Dr. Y. Pannekoek

Scientific staff member (UD)
Main activities
Research, Teaching
Molecular Microbiology of Bacterial Meningitis and Chlamydia infections.
Focus of research

We study the molecular epidemiology and population structure of the main pathogens causing meningitis, Neisseria meningitidis and Streptococcus pneumoniae, and of Chlamydia species causing respiratory infections and sexual transmitted disease. In addition, we study the pathogenesis of meningococcal and invasive pneumococcal disease. We are particularly interested in the bacterial stress response and its regulation by small RNAs (ribo-regulation) in conjunction with alternative sigma factors like sigmaE.
In collaborative studies with Dr. D. van de Beek (Department of Neurology, AMC) we investigate clinical aspects of bacterial meningitis as well correlation between clinical features, outcome and host and bacterial factors.

Key publications
  • Pannekoek Y, Huis In 't Veld RAG, Schipper K, Bovenkerk S, Kramer G, Brouwer MC, van de Beek D, Speijer D, van der Ende A, Neisseria meningitidis Uses Sibling Small Regulatory RNAs To Switch from Cataplerotic to Anaplerotic Metabolism. MBIO 2017;8 (2):e02293-16 [PubMed]
  • Huis In 't Veld RAG, Willemsen AM, van Kampen AHC, Bradley EJ, Baas F, Pannekoek Y, van der Ende A, Deep sequencing whole transcriptome exploration of the σE regulon in Neisseria meningitidis. PLOS ONE 2011;6 (12):e29002 [PubMed]
  • Versteeg B, Bruisten SM, Pannekoek Y, Jolley KA, Maiden MCJ, van der Ende A, Harrison OB, Genomic analyses of the Chlamydia trachomatis core genome show an association between chromosomal genome, plasmid type and disease. BMC GENOMICS 2018;19 (1):130 [PubMed]
  • Pannekoek Y, Huis In 't Veld R, Schipper K, Bovenkerk S, Kramer G, Speijer D, van der Ende A, Regulation of Neisseria meningitidis cytochrome bc1 components by NrrF, a Fur-controlled small noncoding RNA. FEBS OPEN BIO 2017;7 (9):1302-1315 [PubMed]
  • Pannekoek Y, Qi-Long Q, Zhang YZ, van der Ende A, Genus delineation of Chlamydiales by analysis of the percentage of conserved proteins justifies the reunifying of the genera Chlamydia and Chlamydophila into one single genus Chlamydia. PATHOG DIS 2016;74 (6):ftw071 [PubMed]
All Publications
Research programmes

Dr. A. van der Ende PhD (Epidemiology and pathogenesis of bacterial meningitis)