foto

MD PhD C. Verhamme

Position
Medical Specialist
Main activities
Education, Patient care, Research
Specialisation
Neurology, clinical neurophysiology
Focus of research

The Department of Neurology performs clinical and translational research within three research themes: infection & inflammation, cerebrovascular disorders, and movement disorders. The themes are imbedded in the nine translational research programs of Amsterdam Neuroscience, the research institute of neuroscience investigators in the Amsterdam area. All staff members of the Department of Neurology are involved in research and collaborate within Neuroscience Amsterdam, with other academic and non-academic hospitals, and with international research groups.


Infection and inflammation. We perform clinical translational research in the field of neurological infections & inflammation. We perform prospective clinical cohort studies, randomized clinical trials, and experimental research, combining our clinical expertise with groundbreaking, translational approaches using clinical data, human samples, next generation sequencing, in vitro techniques, and mouse models in the era's of bacterial meningitis & encephalitis, infections after stroke, septic encephalopathy, and inflammatory diseases of peripheral nerves and muscles.


Neuromuscular disorders. Our neuromuscular centre is a NFU (Nederlandse federatie van universitaire medische centra) and ERN (European reference network) accredited center for neuromuscular diseases in general, and motor neuron disease (ALS), idiopathic inflammatory myopathy, poliomyelitis, hereditary neuropathies and inflammatory polyneuropathies in particular. Inflammatory diseases of peripheral nerves and muscles are the main focus of the neuromuscular research-line, within the research area neuro-infection and inflammation. The immune mediated neuropathies (e.g. GBS, CIDP, MMN) and idiopathic inflammatory myopathies (e.g. dermatomysositis, IBM) and critical illness neuropathy and myopathy are the specific diseases of interest. This research is patient-driven and translational. More specific, clinical trials, cohort studies and studies investigating immunological and genomic characterization of nerve and muscle inflammation are performed. From these studies we try to arrive at clinically relevant biomarkers of disease activity and predictors of response. For the critical illness neuromyopathies early predictors for disease and outcome are sought.
Improving the diagnostic and therapeutic options available to these patients are thus the starting point. The prevention of nerve and muscle damage and the improvement of the regenerative capacity are some of the key areas for the near future.

I am combining my position at the clinical neurophysiology with a neuromuscular outpatient clinic. Research topics are improving the diagnostic process for inflammatory neuropathies (CIDP, MMN and vasculitis), inflammatory myopathies (myositis) and critical illness neuromyopathy. The emphasis is on neurophysiological techniques, including nerve and muscle ultrasound. In collaboration with the department of radiology we are studying several MRI techniques to improve imaging of peripheral nerves including the plexus. Currently, we are also working on the start of a large national multicenter randomized clinical trial, in which we will compare initial surgical treatment with initial cortiocosteroid injection for carpal tunnel syndrome.

 

Key publications
  • Witteveen Esther, Sommers Juultje, Wieske Luuk, Doorduin Jonne, van Alfen Nens, Schultz Marcus J., van Schaik Ivo N., Horn Janneke, Verhamme Camiel Diagnostic accuracy of quantitative neuromuscular ultrasound for the diagnosis of intensive care unit-acquired weakness: a cross-sectional observational study Annals of intensive care 2017;7 (1):40 [PubMed]
  • Witteveen Esther, Wieske Luuk, van der Poll Tom, van der Schaaf Marike, van Schaik Ivo N., Schultz Marcus J., Verhamme Camiel, Horn Janneke, de Beer Friso M., Bos Lieuwe D. J., Glas Gerie J., van Hooijdonk Roosmarijn T. M., Hoogendijk Arie J., Huson Mischa A., Schouten Laura R. A., Straat Marleen, van Vught Lonneke A., Wiewel Maryse A. Increased Early Systemic Inflammation in ICU-Acquired Weakness; A Prospective Observational Cohort Study Critical care medicine 2017;45 (6):972-979 [PubMed]
  • Verhamme Camiel, King Rosalind H. M., ten Asbroek Anneloor L. M. A., Muddle John R., Nourallah Michelle, Wolterman Ruud, Baas Frank, van Schaik Ivo N. Myelin and Axon Pathology in a Long-Term Study of PMP22-Overexpressing Mice Journal of neuropathology and experimental neurology 2011;70 (5):386-398 [PubMed]
  • Verhamme Camiel, van Schaik Ivo N., Koelman Johannes H. T. M., de Haan Rob J., de Visser Marianne The natural history of Charcot-Marie-Tooth type 1A in adults: a 5-year follow-up study Brain 2009;132 (Part 12):3252-3262 [PubMed]
  • Verhamme Camiel, de Haan Rob J., Vermeulen Marinus, Baas Frank, de Visser Marianne, van Schaik Ivo N. Oral high dose ascorbic acid treatment for one year in young CMT1A patients: a randomised, double-blind, placebo-controlled phase II trial BMC medicine 2009;7 (1):70 [PubMed]
All Publications
Research programmes

Prof. PhD I.N. van Schaik (Neuroinfection & inflammation)

MD PhD J. Horn (Neurology on the Intensive Care Unit)

Prof. MD PhD D. van de Beek (Neuroinfection and Inflammation)

MD PhD C. Verhamme (Promoties)

Current research funding
  • InFlectis BioScience