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P.L. Klarenbeek MD PhD

Position
Medical Specialist
Main activities
Patient care
Specialisation
Clinical Immunology and Rheumatology
Focus of research

Analysis of the T-cell receptor repertoire and B-cell receptor repertoire using next generation sequencing techniques

Key publications
  • Klarenbeek P. L., Remmerswaal E. B. M., ten Berge I. J. M., Doorenspleet M. E., van Schaik B. D. C., Esveldt R. E. E., Koch S. D., ten Brinke A., van Kampen A. H. C., Bemelman F. J., Tak P. P., Baas F., de Vries N. [=Niek], van Lier R. A. W. Deep sequencing of antiviral T-cell responses to HCMV and EBV in humans reveals a stable repertoire that is maintained for many years PLoS pathogens 2012;8 (9):e1002889 [PubMed]
  • Klarenbeek P. L., de Hair M. J. H., Doorenspleet M. E., van Schaik B. D. C., Esveldt R. E. E., van de Sande M. G. H., Cantaert T., Gerlag D. M., Baeten D., van Kampen A. H. C., Baas F., Tak P. P., de Vries N. [=Niek] Inflamed target tissue provides a specific niche for highly expanded T-cell clones in early human autoimmune disease Annals of the rheumatic diseases 2012;71 (6):1088-1093 [PubMed]
  • Klarenbeek Paul L., Tak Paul P., van Schaik Barbera D. C., Zwinderman Aeilko H., Jakobs Marja E., Zhang Zhuoli, van Kampen Antoine H. C., van Lier René A. W., Baas Frank, de Vries Niek Human T-cell memory consists mainly of unexpanded clones Immunology letters 2010;133 (1):42-48 [PubMed]
  • van Gisbergen Klaas P. J. M., Klarenbeek Paul L., Kragten Natasja A. M., Unger Peter-Paul A., Nieuwenhuis Marieke B. B., Wensveen Felix M., ten Brinke Anja, Tak Paul P., Eldering Eric, Nolte Martijn A., van Lier Rene A. W. The costimulatory molecule CD27 maintains clonally diverse CD8(+) T cell responses of low antigen affinity to protect against viral variants Immunity 2011;35 (1):97-108 [PubMed]
  • Doorenspleet M. E., Klarenbeek P. L., de Hair M. J. H., van Schaik B. D. C., Esveldt R. E. E., van Kampen A. H. C., Gerlag D. M., Musters A. [=Anne], Baas F., Tak P. P., de Vries N. [=Niek] Rheumatoid arthritis synovial tissue harbours dominant B-cell and plasma-cell clones associated with autoreactivity Annals of the rheumatic diseases 2014;73 (4):756-762 [PubMed]
All Publications
Research programmes

(Medewerkers buiten research programmes van afdeling Genoomanalyse)

Prof. N. de Vries MD PhD (“Adaptive immunomics”: Immunogenomic approaches to selectively monitor and target adaptive immune responses in immune-mediated inflammatory disease)

Current research funding
  • AMC
  • NIEUWE DEB IND
  • ZonMw (Vrijgesteld)