foto

MD MSc PhD B.R. Pieters

Position
Medical Specialist
Main activities
Education, Patient care, Research
Specialisation
Brachytherapy, Urological tumors, Gyneacological Brachytherapy
Focus of research

Clinical research on prostate brachytherapy and translational research for advanced and automatic treatment planning in the field of brachytherapy

 

Key publications
  • Pieters Bradley R., van der Steen-Banasik Elzbieta, Smits Geert A., de Brabandere Marisol, Bossi Alberto, van Limbergen Erik GEC-ESTRO/ACROP recommendations for performing bladder-sparing treatment with brachytherapy for muscle-invasive bladder carcinoma Radiotherapy and oncology 2017;122 (3):340-346 [PubMed]
  • van Heerden Laura E., van Kesteren Zdenko, Gurney-Champion Oliver J., Houweling Antonetta C., Koedooder Kees, Rasch Coen R. N., Pieters Bradley R., Bel Arjan Image Distortions on a Plastic Interstitial Computed Tomography/Magnetic Resonance Brachytherapy Applicator at 3 Tesla Magnetic Resonance Imaging and Their Dosimetric Impact International journal of radiation oncology, biology, physics 2017;99 (3):710-718 [PubMed]
  • van Heerden Laura E., Houweling Antonetta C., Koedooder Kees, van Kesteren Zdenko, van Wieringen Niek, Rasch Coenraad R. N., Pieters Bradley R., Bel Arjan Structure-based deformable image registration: Added value for dose accumulation of external beam radiotherapy and brachytherapy in cervical cancer Radiotherapy and oncology 2017;123 (2):319-324 [PubMed]
  • Dinkla Anna M., van der Laarse Rob, Koedooder Kees, Petra Kok H., van Wieringen Niek, Pieters Bradley R., Bel Arjan Novel tools for stepping source brachytherapy treatment planning: enhanced geometrical optimization and interactive inverse planning Medical physics 2015;42 (1):348-353 [PubMed]
  • Hafkamp C. J. H., Lapid O., Dávila Fajardo R., van de Kar A. L., Koedooder C., Stalpers L. J., Pieters B. R. Postoperative single-dose interstitial high-dose-rate brachytherapy in therapy-resistant keloids Brachytherapy 2017;16 (2):415-420 [PubMed]
All Publications
Curriculum Vitae

Dr. Bradley R. Pieters was trained as radiation oncologist at the Catholic University Nijmegen (presently Radboud University). The training for radiation oncologist was finalized in 1995. During his training he did a 5 month fellowship on brachytherapy at the Daniel den Hoed Kliniek in Rotterdam and L'Institut Gustav-Roussy in Villejuif. He finalized his training and specialisation in brachytherapy at the Academic Medical Center in Amsterdam. He is by now recognized as a leader in the field of brachytherapy and has several appointments in this field such as the Chair of GEC-ESTRO (Group Européen de Curiethérapie-European Society for Radiotherapy and Oncology).
In 2006 he obtained his Master of Science in clinical epidemiology at the Institute for Research in Extramural Medicine of the Free University Medical Center of Amsterdam. After graduating for PhD he was registered as Post-doctoral Medical-Biological Research Epidemiologist at the National Committee for Medical-Biological Research Training in the Netherlands (SMBWO).

 

Education and Training

2004-2006
Master of Science Epidemiology at the Postgraduate Epidemiology Education of the Institute for Research in Extramural Medicine of the Free University Medical Center of Amsterdam, The Netherlands (director: Prof.dr. L.M. Bouter)

January 1995- March 1995
Brachytherapy fellow, L'Institut Gustave Roussy at Villejuif, France (head brachytherapy department: Dr. A.L. Gerbaulet)

October 1994-- December 1994
Brachytherapy fellow, Dr. Daniel den Hoed Clinic at Rotterdam, The Netherlands (chair: Prof. dr. P.C. Levendag)

1991-1995
Resident Radiotherapy, Academic Hospital Nijmegen, The Netherlands (chair and trainer: Prof. dr. W.A.J. van Daal)

April 1990- December 1990
Resident Internal Medicine, Sint Maartens Gasthuis at Venlo, The Netherlands (head: Dr. J.J.J. Mattousch)

1983-1990
Master of Science (Doctoraal) Medcine at the Catholic University Nijmegen

 

