foto

Drs. I.H. Folkersma MD MSc

Position
Other
Main activities
Patient care
Specialisation
neurosurgeon
Focus of research

traumatic brain injury

pediatric neurosurgery

spinal dysraphism

Key publications
  • Folkersma H , Boellaard R, Yaqub M, Kloet RW, Windhorst AD, Lammertsma AA, Vandertop WP, van Berckel BNM, Widespread and prolonged increase in (R)-(11)C-PK11195 binding after traumatic brain injury. J NUCL MED 2011;52 (8):1235-1239 [PubMed]
  • Folkersma H , Boellaard R, Vandertop WP, Kloet RW, Lubberink M, Lammertsma AA, van Berckel BNM, Reference tissue models and blood-brain barrier disruption: lessons from (R)-[11C]PK11195 in traumatic brain injury. J NUCL MED 2009;50 (12):1975-1979 [PubMed]
  • Folkersma H , Foster Dingley JC, van Berckel BNM, Rozemuller A, Boellaard R, Huisman MC, Lammertsma AA, Vandertop WP, Molthoff CFM, Increased cerebral (R)-[(11)C]PK11195 uptake and glutamate release in a rat model of traumatic brain injury: a longitudinal pilot study. J NEUROINFLAMM 2011;8 (1):67 [PubMed]
  • Folkersma H , Brevé JJP, Tilders FJH, Cherian L, Robertson CS, Vandertop WP, Cerebral microdialysis of interleukin (IL)-1beta and IL-6: extraction efficiency and production in the acute phase after severe traumatic brain injury in rats. ACTA NEUROCHIR 2008;150 (12):1277-84; discussion 1284 [PubMed]
  • Folkersma H , Idema S, Bal MLA, Bleeker FE, Wolf NI, Vandertop WP, De 'groeiende schedelfractuur'. NED TIJDSCHR GENEESKD 2011;155 (42):A3400 [PubMed]
All Publications
Curriculum Vitae

Publicaties:

H Folkersma, CMF Dirven, WP Vandertop. Behandeling van cerebrale arterioveneuze malformaties. NTvIC 2000 (15) 161-8.

H Folkersma, JJA Mooij. Follow-up of 13 patients with surgical treatment of cerebral cavernous malformations: effect on epilepsy and patient disability. Clin Neurol Neurosurg 2001 Jul;103(2):67-71.

H Folkersma, CMF Dirven, WP Vandertop. De behandeling van cerebrale
arterioveneuze malformaties. Ned Tijdschr Neurol 2001 (3) 217-24.

ACJ Ruijs, H Folkersma. Uw gids op internet: traumatisch hersenletsel. Ned Tijdschr Neurol 2002 (5) 405-6.

H Folkersma, SM Peerdeman, MC Visser, EM Vriens, ARJ Girbes, WP Vandertop. Neuromonitoring bij patiënten na ernstig traumatisch hersenletsel. (Neuromonitoring of patients following severe traumatic brain injury) Ned Tijdschr Geneeskd 2003 (29) 1394-8. Review.

H Folkersma, WA van den Brink. In vivo modellen van traumatisch hersenletsel. Ned Tijdschr Neurol 2004 (5) 178-82.

H Folkersma, JJ Spijkstra, MC Visser, CJ de Langen, PE Postmus, WP Vandertop. Een jongeman met heesheid, slikklachten en progressieve kortademigheid. Ned Tijdschr Neurol 2005 (106) 272-7.

MA Kropholler, R Boellaard, A Schuitemaker, H Folkersma, BNM van Berckel, AA Lammertsma. Evaluation of reference tissue models for the analysis of [11C](R)-PK11195 studies. J Cereb Blood Flow Metab 2006 Nov;26(11):1431-41. Epub 2006 Mar 1.

H Folkersma, JJP Brevé, FJH Tilders, CS Robertson, WP Vandertop. Extraction efficiency of Interleukin (IL)-1 beta and IL-6 in vitro and their expression in the extracellular fluid in the acute phase after severe traumatic brain injury in rats using cerebral microdialysis in vivo. Acta Neurochir (Wien). 2008 Dec;150(12):1277-84; discussion 1284. Epub 2008 Nov 25.

Folkersma H, Boellaard R, Vandertop WP, Kloet RW, Lubberink M, Lammertsma AA, van Berckel BN. Reference tissue models and blood-brain barrier disruption: lessons from (R)-11CPK11195. J Nucl Med. 2009 Dec;50(12):1975-9. Epub 2009 Nov 12.

Neervoort FW, Van Ouwerkerk WJ, Folkersma H, Kaspers GJ, Vandertop WP. Surgical morbidity and mortality of pediatric brain tumors: a single center audit. Childs Nerv Syst. 2010 Mar 5. Epub 2010 Mar 5.

