F. Holleman MD PhD

Medical Specialist
Main activities
Education, Patient care, Research, Other
Diabetes research; acute internal medicine
Focus of research

Clinical treatment and complications of diabetes mellitus.

Clinical treatment focus: 1. insulin analogs and insulin therapy 2. Ethnicity 3. Hypoglycemia

Complications: 1. disturbance of glycocalyx and coagulation  2. gut flora and metabolism

Key publications
  • Swinnen Sanne G., Dain Marie-Paule, Aronson Ronnie, Davies Melanie, Gerstein Hertzel C., Pfeiffer Andreas F., Snoek Frank J., DeVries J. Hans, Hoekstra Joost B., Holleman Frits A 24-Week, Randomized, Treat-to-Target Trial Comparing Initiation of Insulin Glargine Once-Daily With Insulin Detemir Twice-Daily in Patients With Type 2 Diabetes Inadequately Controlled on Oral Glucose-Lowering Drugs Diabetes care 2010;33 (6):1176-1178 [PubMed]
  • Siegelaar Sarah E., Holleman Frits, Hoekstra Joost B. L., DeVries J. Hans Glucose Variability; Does It Matter? Endocrine reviews 2010;31 (2):171-182 [PubMed]
  • Vrieze A., Holleman F., Zoetendal E. G., de Vos W. M., Hoekstra J. B. L., Nieuwdorp M. The environment within: how gut microbiota may influence metabolism and body composition Diabetologia 2010;53 (4):606-613 [PubMed]
  • Compatibility of insulin pens and cartridges Lancet 1997;350 (9091):1601-1602 [PubMed]
  • Holleman F., Hoekstra J. B. Insulin lispro New England journal of medicine 1997;337 (3):176-183 [PubMed]
All Publications