Professional experience and career

Dr. Bradley .R. Pieters is currently employed as a radiation oncologist at the Amsterdam UMC, location AMC (University of Amsterdam). His main activities involve brachytherapy in general and also the whole spectrum of urological and gynecological tumors. The focus of his research is on different aspects of brachytherapy. Previously employed at the Netherlands Cancer Institute he began with the first investigations related to brachytherapy for breast cancer. He is the first to introduce the concept of PTV (planning target volume) in brachytherapy in 2001. After moving to the AMC he continued research in the field of brachytherapy, which resulted in the PhD degree on the development of a technique for pulsed-dose rate brachytherapy for prostate cancer. Other clinical studies under his supervision as principal investigator are: PROBACH (randomized trial on brachytherapy boost for prostate cancer; national trial) and POWER (randomized trial on focal prostate brachytherapy; international trial). Both studies have the main focus in reducing treatment related toxicity. In the past 8 years he was involved in projects to optimize brachytherapy treatment plans, making the outcome faster, more accurate, and more robust by the design of new algorithms and machine learning in cooperation with the Centrum voor Wiskunde en Informatica (Center for Mathematics and Computer Science) This research will lead not only to better tumor control, but also to less toxicity because of better treatment plans designed. On top of these clinical advantages, new algorithms and machine learning will make treatment planning faster resulting in a more efficient work process. Other projects in which he is involved with concerns dose distribution uncertainties for cervical cancer, the impact of bowel motility on the radiotherapy dose to the bowels and late effects quantification for pediatric brachytherapy.


Since 2000
Radiation oncologist Amsterdam UMC, location AMC (University of Amsterdam) in Amsterdam

Since april 2018
Chair GEC-ESTRO (Groupe Européen de Curiethérapie-European Society for Radiotherapy and Oncology)

Since 2008
Faculty ESTRO teaching course "Comprehensive and Practical Brachytherapy" (formerly "Modern brachytherapy techniques"). Since 2016 the course director.

23-9-2011
Post-doctoral degree Medical-Biological Research Epidemiology from the National Committee for Medical-Biological Research Training in the Netherlands (SMBWO)

7-10-2010
PhD graduation date 7-10-2010 at the faculty of Medicine at the University of Amsterdam.
PhD thesis title: Pulsed-dose rate brachytherapy in prostate cancer

1996-2000
Radiation oncologist at the Netherlands Cancer Institute / Antoni van Leeuwenhoek Huis in Amsterdam

August 1995-April 1996
Radiation oncologist at the Academic Hospital Nijmegen

 

Awards

Best poster award (granted to A. Dinkla while under my supervision) for the following abstract: A. Dinkla, B.R. Pieters, P. Meijnen, C. Koedooder, N. van Wieringen, R. van der Laarse, J.N. van der Grient, A. Bel. Potential benefit of adaptive treatment planning for PDR prostate brachytherapy. World Congress Brachytherapy 2012.

 

Grants

  • T Alderliesten, P Bosman, L J A Stalpers, B R Pieters. Fast, accurate, and insightful brachytherapy treatment planning for cervical cancer through artificial intelligence. KWF project 12183. 2019.
  • B.R. Pieters, G Kovács, P Hoskin, F-A Siebert. Randomized trial for the evaluation of erectile dysfunction afterwhole or partial gland prostate brachytherapy - (POWER). KWF project 10774. 2017
  • S. Al Uwini, B.R. Pieters, P.C. Levendag. Randomized phase 3 study on the assessment of late toxicity by comparing IMRT high dose external beam radiotherapy only with external beam radiotherapy combined with HDR or PDR brachytherapy in patients with intermediate/high risk prostate cancer (PROBACH). KWF project EMCR 2012-5527. 2012.

 

PhD supervisorship

  • L. van Heerden. Project: Multimodality dose summation assessment and evaluation for cervical cancer. Thesis: Multi-modality radiotherapy in cervical cancer: impact on the 3D dose distribution. PhD defence 6-6-2019 University of Amsterdam.
  • A. Dinkla. Project: Evaluation of stepping source brachytherapy treatment plans obtained by the novel interactive optimization methods EGO and IIP, with a restrictive set of DVH parameters. Thesis: Stepping source prostate brachytherapy: From target definition to dose delivery. PhD defence 12-3-2014 University of Amsterdam.

 

Clinical trial activities/Principal Investigator

  • Randomized trial for the evaluation of erectile dysfunction after whole or partial prostate brachytherapy – POWER (NTR7271), 2018
  • Randomized Phase 3 Study On The Assessment Of Late Toxicity By Comparing IMRT High Dose External Beam Radiotherapy Only With External Beam Radiotherapy Combined With HDR Or PDR Brachytherapy In Patients With Intermediate/high Risk Prostate Cancer – PROBACH (NTR3897), 2013
  • Contrast enhanced ultrasound imaging to support prostate cancer brachytherapy treatment and follow up after treatment (NTR 1168), 2007.
  • Which correction protocol gives the lowest cumulative rectal dose in prostate cancer patients who are treated with external beam radiotherapy? A phase II Modelling study (NTR 879), 2007.