Hedy Folkersma, Jessica C. Foster-Dingley, Bart N.M. van Berckel, Annemieke M. Rozemuller, Ronald Boellaard, Marc Huisman, Adriaan A. Lammertsma, W. Peter Vandertop, Carla F.M. Molthoff. Acute posttraumatic glutamate release and microglial activation in a traumatic brain injury model: a combined microdialysis and longitudinal (R)-[11C]PK11195 PET study. J Neuroinflammation 2011 Jun 14;(8):67

Hedy Folkersma, Ronald Boellaard, Maqsood Yaqub, Reina W. Kloet, Albert D. Windhorst, Adriaan A. Lammertsma, W. Peter Vandertop, Bart N.M. van Berckel. Widespread and prolonged increased (R)-[11C]PK11195 binding after traumatic brain injury. J Nucl Med 2011 Aug;52(8):1235-9. Epub 2011 Jul 15.

MLA Bal, H Folkersma, AFW van der Steeg, EEO Hagebeuk, MA Benninga, WP
Vandertop. Het syndroom van Currarino. Ned Tijdschr Neurol 2011 (5) 236-42.

H Folkersma, S Idema, ML Bal, FE Bleeker, NI Wolf, WP Vandertop. Groeiende schedelfractuur (Growing skull fracture) Ned Tijdschr Geneeskd 2011; 155(42):A3400. Dutch.

Hedy Folkersma, Ronald Boellaard, Dagmar Verbaan, Reina W. Kloet, Adriaan A. Lammertsma, W. Peter Vandertop, Bart N.M. van Berckel, Long-term increased (R)-[11C]PK11195 binding in perilesional traumatic brain injury zones. JCBFM 2014 (submitted)


Wetenschappelijke voordrachten:

H Folkersma, SM Egeler-Peerdeman, WP Vandertop, ARJ Girbes. Intracerebral microdialysis in the detection of vasospasm induced cerebral ischaemia in patients with aneurysmal subarachnoid haemorrhage in the intensive care unit. (oral presentation) European Society of Intensive Care Medicine (ESICM). 12th Annual Congress 3-6 oktober 1999 Berlijn, Duitsland

H Folkersma, SM Egeler-Peerdeman, WP Vandertop, ARJ Girbes. Detectie van cerebrale ischemie ten gevolge van vasospasmen door middel van intracerebrale microdialyse bij patiënten met een aneurysmatische subarachnoïdale bloeding op de intensive care. (oral presentation) Nederlandse Vereniging van Neurochirurgen (NVvN) Wetenschappelijke Najaarsbijeenkomst 17 oktober 1999 Groningen

Hedy Folkersma, John JP Brevé, Fred JH Tilders, W Peter Vandertop. Recovery experiments of IL-1 beta and IL-6 by means of an in vitro microdialysis-perfusion system. (poster + oral presentation) International Neurotrauma Society. INTS 5th International Neurotrauma Symposium 1-5 oktober 2000 Garmisch Partenkirchen, Duitsland

Hedy Folkersma, John JP Brevé, Fred JH Tilders, W Peter Vandertop. Detectie van Interleukine (IL)-1 beta en IL-6 door middel van een in vitro microdialyse-perfusie systeem. (oral presentation) Symposium Experimenteel Onderzoek Heelkundige Specialismen (SEOHS) 17 november 2000 Utrecht

Hedy Folkersma, John JP Brevé, Fred JH Tilders, W Peter Vandertop. Temporal profile of extracellular IL-1 beta and IL-6 following traumatic brain injury. (oral presentation) 3th Users Meeting Microdialysis 18 mei 2001 Brussels, België

Hedy Folkersma, Claudia S Robertson, Fred JH Tilders, W Peter Vandertop. Expression of Interleukin (IL)-1 beta ans IL-6 following severe traumatic brain injury in rats using cerebral microdialysis. (poster) Neurocritical Care 2001 Returning from the dark side of the brain 28-29 september 2001 Cleveland Ohio, U.S.A.

Hedy Folkersma, Claudia S Robertson, Fred JH Tilders, W Peter Vandertop. Detectie van Interleukine (IL)-1 beta en IL-6 na traumatisch hersenletsel door middel van cerebrale microdialyse in de rat. (oral presentation) Symposium Experimenteel Onderzoek Heelkundige Specialismen (SEOHS) 16 november 2001 Nijmegen

Hedy Folkersma, Marc L Schröder, David P Noske, Saskia M Peerdeman, Armand RJ Girbes, W Peter Vandertop. Neuromonitoring bij patiënten na ernstig traumatisch hersenletsel. (oral presentation) Anesthesiologie 26-27 september 2002 Amsterdam

