M.W. Langendam PhD

Assistant Professor
Main activities
Education, Research
Evidence synthesis methodology
Focus of research

Miranda Langendam joined the AMC in 2008, as staff member of the Dutch Cochrane Centre. After the Centre, hosted by the department of Clinical Epidemiology, Biostatistics and Bioinformatics, moved to UMC Utrecht in January 2014 she had the opportunity to stay at AMC to develop an evidence synthesis research line.

The aim of her research is to help patients, health care providers and policy makers making evidence-based health care decisions. Trained as epidemiologist/methodologist she is interested in developing, applying and teaching methods to summarize and present the best available evidence to support health (care) decisions. The research topics she is working address a wide range of health care quations and reach from PICO formulation (e.g. defining the clinical pathway and developing core outcome sets) to guideline implementation strategies. Key words: clinical epidemiology, evidence-based medicine, systematic reviews, meta-analysis, GRADE, guideline development, research & teaching.


Key publications
  • Gopalakrishna Gowri, Leeflang Mariska M. G., Davenport Clare, Sanabria Andrea Juliana, Alonso-Coello Pablo, McCaffery Kirsten, Bossuyt Patrick, Langendam Miranda W. Barriers to making recommendations about medical tests: a qualitative study of European guideline developers BMJ open 2016;6 (9):e010549 [PubMed]
  • Gopalakrishna Gowri, Mustafa Reem A., Davenport Clare, Scholten Rob J. P. M., Hyde Christopher, Brozek Jan, Schünemann Holger J., Bossuyt Patrick M. M., Leeflang Mariska M. G., Langendam Miranda W. Applying Grading of Recommendations Assessment, Development and Evaluation (GRADE) to diagnostic tests was challenging but doable Journal of clinical epidemiology 2014;67 (7):760-768 [PubMed]
  • Langendam Miranda, Carrasco-Labra Alonso, Santesso Nancy, Mustafa Reem A., Brignardello-Petersen Romina, Ventresca Matthew, Heus Pauline, Lasserson Toby, Moustgaard Rasmus, Brozek Jan, Schünemann Holger J. Improving GRADE evidence tables part 2: a systematic survey of explanatory notes shows more guidance is needed Journal of clinical epidemiology 2016;74:19-27 [PubMed]
  • Hooijmans Carlijn R., Rovers Maroeska M., de Vries Rob B. M., Leenaars Marlies, Ritskes-Hoitinga Merel, Langendam Miranda W. SYRCLE's risk of bias tool for animal studies BMC medical research methodology 2014;14:43 [PubMed]
  • Langendam M. W., van der Werf M. J., Huitric E., Manissero D. SERIES "RATIONAL USE OF ANTI-TUBERCULOSIS DRUGS" Edited by G. B Migliori and D. Manissero Number 1 in this Series Prevalence of inappropriate tuberculosis treatment regimens: a systematic review European respiratory journal 2012;39 (4):1012-1020 [PubMed]
All Publications
Research programmes

M.W. Langendam PhD (Evidence synthesis methodology: making sense of evidence)

The research line is largely based on the conceptual framework of the GRADE (Grading Recommendations Assessment, Development and Evaluation) approach. GRADE provides a patient-centred framework to present evidence summaries, to assess and rate the certainty of evidence, to move from evidence to recommendation and to grade the strength of recommendations ( Adopted by many evidence synthesis and guideline development organisations, GRADE is considered the state of the art methodology to develop evidence-based clinical practice guidelines. Her current research aims to contribute to further development of GRADE, e.g. by applying GRADE to different domains (diagnosis, preclinical animal studies, environmental health) and different types of decisions (clinical management, coverage decisions). Evaluating the use of GRADE, implementing GRADE in the Netherlands, consultation and training are also part of Miranda's work.

The main research theme for the coming years is to develop and appraise methods for linking and interpreting different types of evidence and evidence streams. This is particularly relevant in the evaluation of medical tests, where direct evidence on the clinical utility is scarce. Together with the Biomarkers and Test Evaluation (BiTE) program, led by professor Patrick Bossuyt, development of guideline methodology with regard to recommendations about medical tests is a high priority topic. More general, the research line is targeted to improving the quality of systematic reviews and clinical and public health guidelines.

Miranda's work is characterized by a high level of collaboration on local, national and international level (e.g. Health Care Institute (Zorginstituut Nederland), McMaster University, Cochrane, GRADE working group). First of all because a methodologist needs content experts to do meaningful work, but also because evidence synthesis is a rapidly evolving research field and a study design that is often used. At the AMC she is collaborating with colleagues from several departments. The aim for the coming years is to formalize collaboration (e.g. joint grant proposals, PhD students and post-docs), and – with regard to the alliance – to explore collaboration with VUmc (e.g. APH Methodology).

Prof. P.M.M. Bossuyt PhD (BIomarker and Test Evaluation program (BITE))