 

Co-investigator

  • Improving Childhood Cancer Care when Parents Cannot be There – Reducing Medical Traumatic Stress in Childhood Cancer Patients by Bonding with a Robot Companion (Prof. dr. P. Bosman)
  • CT-based innovations in the battle against cancer. Next generation patient-tailored brachytherapy cancer treatment planning (Prof. dr. P. Bosman and dr. T. Alderliesten)
  • 3D study growth disruption after rhabdomyosarcoma treatment (Prof. dr. L. Smeele and Prof. dr. A. Becking).
  • Late effects study after radiation treatment for childhood rabdomyosarcoma in the head and neck region and orbita (Prof. H.A.N. Caron, dr. J.H.M. Merks)

 

Appointments and Affiliations

International

  • April 2018 chair GEC-ESTRO Committee
  • 2014-2019 Member European Institute for Biomedical Imaging Research (EIBIR) image guided radiotherapy working group
  • 2011 Member UroGEC group GEC-ESTRO
  • 2009 GEC-ESTRO Advisory Board
  • 2009 Co-editor Journal of Contemporary Brachytherapy
  • 2008 Faculty GEC-ESTRO

National

  • 2013 Board member “Working Group Urological Tumors” of the Comprehensive Cancer Center Amsterdam (IKNL-Amsterdam)
  • 2010 National Commission on Radiation Dosimetry, Platform Radiation Safety in Hospitals

 

Editorship and Publishing activities

Co-editor for:           

  • Journal of Contemporary Brachytherapy
  • ESTRO newsletter, brachytherapy corner

Editorial Board for: 

  • Brachytherapy since 2014

Journal referee for:

  • Radiotherapy and Oncology (Outstanding reviewer)
  • International Journal of Radiation Oncology, Biology, Physics (Outstanding reviewer)
  • Brachytherapy (Outstanding reviewer)
  • Journal of Contemporary Brachytherapy
  • Practical Radiation Oncology (Recognized reviewer)
  • Advances in Radiation Oncology (Recognized reviewer)
  • Physics and Imaging in Radiation Oncology (Recognized reviewer)
  • Radiation Oncology
  • PLoS One
  • Journal of Urology
  • Scientific Reports
  • Technology in Cancer Research and Treatment
  • Cancer

 

Teaching                   

  • Annual Amsterdam Brachytherapy College workshop, since 2018
  • ESTRO FALCON prostate contouring course, 2016 and 2017
  • Course director ESTRO teaching course  “Comprehensive and Practical Brachytherapy” (formerly “Modern brachytherapy techniques”), since 2016
  • Faculty Onderzoekschool Oncologie Amsterdam, since 2015.
  • Faculty ESTRO teaching course  “Comprehensive and Practical Brachytherapy” (formerly “Modern brachytherapy techniques”), since 2008
  • Faculty INHOLLAND University Graduate School, Haarlem, The Netherlands. Image guided radiotherapy for breast cancer, 2008
  • Faculty INHOLLAND University Graduate School, Haarlem, The Netherlands. IMRT treatment planning, 2007
  • Faculty Nucletron-AMC clinical course “From traditional to modern brachytherapy. Transferring from LDR to PDR”

 

[1-75]

[1]        Balgobind BV, Koedooder K, Ordoñez Zúñiga D, Dávila Fajardo R, Rasch CR Pieters BR. A review of the clinical experience in pulsed dose rate brachytherapy. Br J Radiol 2015:20150310.

[2]        Blank LE, Koedooder K, Pieters BR, van der Grient HN, van de Kar M, Buwalda J, Balm AJ, Merks JH, Strackee SD, Freling NJ Koning CC. The AMORE protocol for advanced-stage and recurrent nonorbital rhabdomyosarcoma in the head-and-neck region of children: A radiation oncology view. Int J Radiat Oncol Biol Phys 2009;74:1555-1562.

[3]        Blank LECM, Koedooder K, van der Grient HNB, Wolffs NAW, van de Kar M, Merks JH, Pieters BR, Saeed P, Baldeschi L, Freling NJ Koning CCE. Brachytherapy as part of the multidisciplinary treatment of childhood rhabdomyosarcomas of the orbit. Int J Radiat Oncol Biol Phys 2010;77:1463-1469.

