- Bakermans Adrianus J., Abdurrachim Desiree, van Nierop Bastiaan J., Koeman Anneke, van der Kroon Inge, Baartscheer Antonius, Schumacher Cees A., Strijkers Gustav J., Houten Sander M., Zuurbier Coert J., Nicolay Klaas, Prompers Jeanine J. In vivo mouse myocardial P-31 MRS using three-dimensional image-selected in vivo spectroscopy (3D ISIS): technical considerations and biochemical validations NMR in biomedicine 2015;28 (10):1218-1227 [PubMed]
- Bakermans Adrianus J., Abdurrachim Desiree, Moonen Rik P. M., Motaal Abdallah G., Prompers Jeanine J., Strijkers Gustav J., Vandoorne Katrien, Nicolay Klaas Small animal cardiovascular MR imaging and spectroscopy Progress in nuclear magnetic resonance spectroscopy 2015;88-89:1-47 [PubMed]
- Bakermans Adrianus J., van Weeghel Michel, Denis Simone, Nicolay Klaas, Prompers Jeanine J., Houten Sander M. Carnitine supplementation attenuates myocardial lipid accumulation in long-chain acyl-CoA dehydrogenase knockout mice Journal of inherited metabolic disease 2013;36 (6):973-981 [PubMed]
- Bakermans Adrianus J., Dodd Michael S., Nicolay Klaas, Prompers Jeanine J., Tyler Damian J., Houten Sander M. Myocardial energy shortage and unmet anaplerotic needs in the fasted long-chain acyl-CoA dehydrogenase knockout mouse Cardiovascular research 2013;100 (3):441-449 [PubMed]
- Bakermans Adrianus J., Geraedts Tom R., van Weeghel Michel, Denis Simone, João Ferraz Maria, Aerts Johannes M. F. G., Aten Jan, Nicolay Klaas, Houten Sander M., Prompers Jeanine J. Fasting-induced myocardial lipid accumulation in long-chain acyl-CoA dehydrogenase knockout mice is accompanied by impaired left ventricular function Circulation. Cardiovascular imaging 2011;4 (5):558-565 [PubMed]
MEng PhD A.J. Nederveen (Applied MR Physics)
This research line focusses on designing and validating quantitative MRI methods, mainly in the field of cardiovascular, muscular and oncologic imaging.
MRI of the arterial wall is a promising technique allowing plaque phenotyping. Plaque segmentation based on MRI data is however still cumbersome because of the lack of a normalized intensity unit for MRI, motion artefacts, and the rather low (anisotropic) resolution. We are developing a pipeline for quantitative plaque analysis on MRI (T1, T2, ADC) that will allow clinical implementation of high resolution MRI based carotid plaque phenotyping in patients at increased cardiovascular risk. Carotid MR is further improved by designing MR methods to accurately measure wall shear stress (WSS) patterns in 3D.
Arterial spin labeling (ASL) is a non-invasive magnetic resonance imaging (MRI) technique for the quantification of cerebral perfusion. ASL does not involve intravenous injection of contrast agents or exposure to ionizing radiation. It is an attractive tool in the pediatric population and in longitudinal studies with repeated measurements. Previously our group studied ASL in a group of children suffering from sickle cell disease. Abnormal perfusion patterns may predict silent infarctions in this patient population. This research is presently being continued in a larger group of adult patients. ASL is also applied in neurodegenerative diseases such as Alzheimer’s disease, since perfusion deficits detected by ASL are believed to be associated with disease progression.
Measuring the diffusion directional anisotropy enables reconstructions of local muscle fiber bundle orientations, which can be combined to provide three dimensional visualizations of muscle architecture. We aim to develop anatomical MRI and DTI protocols to advance tools for muscle segmentation and quantification of muscle specific architectural parameters. The combination of muscle DTI and MR elastography delivers a unique window on muscle pathology. Clinical applications comprise the imaging of the pelvic floor, the heart muscle, forearm muscles and nerves, upper leg muscles (postpolio syndrome) and the gluteus maximus muscle.
Quantitative imaging also bears promise in the field of oncology. We have built a strong program for evaluating and predicting tumour response based on functional imaging. We pioneered the benefit of 7T high field imaging for probing the metabolic constituents of tumour tissue.
PhD J.M. den Harder
MEng L. Voskuilen