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J.W. Ganzevoort MD PhD

Position
Medical Specialist
Main activities
Patient care
Specialisation
Gynecologist, Perinatologist
Focus of research

Hypertensive disorders of pregnancy (preeclampsia, HELLP-syndrome): management during pregnancy; recurrence risks in next pregnancies; long-term (vascular) morbidity; 

Diagnosis and management of Fetal growth Restriction

Key publications
  • Gordijn S. J., Beune I. M., Thilaganathan B., Papageorghiou A., Baschat A. A., Baker P. N., Silver R. M., Wynia K., Ganzevoort W. Consensus definition of fetal growth restriction: a Delphi procedure Ultrasound in obstetrics & gynecology 2016;48 (3):333-339 [PubMed]
  • van Oostwaard Miriam F., Langenveld Josje, Schuit Ewoud, Papatsonis Dimitri N. M., Brown Mark A., Byaruhanga Romano N., Bhattacharya Sohinee, Campbell Doris M., Chappell Lucy C., Chiaffarino Francesca, Crippa Isabella, Facchinetti Fabio, Ferrazzani Sergio, Ferrazzi Enrico, Figueiró-Filho Ernesto A., Gaugler-Senden Ingrid P. M., Haavaldsen Camilla, Lykke Jacob A., Mbah Alfred K., Oliveira Vanessa M., Poston Lucilla, Redman Christopher W. G., Salim Raed, Thilaganathan Baskaran, Vergani Patrizia, Zhang Jun, Steegers Eric A. P., Mol Ben Willem J., Ganzevoort Wessel Recurrence of hypertensive disorders of pregnancy: an individual patient data metaanalysis American journal of obstetrics and gynecology 2015;212 (5):624.e1-624.17 [PubMed]
  • Lees Christoph C., Marlow Neil, van Wassenaer-Leemhuis Aleid, Arabin Birgit, Bilardo Caterina M., Brezinka Christoph, Calvert Sandra, Derks Jan B., Diemert Anke, Duvekot Johannes J., Ferrazzi Enrico, Frusca Tiziana, Ganzevoort Wessel, Hecher Kurt, Martinelli Pasquale, Ostermayer Eva, Papageorghiou Aris T., Schlembach Dietmar, Schneider K. T. M., Thilaganathan Baskaran, Todros Tullia, Valcamonico Adriana, Visser Gerard H. A., Wolf Hans, Aktas Ayse, Borgione Silvia, Chaoui Rabih, Cornette Jerome M. J., Diehl Thilo, van Eyck Jim, Fratelli Nicola, van Haastert Inge-Lot, Lobmaier Silvia, Lopriore Enrico, Missfelder-Lobos Hannah, Mansi Giuseppina, Martelli Paola, Maso Gianpaolo, Maurer-Fellbaum Ute, Mensing van Charante Nico, de Tollenaer Susanne Mulder, Napolitano Raffaele, Oberto Manuela, Oepkes Dick, Ogge Giovanna, van der Post Joris, Prefumo Federico, Preston Lucy, Raimondi Francesco, Reiss Irwin K. M. 2 year neurodevelopmental and intermediate perinatal outcomes in infants with very preterm fetal growth restriction (TRUFFLE): a randomised trial Lancet 2015;385 (9983):2162-2172 [PubMed]
  • Magee Laura A., von Dadelszen Peter, Rey Evelyne, Ross Susan, Asztalos Elizabeth, Murphy Kellie E., Menzies Jennifer, Sanchez Johanna, Singer Joel, Gafni Amiram, Gruslin Andrée, Helewa Michael, Hutton Eileen, Lee Shoo K., Lee Terry, Logan Alexander G., Ganzevoort Wessel, Welch Ross, Thornton Jim G., Moutquin Jean-Marie Less-Tight versus Tight Control of Hypertension in Pregnancy New England journal of medicine 2015;372 (5):407-417 [PubMed]
  • Ganzevoort Wessel, Alfirevic Zarko, von Dadelszen Peter, Kenny Louise, Papageorghiou Aris, van Wassenaer-Leemhuis Aleid, Gluud Christian, Mol Ben Willem, Baker Philip N. STRIDER: Sildenafil Therapy In Dismal prognosis Early-onset intrauterine growth Restriction--a protocol for a systematic review with individual participant data and aggregate data meta-analysis and trial sequential analysis Systematic reviews 2014;3 (1):23 [PubMed]
All Publications
Curriculum Vitae