[4]        Bolla M, Maingon P, Carrie C, Villa S, Kitsios P, Poortmans PM, Sundar S, van der Steen-Banasik EM, Armstrong J, Bosset JF, Herrera FG, Pieters B, Slot A, Bahl A, Ben-Yosef R, Boehmer D, Scrase C, Renard L, Shash E, Coens C, van den Bergh AC Collette L. Short Androgen Suppression and Radiation Dose Escalation for Intermediate- and High-Risk Localized Prostate Cancer: Results of EORTC Trial 22991. J Clin Oncol 2016.

[5]        Bos M, Ordoñez Marmolejo R, Rasch CRN Pieters BR. Bladder preservation with brachytherapy compared to cystectomy for T1-T3 muscle-invasive bladder cancer: a systematic review. J Contemp Brachytherapy 2014;6:191-199.

[6]        Bosschieter J, Vis AN, van der Poel HG, Moonen LM, Horenblas S, van Rhijn BWG, Pieters BR, Nieuwenhuijzen JA Hendricksen K. Robot-assisted Laparoscopic Implantation of Brachytherapy Catheters in Bladder Cancer. Eur Urol 2017.

[7]        Bouter A, Alderliesten T, Pieters BR, Bel A, Niatsetski Y Bosman PAN. GPU-accelerated bi-objective treatment planning for prostate high-dose-rate brachytherapy. Med Phys 2019.

[8]        Clement SC, Schoot RA, Slater O, Chisholm JC, Abela C, Balm AJ, van den Brekel MW, Breunis WB, Chang YC, Davila Fajardo R, Dunaway D, Gajdosova E, Gaze MN, Gupta S, Hartley B, Kremer LC, van Lennep M, Levitt GA, Mandeville HC, Pieters BR, Saeed P, Smeele LE, Strackee SD, Ronckers CM, Caron HN, van Santen HM Merks JH. Endocrine disorders among long-term survivors of childhood head and neck rhabdomyosarcoma. Eur J Cancer 2015;54:1-10.

[9]        de Boer P, Jurgenliemk-Schulz IM, Westerveld H, de Leeuw AAC, Davila-Fajardo R, Rasch CRN, Pieters BR Stalpers LJA. Patterns of care survey: Radiotherapy for women with locally advanced cervical cancer. Radiother Oncol 2017;123:306-311.

[10]      Dinkla A, Pieters BR, Koedooder K, van Wieringen N, van der Laarse R, van der Grient JN, Rasch CR, Koning CC Bel A. Improved tumor control probability with MRI-based prostate brachytherapy treatment planning. Ann Oncol 2013;52:658-665.

[11]      Dinkla AM, Pieters BR, Koedooder K, Meijnen P, van Wieringen N, van der Laarse R, van der Grient JN, Rasch CR Bel A. Deviations from the planned dose during 48hours of stepping source prostate brachytherapy caused by anatomical variations. Radiother Oncol 2013;107:106-111.

[12]      Dinkla AM, Pieters BR, Koedooder K, van Wieringen N, van der Laarse R Bel A. Prostate volume and implant configuration during 48 hours of temporary prostate brachytherapy: limited effect of oedema. Radiat Oncol 2014;9:272.

[13]      Dinkla AM, van der Laarse R, Kaljouw E, Pieters BR, Koedooder K, van Wieringen N Bel A. A comparison of inverse optimization algorithms for HDR/PDR prostate brachytherapy treatment planning. Brachytherapy 2015;14.

[14]      Dinkla AM, van der Laarse R, Koedooder K, Kok HP, van Wieringen N, Pieters BR Bel A. Novel tools for stepping source brachytherapy treatment planning: Enhanced geometrical optimization and interactive inverse planning. Med Phys 2015;42:348-353.

[15]      Freling NJM, Merks JHM, Saeed P, Balm AJM, Bras J, Pieters BR, Adam JA van Rijn RR. Imaging findings in craniofacial childhood rhabdomyosarcoma. Pediatr Radiol 2010;40:1723-1738.

[16]      Hafkamp CJ, Lapid O, Davila Fajardo R, van de Kar AL, Koedooder C, Stalpers LJ Pieters BR. Postoperative single-dose interstitial high-dose-rate brachytherapy in therapy-resistant keloids. Brachytherapy 2017.

[17]      Han P, Rotman M, Schulsinger AR, Pieters BR, Koning CCE, Pos FJ, Hulshof MCCM Poortmans P. Bladder cancer. Heidelberg: Springer-Verlag, 2012.

[18]      Haverkort MAD, van de Kamer JB, Pieters BR, Koning CC, van Herk M van Tienhoven G. Adaptive margin radiotherapy for patients with prostate carcinoma: What's the benefit? Radiother Oncol 2012;105:203-206.

