nordisk B.V.
  • UMC St. Radboud
  • ZonMw