Curriculum Vitae 

1999 Medical degree (cum laude); BIG-registration#: 39049404801
1999 - 2004 PhD-researcher, Dept. Obstetrics & Gynecology, Academisch Medisch Centrum (AMC), Universiteit van Amsterdam. Supervisor H. Wolf (AMC); Prof. Dr. JIP de Vries; “Preeclampsia Eclampsia TRial Amsterdam” Clinical trial on effects of plasma volume expansion on hemodynamics and clinical outcomes in patients with severe early-onset hypertensive disorders of pregnancy (preeclampsia, HELLP-syndrome, severe fetal growth restriction).
2004 - 2010 Resident Gynecology, Cluster AMC, Professor OP Bleker and Professor MJ Heineman; Spaarne Ziekenhuis Haarlem/Hoofddorp, MH Emanuel; Zaans Medisch Centrum (ZMC), H Doornbos;
07-09-2007 PhD-thesis Universiteit van Amsterdam. Promotores Prof. Dr. JAM van der Post & Prof. Dr. GJ Bonsel; Co-promotores Dr. H. Wolf & Prof. Dr. JIP de Vries. Title: Plasma volume expansion in early-onset hypertensive disorders of pregnancy
2010-2012 Gynecologist, Fellowship Perinatology, AMC
2012-present Gynecologist Perinatologist, AMC
 

Research projects involved

2000 - PETRA, RCT plasma volume expansion in temporising management of severe early-onset hypertensive disorders of pregnancy
2006 - Truffle, RCT in monitoring and intervention strategy in severe early fetal growth restriction
2007 - TOTEM, RCT immediate delivery versus temporising management of severe early-onset hypertensive disorders of pregnancy (Duvekot)
2008 - Glycocalyx in pre-eclampsia (Van den Born)
2009 - prediction modelling in recurrence of hypertensive disorders of pregnancy. Meta-analysis. Cohort studies and individual patient data meta-analysis.
2009 - CHIPS, RCT management of chronic hypertension in pregnancy (Magee)
2010 - Queen of hearts, hypertensive disorders of pregnancy and long-term cardiovascular risks: retrospective and prospective cohort studies (including planned intervention studies)
2013 - STRIDER, RCT sildenafil for severe early-onset FGR, main applicant
2017 - Dutch TRUFFLE, Cohort with nested RCT on early intervention (delivery) in children identified as FGR by abnormal Doppler studies within a group of SGA-children, main applicant
2013 - ObsEva, Phase 1-? Studies for new tocolytic drug
 

Courses followed

2008 Operatieve Verloskunde - Leiderdorp, NL
2009 NLS Provider Course - Riel, NL
2010 ISUOG Advanced Course Ultrasound in Obstetrics - London, UK
2010 ISSHP - Melbourne, Australia
2011 SMFM - San Francisco, USA
2011 MOET Provider Course - Riel, NL
2011 & 2012 & 2013 Teach The Teacher – Communication skills - Amsterdam, NL
 

Teaching positions

Member of team training residents Gynecology & Obstetrics, interns (co-assistenten).
Teacher at Amstel Academie for Obstetric Nursing  

Memberships

Organisations: NVOG, KNMG, ISSHP, ISUOG.
ICT-committee of the CPZ (College Perinatale Zorg)
Editor of the NTOG 

Research programmes

J.W. Ganzevoort MD PhD (Placental disorders of Pregnancy: Fetal Growth Restriction and Hypertension)

The program focuses on the maternal-fetal syndromes of placental insufficiency, the maternal including pre-eclampsia and HELLP-syndrome; the fetal including fetal growth restriction.

I am leading in international consensus procedures on nomenclature, international cooperation in the STRIDERproject (with five simultaneous RCTs) on treatment of FGR, TRUFFLE projects on diagnosis/monitoring/intervention in FGR.

PhD Students
I.M. Beune MD

Others
F. Beukers MD

Prof. J.A.M. van der Post MD PhD (Reproductive Health, placental disease and maternal and fetal diseases)

Current research funding
  • Crediteurenadm. VUmc, p/a Profource Service Center
  • ZonMw