[19]      Haverkort MAD, van de Kamer JB, Pieters BR, van Tienhoven G, Assendelft E, Lensing AL, van Herk M, de Reijke TM, Stoker J Koning CCE. Position verification for prostate: effect on rectal wall dose. Int J Radiat Oncol Biol Phys 2011;80:462-468.

[20]      Hulshof MC, Pieters BR Koning CC. Bladder conserving treatment for bladder cancer: potential ao and development in radioterapy. Ned Tijdschr Geneeskd 2013;157:A5556.

[21]      Hurkmans CW, Borger JH, Bos LJ, van der Horst A, Pieters BR, Lebesque JV Mijnheer BJ. Cardiac and lung complication probabilities after breast cancer irradiation. Radiother Oncol 2000;55:145-151.

[22]      Hurkmans CW, Borger JH, Pieters BR, Russell NS, Jansen EP Mijnheer BJ. Variability in target volume delineation on CT scans of the breast. Int J Radiat Oncol Biol Phys 2001;50:1366-1372.

[23]      Hurkmans CW, Bruinvis IA, Pieters BR, Borger JH, Dwarswaard M, Uiterwaal GJ, Damen EMF, Mijnheer BJ Bartelink H. An improved technique for irradiation of the breast and internal mammary - medial supraclavicular (IM-MS) lymph nodes. Radiother Oncol 1998;48:S140.

[24]      Hurkmans CW, Saarnak AE, Pieters BR, Borger JH Bruinvis IA. An improved technique for breast cancer irradiation including the locoregional lymph nodes. Int J Radiat Oncol Biol Phys 2000;47:1421-1429.

[25]      Jurdy L, Merks JH, Pieters BR, Mourits MP, Kloos RJ, Strackee SD Saeed P. Orbital Rhabdomyosarcomas: a review. Saudi J Ophtalmol 2013;27:167-175.

[26]      Kaljouw E, Pieters B, Koedooder K, Lucas C Koning C. Benefits of a dual sagittal crystal transducer for ultrasound imaging during I-125 seed implantation for permanent prostate brachytherapy. J Contemp Brachytherapy 2012;4:141-145.

[27]      Kaljouw E, Pieters BR, Kovacs G Hoskin PJ. A Delphi consensus study on salvage brachytherapy for prostate cancer relapse after radiotherapy, a Uro-GEC study. Radiother Oncol 2016;118:122-130.

[28]      Kirchheiner K, Potter R, Tanderup K, Lindegaard JC, Haie-Meder C, Petric P, Mahantshetty U, Jurgenliemk-Schulz IM, Rai B, Cooper R, Dorr W, Nout RA Group EC. Health-Related Quality of Life in Locally Advanced Cervical Cancer Patients After Definitive Chemoradiation Therapy Including Image Guided Adaptive Brachytherapy: An Analysis From the EMBRACE Study. Int J Radiat Oncol Biol Phys 2016;94:1088-1098.

[29]      Koedooder K, van Wieringen N, van der Grient HNB, van Herten Y, Pieters BR Blank LECM. Safety aspects of pulsed dose rate brachytherapy: Analysis of errors in 1,300 treatment sessions. Int J Radiat Oncol Biol Phys 2008;70:953-960.

[30]      Koning CCE, Blank LECM, Koedooder C, van Os RM, van de Kar M, Jansen E, Battermann JJ, Beijert M, Gernaat C, van Herpen KAM, Hoekstra C, Horenblas S, Jobsen JJ, Krol ADG, Lybeert MLM, van Onna IEW, Pelger RCM, Poortmans P, Pos FJ, van der Steen-Banasik E, Slot A, Visser A Pieters BR. Brachytherapy after external beam radiotherapy and limited surgery preserves bladders for patients with solitary pT1-pT3 bladder tumors. Ann Oncol 2012;23:2948-2953.

[31]      Laan JJ, van Lonkhuijzen L, van Os RM, Tytgat KM, Davila Fajardo R, Pieters BR, Stalpers LJA Westerveld GH. Socioeconomic status as an independent risk factor for severe late bowel toxicity after primary radiotherapy for cervical cancer. Gynecol Oncol 2017;147:684-689.

[32]      Lipman D, Pieters BR De Reijke TM. Improving postoperative radiotherapy following radical prostatectomy. Expert Rev Anticancer Ther 2017:1-13.

[33]      Meccariello G, Merks JHM, Pieters BR, van Furth WR, Saeed P, Schoot RA, Freling NJM, Bras J, Strackee SD, Balm AJM Georgalas C. Endoscopic management of Ewing's sarcoma of ethmoid sinus within the AMORE framework: A new paradigm. Int J Pediatr Otorhinolaryngol 2013;77:139-143.

