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G.B. Afink PhD

Position
Scientific staff member (UD)
Main activities
Research
Specialisation
Molecular Biology
Focus of research

About 25% of all pregnancies are complicated by gestational disease, of which severe hypertension (i.e. early preeclampsia and HELLP syndrome) and preterm labour are the leading cause of pregnancy-related maternal morbidity and mortality and poor neonatal outcome. Although there is consensus that the causal organ for these gestational diseases is the placenta the underlying multifactorial molecular causes and early and reliable clinical biomarkers that explain and predict development of obstetrical disease during the course of pregnancy are not available.

Key publications
  • Ho L, van Dijk M, Chye STJ, Messerschmidt DM, Chng SC, Ong S, Yi LK, Boussata S, Goh GHY, Afink GB, Lim CY, Dunn NR, Solter D, Knowles BB, Reversade B, ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice. SCIENCE 2017;357 (6352):707-713 [PubMed]
  • van Uitert M, Moerland PD, Enquobahrie DA, Laivuori H, van der Post JAM, Ris-Stalpers C, Afink GB, Meta-Analysis of Placental Transcriptome Data Identifies a Novel Molecular Pathway Related to Preeclampsia. PLOS ONE 2015;10 (7):e0132468 [PubMed]
  • Jebbink J, Veenboer G, Boussata S, Keijser R, Kremer AE, Elferink RO, van der Post J, Afink G, Ris-Stalpers C, Total bile acids in the maternal and fetal compartment in relation to placental ABCG2 expression in preeclamptic pregnancies complicated by HELLP syndrome. BBA-MOL BASIS DIS 2015;1852 (1):131-136 [PubMed]
  • Kleinrouweler CE, van Uitert M, Moerland PD, Ris-Stalpers C, van der Post JAM, Afink GB, Differentially expressed genes in the pre-eclamptic placenta: a systematic review and meta-analysis. PLOS ONE 2013;8 (7):e68991 [PubMed]
  • Jebbink J, Keijser R, Veenboer G, van der Post J, Ris-Stalpers C, Afink G, Expression of Placental FLT1 Transcript Variants Relates to Both Gestational Hypertensive Disease and Fetal Growth. HYPERTENSION 2011;58 (1):70-U129 [PubMed]
All Publications
Research programmes

Prof. dr. J.A.M. van der Post MD PhD (Reproductive Health, placental disease and maternal and fetal diseases)

Prof. dr. S. Repping (Reproduction & Development -- Human Reproduction)