Marc A Kropholler, Bart NM van Berckel, Alie Schuitemaker, Hedy Folkersma, Gert Luurtsema, Albert D Windhorst, Ronald Boellaard, Adriaan A Lammertsma. Evaluation of reference tissue models for analysing (R)-[11C]PK11195 studies. (poster) Brain05 7-11 juni 2005 Amsterdam

Hedy Folkersma, Bart NM van Berckel, Ronald Boellaard, Reina Kloet, Adriaan A Lammertsma, W Peter Vandertop. Microglia activatie na traumatisch hersenletsel (TBI): een (R)-[11C]PK11195 positron emissie tomografie (PET) studie. (oral presentation) Nederlandse Vereniging van Neurochirurgen (NVvN) wetenschappelijke wintermeeting 27 januari 2006 Amersfoort

Hedy Folkersma. Triviaal hersenletsel in de oudere patiënt (invited lecture) 3e nascholingscursus neurologie en neuropsychiatrie in de geriatrie 18-24 maart 2006 Wengen, Zwitserland

Hedy Folkersma, Bart NM van Berckel, Ronald Boellaard, Reina W Kloet, Adriaan A Lammertsma, W Peter Vandertop. Microglia activation after traumatic brain injury (TBI): a (R)-[11C]PK11195 positron emission tomography (PET) study in TBI patients. (oral presentation) 8th International Neurotrauma Symposium INTS 21-25 mei 2006 Rotterdam

Bart NM van Berckel, Hedy Folkersma, Ronald Boellaard, Reina W Kloet, Mark Lubberink, Alie Schuitemaker, Adriaan A Lammertsma, W Peter Vandertop. Microglia activation after traumatic brain injury. (poster) 6th Neuroreceptor Mapping Conference (NRM06) 6-8 juli 2006 Kopenhagen, Denemarken

Hedy Folkersma, Bart NM van Berckel, Ronald Boellaard, Alie Schuitemaker, Reina W Kloet, Adriaan A Lammertsma, W Peter Vandertop. Microglia activation after traumatic brain injury (TBI): a (R)-[11C]PK11195 positron emission tomography (PET) study in TBI patients. (oral presentation) EANS, the European neurosurgical training course (head injury/functional) 21 februari 2007 Antalya, Turkije

Carla F.M. Molthoff, Hedy Folkersma, Jessica C. Foster-Dingley, Bart N.M. van Berckel, Annemieke M. Rozemuller, Ronald Boellaard, Marc Huisman, Adriaan A. Lammertsma, W. Peter Vandertop. Acute posttraumatic glutamate release and microglial activation in a traumatic brain injury model: a combined microdialysis and longitudinal (R)-[11C]PK11195. (oral presentation) Neuroreceptor Mapping Conference (NRM10) 22-24 juli 2010 Glasgow, Engeland.

Hedy Folkersma, Ronald Boellaard, Maqsood Yaqub, Reina W. Kloet, Albert D. Windhorst, Adriaan A. Lammertsma, W. Peter Vandertop, Bart N.M. van Berckel
Prolonged Increased And Widespread (R)-[11C]PK11195 Binding After Human Traumatic Brain Injury. (poster) Neuroreceptor Mapping Conference (NRM10) 22-24 juli 2010 Glasgow, Engeland.

Hedy Folkersma. Neurotrauma (invited lecture). Congres Traumatologie en acute geneeskunde. Nederlandse Vereniging voor Intensive Care Geneeskunde (NvIC) 16 september 2011 Reehorst, Ede

Hedy Folkersma. “traumatisch hersenletsel bij kinderen” (workshop) Symposium Acute Zorg rondom het Kind. Edupack 24 maart 2012 Lelystad

Hedy Folkersma. “kindermishandeling” (workshop) Symposium Acute Zorg rondom het Kind. Edupack 21 maart 2013 Lelystad

Hedy Folkersma, Marie-Lise van Veelen, Erwin Cornips, Eelco Hoving. (invited lecture) The Dutch Pediatric Neurosurgery Society. 06 oktober 2012 Marseille, France

Hedy Folkersma. Neurotrauma (invited lecture) The dark side of the brain. Congres Traumatologie en acute geneeskunde. Nederlandse Vereniging voor Intensive Care Geneeskunde (NvIC) 20 september 2013 Reehorst, Ede

Hedy Folkersma. “cerebrale inklemming bij kinderen” (workshop) Symposium Acute Zorg rondom het Kind. Edupack 27 maart 2014 Lelystad
 

Other research related activities
  • Membership of advisory board / Consultant, ESPN european society for pediatric neurosurgery
  • Membership of advisory board / Consultant, Dutch Society for Neurosurgery /pediatric neurosurgery
  • Contribution to guidelines and protocols, NVvN sectie kinderneurochirurgie: "behandeling hydrocephalus bij 0-2 jarigen