[34]      Petric P, Kirisits C, Perez-Calatayud J, Mahantshetty U, Song WY Pieters BR. Applicators. In: Song WY, Tanderup K and Pieters BR, eds. Emerging technologies in brachytherapy. Boca Raton: CRC Press, 2017.

[35]      Piet AHM, Hulshof MCCM, Pieters BR, Pos FJ, de Reijke TM Koning CCE. Clinical results of a concomitant boost radiotherapy technique for muscle-invasive bladder cancer. Strahlenther Onkol 2008;184:313-318.

[36]      Pieters B. Intensity-modulated radiotherapy and stereotactic body radiotherapy. In: Sanchez-Salas R and Desai M, eds. Image-guided therapies for prostate and kidney cancers. Montreal: Société Internationale d'Urologie (SIU), 2016; 317-321.

[37]      Pieters BR. A comparison in cosmetic outcome between per-operative interstitial breast implants and delayed interstitial breast implants after external beam radiotherapy. Radiother Oncol 2003;67:159-164.

[38]      Pieters BR. Pulsed-dose rate brachytherapy in prostate cancer. In: Kovács G and Hoskin P, eds. Interstitial prostate brachytherapy. Berlin: Springer, 2013; 111-117.

[39]      Pieters BR Bartelink H. The role of hormonal treatment for locally advanced breast cancer. Amsterdam: Elsevier, 2000.

[40]      Pieters BR, de Back DZ, Koning CCE Zwinderman AH. Comparison of 3 radiotherapy modalities on biochemical control and overall survival for the treatment of prostate cancer; a systematic review. Radiother Oncol 2009;93:168-173.

[41]      Pieters BR Geijsen ED. Results of PDR treatments: The AMC PDR experience. In: Kovács G and Hoskin P, eds. Interstitial prostate brachytherapy. Berlin: Springer, 2013; 203-206.

[42]      Pieters BR, Geijsen ED, Koedooder K, Blank LECM, Rezaie E, van der Grient JNB, de Reijke TM Koning CCE. Treatment results of PDR brachytherapy combined with external beam radiotherapy in 106 patients with intermediate- to high-risk prostate cancer. Int J Radiat Oncol Biol Phys 2011;79:1037-1042.

[43]      Pieters BR Hulshof MCCM. De plaats van radiotherapie in de behandeling van het prostaatcarcinoom. Ned Tijdschr Oncol 2004;1:190-197.

[44]      Pieters BR, Koning CC Horenblas S. Re: does partial cystectomy compromise oncologic outcomes for patients with bladder cancer compared to radical cystectomy? A matched case-control analysis. J Urol 2013;189:1600-1601.

[45]      Pieters BR, Maher M Gerbaulet AL. Brachytherapy in the management of breast cancer: A review. Cancer Treat Rev 1996;21:527-539.

[46]      Pieters BR, Rezaie E, Geijsen ED, Koedooder K, van der Grient JNB, Blank LECM, de Reijke TM Koning CCE. Development of late toxicity and IPSS resolution after external beam radiotherapy combined with PDR brachytherapy for prostate cancer. Int J Radiat Oncol Biol Phys 2011;81:758-764.

[47]      Pieters BR, Saarnak AE, Steggerda MJ Borger JH. A method to improve the dose distribution of interstitial breast implants using geometrically optimized stepping source techniques and dose normalization. Radiother Oncol 2001;2001:63-70.

[48]      Pieters BR van Daal WA. Spinale epidurale metastasen (brief aan de redactie). Ned Tijdschr Geneeskd 1992;136:242.

[49]      Pieters BR, van de Kamer JB, van Herten YRJ, van Wieringen N, D'Olieslager GM, van der Heide UA Koning CCE. Comparison of biologically equivalent dose–volume parameters for the treatment of prostate cancer with concomitant boost IMRT versus IMRT combined with brachytherapy. Radiother Oncol 2008;88:46-52.

[50]      Pieters BR, van der Grient JNB, Blank LECM, Koedooder K, Hulshof MCCM de Reijke TM. Minimal displacement of novel self-anchoring catheters suitable for temporary prostate implants. Radiother Oncol 2006;80:69-72.

[51]      Pieters BR, van der Steen-Banasik E, Smits GA, De Brabandere M, Bossi A Van Limbergen E. GEC-ESTRO/ACROP recommendations for performing bladder-sparing treatment with brachytherapy for muscle-invasive bladder carcinoma. Radiother Oncol 2016.

[52]      Pieters BR, van der Steen-Banasik E Van Limbergen E. Urinary bladder cancer. In: van Limbergen E, Pötter R, Hoskin P and Baltas D, eds. The GEC ESTRO handbook of brachytherapy, ed. 2nd. Brussels: ESTRO, 2015.

