MD PhD R.A. Bem

Medical Specialist
Main activities
Patient care, Research
Focus of research

1) The acute respiratory distress syndrome (ARDS).
2) Acute lung injury in animals.
3) Severe pneumovirus (e.g. RSV) lung disease in humans and animals. 

In these fields, specific research topics include:
- cellular mechanisms of lung epithelial injury (e.g. pro-apoptotic pathways)
- pro-inflammatory responses (e.g. neutrophil activation)
- children, effect of age
- effect of mechanical ventilation
- cardiovascular and fluid effects

Studies under progress are translational projects including experiments with human patient material (ex vivo and in vitro) and animal research.

Key publications
  • Bem Reinout A., Domachowske Joseph B., Rosenberg Helene F. Animal models of human respiratory syncytial virus disease American journal of physiology. Lung cellular and molecular physiology 2011;301 (2):L148-L156 [PubMed]
  • Cortjens Bart, de Boer Onno J., de Jong Rineke, Antonis Adriaan Fg, Sabogal Piñeros Yanaika S., Lutter René, van Woensel Job Bm, Bem Reinout A. Neutrophil extracellular traps cause airway obstruction during respiratory syncytial virus disease Journal of pathology 2016;238 (3):401-411 [PubMed]
  • Bem Reinout A., van Woensel Job B. M., Lutter Rene, Domachowske Joseph B., Medema Jan Paul, Rosenberg Helene F., Bos Albert P. Granzyme A- and B-Cluster Deficiency Delays Acute Lung Injury in Pneumovirus-Infected Mice Journal of immunology (Baltimore, Md. 2010;184 (2):931-938 [PubMed]
  • Bem Reinout A., Bos Albert P., Wösten-van Asperen Roelie M., Bruijn Martijn, Lutter Rene, Sprick Martin R., van Woensel Job B. M. Potential Role of Soluble TRAIL in Epithelial Injury in Children with Severe RSV Infection American journal of respiratory cell and molecular biology 2010;42 (6):697-705 [PubMed]
  • Bem Reinout Alexander, van Woensel Job B. M., Bos Albert P., Koski Amy, Farnand Alex W., Domachowske Joseph B., Rosenberg Helene F., Martin Thomas R., Matute-Bello Gustavo Mechanical ventilation enhances lung inflammation and caspase activity in a model of mouse pneumovirus infection American journal of physiology. Lung cellular and molecular physiology 2009;296 (1):L46-L56 [PubMed]
All Publications