[53]      Pieters BR, Wijkstra H, van Herk M, Kuipers R, Kaljouw E, de la Rosette J Koning C. Contrast-enhanced ultrasound as support for prostate brachytherapy treatment planning. J Contemp Brachytherapy 2012;4:67-74.

[54]      Postema AW, De Reijke TM, Ukimura O, Van den Bos W, Azzouzi AR, Barret E, Baumunk D, Blana A, Bossi A, Brausi M, Coleman JA, Crouzet S, Dominguez-Escrig J, Eggener S, Ganzer R, Ghai S, Gill IS, Gupta RT, Henkel TO, Hohenfellner M, Jones JS, Kahmann F, Kastner C, Kohrmann KU, Kovacs G, Miano R, van Moorselaar RJ, Mottet N, Osorio L, Pieters BR, Polascik TJ, Rastinehad AR, Salomon G, Sanchez-Salas R, Schostak M, Sentker L, Tay KJ, Varkarakis IM, Villers A, Walz J De la Rosette JJ. Standardization of definitions in focal therapy of prostate cancer: report from a Delphi consensus project. World J Urol 2016;DOI 10.1007/s00345-016-1782-x.

[55]      Saarnak A, Hurkmans CW, Pieters BR, R.A. VO, Schultze Kool RJ, Hart AA Muller SH. Accuracy of internal mammary lymph node localization using lymphoscintigraphy, sonography and CT. Radiother Oncol 2002;65:79-88.

[56]      Salembier C, Villeirs G, De Bari B, Hoskin P, Pieters BR, Van Vulpen M, Khoo V, Henry A, Bossi A, De Meerleer G Fonteyne V. ESTRO ACROP consensus guideline on CT- and MRI-based target volume delineation for primary radiation therapy of localized prostate cancer. Radiother Oncol 2018;127:49-61.

[57]      Schmid MP, Beaulieu L, Nesvacil N, Pieters BR, Postema AW, Schalk SG, Siebert F-A Wijkstra H. Ultrasound. In: Song WY, Tanderup K and Pieters BR, eds. Emerging technologies in brachytherapy. Boca Raton: CRC Press, 2017.

[58]      Schoot RA, Saeed P, Freling NJ, Blank LE, Pieters BR, van der Grient JN, Strackee SD, Bras J, Caron HN, Merks JH, Amsterdam H Neck Working Group on Childhood T. Local Resection and Brachytherapy for Primary Orbital Rhabdomyosarcoma: Outcome and Failure Pattern Analysis. Ophthal Plast Reconstr Surg 2016;32:354-360.

[59]      Schoot RA, Slater O, Ronckers CM, Zwinderman AH, Balm AJ, Hartley B, van den Brekel MW, Gupta S, Saeed P, Gajdosova E, Pieters BR, Gaze MN, Mandeville HC, Davila Fajardo R, Chang YC, Gains JE, Strackee SD, Dunaway D, Abela C, Mason C, Smeele LE, Chisholm JC, Levitt GA, Kremer LC, Grootenhuis MA, Maurice-Stam H, Stiller CA, Hammond P, Caron HN Merks JHM. Adverse events of local treatment in long-term head and neck rhabdomyosarcoma survivors after external beam radiotherapy or AMORE treatment. Eur J Cancer 2015;51:1424-1434.

[60]      Schoot RA, Theunissen EA, Slater O, Lopez-Yurda M, Zuur CL, Gaze MN, Chang YC, Mandeville HC, Gains JE, Rajput K, Pieters BR, Davila Fajardo R, Talwar R, Caron HN, Balm AJ, Dreschler WA Merks JH. Hearing loss in survivors of childhood head and neck rhabdomyosarcoma; a long-term follow-up study. Clin Otolaryngol 2015;41:276-283.

[61]      Song WY, Tanderup K Pieters BR. Emerging technologies in brachytherapy. In: Webster JG, Russell Ritenour E, Tabakov S and Ng K-H, eds. Medical physics and biomedical engineering. Boca Raton: CRC Press, 2017.

[62]      Tagliaferri L, Kovacs G, Aristei C, De Sanctis V, Barbera F, Morganti AG, Casa C, Pieters BR, Russi E, Livi L, Corvo R, Giovagnoni A, Ricardi U, Valentini V, Magrini SM Directors of the Italian Radiation Oncology S. Current state of interventional radiotherapy (brachytherapy) education in Italy: results of the INTERACTS survey. J Contemp Brachytherapy 2019;11:48-53.

[63]      Uitterhoeve ALJ, Koolen MGJ, van Os RM, Koedooder K, van de Kar M, Pieters BR Koning CCE. Accelerated high-dose radiotherapy alone or combined with either concomitant or sequential chemotherapy; treatments of choice in patients with non-small cell lung cancer,. Radiat Oncol 2007;2:1-10.

[64]      Vaarwerk B, Hol MLF, Schoot RA, Breunis WB, de Win MML, Westerveld H, Davila Fajardo R, Saeed P, van den Brekel MW, Pieters BR, Strackee SD, Smeele LE Merks JHM. AMORE treatment as salvage treatment in children and young adults with relapsed head-neck rhabdomyosarcoma. Radiother Oncol 2019;131:21-26.

[65]      Vaarwerk B, Schoot RA, Maurice-Stam H, Slater O, Hartley B, Saeed P, Gajdosova E, van den Brekel MW, Balm AJM, Hol MLF, van Jaarsveld S, Kremer LCM, Ronckers CM, Mandeville HC, Pieters BR, Gaze MN, Davila Fajardo R, Strackee SD, Dunaway D, Smeele LE, Chisholm JC, Caron HN, Grootenhuis MA Merks JHM. Psychosocial well-being of long-term survivors of pediatric head-neck rhabdomyosarcoma. Pediatr Blood Cancer 2018:e27498.

[66]      van Asten WN, Beijneveld WJ, Pieters BR, van Lier HJ, Wijn PF Skotnicki SH. Assessment of aortoiliac obstructive disease by Doppler spectrum analysis of blood flow velocities in the common femoral artery at rest and during reactive hyperemia. Surgery 1991;109:633-639.

[67]      van de Wetering FT, Verleye L, Andreyev HJ, Maher J, Vlayen J, Pieters BR, van Tienhoven G Scholten RJ. Non-surgical interventions for late rectal problems (proctopathy) of radiotherapy in people who have received radiotherapy to the pelvis. Cochrane Database Syst Rev 2016;4:CD003455.

[68]      van der Meer MC, Bosman PAN, Pieters BR, Niatsetski Y, van Wieringen N, Alderliesten T Bel A. Sensitivity of dose-volume indices to computation settings in high-dose-rate prostate brachytherapy treatment plan evaluation. J Appl Clin Med Phys 2019;20:66-74.

[69]      van Heerden LE, Gurney-Champion OJ, van Kesteren Z, Houweling AC, Koedooder C, Rasch CR, Pieters BR Bel A. Quantification of image distortions on the Utrecht interstitial CT/MR brachytherapy applicator at 3T MRI. Brachytherapy 2015.

[70]      van Heerden LE, Houweling AC, Koedooder K, van Kesteren Z, van Wieringen N, Rasch CRN, Pieters BR Bel A. Structure-based deformable image registration: Added value for dose accumulation of external beam radiotherapy and brachytherapy in cervical cancer. Radiother Oncol 2017;123:319-324.

[71]      van Heerden LE, van Kesteren Z, Gurney-Champion OJ, Houweling AC, Koedooder K, Rasch CRN, Pieters BR Bel A. Image Distortions on a Plastic Interstitial Computed Tomography/Magnetic Resonance Brachytherapy Applicator at 3 Tesla Magnetic Resonance Imaging and Their Dosimetric Impact. Int J Radiat Oncol Biol Phys 2017;99:710-718.

[72]      van Heerden LE, van Wieringen N, Koedooder K, Rasch CRN, Pieters BR Bel A. Dose warping uncertainties for the accumulated rectal wall dose in cervical cancer brachytherapy. Brachytherapy 2017.

[73]      van Heerden LE, Visser J, Koedooder K, Rasch CRN, Pieters BR Bel A. Role of deformable image registration for delivered dose accumulation of adaptive external beam radiation therapy and brachytherapy in cervical cancer. Journal of Contemporary Brachytherapy 2018;10:542-550.

[74]      van Herten YRJ, van de Kamer JB, van Wieringen N, Pieters BR Bel A. Dosimetric evaluation of prostate rotations and their correction by couch rotations. Radiother Oncol 2008;88:156-162.

[75]      Vanneste BGL, Meijnen P, Hammerstein CSJ, Bijker N, van Os RM, Stalpers LJA Pieters BR. Postoperative brachytherapy for endometrial cancer using a ring applicator. Brachytherapy 2015;14:273-278.

 

 

                             

 

                             

 

                             

 

                             

 

                             

 

 

Research programmes

Prof. PhD C.R.N. Rasch (Image guided and physics application in the clinic)

Current research funding
  • KWF Kankerbestrijding